• 대한기계학회논문집A
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• 제27권11호
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• pp.1907-1916
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• 2003

During decades, there has been much progress in understanding of the inelastic behavior of the materials and numerous inelastic constitutive equations have been developed. The complexity of these constitutive equations generally requires a stable and accurate numerical method. To obtain the increment of state variable, its evolution laws are linearized by several approximation methods, such as general midpoint rule(GMR) or general trapezoidal rule(GTR). In this investigation, semi-implicit integration schemes using GTR and GMR were developed and implemented into ABAQUS by means of UMAT subroutine. The comparison of integration schemes was conducted on the simple tension case, and simple shear case and nonproportional loading case. The fully implicit integration(FI) was the most stable but amplified the truncation error when the nonlinearity of state variable is strong. The semi-implicit integration using GTR gave the most accurate results at tension and shear problem. The numerical solutions with refined time increment were always placed between results of GTR and those of FI. GTR integration with adjusting midpoint parameter can be recommended as the best integration method for viscoplastic equation considering nonlinear kinematic hardening.

• Journal of Pharmaceutical Investigation
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• 제37권5호
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• pp.315-321
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• 2007

The purpose of the present study was to evaluate the bioequivalence of two lercanidipine hydrochloride tablets, Zanidip tablet (LG Life Sciences Ltd., Korea, reference drug) and Samchundang Lercanidipine tablet 10 mg (Sam Chun Dang Pharm. Co. Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (amlodipine maleate) to human serum, serum samples were extracted using hexan-isoamyl alcohol (100:1, v/v). Compounds were analyzed by liquid chromatography/tandem mass spectrometry. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient of 0.9999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL which was sensitive enough for pharmacokinetic studies. Thirty healthy male Korean volunteers received each medicine at the lercanidipine hydrochloride dose of 20 mg in a $2\;{\times}\;2$ crossover study. There was a one-week washout period between the doses. Serum concentrations of lercanidipine were monitored by an LC/MS/MS fer over a period of 24 hr after the administration. $AUC_t$ (the area under the serum concentration-time curve from time 0 to 24 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (the maximum serum drug concentration) and $T_{max}$ (the time to reach $C_{max}$) were compiled from the serum concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters, indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Samchundang Lercanidipine/Zanidip were log 0.9505-log 1.2258 and log 0.9987-log 1.2013, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Samchundang Lercanidipine tablet 10 mg and Zanidip tablet are bioequivalent.