• 대한물리치료과학회지
• /
• 제7권2호
• /
• pp.629-639
• /
• 2000

The purpose of this study is to find out what effects aerobic exercises and acupuncture point stimuli have on the blood. For this purpose, we reviewed 10 papers on aerobic exercises and 10 papers on the stimuli to acupuncture points and compared the changes of HDL-C, seroenzyme GOT and GPT. The results showed that HDL-C increased significantly after aerobic exercises; more so than before as stated in the papers on aerobic exercises. On the other hand, HDL-C decreased significantly after acupuncture point stimuli; more so than before as stated in the papers on the stimuli to acupuncture points. Seroenzyme GOT increased more significantly after aerobic exercises than shown before in the papers on aerobic exercises. However, there was a more significant decrease after the stimulus than shown before in the papers on acupuncture points stimuli. Seroenzyme GPT increased more significantly after aerobic exercises than shown before in the papers on aerobic exercises. There were no significant differences before and after on, the acupuncture points stimuli, according to those papers. Therefore, as HDL-C increased significantly when doing aerobic exercises, aerobic exercises prove to be a more effective treatment method than stimuli to the acupuncture points for patients with hyperlipidemia. However, from the facts that seroenzyme GOT and GPT increased significantly after aerobic exercises, we find that aerobic exercises may be more of a burden on the tissues of the liver, skeletal muscles, stomach, etc. than the stimuli to acupuncture points.

• Korean Journal of Acupuncture
• /
• 제23권2호
• /
• pp.167-176
• /
• 2006

목 적 : 본 연구는 태충(太衝) 및 양지혈(陽池穴) 에 대한 전침(電鍼)이 galactosamine 을 이용한 백서의 간독성(肝毒性)을 실험적으로 유발시킨 모델에서 예방효과(豫防效果)를 알아보고자 혈청중의 $\gamma\;-GTP$, GOT, GPT, LDH, total bilirubin, total cholesterol, triglyceride 의 변화를 관찰하였다. 방 법 : 간독성은 각 군들은 간독성을 유발하지 않고 무처치한 정상군, 간독성을 유발하고 난 후 무처치한 대조군, 각각 10 Hz, 50 Hz, 100 Hz 전침을 20 일간 10 회 시행한 후 간독성을 유발한 Pre 10, Pre 50, Pre 100군 등으로 분류하였다. 결 과 : 태충(太衝) 양지혈(陽池穴)에 대한 전침(電鍼) 치료(治療)의 예방효과(豫防效果)에서는 Pre 10 군에서는 ${\gamma}\;-GTP$, GOT, GPT, total cholesterol, triglyceride이 Pre 50군에서는 ${\gamma}\;-GTP$GOT, GPT, LDH, total bilirubin, total cholesterol이, Pre 100 군에서는 ${\gamma}\;-GTP$, GOT, LDH, total bilirubin, total cholesterol이 대조군에 비해 감소하였다. 결 론 : 위의 결과를 종합해보면 간독성에 대하여 태충(太衝) 양지혈(陽池穴)의 전침(電鍼)을 시행한 모든 군에서 간능과 지절대사에서 간손상에 대한 유의한 예방효과를 나타내었다.

• 한국식품영양과학회지
• /
• 제27권4호
• /
• pp.724-730
• /
• 1998

Effects of raw soy flour(RSY) and black(RSB) feeding on protein concentration of liver and serum, and GOT, GPT and alkaline phosphatase activities of serum in diabetic and nondiabetic rats were studied. Male rats(Sprague-Dawley), mean weight of (338.4$\pm$19.2g) were assigned to six dietary groups and fed with the assigned diet for 28 days. For each experimental, some rats were injected with streptozotocin intraperitoneally(L.P.) to induce diabets, and other rats were injected with buffer L.P. as a control group. The liver, kidney and spleen weights relative to bo요 weigth were higher in raw yellow soy flour diet diabetes(D-RSY) and black soy flour diet diabetes(D-RSB) groups than control, but the body weights were lower than control. The protein and albumin concentrations of liver and serum were lower in D-RSY and D-RSB groups than control. The albumin concentration of serum in D-RSB group was lower than control. The GOT activities of serum in RSY and RSB groups were increased compared with control, but the GPT activities were lower in diabetic control, D-RSY and D-RSB groups than control. The alkaline phosphatase activities of serum in RSY and RSB groups were higher than control, but those in D-RSY and D-RSB groups were lower than diabetic control.

• 대한의생명과학회지
• /
• 제16권2호
• /
• pp.96-104
• /
• 2010

In this study, the effects of HP4060, a pomegranate extract, on Sprague-Dawley (SD) female rats were investigated. SD rats used in the experiment were divided into 3 groups: a control group, 100 mg HP4060/kg rat powder fed group, and 25 mg HP4060/kg rat liquid fed group. After 20 days of administration, the changes of the brain neurotransmitters were measured. The data showed that the concentration of the serotonin and the norepinephrine were increased, whereas that of the epinephrine was decreased in HP4060 administered groups. In addition, the improving effect of HP4060 on depression symptom of menopause women were shown by increased immobility time of the SD rates in a separate experiment. The uterus weight of HP4060 fed groups were also shown to be increased. In order to monitor toxic effect of HP4060, glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) levels were measured, and the results showed that no significant difference in GOT and GPT levels among experimental groups implying no significant toxic side effects of HP4060. According to these results, it seems clear that HP4060 may improve symptoms of hot flush and depression caused by menopause without significant level of toxic effects.

• 동의생리병리학회지
• /
• 제20권6호
• /
• pp.1785-1788
• /
• 2006

Nonalcoholic steatohepatitis(NASH) may progress to advanced liver disease. The diagnosis is made on liver biopsy when investigating a patient with raised transaminases and an otherwise negative biochemical and serological work-up. The subject was a obese male patient who had unexplained raised GOT, GPT. He had no alcoholic consumption and drug ingested. On serological examination, HBsAg and Anti-HCV test are negative. The subject was diagnosed as NASH, and was treated with oriental treatment for obesity. After 2months treatment the raised GOT, GPT decreased to normal range.

• 한국자원식물학회지
• /
• 제19권2호
• /
• pp.296-299
• /
• 2006

마황 추출액이 흰쥐의 혈액내 지질구성, 간장기능 및 혈구성상에 미치는 영향을 검토했다. 혈장내 FFA 농도는 처리군 간에 유의한 차이를 나타내지 않았다. 그러나 triglyceride 농도는 마황 첨가량이 증가함에 따라 감소하였다. 총콜레스테롤량은 마황 첨가군에서 현저하게 감소했다. 그러나 HDL 및 LDC-cholesterol 농도는 처리군 간에 유의한 차이를 나타내지 않았다. GOT 활성치는 마황 첨가군에서 높은 경향을 보였으나, GPT 활성치는 처리군 간에 유의한 차이를 나타내지 않았다. RBC는 마황 첨가군에서 높은 수치를 보였으나, Hb 및 PCV는 처리군 간에 유의한 차이를 보이지 않았다. WBC 총수는 처리군 간에 유의한 차이를 나타내지 않았다. 백혈구 구성비는 neutrophils의 비율이 마황 첨가군에서 증가하는 경향을 보였으나 나머지 종류들은 처리군 간에 유의한 차이를 나타내지 않았다.

• 한국식품과학회지
• /
• 제30권1호
• /
• pp.192-198
• /
• 1998

제초제 paraquat의주된 독성 기전이 인체내 대사과정중 생성되는 superoxide anion radical $(O_{2-})$에 의한 것이라고 최근 보고된 바, 항산화작용을 갖는 taurine을 가지고 paraquat 독성 경감 효과 및 억제 기전에 관한 실험을 하게 되었으며 다음과 같은 결론을 얻게 되었다. 혈액생화학적인자 분석을 종합해 보면 paraquat의 독성 경감효과는 taurine, aloesin, ${\beta}-carotene$ 중 taurine이 가장 우수하였으며, aloesin도 효과가 있는 것으로 나타났다. In vivo에서 taurine은 혈액생화학적 검사에서 paraquat에 의해 유도된 간독성 지표인 sGPT. sGOT치, 신장독성 지표인 BUN, creatinine치 및 조직 손상의 지표인 ALP, MDA치를 정상으로 회복시켰다. 폐조직중의 MDA량, ALP 활성 및 collagen 량이 정상치로 회복이 되었다. 이로써 taurine은 paraquat의 폐독성 및 각 장기의 독성을 효과적으로 경감 시켜 준다는 사실을 확인할 수 있었다.

• Journal of Acupuncture Research
• /
• 제22권3호
• /
• pp.145-153
• /
• 2005

비만이 질병으로 인식되기 시작하면서 치료에 대한 관심이 높아져 가고 있으며, 한방 치료에 대한 효과 및 부작용에 대한 연구가 필요한 실정이다. 이에 의정부 한방병원에 비만 치료를 위해 내원한 20명을 대상으로 조위승청탕 가미방 치료 후에 조사한 결과는 다음과 같다. 1. 비만 환자 20명에 대한 전기침 치료 및 약물 요법 치료 후 체중감소 결과는 치료 1주 후 평균 $1.33{\pm}0.85kg$, 2주 후에 평균 $2.45{\pm}1.64kg$, 3주 후에 평균 $3.25{\pm}2.09kg$, 4주 후에 평균 $4.15{\pm}2.38kg$이 감소된 것으로 나타났으며, BMI는 치료 4주 후 $1.62{\pm}1.05$ 감소된 것으로 나타났다. 2. BMI 기준으로 4주 치료 후 위험체중에서 평균 $3.15{\pm}1.74kg$ 감소하였고, 비만 Class I에서 평균 $3.57{\pm}1.62kg$ 감소하였으며, 비만 Class II에서 평균 $6.98{\pm}2.88kg$ 감소하였다. 3. 태음인에서 $4.47{\pm}2.51kg$가 감소되었으며, 소음인에서 $3.20{\pm}0kg$ 감소되었으며, 소양인에서 $2.50{\pm}1.93kg$ 감소되었다. 4. 복약이후 식욕의 감소에 따른 체중감소량은 식욕의 저하군에서 평균 $4.94{\pm}2.64kg$ 감소하였고, 보통에서는 $3.35{\pm}1.25kg$ 식욕 증가 군에서는 $2.25{\pm}2.62kg$ 감소하였다. 5. 치료 후 체지방율은 평균 $3.16{\pm}1.25%$ 감소되었다. 6. 치료 전 후에 혈압과 맥박 모두 증가나 감소는 없었으며, 정상적으로 나타났으며, 치료 전 측정한 수치와 치료 4주 후에 재측정한 BUN, Cr, GOT, GPT는 모두 참고치 이하에서 변화를 보여 정상 소견으로 나타났으며, 각종 호소 증상으로 자율신경계 항진 증상은 11명이 호소하였으며, 불면이 1례, 발한이 9례, 심계 항진이 1례였다. 위장관 증상은 7명이 호소하였으며, 오심이 3례, 복통이 4례였으며 기타 증상으로 3명이 호소하였으며 두통이 2례 현훈이 1례였다.

• 한국동물위생학회지
• /
• 제15권2호
• /
• pp.128-133
• /
• 1992

To obtain the basic data for blood chemistry, the effects of the time elapse of serum separation on bovine blood chemical values were investigated. The results obtained are summerized as follows : 1. The constant fluctuation tendency and significance was not detected in GOT, GPT, BUN, Creatinine, ALP, CPX, Cholesterol, Ca, Mg and Pi. 2. Glucose showed the decrease tendency according to the time elapse of serum separation. As the values at 12 and 24 hours showed significant lower values than those at 1 and 2 hours (p＜0.01) it was thougth that separation time of serum should be focussed for the glucose determination.

• Environmental Analysis Health and Toxicology
• /
• 제13권3_4호
• /
• pp.117-123
• /
• 1998

Paraquat is a useful nonselective herbicide widely used throughout the world. However, accidental or intentional ingestion of the paraquat cause fetal pulmonary injuring. But there is not suitable antidote of paraquat intoxication and therapeutic agents now be used are not effective. So, in this study we intended to evaluate the inhibitory effects of DDB(dimethyl-4,4'dimethoxy-5,6,5',6'-dimethylene dioxyphenyl-2,2'-dicarboxylate) on paraquat toxicity. DDB (100mg/kg) was administered orally to SD rats lhr after paraquat(50mg/kg) injection. After 24 hours, the biochemical parameters of blood and tissues were examined. In paraquat treated groups sGPT, sGOT, BUN, creatinine, MDA and alkaline phosphatase levels in blood and MDA, glucose-6-phosphatase activity in tissues were elevated by 2 to 5 times of normal values. However in schizandrin treated groups, sGPT, sGOT, MDA and alkaline phosphatase activity in blood and MDA and glucose-6-phosphatase activity were significantly decreased to notmal levels but not in biochemical parameters of nephrotoxicity, BUN and creatinine levels. Therefore, we concluded that schizandrin can be used as an antidote of pulmono, hepatotoxicity of paraquat.