• Journal of Nutrition and Health
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• 제55권1호
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• pp.1-9
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• 2022

In the past few decades, great progress has been made on understanding the interaction between nutrition and health status. But despite this wealth of knowledge, health problems related to nutrition continue to increase. This leads us to postulate that the continuing trend may result from a lack of consideration for intra-individual biological variation on dietary responses. Precision nutrition utilizes personal information such as age, gender, lifestyle, diet intake, environmental exposure, genetic variants, microbiome, and epigenetics to provide better dietary advices and interventions. Recent technological advances in the artificial intelligence, big data analytics, cloud computing, and machine learning, have made it possible to process data on a scale and in ways that were previously impossible. A big data platform is built by collecting numerous parameters such as meal features, medical metadata, lifestyle variation, genome diversity and microbiome composition. Sophisticated techniques based on machine learning algorithm can be used to integrate and interpret multiple factors and provide dietary guidance at a personalized or stratified level. The development of a suitable machine learning algorithm would make it possible to suggest a personalized diet or functional food based on analysis of intra-individual metabolic variation. This novel precision nutrition might become one of the most exciting and promising approaches of improving health conditions, especially in the context of non-communicable disease prevention.

• Advances in Computational Design
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• 제7권2호
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• pp.153-171
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• 2022

The present study aimed to find a way to create forms that can simultaneously meet several architectural requirements by applying generative design methods specifically focused on cellular automata. In other words, it is tried to find various forms of architecture that all have common features. Because of the useful features of cellular automata, we decided to use it to generate various forms, but make a relation between the discrete nature of cellular automata and the continuous nature of architecture, was the major problem of our project. To achieve this goal, three consecutive stages were designed. In the first stage, independent variables including the location of the building, the height of the building, and the building area were considered as the inputs of the model. In the second stage, after locating the building, the building's main shell was designed as a hidden geometry for the cellular automata and then the cellular automata were determined based on this shell. The main result of this research is establishing a logical relationship between the discrete geometry of the cellular automata and the continuous search space such that it creates various optimized forms. Although we specify the site plan of this project at Iran-Tehran, this research can be generalized to various design sites as well as different projects, allowing the architectsto alter the cell dimensions, cell density, etc., based on their opinion and project needs.

• Mycobiology
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• 제49권6호
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• pp.559-581
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• 2021

The coastal marine ecosystems of Vietnam are one of the global biodiversity hotspots, but the biodiversity of marine fungi is not well known. To fill this major gap of knowledge, we assessed the genetic diversity (ITS sequence) of 75 fungal strains isolated from 11 surface coastal marine and deeper waters in Nha Trang Bay and Van Phong Bay using a culture-dependent approach and 5 OTUs (Operational Taxonomic Units) of fungi in three representative sampling sites using next-generation sequencing. The results from both approaches shared similar fungal taxonomy to the most abundant phylum (Ascomycota), genera (Candida and Aspergillus) and species (Candida blankii) but were different at less common taxa. Culturable fungal strains in this study belong to 3 phyla, 5 subdivisions, 7 classes, 12 orders, 17 families, 22 genera and at least 40 species, of which 29 species have been identified and several species are likely novel. Among identified species, 12 and 28 are new records in global and Vietnamese marine areas, respectively. The analysis of enzyme activity and the checklist of trophic mode and guild assignment provided valuable additional biological information and suggested the ecological function of planktonic fungi in the marine food web. This is the largest dataset of marine fungal biodiversity on morphology, phylogeny and enzyme activity in the tropical coastal ecosystems of Vietnam and Southeast Asia. Biogeographic aspects, ecological factors and human impact may structure mycoplankton communities in such aquatic habitats.

• Journal of Microbiology and Biotechnology
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• 제32권12호
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• pp.1497-1505
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• 2022

Recently, the concept of personalized nutrition has been developed, which states that food components do not always lead to the same metabolic responses, but vary from person to person. Although this concept has been studied based on individual genetic backgrounds, researchers have recently explored its potential role in the gut microbiome. The gut microbiota physiologically communicates with humans by forming a bidirectional relationship with the micronutrients, macronutrients, and phytochemicals consumed by the host. Furthermore, the gut microbiota can vary from person to person and can be easily shifted by diet. Therefore, several recent studies have reported the application of personalized nutrition to intestinal microflora. This review provides an overview of the interaction of diet with the gut microbiome and the latest evidence in understanding the inter-individual differences in dietary responsiveness according to individual baseline gut microbiota and microbiome-associated dietary intervention in diseases. The diversity of the gut microbiota and the presence of specific microorganisms can be attributed to physiological differences following dietary intervention. The difference in individual responsiveness based on the gut microbiota has the potential to become an important research approach for personalized nutrition and health management, although further well-designed large-scale studies are warranted.

• BMB Reports
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• 제55권12호
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• pp.621-626
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• 2022

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may be intimately related to neurodegenerative diseases, including ALS. Acid sphingomyelinase (ASM), a sphingolipid-metabolizing enzyme, is considered an important mediator of neurodegenerative diseases. Herein, we show that ASM activity increases in samples from patients with ALS and in a mouse model. Moreover, genetic inhibition of ASM improves motor function impairment and spinal neuronal loss in an ALS mouse model. Therefore, these results suggest the role of ASM as a potentially effective target and ASM inhibition may be a possible therapeutic approach for ALS.

• ALGAE
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• 제37권4호
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• pp.281-291
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• 2022

Quantifying the abundance of Chattonella species is necessary to effectively manage the threats from ichthyotoxic raphidophytes, which can cause large-scale mortality of aquacultured fish in temperate waters. The identification and cell counting of Chattonella species have been conducted primarily on living cells without fixation by light microscopy because routine fixatives do not retain their morphological features. Species belonging to the Chattonella marina complex, including C. marina and C. marina var. ovata, had high genetic similarities and the lack of clear morphological delimitations between the species. To estimate the abundance of C. marina complex in marine plankton samples, we developed a protocol based on the droplet digital polymerase chain reaction (ddPCR) assay, with C. marina complex-specific primers targeting the internal transcribed spacer (ITS) region of the rDNA. Cell abundance of the C. marina complex can be determined using the ITS copy number per cell, ranging from 25 ± 1 for C. marina to 112 ± 7 for C. marina var. ovata. There were no significant differences in ITS copies estimated by the ddPCR assay between environmental DNA samples from various localities spiked with the same number of cells of culture strains. This approach can be employed to improve the monitoring efficiency of various marine protists and to support the implementation of management for harmful algal blooms, which are difficult to analyze using microscopy alone.

• 대한두경부종양학회지
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• 제39권1호
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• pp.1-9
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• 2023

Technological advancement in human genome analysis and ICT (information & communication technologies) brought 'precision medicine' into our clinical practice. Precision medicine is a novel medical approach that provides personalized treatments tailored to each individual by precisely segmenting patient populations, based on robust data including a person's genetic information, disease information, lifestyle information, etc. Precision medicine has a potential to be applied to treating a range of tumors, in addition to non-small cell lung cancer, in which precision oncology has been actively practiced. In this article, we are reviewing precision medicine in head and neck cancer (HNC) with focus on tumor agnostic biomarkers and treatments such as NTRK, MSI-H/dMMR, TMB-H and BRAF V600E, all of which were recently approved by U.S. Food and Drug Administration (FDA).

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2125-2138
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• 2023

The printed circuit heat exchanger (PCHE) with airfoil fins has the benefits of high compactness, high efficiency and superior heat transfer performance. A novel multi-objective optimization approach is presented to design the airfoil fin PCHE in this paper. Three optimization design variables (the vertical number, the horizontal number and the staggered number) are obtained by means of dimensionless airfoil fin arrangement parameters. And the optimization objective is to maximize the Nusselt number (Nu) and minimize the Fanning friction factor (f). Firstly, in order to investigate the impact of design variables on the thermal-hydraulic performance, a parametric study via the design of experiments is proposed. Subsequently, the relationships between three optimization design variables and two objective functions (Nu and f) are characterized by an improved particle swarm optimization-backpropagation artificial neural network. Finally, a multi-objective optimization is used to construct the Pareto optimal front, in which the non-dominated sorting genetic algorithm II is used. The comprehensive performance is found to be the best when the airfoil fins are completely staggered arrangement. And the best compromise solution based on the TOPSIS method is identified as the optimal solution, which can achieve the requirement of high heat transfer performance and low flow resistance.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2022년도 추계학술대회
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• pp.211-211
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• 2022

Amaranth is a nutritious and broadly adapted seed crop in high demand around the world. A preliminary approach for understanding the genetics of amaranth resources entails a morphologic characterization, which can provide the basis for breeding the first variety in Korea, leading to satisfying the needs of farmers and consumers. Therefore, this study aimed to evaluate the phenotypic characteristics of ten genetic amaranth accessions for the selection of outstanding accessions in terms of yield and grain quality. A randomized complete block design was used, with fifteen replications for each accession under field conditions. Five quantitative and three qualitative descriptors were evaluated with descriptive analysis. The results showed that the accessions with plant heights smaller than the average (>112.7 cm) presented lower yields and smaller seed sizes, thus decreasing the grain quality. The cluster analyses established groups of accessions with good yields (>30.1 g of seeds per plant) and stable morphological characteristics. Based on yield and morphological descriptors, the proposed selection index indicated four accessions as potential parents for amaranth breeding programs in Kora.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2023년도 춘계학술대회
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• pp.156-156
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• 2023

Salinity is a major abiotic stress that limits rice productivity in many regions of the world. In order to develop salt stress tolerant rice plants, genetic engineering is a promising approach. We characterized the molecular function of rice C3H2C3 as a really interesting new gene (RING). Oryza sativa RING finger protein H2-3 (OsRFPH2-3) was highly expressed in 100 mM NaCl. To identify the localization of OsRFPH2-3, we fused vectors that include C-terminal GFP protein (35S;;OsRFPH2-3-GFP). OsRFPH2-3 was expressed in the nucleus in rice protoplasts. An in vitro ubiquitin assay demonstrated that OsRFPH2-3 possessed E3-ubiquitin ligase activity. However, the mutated OsRFPH2-3 were not possessed any E3-ubiquitin ligase activity. Under salinity conditions, OsRFPH2-3-overexpressing plants exhibited higher chlorophyll, proline, SOD, POD, CAT, and soluble sugar contents and lower H₂O₂ accumulation than wild-type plants, supporting transgenic plants with enhanced salinity tolerance phenotypes. OsRFPH2-3-overexpressing plants exhibited low Na+ accumulation and Na+/K+ ratios in their roots. Theses results suggest that overexpression of OsRFPH2-3 can make plant insensitivity about salinity conditions.