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Synthesis of Lysophosphatidylcholine Analogues Using D-Mannitol as a Chiral Template and Their Biological Activity for Sepsis

  • Heo, Hye Jin;Jung, Jun-Sub;Lee, Jung Ho;Han, Su Young;Bang, Hyun Bae;Song, Dong-Keun;Jun, Jong-Gab
    • Bulletin of the Korean Chemical Society
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    • v.27 no.8
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    • pp.1149-1153
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    • 2006
  • LPC analogues including natural and unnatural LPC, 3-L-2-PC, acetylated LPC and ethylene glycol derivative are prepared from D-mannitol using in convenient procedures by only changing the synthetic sequences, and their protective activities against cecal ligation and puncture (CLP)-induced severe sepsis are compared. The chirality at C2 position in LPC is found to be required as (S)-configuration for sepsis inhibition, comparing from the protection activity between LPC 6 and unnatural LPC 8. The hydroxyl functionality is also very important and required at C2 or C3 position as shown in the protection activities of ethylene glycol analogue 11 and 3-L-2-PC 9.

A Study on Double Bottom Structural Criterion of Oil Tanker under DWT 500 (재화중량 500톤 미만 유조선의 이중저구조기준 연구)

  • Lee, Sang-Gab;Yoon, Yeo-Hoon;Bae, Jun-Yong
    • Journal of Korea Ship Safrty Technology Authority
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    • s.23
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    • pp.2-13
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    • 2007
  • With the effectuation of the amendment of MARPOL 73/78 on 5 April 2005, enforcement regulations of Marine Pollution Prevention Act were revised in domestic on 12 March 2005 that double hull structure was required to the small single bottom oil tankers under DWT(deadweight tonnage) 500 ton for the protection of the marine pollution casualties. The objective of this study is to develop the double bottom structure of small oil tanker under DWT 500 ton with superior crashworthiness and to establish its suitable standard to double bottom structure. The promoting strategy of this R&D is classified into the crashworthy structural analysis of small oil tankers using LS/DYNA3D code and the examination of their damage stabilities according to tonnage. It could be thought that the desirable inner bottom height should be above the B/7.5 and its minimum height 0.65m for the domestic small oil tanker under DWT 500ton.

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Approximation of Frequent Itemsets with Maximum Size by One-scan for Association Rule Mining Application (연관 규칙 탐사 응용을 위한 한 번 읽기에 의한 최대 크기 빈발항목 추정기법)

  • Han, Gab-Soo
    • The KIPS Transactions:PartD
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    • v.15D no.4
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    • pp.475-484
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    • 2008
  • Nowadays, lots of data mining applications based on continuous and online real time are increasing by the rapid growth of the data processing technique. In order to do association rule mining in that application, we have to use new techniques to find the frequent itemsets. Most of the existing techniques to find the frequent itemsets should scan the total database repeatedly. But in the application based on the continuous and online real time, it is impossible to scan the total database repeatedly. We have to find the frequent itemsets with only one scan of the data interval for that kind of application. So in this paper we propose an approximation technique which finds the maximum size of the frequent itemsets and items included in the maximum size of the frequent itemsets for the processing of association rule mining.

Overhead Hoist Transport Control System Design Using UML (UML을 적용한 OHT 제어 시스템 설계)

  • Sim, Gab-Sig;Jung, Tae-Young
    • The KIPS Transactions:PartD
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    • v.11D no.2
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    • pp.461-470
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    • 2004
  • As the semiconductor industrials change 200㎜-sized semiconductor wafer production process to 300㎜-sized one, it requires to develop the software for monitoring and simulating the robot which transfers a 300㎜-sized semiconductor wafer. Because such a software don't run at standalone but communicate MCS(Material Control System) and Its subsystem a robot, its architecture is very complex. Therefore, in order to develop such a software systematically, we must utilize an object-oriented development methodology. UML. This paper presents an UML process application developing the software for monitoring and simulating the robot which transfers a semiconductor wafer on the production process.

Design of MMIC Variable Gain LNA Using Behavioral Model for Wireless LAM Applications (거동모델을 이용한 무선랜용 MMIC 가변이득 저잡음 증폭기 설계)

  • Park, Hun;Yoon, Kyung-Sik;Hwang, In-Gab
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.6A
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    • pp.697-704
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    • 2004
  • This paper describes the design and fabrication of an MMIC variable gain LNA for 5GHz wireless LAN applications, using 0.5${\mu}{\textrm}{m}$ gate length GaAs MESFET transistors. The advantages of high gain and low noise performance of E-MESFETS and excellent linear performance of D-MESFETS are combined as a cascode topology in this design. Behavioral model equations are derived from the MESFET nonlinear current voltage characteristics by using Turlington's asymptote method in a cascode configuration. Using the behavioral model equations, a 4${\times}$50${\mu}{\textrm}{m}$ E-MESFET as a common source amplifier and a 2${\times}$50${\mu}{\textrm}{m}$ D-MESFET as a common gate amplifier are determined for the cascode amplifier. The fabricated variable gain LNA shows a noise figure of 2.4dB, variable gain range of more than 17dB, IIP3 of -4.8dBm at 4.9GHz, and power consumption of 12.8mW.

Design of Fractal Structure Wideband Antenna for 4G IMT-Advanced AccessPoint Applications (4세대 이동통신 Accesspoint용 Fractal구조 광대역 안테나 설계)

  • Kim, Dong-Hwan;Kim, Gab-Gi
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.14 no.1
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    • pp.195-201
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    • 2014
  • In this paper, an AccessPoint compact microstrip patch antenna was designed by using L-shaped feeding structure of a Fractal Structure and the compact antenna can be obtained by the rare formed presence of the resonance flow which is called "Crossed-Diagonal". CST's MicroWave5.0 was used for the design. As the operating characteristics of the patch antenna, it showed the characteristic of 1031 [MHz] or 29.4% in the range of 3.202 [GHz] ~ 4.233 [GHz] when an input return loss is less -10 [dB] and VSWR 2:1, also as it is in this paper, we got simulation results such as, gains of the E-plane and H-plane are 8.7 [dBi] and 8.6 [dBi] for this is the single patch, and 3 [dB] beamwidth is $43.9^{\circ}$ at E-plane and $78.7^{\circ}$ at H-plane.

A Analysis on wireless performance of unified data transmission in a subway and railway (18GHz 차지상간통합데이터전송 시스템의 지하 및 지상구간 무선특성 분석)

  • Jeong, Sang-Guk;An, Tae-Ki;Kim, Baek-Hyun;Choi, Gab-Bong
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.13 no.6
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    • pp.1083-1090
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    • 2009
  • In 18GHz using unified data transmission in a subway and railway, Influence of the multipath fading is big and an arrival range of the micro wave takes the influence greatly according to the transmit angle and receive angle because it not diffracted. This thesis analyzed microwave property underground tunnel and ground railway at unified data transmission in subway and railway. Antenna gain of directional antenna many used unified transmission in an subway and railway, is used 15dBi and 10dBi in simulation. Transmitter's property is compared underground tunnel to ground railway about curved railway of R=100, R=200, R=400. Specification of transmitter is used sample unified transmission system in subway and railway of KRRI(korea railroad research Institute). Transmitter's power is 20dBm and Reciever's sensitivity is -90dBm. According to result of simulation.

Development of 3-D Web Graphic Library Using Java (자바를 이용한 3차원 웹 그래픽 라이브러리의 개발)

  • Jeong, Gab-Joong
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.8
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    • pp.1709-1715
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    • 2005
  • This paper describes the development of 3-D web graphic library for dynamic web graphic design. The 3-D web graphic library developed in this per supports creation of 3-D objects like cube and sphere objects, elimination of hidden line and surface, and the shading of diffuse and specular reflections. It provides, in drawing, perspective projection of an object depth first sort of multiple objects, and wire frame and solid models. It also supports texture mapping function for realistic and dynamic web application in application software. Each created 3-D object gives functions for the scaling, translation, and rotation of itself. It can be used for the development of dynamic web application software and the advertisement of information for business and tourism as a 3-D web graphic library engine. It is written in 'Java' language and runs on web browsers with Java virtual machine without any dependancy of client computer system.

Development of a 3D Brickwork Game Using Java (Java를 이용한 3차원 벽돌 쌓기 게임 개발)

  • Baek, Tae-Gwan;Seo, Sang-Jin;Jeong, Gab-Joong
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2007.06a
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    • pp.121-124
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    • 2007
  • This paper describes the development of a brickwork game with three-dimensional computer graphics as one of web-based game contents. Client user using web can access and run lava applet program with the independence of hardware system. It consists of graphic user interface module, initial space generation module, event handler module, player control module, and thread control module. It uses 3-D array data structure for the 3-D graphic objects that are located in three-dimensional space for high-speed object searching and sorting. It enhances to compare with predetermined construction in three-dimensional space. We can use the developed racing game to inform game users of information for an advertisement like tourism information, and can apply the proposed 3-D drawing technology to 3-D game graphic engine core.

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Co-expression of Gamma-Aminobutyrate Aminotransferase and Succinic Semialdehyde Dehydrogenase Genes for the Enzymatic Analysis of Gamma-Aminobutyric Acid in Escherichia Coli

  • So, Jai-Hyun;Lim, Yu-Mi;Kim, Sang-Jun;Kim, Hyun-Ho;Rhee, In-Koo
    • Journal of Applied Biological Chemistry
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    • v.56 no.2
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    • pp.89-93
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    • 2013
  • Gamma-aminobutyric acid (GABA) aminotransferase (gabT) and succinic semialdehyde dehydrogenase (gabD) genes from Pseudomonas fluorescens KCCM 12537 were cloned into a single pETDuet-1 vector and co-expressed in Escherichia coli BL21(DE3) simultaneously. The mixture of both enzymes, called GABase, is the key enzyme for the enzymatic analysis of GABA. The molecular mass of the GABA aminotransferase and succinic semialdehyde dehydrogenase were determined to be 52.8 and 46.7 kDa following computations performed with the pI/Mw program, respectively. The GABase activity between pH 6.0 and 9.0 for 24 h at $4^{\circ}C$ remained over 75%, but under pH 6.0 decreased rapidly. The GABase activity between 25 and $35^{\circ}C$ by the treatment at pH 8.6 for 30 min remained over 80%, but over $35^{\circ}C$ decreased rapidly. When the activity against GABA was defined as 100%, the purified GABase activity against 5-aminovaleric acid having a similar structure to GABA showed 47.7% and GABase activity against ${\beta}$-alanine, ${\varepsilon}$-amino-n-caproic acid, $_L$-ornithine, $_L$-lysine, and $_L$-aspartic acid showed between 0.3 to 2.3%. The GABA content was analyzed with this co-expressed GABase, compared with the other GABase which was available commercially. As a result, the content of GABA extracted from brown rice, dark brown rice, and black rice were $26.4{\pm}3.5$, $40.5{\pm}4.7$ and $94.7{\pm}9.3{\mu}g/g$, which were similar data of other GABase in the error ranges.