• The Korean Journal of Nuclear Medicine Technology
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• v.16 no.1
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• pp.96-101
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• 2012

Purpose: Glomerular filtration rate is an important index for assessment of renal function, early discovery of renal disease, and progress observation of chronic renal disease patients. In the present study, the objective is to conduct a comparative analysis of differences between Gates and Modified Gates method in dynamic renal scintigraphy based on MDRD (Modification of Diet Renal Disease) formula using blood collection. Materials and Methods: Renal scintigraphy was performed for 45 patients who visited our hospital between November 2010 and August 2011. For 20 patients of those tested, glomerular filtration rates from Gates method and MDRD formula using AGUS equipment, were compared. For the other 20 patients, glomerular filtration rates from Modified Gates method and MDRD formula using INFINIA equipment. Finally, Gates and Modified Gates method were compared for 5 patients who indicated no change in glomerular filtration rates from MDRD formula during progress observation. Results: Glomerular filtration rates from both Gates and Modified Gates method showed a high correlation with those from MDRD formula ($p$<0.01, r=0.903, r=0.867), with a paired difference mean for Gates method of $2.05{\pm}2.54mL/min/1.73m$, and that for Modified Gates method of $25.2{\pm}3.71mL/min/1.73m$. Finally, the values for Gates method and those for Modified Gates method showed a high correlation for the five patients ($p$<0.05, r=0.949), with a paired difference mean of $20.4{\pm}8.84mL/min/1.73m$. Conclusion: Glomerular filtration rates from Gates method, Modified Gates method and MDRD formula showed mutually high correlations. If the tests are performed with recognition for the correlations between Gates and Modified Gates method used in a dynamic renal scintigraphy, then an accurate assessment of renal function is considered possible with an improved diagnostic ability.

• Journal of radiological science and technology
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• v.46 no.5
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• pp.417-425
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• 2023

The glomerular filtration rate (GFR) has been the subject of much research as a key indicator for diagnosing, treating, and monitoring kidney function. The gamma camera method (Gates method) is simple and allows simultaneous acquisition of GFR and renal scintigraphy for each kidney, however its accuracy is inferior. This study aimed to investigate changes in GFR depending on how region of interest (ROI) are set up, which is one of many factors influencing accuracy. GFR was calculated by setting the ROI for each phase of the image acquisition time (Gates-1: 0~1 minutes, Gates-2: 1~3 minutes, Gates-3: 3~27 minutes), and statistical significance was verified based on probability value 0.05 through ANOVA analysis. While there was no statistically significant difference among results from Gates-1, 2, 3 (p=0.481>0.05), overall results from the Gates method tended to overestimate compared to those from the multiple blood sampling-dual exponential (MBSDE) method. When comparing averages between phases, results from Gates-2 were most similar to those from the MBSDE method. Moreover, paired t-test p-values between MBSDE method and phases were as follows Gates-1: 0.021 (p<0.05), Gates-2: 0.280 (p>0.05), and Gates-3: 0.164 (p>0.05) indicating that only Gates-1 had statistically significant differences compared with MBSDE method. Thus, setting ROI around 2~3 minutes is calculated can aid in accurately determining GFR when Gates Method.

• Nuclear Engineering and Technology
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• v.53 no.4
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• pp.1146-1156
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• 2021

Single-unit probabilistic safety assessment (SUPSA) has complex Boolean logic equations for accident sequences. Multi-unit probabilistic safety assessment (MUPSA) model is developed by revising and combining SUPSA models in order to reflect plant state combinations (PSCs). These PSCs represent combinations of core damage and non-core damage states of nuclear power plants (NPPs). Since all these Boolean logic equations have complemented gates (not gates), it is not easy to generate exact Boolean solutions. Delete-term approximation method (DTAM) has been widely applied for generating approximate minimal cut sets (MCSs) from the complex Boolean logic equations with complemented gates. By applying DTAM, approximate conditional core damage probability (CCDP) has been calculated in SUPSA and MUPSA. It was found that CCDP calculated by DTAM was overestimated when complemented gates have non-rare events. Especially, the CCDP overestimation drastically increases if seismic SUPSA or MUPSA has complemented gates with many non-rare events. The objective of this study is to suggest a new quantification method named probability subtraction method (PSM) that replaces DTAM. The PSM calculates accurate CCDP even when SUPSA or MUPSA has complemented gates with many non-rare events. In this paper, the PSM is explained, and the accuracy of the PSM is validated by its applications to a few MUPSAs.

• Journal of Information Display
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• v.6 no.1
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• pp.17-21
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• 2005

We explored a new way of designing dynamic logic gates with low temperature polysilicon thin film transistors to increase the speed. The proposed architecture of logic gates utilizes the structural advantage of smaller junction capacitance of thin film transistors. This method effectively blocks leakage of current through the thin film transistors. Furthermore, the number of transistors used in logic gates is reduced thereby reducing power consumption and chip area. Through HSPICE .simulation, it is confirmed that the circuit speed is also improved in all logic gates designed.

• The Korean Journal of Nuclear Medicine
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• v.38 no.4
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• pp.306-310
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• 2004

Purpose: The aim was to assess how the background site affects the Gates' glomerular filtration rate(GFR) measurement using Tc-99m-DTPA in correlation with GFR by I-125-lothalamate method. Material and methods: The study populations were 63 adults with 39 men and 24 women aged from 20 to 59 yrs (mean=37.9 yrs). The fellowing five background regions of interest were used in measurement of GFR using Gates' method: 1) lower side of each kidney(subrenal), 2) around each kidney(circumferential), 3) upper side of each kidney(suprarenal), 4) lateral side of each kidney(lateral), 5) between the two kidneys(inter-renal). We also measured GFR using I-125-iothalamate in each subject. The two studies were separated by 1 to 3 weeks. The subjects were divided into two groups by renal depth. Group 1 with renal $depth{\geq}7cm$ and group 2 with renal depth<7cm. We calculated the means and standard deviations of the GFRs measured by two studies. And we statistically analyzed the correlation and differences among GFRs by Gates' method and the GFR by iothalamate method with correlation analysis. Results: The GFRs by Gates' method using suprarenal and inter-renal background correction showed better correlation with the GFR measured by I-125-iothalamate. And GFRs measured by Gates' method showed statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal depth<7cm. But GFRs measured by Gates' method did not show statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal $depth{\geq}7cm$. Conclusion: GFRs measured with Gates' method showed higher correlation with the GFR measured by I-125-iothalamate when the regions of interest were plated over the suprarenal and inter-renal backgrounds. And GFRs measured with Gates method showed statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal depth<7cm.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.4
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• pp.745-750
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• 2007

In this paper, we propose a new gate modification method using the input vector maximizes the number of gates in WLS within the optimum range of the minimum leakage power. We prove that MLV is not always the optimal solution, and that the leakage power and area can decrease when modifying the gates using the input vector for which the number of gates in WLS is maximized within the optimum range of the minimum leakage power for the circuits applying the IVC technique and gate modification method. Using the proposed method, the gate-level description circuit can be converted to the modified circuit which reduces the leakage power by chip designer, and the modified circuit can be applied without any modification in design flow.

• The Korean Journal of Nuclear Medicine Technology
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• v.13 no.3
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• pp.61-66
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• 2009

Purpose: Glomerular filtration rate (GFR) is considered as the best overall index for the level of renal function, diagnosis of doubtful kidney disease, progress observation from chronic kidney disease and is measured with the various methods. In this study, We measured standard GFR by Gates method and attempted to compare the result with serum creatinin-based, Cockcroft-Gault(C-G) formula and Modification of Diet in Renal Disease (MDRD) formula. Materials and methods: 217 patients (127 men, 90 women, mean age $51.3{\pm}16.9$) with various renal function were examined. we compared the GFR using $^{99m}Tc$-DTPA (Gates), C-G formula and MDRD formula. Results: Significant correlations were noted between 2 different GFR estimates (from C-G formula: r=0.864, p<0.0001, MDRD formula: r=0.831, p<0.0001) and $^{99m}Tc$-DTPA (Gates) GFR. Average of serum creatinine (Scr) was measured with $3.0{\pm}3.1\;mg/dL$, In patients with normal renal function (Scr<1.5 mg/dL), $^{99m}Tc$-DTPA (Gates) GFR was statistically significant to C-G formula (p<0.0001) and MDRD formula (p<0.0001). In patients with mild to moderate renal insufficiency (1.5$^{99m}Tc$-DTPA (Gates) GFR was not statistically significant to C-G formula (p=0.181) and MDRD formula (p=0.127). In patients with severe renal insufficiency (Scr>4.0mg/dL), $^{99m}Tc$-DTPA (Gates) GFR was statistically significant to C-G formula and MDRD formula (p<0.0001). Conclusions: Glomerular filtration rate using Gates method was closly correlated to C-G formula and MDRD formula. In patients with normal renal function, $^{99m}Tc$-DTPA (Gates) GFR was significantly lower than C-G formula and MDRD formula. In patients with mild to moderate renal insufficiency, $^{99m}Tc$-DTPA (Gates) GFR was simmilar with C-G formula and MDRD formula. In patients with severe renal insufficiency, $^{99m}Tc$-DTPA (Gates) GFR was significantly higher than C-G formula and MDRD formula. None of the three different methods was clearly superior to the others.

• Nuclear Engineering and Technology
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• v.51 no.2
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• pp.444-452
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• 2019

To assess the availability of a nuclear power plant's dynamic systems, it is necessary to consider the impact of dynamic interactions, such as components, software, and operating processes. However, there is currently no simple, easy-to-use tool for assessing the availability of these dynamic systems. The existing method, such as Markov chains, derives an accurate solution but has difficulty in modeling the system. When using conventional fault trees, the reliability of a system with dynamic characteristics cannot be evaluated accurately because the fault trees consider reliability of a specific operating configuration of the system. The dynamic reliability graph with general gates (DRGGG) allows an intuitive modeling similar to the actual system configuration, which can reduce the human errors that can occur during modeling of the target system. However, because the current DRGGG is able to evaluate the dynamic system in terms of only reliability without repair, a new evaluation method that can calculate the availability of the dynamic system with repair is proposed through this study. The proposed method extends the DRGGG by adding the repair condition to the dynamic gates. As a result of comparing the proposed method with Markov chains regarding a simple verification model, it is confirmed that the quantified value converges to the solution.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.5
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• pp.571-580
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• 2021

When constructing railway stations, gates shall be located in appropriate locations for convenient use. However, to reduce construction costs, the number of gates was minimized and the location was not appropriately placed to the direction of many users. This study proposed a method to calculate the benefits of additional gate installations using the improvement of pedestrian traffic flow, occupied area and travel time as economic effects. In particular, a method of estimating the percentage of people using certain gates and the number of people by route within the station was proposed. This method was applied to analyze the effect of additional gates to Gwang-myeong Station on the Shinansan Line, which is to be opened in 2025. The effect has only improved in mobility. The first year of its opening was estimated at 5.91 billion won for mobility and 75.8 billion won for cost, and the B/C was 1.21 for 30 years after its opening. It is expected that this method will be applied to systematic effect analysis when additional gates are installed at unopened railway stations as well as existing railway stations.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.41 no.6
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• pp.715-725
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• 2021

When constructing railway stations, gates shall be located in appropriate locations for convenient use. However, to reduce construction costs, the number of gates was minimized and the location was not appropriately placed to the direction of many users. This study proposed a method to calculate the benefits of additional gate installations using the improvement of pedestrian traffic flow, occupied area and travel time as economic effects. In particular, a method of estimating the percentage of people using certain gates and the number of people by route within the station was proposed. This method was applied to analyze the effect of additional gates to Gwang-myeong Station on the Shinansan Line, which is to be opened in 2025. The effect has only improved in mobility. The first year of its opening was estimated at 5.91 billion won for mobility and 75.8 billion won for cost, and the B/C was 1.21 for 30 years after its opening. It is expected that this method will be applied to systematic effect analysis when additional gates are installed at unopened railway stations as well as existing railway stations.