Browse > Article

GFRs Measured by Gates' Method According to 5 Background Sites: Comparison with GFR Measured by I-125-Iothalamate Method  

Jung, Hyun-Seok (Department of Radiology, The Catholic University of Korea)
Chung, Yong-An (Department of Radiology, The Catholic University of Korea)
Kim, Sung-Hoon (Department of Radiology, The Catholic University of Korea)
Kim, Chung-Ho (Department of Radiology, The Catholic University of Korea)
Lee, Sung-Young (Department of Radiology, The Catholic University of Korea)
Sohn, Hyung-Seon (Department of Radiology, The Catholic University of Korea)
Baik, Jun-Hyun (Department of Radiology, The Catholic University of Korea)
Chung, Soo-Kyo (Department of Radiology, The Catholic University of Korea)
Publication Information
The Korean Journal of Nuclear Medicine / v.38, no.4, 2004 , pp. 306-310 More about this Journal
Abstract
Purpose: The aim was to assess how the background site affects the Gates' glomerular filtration rate(GFR) measurement using Tc-99m-DTPA in correlation with GFR by I-125-lothalamate method. Material and methods: The study populations were 63 adults with 39 men and 24 women aged from 20 to 59 yrs (mean=37.9 yrs). The fellowing five background regions of interest were used in measurement of GFR using Gates' method: 1) lower side of each kidney(subrenal), 2) around each kidney(circumferential), 3) upper side of each kidney(suprarenal), 4) lateral side of each kidney(lateral), 5) between the two kidneys(inter-renal). We also measured GFR using I-125-iothalamate in each subject. The two studies were separated by 1 to 3 weeks. The subjects were divided into two groups by renal depth. Group 1 with renal $depth{\geq}7cm$ and group 2 with renal depth<7cm. We calculated the means and standard deviations of the GFRs measured by two studies. And we statistically analyzed the correlation and differences among GFRs by Gates' method and the GFR by iothalamate method with correlation analysis. Results: The GFRs by Gates' method using suprarenal and inter-renal background correction showed better correlation with the GFR measured by I-125-iothalamate. And GFRs measured by Gates' method showed statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal depth<7cm. But GFRs measured by Gates' method did not show statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal $depth{\geq}7cm$. Conclusion: GFRs measured with Gates' method showed higher correlation with the GFR measured by I-125-iothalamate when the regions of interest were plated over the suprarenal and inter-renal backgrounds. And GFRs measured with Gates method showed statistically significant correlation with the GFR measured by I-125-iothalamate in the group with renal depth<7cm.
Keywords
Tc-99m-DTPA; I-125-Iothalamate; Background; Renal scintigraphy; Glomerular filtration rate; Renal depth;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Peters A.M., George P, Ballardie F, Gordon I, Todd-Pokropek A. Appropriate selection of background for Tc-99m DTPA renography. Nucl Med Commun 1988;9:973-85
2 Israelit AH, Long DL, White MG, Hull AR. Measurement of glomerular filtration rate utilizing a single subcutaneous injection of I-125 iothalamate. Kidney international 1973;4:346-9   DOI   ScienceOn
3 Gates GF. Glomerular filtration rate: estimation from fractional renal accumulation of 99m-Tc DTPA(stannous). AJR 1982;138:565
4 Inoue Y, Machida K, Norinari H, Takahashi T. Background Correction in Estimating Initial Renal Uptake: Comparison Between Tc-99m MAG3 and Tc-99m DTPA. Clin Nucl Med 1994;19:1049-54   DOI   ScienceOn
5 Elwood CM, Sigman EM. The measurement of glomerular filtration rate and effective renal plasma flow in man by I-125 iothalamate and I-131 iodopyracet. Circulation 1967;36:441-8   DOI   PUBMED   ScienceOn
6 Sigman EM, Elwood CM, Know F. The measurement of glomerular filtration rate in man with sodium iothalamate I-131(Conray). J Nucl Med 1965;7:60-8
7 Adefuin PY, Gur A, Siegel NJ, Spencer RP, Hayslett JP. Single Subcutaenous Injection of Iothalamate Sodium I-125 to Measure Glomerular Filtration Rate. JAMA 1976;235:1467-9   DOI   ScienceOn
8 Maher FT, Nolan NG, Elveback LR. Comparison of simultaneous clearance of I-125 labeled sodium iothalamate(Glofil) and of inulin. Mayo Clin Proc 1971;46:690-1   PUBMED
9 Yoo IR, Kim SH, Chung YA, Jung HS, Lee HG, Park YH, et al. Development of Formulas for the Estimation of Renal Depth and Application in the Measurement of Glomerular Filtration Rate in Koreans. Korean J Nuc Med 2003;34:418-25
10 Lawson RS. Mathematics. In: O'Reilly PH, Shields RA, Testa HJ, editors. Nuclear medicine in urology and nephrology. London:Butterworth 1986. p. 247-70
11 Blaufox, Aurell M, Bubeck B, Fommei E, Piepsz A, Russell C et al. Report of the Radionuclides in Nephrourology Committee on Renal Clearance. J Nucl Med 1996;37:1883-90   PUBMED