• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2935-2940
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• 2016

Breast cancer is the most frequent type of cancer diagnosed among women worldwide and also in Thailand. Estrogen and estrogen receptors exert important roles in its genesis and progression. Several cytokines have been reported to be involved in the microenvironment that promotes distant metastasis via modulation of immune and inflammatory responses to tumor cells. Estrogen receptor genetic polymorphisms and several cytokines have been reported to be associated with breast cancer susceptibility and aggressiveness. To investigate roles of genetic polymorphisms in estrogen receptor alpha (ESR1) and interleukin 6 (IL6), breast cancer patients and control subjects were recruited from the Division of Head, Neck and Breast Surgery (Siriraj Hospital, Bangkok, Thailand). Polymorphisms in ESR1 (rs3798577) and IL6 (rs1800795 and rs1800797) were evaluated by real-time PCR in 391 breast cancer patients and 79 healthy controls. Associations between genetic polymorphisms and clinicopathological data were determined. There was no association between genetic polymorphisms and breast cancer susceptibility. However the ESR1 rs3798577 CT genotype was associated with presence of lymphovascular invasion (OR=2.07, 95%CI 1.20-3.56, p=0.009) when compared to the TT genotype. IL6 rs1800795 CC genotype was associated with presence of extranodal extension (OR= 2.30, 95%CI 1.23-4.31, p=0.009) when compared to the GG genotype. Survival analysis showed that IL6 rs1800797 AG or AA genotypes were associated with lower disease-free survival. These findings indicate that polymorphisms in ESR1 and IL6 contribute to aggressiveness of breast cancer and may be used to identify high risk patients.

• Journal of Korean Philosophical Society
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• v.141
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• pp.133-166
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• 2017

The main aim of this paper is to show why justice is based on convention, not nature, in David Hume. Most philosopher, since Aristotle, have considered justice in relation to distribution. This understanding of justice continues up to modern times, and is handled especially in relation to ownership or private property in modern times. In modern times, private property is regarded as an absolute right that should not be violated in any case. Hume identifies this private property with justice. The absolute inviolability of private property is equivalent to never violate to justice. Hume is concerned with the question of where this justice originate. In other words, Hume is not concerned with the Kantian justification of justice, but rather with the psychological discussion of the genesis process of the idea of justice. Hume's answer is that "social utility" is its origin. Public societies are necessary conditions for human being. In other words, if public societies do not exist, humans can not exist. How then can a public society, which is a prerequisite for human being, exist or can be maintained? According to Hume, it is maintained by means of justice. So where is the ground for justice? Hume argues that the basis of justice is not nature, but human conventions. Man accepts justice tacitly and by doing so man can maintains his being. This is a rough insight of Hume. Hume uses a wide variety of concepts to carry out his argument. In this paper, we focus on how the idea of justice in human mind, based on these various concepts presented by Hume, is formed.

• Korean Journal of Soil Science and Fertilizer
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• v.19 no.3
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• pp.205-210
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• 1986

A soil micromorphological study of clayey terrace soils in Yeongnam area was carried out to investigate the soil genetic features and to distinguish the soil parent materials. Dominant plasmic fabrics in the terrace soils were vosepic, mosepic, insepic, and masepic of sepic fabrics but the Geugrag and Upyeong in Yeongil sequence have an asepic fabrics. Embedded grain cutans in the terrace soils were characterized by having porphyroskelic related distribution. Among pedological features of the B horizons of the terrace soils, the argillic cutans of ferriargillans and glaebules of manganiferrous concretions were the dominant in mineralogical composition, and the papules are abundant in the most terrace soils indicating that the soils are generally old. The substrata of the Bancheon in Yeongcheon and Upyeong in Yeongil area were so different from the terrace deposits in plasmic fabrics that these soils were believed to be composed of bisequum profiles. Because of having the free grain cutans, it was considered that the substrata of Bancheon in Yeongcheon and Upyeong in Yeongil area might have a period of soil formation before deposition of the terrace materials.

• Economic and Environmental Geology
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• v.52 no.3
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• pp.213-221
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• 2019

The Wugang banded iron formation (BIF) is located within the Taihua complex at the southern margin of the North China Craton (NCC). In this study, we analyzed major elements and rare-earth elements in iron ores from the Wugang BIF, to study the type of BIFs and their formation mechanism in combination with previously-published data from the literature. We found that the iron ores from the Wugang BIF display two types of banding textures, which can be described as weak banding or no banding. The samples are composed of coarse-grained magnetite, quartz, pyroxene, and amphibole. Based on our geochemical results, mixing of a hydrothermal fluid with sea water led to the precipitation of the Wugang BIF, and there is evidence of crustal contamination. These results, combined with previous literature data, almost all of the iron ores lack Ce anomalies, though some samples show negative Ce anomalies. Our results indicate that the Wugang BIF was formed in a dominantly reducing environment, although the surfaces were relatively oxidized. Geochemical evidence suggests that the Wugang BIF iron ores were formed in a near-shore continental-shelf environment or in a back-arc basin. The BIF is known as interbedded with migmatite, amphibole gneiss, minor quartz and marble, which indicating lack of volcanic materials input. This study, combined with previous results on geochemical interpretation of related wall rock of Wugang BIF, demonstrated that Wugang BIF belongs to Superior-type BIF.

• Korean Journal of Heritage: History & Science
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• v.37
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• pp.151-168
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• 2004

The Mireuk Temple Stone pagoda is the largest scale of the existing Stone Pagoda in Korea. A research until now postulates that the Stone pagoda at Mireuk Temple site is composed of nine stories total. However it does not have any records of the detail, dimension, and related methods, etc, even though it is a tectonically large scale building. Only one source of the description is based upon a story which is a sort of Korean myth or traditional story (Samkukyousa, Mu dynasty), although a historical description from a myth or a story is a polemical issue and still needed research in order to prove the truth. One of the ways to make a proof of the truth is an architectural research from the typology of the plane. The types of the plane are differentiated from each era. Therefore, the typology of the plane presents a reason or a proof for the age of the pagoda. Furthermore, the typology of the plane is crucial part in the research of the historical style and it could help the historical style of the Mireuk temple stone pagoda. Research until now shows that the Mireuk temple stone pagoda is the genesis of the stone pagoda shaped after wooden one. It is impossible to find any previous one from the stone pagoda at Mireuk Temple site in Korea. So it is easier to find any previous example from the history of China because Buddhist pagoda-most pagodas are something to do with Buddhism-in Korea is introduced by India via China. This research presents the periodical variation of stone and brick pagoda in both countries. It concludes that the Mireuk temple stone pagoda has $7^{th}$ century's plane type.

• Management & Information Systems Review
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• v.38 no.1
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• pp.83-101
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• 2019

Blockchain is considered as an innovative technology along with Artificial Intelligence, Big Data, and Internet of Things. However, since the inception of the genesis of blockchain technology, the cryptocurrency Bitcoin, the technology is not utilized widely, not let alone disruptive applications. Most of the blockchain research deals with the cryptocurrency, general descriptions of the technology such as trend, outlook of the technology, explanation of component technology, and so on. There are no killer applications like Facebook or Google, of course. Reflecting on the slow adoption by businesses, we wanted know about the current status of the research on blockchain in Korea. The main purpose of this paper is to help business practitioners to identify the application of blockchain to enhance the competitiveness of their organization. To do that, we first use the framework by Iansiti et al (2017) and categorize the blockchain related articles published in Korea according to the framework. This is to provide a benchmark or cases of other organizations' adoption of blockchain technology. Second, based on the value proposition of blockchain applications, we suggest evolutionary paths for adopting them. Third, from the demand pull perspective of technology adoption for innovation, we propose applicable areas where blockchain applications can be introduced. Fourth, we use the value chain model to find out the appropriate domains of blockchain applications in the corporate value chains. And the five competitive forces models is adopted to find ways of lowering the power of forces by incorporating blockchain technology.

• Korean Journal of Mineralogy and Petrology
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• v.34 no.1
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• pp.69-81
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• 2021

The exposed rocks in the Zacatecas state include mainly Mesozoic sedimentary and volcanic, Cenozoic volcanic and plutonic rocks. Paleozoic metamorphic rocks found in the northwestern portion of the state are considered as the most ancient rocks. These rocks correspond to the Caopas Formation which underlays the Later Paleozoic Rodeo Formation. The Mesozoic sequences are represented by a marine sedimentary sequence of the Later Triassic and the red beds of the Triassic-Jurassic Nazas Formation. The marine sediments of the Upper Jurassic overlay the Nazas Formation or metamorphic rocks from the Paleozoic. The Cretaceous sequences comprises marine sedimentary rocks in the north and northeast, and a volcanosedimentary set in the center and southeast. The Cenozoic is represented by volcanic nondifferentiated rocks, intrusive igneous rocks of acid and intermediate composition, and continental conglomerates with evaporitic sediments. The Quarternary sequences includes basalts, piedmont deposits, alluviums and occasionally, layers of evaporites and saltpeter. Furthermore, a great diversity of mineral deposits of both metallic and nonmetallic types occur in Zacatecas state. The rocks composing these deposits are extremely varied and include formations from Paleozoic to Tertiary. The mineralization age of ore deposits corresponds to the Tertiary in approximately 90%, and their genesis is mainly considered as epigenetic.

• Journal of the Korean earth science society
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• v.43 no.1
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• pp.23-29
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• 2022

Although tropical cyclones with wind speeds weaker than 17 ms^-1 (weak tropical cyclones: WTCs) can cause significant damage, particularly over the Seoul metropolitan area, only a few studies have focused on WTC activity over South Korea. In this study, we found that WTC activity is likely associated with the Pacific Decadal Oscillation (PDO). During the negative phases of the PDO, landfall frequency of WTCs increased significantly compared to the positive phases at 95% confidence level. When related to the negative phases of the PDO, a positive relative vorticity anomaly is found in the northern sector of the western North Pacific while a negative relative vorticity anomaly and enhanced vertical wind shear prevail in the southern sector of the WNP. These factors are favorable for the northward shift of the genesis location of tropical cyclones on average, thereby reducing the total lifetime of WTCs. Moreover, a high-pressure anomaly over the Japanese islands would shift a tropical cyclone track westward in addition to the landfall location. Consequently, the effects of the topographical friction and the Yellow Sea Bottom Cold Water on a tropical cyclone may increase. These conditions could result in a weaker lifetime maximum intensity and landfall intensity, ultimately resulting in WTCs becoming more frequent over South Korea during the negative phases of the PDO.

• Economic and Environmental Geology
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• v.55 no.5
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• pp.465-475
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• 2022

The seafloor massive sulfide deposits are important mineral resources for base and precious metals, and their ore genesis and metal contents are mainly controlled by wall-rock leaching process and/or magmatic volatile input from the underlying magma chamber. However, the contribution of two different metal sources to the seafloor hydrothermal mineralization significantly varies in diverse geological settings and thus still remains controversial. In this review, mineralogical and geochemical characteristics of SMS deposits from mid-ocean ridges (MORs) and volcanic arcs were investigated to understand the contribution from different metal sources and to suggest future challenges that need to be addressed. As a result, the genetic occurrences of enargite and cubanite, galena and barite indicate the effects of magmatic input and water-rock interaction, respectively. Also, the distributional behaviors of Co, As, and Hg in pyrite and FeS content of sphalerite could be useful empirical indicators to discriminate the significant roles of different metal sources between MOR and Arc settings. To date, as most studies have focused on sulfide samples recovered from the seabed, further studies on magmatic sulfides and sulfate minerals are required to fully understand the genetic history of SMS deposits.

• Journal of Korean Philosophical Society
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• no.93
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• pp.231-260
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• 2011

Simondon's theory of individuation and methodology of transduction presents a possibility of contemporary natural philosophy and a new perspective about the relation between philosophy and sciences. According to Simondon's anti-substantial viewpoint, being, as a metastable system charged with potential energy, complicates itself with quantum leaps transversing successive equilibriums. Individuation is the becoming of phases of being which transits from preindividual state to individuated states. Physical individuation as a paradigmatic model of individuation in general demonstrates not only insufficiency of form-oriented hylomorphism, but also spontaneous formational capacity of matter and reality of energetic relational operation immanent in matter. Genesis of a individual (structure or form) occurs as a resolution of the disparation between orders of magnitude, that is, the difference of potentials immanent in nature through the internal resonance, communication by information, transductive relation between the opposites. I'm trying to show that Simondon revives 'physis' of ancient natural philosophy by his own transductive applications of contemporary physics' conceptions, and therefore suggest a new non-reductive materialism. Especially Simondon's 'transduction' which is neither induction, deduction, nor dialectic, but an original ontological process and a peculiar method of thinking, I think, is worthy of note in order to construct network of knowledge and inter-relation between various sciences.