• Toxicological Research
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• v.16 no.3
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• pp.179-185
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• 2000

Zinc is known to generate reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide ($H_2O_2$), which eventually contribute to cytotoxicity in a variety of cell types. Here in, we demonstrated that zinc decreased the viability of C6 glial cells in a time and dose-dependent manner, which was revealed as apoptosis characterized by ladder-pattern fragmentation of genomic DNA. chromatin condensation and DNA fragmentation in Hoechst dye staining. Zinc-induced apoptosis of C6 glial cells was prevented by the addition of catalase and antioxidants including reduced glutathione (GSH), N-acetyl-L-cysteine (NAC) and pyrrolidinedithiocarbamate (PDTC). Wefurther confirmed that zinc decreased intrac-ellular levels of GSH and generated $H_2O_2$in C6 glial cells. Moreover, antioxidants also decreased the generation of zinc-induced $H_2O_2$ in C6 glial cells. These data indicated that zinc-induced the apoptotic death of C6 glial cells via generation of reactive oxygen species such as $H_2O_2$.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.41-45
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• 2006

The fabrication process of fiber placement system of carbon fiber reinforced plastic (CFRP) requires real time process control and reliable inspection to ensure quality by preventing defects such as delamination and void. Therefore, novel non-contact inspection technique is required during the non-destructive evaluation in a fiber placement system. For the inspection of delamination in CFRP, various methods to receive laser-generated ultrasound were applied by using piezoelectric transducer, air-coupled transducer, wavelet transform and scanning laser ultrasonic technique. Laser-generated ultrasound was received with a conventional piezoelectric sensor in contacting manner. Then signal characteristics due to defects were analyzed to find a factor for detecting defects. Air-coupled transducer was used for reception of laser-generated guided wave using linear slit array in order to generate high frequency guided wave. And line scan technique was used to confirm the capability of on-line application. The high frequency component of laser-generated guided wave received with piezoelectric sensor disappeared after propagating through delamination region. Nevertheless, it was failed to receive high frequency guided wave in using air-coupled transducer. The first peak of the frequency spectrum under 100kHz in the delamination region is higher than in the sound region. By using this feature, the line scanned frequency data were acquired in fully non-contact generation and reception of ultrasound. This method was proved as useful technique for detecting delamination in CFRP.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.10
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• pp.963-968
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• 2010

This paper handles ZMP based control that is inspired by neural networks for humanoid robot walking on varying sloped surfaces. Humanoid robots are currently one of the most exciting research topics in the field of robotics, and maintaining stability while they are standing, walking or moving is a key concern. To ensure a steady and smooth walking gait of such robots, a feedforward type of neural network architecture, trained by the back propagation algorithm is employed. The inputs and outputs of the neural network architecture are the ZMPx and ZMPy errors of the robot, and the x, y positions of the robot, respectively. The neural network developed allows the controller to generate the desired balance of the robot positions, resulting in a steady gait for the robot as it moves around on a flat floor, and when it is descending slope. In this paper, experiments of humanoid robot walking are carried out, in which the actual position data from a prototype robot are measured in real time situations, and fed into a neural network inspired controller designed for stable bipedal walking.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.204-206
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• 2007

In this study, we introduce the optimization method of fuzzy inference systems that is based on Hierarchical Fair Competition-based Parallel Genetic Algorithms (HFCGA) and information data granulation, The granulation is realized with the aid of the Hard C-means clustering and HFCGA is a kind of multi-populations of Parallel Genetic Algorithms (PGA), and it is used for structure optimization and parameter identification of fuzzy model. It concerns the fuzzy model-related parameters such as the number of input variables to be used, a collection of specific subset of input variables, the number of membership functions, the order of polynomial, and the apexes of the membership function. In the optimization process, two general optimization mechanisms are explored. The structural optimization is realized via HFCGA and HCM method whereas in case of the parametric optimization we proceed with a standard least square method as well as HFCGA method as well. A comparative analysis demonstrates that the proposed algorithm is superior to the conventional methods. Particularly, in parameter identification, we use the UNDX operator which uses multiple parents and generate offsprings around the geographic center off mass of these parents.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.1
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• pp.147-162
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• 1997

When designing workplaces or arranging controls on panel, devices and controls should be placed within the reach of operator's arm or foot to guarantee effective performances. Most of the existing research on the reach volume were based on measurements of a few subject's arm reach, and limited to Caucasian and Chinese populations. Furthermore, reach volume considering foot or trunk motion have not been investigated. Range of human joint motion and that of two degrees of freedom motion are needed to generate reach volume analytically using the sweeping algorithm. However, range of two degrees of freedom motion has not been measured up to now. Therefore, range of two degrees of freedom motion was measured in this research, where 47 college students were participated voluntarily as subjects. The results showed that the motion of one joint can be limited by the motion of another motion, that is to say, the shoulder flexion was decreased significantly when the shoulder was adducted or abducted. Second, new approximate algorithms generating reach volumes were suggested, in which range of two degrees of freedom motion was used as input data. Depending upon the body segment included such as trunk, arm and leg, three types of reach volume were provided, in which the human body was modeled as a multilink system based on the robot kinematics and the sweeping method was employed. Reach volume generated analytically in this study showed statistically reasonable results when compared with that obtained from direct measurement.

• Journal of Electrical Engineering and Technology
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• v.8 no.3
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• pp.421-427
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• 2013

The dependence between wind speeds in multiple wind sites has a considerable impact on the reliability of power systems containing wind energy. This paper presents a new method to generate dependent wind speed time series (WSTS) based on copulas theory. The basic feature of the method lies in separating multivariate WSTS into dependence structure and univariate time series. The dependence structure is modeled through the use of copulas, which, unlike the cross-correlation matrix, give a complete description of the joint distribution. An autoregressive moving average (ARMA) model is applied to represent univariate time series of wind speed. The proposed model is illustrated using wind data from two sites in Canada. The IEEE Reliability Test System (IEEE-RTS) is used to examine the proposed model and the impact of wind speed dependence between different wind regimes on the generation system reliability. The results confirm that the wind speed dependence has a negative effect on the generation system reliability.

• Industrial Engineering and Management Systems
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• v.14 no.3
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• pp.236-247
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• 2015

This study aims to examine the effects of industrial clustering and manufacturing flexibility on innovation capability and operational performance. This study follow a survey method to collect data pertaining to the phenomena of industrial clustering, manufacturing flexibility, innovation capability, and operational performance by utilizing a single respondent design. A total of 124 Indonesian manufacturing SMEs are taken to test the proposed theoretical model by utilizing covariance-based structural equations modeling approach. It was found that both industrial clustering and manufacturing flexibility was positively associated with operational performance and innovation capability as well. In addition, innovation capability may account for the effects of industrial clustering and manufacturing flexibility on operational performance. This implies that manufacturing SMEs have to reorient their production and operation perspectives, including agglomerate with other similar or related SMEs to develop and utilize their own resources. The SMEs also need to possess some degree of manufacturing flexibility in respond to the uncertain environment and market changes. In addition, the SMEs should put a greater emphasize to use industrial cluster and manufacturing flexibility benefits to generate innovation capability to achieve high performance.

• Journal of the Korean Society of Safety
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• v.21 no.6 s.78
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• pp.38-45
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• 2006

Polymeric floorings mainly consisted of PVC are easily decomposed by many kinds of hot environmental factors, then generate hazardous asphyxiate gases and/or toxic gases etc. Therefore the mechanism of decomposition and quantitative toxic indices of products are very important for preventing safety and health disasters, especially in case of confined area. So we have investigated decomposition kinetics, numbers of process involved, toxicity indices of product and so on, using DSC, TGA, FT-IR and Pyrolyzer-GC/MS. The thermal decomposition process of polymeric floorings can be mainly divided by dehydrochlorinated reaction and polyene decomposition step, and activation energies of those are approximately $53.93{\sim}62.42kcal/mol$. Especially lethal concentration($LC_{50}$), fractional effective dose (FED) are calculated by measuring the amount of decomposition product. The values on $LC_{50}$ of sample G are ranged $2,003{\sim}2,019(mg/m^{3})$ in case of sample K and H are $1,877,\;1,998(g/m^{3})$ respectively. Even if the results are estimated by calculation method without animal test and/or clinical demonstration, these values could be very useful data for occupational health, hygiene and safety control.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5565-5571
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• 2015

Background: Previous studies evaluating the association between the excision repair cross complementing group 5 (ERCC5) gene rs17655 polymorphism and colorectal cancer susceptibility generated controversial results. To generate large-scale evidence on whether the ERCC5 rs17655 polymorphism might indeed be associated with colorectal cancer susceptibility, the present meta-analysis was performed. Materials and Methods: Data were collected from PubMed, Embase and Web of Science, with the last report up to Apr 03, 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Results: A total of nine studies including 5,102 cases and 6,326 controls based on the search criteria were included and significant associations were found between ERCC5 rs17655 polymorphism CG vs GG overall (OR = 1.29, 95% CI =1.18~1.40) and in the dominant model (OR=1.23, 95% CI =1.13~1.33). On subgroup analysis by ethnicity and source of controls, the ERCC5 rs17655 polymorphism was found to correlate with the pathogenesis of colorectal cancer among Asians and Caucasians and with hospital-based populations. Conclusions: This meta-analysis suggests that the ERCC5 rs17655 polymorphism might contribute to genetic susceptibility to colorectal cancer.

• Proceedings of the KSME Conference
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• 2000.04a
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• pp.714-719
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• 2000

In this paper, an application program is made to simulate the behavior of a ship block under various crane works and to generate data of lu9 reactions and wire tensions. The program is based on a CAD program, Pro/ENGINEER. A ship is composed of more than 100 ship blocks. In order to lift, move, turn, or put a ship block at a convenient location fur assembling, workers in a shipyard use cranes, wires, and lugs temporarily attached to the block. In the procedure of lifting and turning a ship block with a crane, it is important to find suitable lug points and wires to do the handling efficiently and prevent accidents. Evaluation of forces in lugs and wires is necessary, but the problem is rather complex due to nonlinearity and nonuniqueness. In the present development, the nonlinear system of equations for quasi-static equilibriums is derived and a Newton type solution method is adopted to solve the system. The importance of initial estimates to the solution is illustrated and two approaches are utilized and compared. With the program developed, users can assign lug points on the CAD model by mouse and choose various linking devices at each crane point. Users can try to simulate the motion for any prescribed conditions, compare the motion of the block and the reactions and choose appropriate lug points and the type of wires and lugs.