• 약학회지
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• 제48권4호
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• pp.219-225
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• 2004

The present investigation was undertaken to examine the anticancer activity of the methanol extract from Houttuynia cordata on ICR mouse with induced abdominal cancer and L1210 cancer cells. When the methanol extract of Houttuynia cordata (10∼200 $\mu\textrm{g}$/$m\ell$) was administered orally to ICR mouse with abdominal cancer, 47.8% of the best life prolonging effect was obtained. In case of cytotoxicity study (inhibition of cell proliferation) of Houttuynia cordata extract against L1210 cells, $IC_{50}$/ was found to be 62.8 $\mu\textrm{g}$/$m\ell$. In contrast to such considerable toxicity against cancer cell line, the toxicity demonstrated by the identical extract against normal lymphocytes was very meagre as shown to be < 5% compared with 86.5% in case of L1210 cells at the same condition. To get an insight into the reaction mechanism undelying the anticancer activity, $O_2$ion quantity and antioxidant enzyme activities such as superoxide dismiutase (SOD) and glutathione peroxidase (GPx) of L1210 cells in the presence of Houttuynia cordata extract were measured. The increased values of SOD and GPx enzyme activities in addition to the augmented generation of $O_2$ ion in L1210 cells implied that the reactive oxygen species induding $O_2$ion which were presumably induced by Houttuynia cordata extract might have participated in the process of L1210 cells cytotoxicity.

• 산업경영시스템학회지
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• 제32권3호
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• pp.110-117
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• 2009

This paper introduces a case study for efficient generation of production schedules in a tube manufacturing system. The considered scheduling problem consists of two sub problems : lot sizing for a job and Job sequencing. Since these problems require simulation optimization in which the performance measures are obtained by simulation execution, the trade-off between solution quality and computation time is an important issue. In this study, the optimal lot size for every product type is determined from simulation experiments. Then, target production quantity for each product type is transformed to several jobs such that a Job consists of determined lot size. To obtain the good solution for a Job sequence in a reasonable time, a number of alternatives are generated from heuristic rules developed by intuition and analysis of the considered system, and a job sequence is selected from simulation experiments.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4733-4739
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• 2015

Background: Oral cancer is the most common cancer among men and second only to breast cancer among women in Pakistan. For the effective control and prevention of oral cancer, Pakistan needs to recognize the importance of research and generation of the evidence-base which can inform policy making and planning and implementation of intervention programs. The objective of this review was to quantify oral cancer research output in Pakistan. Materials and Methods: A systematic electronic search in "Medline", "ISI-Web of Science" and "Pakmedinet", supplemented by a Google search, was carried out in January and February, 2014, to identify literature from Pakistan relevant to oral cancer. The selection of publications for the review was carried out according to preset criteria. Data were recorded and analyzed using Microsoft Excel. Results: A total of 166 publications comprising 62 case series, 36 cross sectional, 31 case control, 10 basic laboratory research, eleven reviews and two trials, were included in this review. Some 35 % of the publications focused on risk factors for oral cancer. COMSATS Institute of Information Technology was the institution with the highest contribution. Conclusions: There is a lack of research in the field of oral cancer research in Pakistan. Focused efforts should be put in place to improve both quality and quantity of oral cancer research in the country.

• 한국신뢰성학회지:신뢰성응용연구
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• 제5권2호
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• pp.261-272
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• 2005

In evaluation of electronic reliability on the PCB(Printed Circuit Board), electrochemical migration is one of main test objects. The phenomenon of electrochemical migration occurs In the environment of the high humidity and the high temperature under bias through a continuous aqueous electrolyte. In this paper, the generating mechanism of electrochemical migration is investigated by using water droll acceleration test under various waters. The waters used in the water drop test are city water, distilled water and ionic water. It found that the generated velocity of electrochemical migration depended on the temperature of water and the electrolyte quantity which included in the various waters.

• 전기전자학회논문지
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• 제18권1호
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• pp.159-164
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• 2014

본 논문에서는 하나의 태양광 모듈에 대한 전력 변환기인 마이크로 컨버터의 개발을 목표로 하고 있다. 중앙집중형 태양광발전시스템이 부분적인 음영에 의해서 성능저하가 발생하는데 반해 단일 태양광모듈의 전력변환기는 태양광모듈의 발전량을 최대화 할 수 있다. 전력 변환기는 지속적으로 각 모듈의 최대 전력 점을 추적하여 태양 광 발전 시스템의 에너지 출력을 증가시킨다. 태양광 전력 변환기의 반도체 스위치 및 외부 장치의 수를 최소화하고, 또한 동기 정류기를 사용하여, 320W급의 태양광 마이크로 컨버터를 개발하였으며, 시뮬레이션과 실험에 적용하여 효율성을 검증하였다.

• 한국분무공학회지
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• 제8권1호
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• pp.9-15
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• 2003

The liquid phase LPG injection (LPLI) system is considered as one of the next generation fuel supply systems for LPG, vehicles, since it can accomplish the higher power, higher efficiency, and lower emission characteristics than the existing mixer type fuel supply system. However, during the injection of liquid LPG fuel into the inlet duct of an engine, a large quantity of heat is extracted due to evaporation of fuel. A problem is that the moisture in the air freezes around the outlet of a nozzle, which is called icing Phenomenon. It may cause damage to the outlet nozzle of an injector. The frozen ice deposit detached from the nozzle also may cause a considerable damage to the inlet valve or valve seat. In this work, the experimental investigation of the icing phenomenon was carried out. The results showed that the icing phenomenon and process were mainly affected by humidity of inlet air instead of the air temperature in the inlet duct. Also, it was observed that the icing occurs first in the inlet of a nozzle, and grows considerably at the upper part of the nozzle inlet and the opposite side of the nozzle entrance. An LPG fuel, mainly consisting of butane, has lower latent heat of vaporization than that of propane, which is an advantage in controlling the icing phenomenon.

• 한국전기전자재료학회논문지
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• 제15권7호
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• pp.576-582
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• 2002

Nonvolatile semiconductor memory devices with reoxidized nitrided oxide(RONO) gate dielectrics were fabricated, and nitrogen distribution and bonding species which contribute to memory characteristics were analyzed. Also, memory characteristics of devices depending on the anneal temperatures were investigated. The devices were fabricated by retrograde twin well CMOS processes with $0.35\mu m$ design rule. The processes could be simple by in-situ process in growing dielectric. The nitrogen distribution and bonding states of gate dielectrics were investigated by Dynamic Secondary Ion Mass Spectrometry(D-SIMS), Time-of-Flight Secondary Ion Mass Spectrometry(ToF-SIMS), and X-ray Photoelectron Spectroscopy(XPS). As the nitridation temperature increased, nitrogen concentration increased linearly, and more time was required to form the same reoxidized layer thickness. ToF-SIMS results showed that SiON species were detected at the initial oxide interface which had formed after NO annealing and $Si_2NO$ species within the reoxidized layer formed after reoxidation. As the anneal temperatures increased, the device showed worse retention and degradation properties. It could be said that nitrogen concentration near initial interface is limited to a certain quantity, so the excess nitrogen is redistributed within reoxidized layer and contribute to electron trap generation.

• 대한기계학회논문집B
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• 제33권12호
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• pp.947-951
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• 2009

LED has the merits of high reliability, semi-permanent life, rapid-response and its small size for use as light source of head lamp. But the dependence of its performance and life on temperature affect on its practical use. Which dependence makes problem when the LED is heated up to a higher temperature level by self-generation of heat, due to "highly integration" to get enough quantity of light. To solve this problem, effective cooling system is needed that consider conduction, convection and radiation. This study points out the limits of natural convection cooling system and propose of forced convection with heat sink. Also, it describes a correlation between heat sink area and fluid velocity using numerical analysis to optimize the cooling system.

• 한국분무공학회지
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• 제19권4호
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• pp.204-210
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• 2014

Experimental study was conducted to investigate the effect of EGR(exhaust gas recirculation) on engine noise using single cylinder combustion ignition engine. Under constant engine rotary speed of 1200 RPM, 8 mg fuel quantity was injected with 15, 18 and 21% of oxygen ratio and 1400 bar of injection pressure. Using the in-cylinder pressure data acquired by a piezoelectric transducer, the engine performance parameters were calculated. Radiated engine noise measured for 10 seconds was analyzed using spectral characteristics and sound quality metrics such as loudness, sharpness, roughness. From the obtained engine performance parameters and sound quality metrics, effect of oxygen ratio of the premixed air, start of injection timing on frequency characteristic and sound quality metrics were analyzed. Correlation analysis was conducted between MPRR(maximum pressure rise rate), RI(ringing intensity) and sound quality metrics. RI was identified as the most important factor having influence on the sound quality metrics.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 The 6th International Symposium of East Asian Resources Recycling Technology
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• pp.9-18
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• 2001

1. EAF Dust in Japan - Generation and Characteristics. The quantity of dust generated from EAF shops in Japan was estimated to be 520,000 tons/year in 1999. Extremely fine dust (or fume) is formed in the EAF by metal vaporization. Its characteristics such as chemical compositions, phases, particle size, leaching of heavy metal are mentioned. 2. EAF Dust Treatment Methods in Japan. In 1999, 61% of EAF dust was treated by regional zinc recovery processing routes, 25% went to landfill disposal, 4% was reused as cement material, and 10% was treated by on-site processing routes. The problems of EAF dust treatment methods in Japan are: (1) very high treatment cost, and (2) heavy environmental load (leaching of heavy metal, emission of dioxins, depletion of disposal sites, etc). It has been much hoped for that new dust management technology would be developed. 3. New technology of EAF dust treatment in Japan. In Japan, some new technologies of EAF dust treatment have been developed, and some others are in the developing stages. Following five processes are mentioned:. (1) Smelting reduction process by Kawasaki Steel, (2) DSM process by Daido Steel, (3) VHR process by Aichi Steel, (4) On-site dust direct recycling technology, and (5) Process technology of direct separation and recovery of iron and zinc metals contained in high temperature EAF off gas by the Japan Research and Development Center fur Metals.