• Journal of Advanced Navigation Technology
• /
• v.12 no.6
• /
• pp.567-573
• /
• 2008

According to the ICAO's Global Air Navigation Plan for CNS/ATM - Communications, Navigation, and Surveillance - systems, employing digital technologies, including satellite systems together with various levels of automation, are to be applied in support of a seamless global air traffic management system. For the future navigation, the focus of future implementation efforts can be placed entirely on an expected gradual migration toward GNSS-based navigation, Korea has been considered various options for airspace GNSS augmentation system: GBAS, SBAS and GRAS. This paper discusses current status and future trend of GNSS airspace navigation systems, and presents the results of possible augmentation options and scenarios to analyze system availabilities which could lead to the conclusion of the best program for Korea. The results showed that Korea could have sufficient availabilities from en-route to CAT-I approach with ABAS and GBAS. The study was in cooperated with MITRE, an American research company.

• Parasites, Hosts and Diseases
• /
• v.43 no.1 s.133
• /
• pp.27-32
• /
• 2005

Toxoplasma gondii tachyzoites were isolated from an ocular patient in the Republic of Korea and maintained in the laboratory (designated KI-1). In the present study, its genotype was determined by analyzing dense granule antigen 6 (GRA6) gene and surface antigen 2 (SAG2) gene as typing markers. Digestion of the amplification products of GRA6 and of the 5' and 3' ends of SAG2, respectively, with Mse I, Sau3A I, and Hha I, revealed that KI-1 is included in the genotype I, which includes the worldwide virulent RH strain. In addition, when the whole sequences of the coding regions of SAG1, rhoptry antigen 1 (ROP1), and GRA8 genes of KI-1 were compared with those of RH, minor nucleotide polymorphisms and amino acid substitutions were identified. These results show that KI-1 is a new geographical strain of T. gondii that can be included in the genotype I.

• Parasites, Hosts and Diseases
• /
• v.48 no.3
• /
• pp.195-201
• /
• 2010

We studied on the proteomic characteristics of Toxoplasma gondii KI-1 tachyzoites which were originally isolated from a Korean patient, and compared with those of the well-known virulent RH strain using 2-dimensional electrophoresis (2-DE), mass spectrometry, and quantitative real-time PCR. Two-dimensional separation of the total proteins isolated from KI-1 tachyzoites revealed up to 150 spots, of which 121 were consistent with those of RH tachyzoites. Of the remaining 29 spots, 14 showed greater than 5-fold difference in density between the KI-1 and RH tachyzoites at a pH of 5.0-8.0. Among the 14 spots, 5 from the KI-1 isolate and 7 from the RH strain were identified using MALDI-TOF mass spectrometry and database searches. The spots from the KI-1 tachyzoties were dense granule proteins (GRA 2,3,6, and 7), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGRPTase), and uracil phosphoribosyltransferase (UPRTase). The spots from the RH strain were surface antigen 1 (SAG 1), L-lactate dehydrogenase (LDH), actin, chorismate synthase, peroximal catalase, hexokinase, bifunctional dihydrofolate reductase-thymidylate synthase (DHTR-TS), and nucleosidetriphosphatases (NTPases). Quantitative real-time PCR supported our mass spectrometric results by showing the elevated expression of the genes encoding GRA 2,3, and 6 and UPRTase in the KI-1 tachyzoites and those encoding GRA 7, SAG 1, NTPase, and chorismate synthase in the RH tachyzoites. These observations demonstrate that the protein compositions of KI-1 and RH tachyzoites are similar but differential protein expression is involved in virulence.

• Geomechanics and Engineering
• /
• v.18 no.5
• /
• pp.515-525
• /
• 2019

A karst collapse, as a natural hazard, is totally different to a normal collapse. In recent years, karst collapses have caused substantial economic losses and even threatened human safety. A risk assessment model for karst collapse was developed based on the fuzzy analytic hierarchy process (FAHP) and grey relational analysis (GRA), which is a simple and effective mathematical algorithm. An evaluation index played an important role in the process of completing the risk assessment model. In this study, the proposed model was applied to Jiaobai village in southwest China. First, the main controlling factors were summarized as an evaluation index of the model based on an investigation and statistical analysis of the natural formation law of karst collapse. Second, the FAHP was used to determine the relative weights and GRA was used to calculate the grey relational coefficient among the indices. Finally, the relational sequence of evaluation objects was established by calculating the grey weighted relational degree. According to the maximum relational rule, the greater the relational degree the better the relational degree with the hierarchy set. The results showed that the model accurately simulated the field condition. It is also demonstrated the contribution of various control factors to the process of karst collapse and the degree of collapse in the study area.

• Parasites, Hosts and Diseases
• /
• v.55 no.5
• /
• pp.491-503
• /
• 2017

The effects of tyrosine kinase inhibitors (TKIs) were evaluated on growth inhibition of intracellular Toxoplasma gondii in host ARPE-19 cells. The number of tachyzoites per parasitophorous vacuolar membrane (PVM) was counted after treatment with TKIs. T. gondii protein expression was assessed by western blot. Immunofluorescence assay was performed using Programmed Cell Death 4 (PDCD4) and T. gondii GRA3 antibodies. The TKIs were divided into 3 groups; non-epidermal growth factor receptor (non-EGFR), anti-human EGFR 2 (anti-HER2), and anti-HER2/4 TKIs, respectively. Group I TKIs (nintedanib, AZD9291, and sunitinib) were unable to inhibit proliferation without destroying host cells. Group II TKIs (lapatinib, gefitinib, erlotinib, and AG1478) inhibited proliferation up to 98% equivalent to control pyrimethamine ($5{\mu}M$) at $20{\mu}M$ and higher, without affecting host cells. Group III TKIs (neratinib, dacomitinib, afatinib, and pelitinib) inhibited proliferation up to 98% equivalent to pyrimethamine at $1-5{\mu}M$, but host cells were destroyed at $10-20{\mu}M$. In Group I, TgHSP90 and SAG1 inhibitions were weak, and GRA3 expression was moderately inhibited. In Group II, TgHSP90 and SAG1 expressions seemed to be slightly enhanced, while GRA3 showed none to mild inhibition; however, AG1478 inhibited all proteins moderately. Protein expression was blocked in Group III, comparable to pyrimethamine. PDCD4 and GRA3 were well localized inside the nuclei in Group I, mildly disrupted in Group II, and were completely disrupted in Group III. This study suggests the possibility of a vital T. gondii TK having potential HER2/4 properties, thus anti-HER2/4 TKIs may inhibit intracellular parasite proliferation with minimal adverse effects on host cells.

• Journal of Ginseng Research
• /
• v.27 no.2
• /
• pp.56-61
• /
• 2003

This study was designed to compare the antidiabetic activities between Ginseng Radix Alba (GRA), Ginseng Radix Rubra (GRR) and Panax Quinquefoli Radix (PQR) in multiple low dose (MLD) streptozotocin (STZ) (20 mg/kg i.p injection far 5 days) induced diabetic rats. In the glucose tolerance test, 500 mg/kg of each ginseng ethanol extract was administered intraperitoneally 30 min before glucose challenge. While GRA failed to lower blood glucose level, GRR and PQR both significantly prevented the hyperglycemia when compared with the control group. In the MLD STZ-induced diabetic rats, 300 mg/kg of each ginseng ethanol extract was administered intraperitoneally for 2 weeks. Plasma glucose and insulin levels were markedly improved in all treatment groups. While GRR showed the highest antidiabetic activity, and GRA and PQR revealed somewhat equipotent antidiabetic activities, but less than that in GRR-treated group as far as blood parameters and diabetic symptoms such as polyphagia and polydipsia are concerned. Blood glucose levels were closely associated with plasma insulin levels, and this result may suggest that ginseng ethanol extracts showed the activity to enhance insulin secretion as well as preventing destruction of pancreatic islet cells. To elucidate the relationship between antidiabetic activity and ginsenoside profiles, seven major ginsenosides were quantified by HPLC. We figured out the fact that protopanaxatriol (PPT): proptopanaxadiol (PPD) ratio might play an important role in its hypoglycemia effects.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.9
• /
• pp.647-654
• /
• 2016

In the defense industry, national security takes priority over economic sense and this has translated into high cost and long-term research and development. However, the exponential growth of technology and rapid changes in the security situation in recent years have resulted in a call for the development of systems at a low cost within a short period of time. In order to implement a modularization strategy in the field of defense, the introduction of line replaceable units in OO systems needs to be prioritized. This study selects six criteria following a literature review and prioritizes 11 modules for OO systems using the project evaluation method, Grey Relational Analysis (GRA). Based on the GRA results, the grey relational grades were derived as 0.83, 0.81 and 0.80 for the M11 (Main board), M8 (EMI module), M3 (Single board computer) modules, respectively. The cost and time of development is expected to be reduced in accordance with the grey relational grade. The results of this research could be utilized for decision making on adopting modularization in similar system development or product improvement programs (PIPs).

• Microbiology and Biotechnology Letters
• /
• v.28 no.3
• /
• pp.185-187
• /
• 2000

Instead of using binary HPLC pump which is usually used for the generation of solvent gradient for the analysis of amino acid an isocratic HPLC pump and conventional gra-dient maker were demonstrated to perform such analysis withmuch lower expenses and similar efficiency.

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.12
• /
• pp.1005-1015
• /
• 2020

This paper aims to propose a Comprehensive Decision Support Model to evaluate retail companies' financial performance traded on the Vietnam Stock Exchange Market. The financial performance has been examined in terms of the valuations ratios, profitability ratios, growth rates, liquidity ratios, efficiency ratios, and leverage ratios. The data of twelve companies from the first quarter to the fourth quarter of 2019 and the first quarter of 2020 were employed. The weights of 18 chosen financial ratios are calculated by using the Standard Deviation method (SD). Grey Relational Analysis technique was applied to obtain the final ranking of each company in each quarter. The results showed that leverage ratios have the most significant impact on the retail companies' financial performance and gives some long-term investment recommendations for stakeholders and indicated that the Taseco Air Services Joint Stock Company (AST), Mobile World Investment Corporation (MWG), and Cam Ranh International Airport Services Joint Stock Company (CIA) are three of the top efficient companies. The three of the worst companies are Viglacera Corporation (VGC), Saigon General Service Corporation (SVC), and HocMon Trade Joint Stock Company (HTC). Furthermore, this study suggests that the GRA model could be implemented effectively to ranking companies of other industries in the future research.

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.11
• /
• pp.549-556
• /
• 2020

Real estate markets play an essential role in the economic development of both developed and developing countries. Investment decisions in private real estate demand the consideration of several qualitative and quantitative criteria. Especially in Vietnam, demand for housing, apartments are rising which has resulted because of the migration from rural to urban areas. This study aims to determine the influencing factors of the real estate purchasing behavior and then recommend a grey Multi-Criteria Decision Making (MCDM) support model to evaluate real estate alternatives based on a numerical example in Vietnam. A set of essential criteria are identified based on experts' opinion, and the proposed determinants are initial investment, maintenance cost, prestige location, distance to interesting places, parking lot, public transportation, property condition, total area size, number of rooms, and neighbors. The subjective weights were obtained by using the Decision-Making Trial and Evaluation Laboratory (DEMATEL) model, and the Grey Relational Analysis (GRA) technique is employed to prioritize and rank real estate alternatives. The results reveal that this approach can be useful to make purchasing decisions for many kinds of real estate property under uncertain business environments. These findings indicate that the presented hybrid model has advantages in granting flexibility to the preferences of decision makers.