• Journal of Environmental Science International
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• v.13 no.10
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• pp.939-946
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• 2004

The relationships between subjective symptoms of toluene exposed workers and concentration of their urinary excretion of hippuric acid were investigated. The exposed groups of 146 workers exposed to toluene and the control groups of 47 workers have never been exposed to toluene in Ulsan area were selected and studied. Hippuric acid was measured by HPLC, and counts of blood cells and liver function test were also performed. The mean value of urinary hippuric acid concentration of the control group was 0.322($\pm$0.267) g/L, while that of the exposed group was 1.260($\pm$0.395) g/L. As the concentration of hippuric acid had statistical proximity in $0.1\%$ level, WBC, GOT, and GPT didn't have any proximity(P>0.05). The exposed group showed lower level of leucocyte counts 6522.40(1710.3) than the control group 6891.50(1483.7). The exposed group showed higher level of GOT(25.75), GPT(27.09) than GOT(23.75), GPT(25.21) of the control group. Dried skin was the highest complained symptom of toluene exposed workers, the second strained eye, the third poor auditory function, and the fourth was headache.

• The Journal of Dong Guk Oriental Medicine
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• v.5
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• pp.167-186
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• 1996

This study aimed to evaluate the protective effect of the MeoH extract of Ikhwangsan against galactosamine-induced hepatotoxicity. In the experiments, after treated with Ikhwangsan methanol extract to the rats for 15days and then induced hepatotoxicity with galactosamine for 2days. Then content of glutathione, level of lipid peroxide and activity of GOT GPT in the hepatic tissue, activity of GOT GPT ${\gamma}$-GTP ALP and ratio albumin/globulin in serum were measured. The results were obtained as followed : 1. The content of hepatic glutathione was significantly reduced by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably increased. 2. The level of hepatic lipid peroxide was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 3. The activity of GOT GPT in the hepatic tissue was significantly constrained by galactisamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably increased. 4. The activity of GOT GPT in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 5. The activity of ${\gamma}$-GTP in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was reduced. 6. The activity of ALP in serum was increased by galactosamine. The test group which have been pre-treated by Ikhwangsan was confirmed considerably reduced. 7. The ratio albumin/globulin in serum was reduced by galactosamine. The test group which have been pre-treated by Ikhwangsan was increased.

• Journal of Ginseng Research
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• v.4 no.1
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• pp.31-39
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• 1980

This study was prepared to observe some enzyme activities in the liver of mice treated with extracts of Ginseng anticancer compound, separated from the petroleum ether extracts by silicic acid chromatography, has the cytotoxic activity against cancer cells. Swiss mice, 72 heads were used (or this experiment and they were divdied into control, test group I and test group If, that test group I was injected crude extract and test group II was injected anticancer compound, while the control group was injected 0.9% NaCl solution. The injections were carried out 1,2,4 and 8 times once a day for 1-8 day, respectively. The liver was removed carefully from the mice at 24 hours after drugs injected, and homogenized at 4$^{\circ}C$ for enzyme study. The activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase(GPT) were determined by Reitmen and Frankel method and lactic acid dehydrogenase activity was determined by Wroblewski methods in vitro. The results obtained are summarized as follows; 1. The GOT activity was increased 26%, crude extract and 16%, anticancer compound than those of control at 1st injected groups and decreased gradually according to increase of injection time, at 8th injected groups, the GOT activity was decresed by 16%, crude extract and 12%, anticancer compound. 2. The GPT activity was not changed significantly at 1st and 2nd injected groups, but, at 4th injected groups, the GPT activity was decreased 20%, crude extract and 14%, anticancer compound. While the GPT activity was recovered to normal value at 8th injected groups. 3. At 1st injected groups, the LDH activity was increased 17%, anticancer compound, while those of crude extract was shown normal value. At 2nd injected groups, the LDH activity increased 35yo:, crude extract while those of anticancer compound was showed normal value. And the LOH activity was recovered gradually at 4th and 8th injected groups.

• Journal of the Korean Society of Food Science and Nutrition
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• v.22 no.1
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• pp.19-26
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• 1993

In this study rats in fasting or fed protein free restricted diet including only fat showed much lowered level of serum cholesterol and triglyceride accompanied by utmost weight loss and high level of blood urea nitrogen indicated the tissue degradation, especially in liver with signs of damage or necrosis of hepatic parenchymal cell leading to elevated glutamic pyruvate transaminase value and to death. Rats fed only perilla oil in starvation or as fat source in normal diet dropped down the level of serum cholesterol and triglyceride compared to beef tallow fed rat. But with evidence of glutamic pyruvate transaminase values which was significantly elevated long term ingestion of perilla oil is likely to cause the lesion or any damage of hepatic function.

• Journal of Pharmacopuncture
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• v.8 no.3
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• pp.21-29
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• 2005

In order to Experimental study effects of ${\ulcorner}Triglii\;Semen{\lrcorner}$ on the blood in Rats, we have made rats by administering Animal control chamber for two weeks, then have administered. The results is were summerized as follows: 1. The total cholesterol, triglyceride and Hct, Hb by generally rats oral ingestion by Triglii semen of the sample group were decreased as compared with those of the control group. 2. GOT, GPT by generally rats oral ingestion were increased as compared those of control group. According to the above results, Triglii Semen showed inhibition on decrease of serum total cholesterol and Hb, Hct, WBC, RBC contents as well as inhibition on increase of GOT, GPT.

• Journal of Sericultural and Entomological Science
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• v.20 no.1
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• pp.5-10
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• 1978

The effects of foliar spray of Kinetin (6-Furfurylaminopurine) on the growth of mulberry tree and the metabolic activities in the leaves were measured. The results of this experimented are summarized as follows: 1. Foliar application of Kinetin was effective in increasing of leaf area, the fresh and dry weight of the leaves, the length and diameter of shoots. 2. Chlorophyll content was generally increased in all treated leaves. 3. All the treated leaves were higher in GOT activity than the control leaves but were lower in GPT activities. 4. The activities of the carbohydrate metabolism in the mulberry leaves were higher than that of the control in all treated leaves.

• Journal of Environmental Health Sciences
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• v.33 no.3
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• pp.202-206
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• 2007

Petasites japonicus (Compositae) is a perennial herb which has been used as treatment of antitussive, expectorant, sedatives, paralysis, diurectics in folk remedies. The pharmacological studies of this natural drug have not yet estabilished. So, we examined anti-lipid peroxidative effects and liver protective effect on $CCl_4$ induced lipid peroxidation and hepatotoxicity in rats. In vivo liver lipid, MeOH Ex. revealed significant increase of anti-lipid peroxidative effects according to concentration dependently. In chemical parameters obtained from serum analysis, MeOH Ex. as a increase of medicine concentration (0.25 g/kg, 0.5 g/kg, 1.0 g/kg), GOT, GPT, AlP decreased. In 0.5 g/kg GPT administered group, there was relative in GOT, AlP. Cholesterol decreased in 1.0 g/kg and 1.0 g/kg administered group, BUN decreased relatively in 1.0 g/kg administered group.

• Microbiology and Biotechnology Letters
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• v.28 no.4
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• pp.209-213
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• 2000

The cultured mycelia of Ganoderma lucidum were extracted and the extract was separated into six fractions by organic solvent fractionation. The antihepatotoxic activity of all the fractions was evaluated by measuring activities of glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT). Among the fractions tested, the high-polarity fractions such as aqueous and n-butanol fractions significantly reduced activities of GPT and GOT in CCl4- and galactosamine-intoxicated rat primary hepatocytes. When intracellular synthetic activities were measured by pulsing the rate primary cultured hepatocytes with [3H]-uridine and [3H]-leucine, activities of DNA, RNA and protein. When direct toxicities of the fractions were measured against human hepatoma(SK-Hep-1), the non-polarity fractions such as n-butanol and ethyl acetate fractions showed potent direct cytotoxicities even at the concentration of 1 $\mu\textrm{g}$/ml. These data showed that Ganoderma lucidum has hepatoprotective and hepatotoxic recovery principles in its mycelia.

• Annual Conference on Human and Language Technology
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• 2021.10a
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• pp.118-123
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• 2021

현대 사회에서 소셜 네트워킹 서비스의 증가와 확산은 많은 정보를 쉽고 빠르게 얻을 수 있도록 하였지만 허위·과장 정보의 확산이 큰 문제로 자리잡고 있다. 최근 해외에서는 이들을 자동으로 분류 및 판별하고자하는 Fact 검증 모델에 관한 연구 및 모델 학습을 위한 데이터의 제작 및 배포가 활발히 이루어지고 있다. 그러나 아직 국내에서는 한국어 Fact 검증을 위한 데이터가 많이 부족한 상황이기 때문에 본 논문에서는 최근 좋은 성능을 보이는 openai 의 GPT-3를 한국어 태스크에 적용시킨 HyperCLOVA 를 이용하여 한국어 Fact 검증 데이터 셋을 자동으로 구축하고 이를 최신 Fact 검증 모델들에 적용하였을 때의 성능을 측정 및 분석 하고자 하였다.

• Proceedings of the Korean Society of Computer Information Conference
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• 2023.01a
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• pp.303-305
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• 2023

본 논문에서는 트랜스포머를 사용한 이미지 캡셔닝 방법과 비디오 캡셔닝 방법을 제안한다. 트랜스포머의 입력으로 사전 학습된 이미지 클래스 분류모델을 거쳐 추출된 특징을 트랜스포머의 입력으로 넣고 인코더-디코더를 통해 이미지와 비디오의 캡션을 출력한다. 이미지 캡셔닝의 경우 한글 데이터 세트를 학습하여 한글 캡션을 출력하도록 학습하였으며 비디오 캡셔닝의 경우 MSVD 데이터 세트를 학습하여 학습 후 출력 캡션의 성능을 다른 비디오 캡셔닝 모델의 성능과 비교하였다. 비디오 캡셔닝에서 성능향상을 위해 트랜스포머의 디코더를 변형한 GPT-2를 사용하였을 때 BLEU-1 점수가 트랜스포머의 경우 0.62, GPT-2의 경우 0.80으로 성능이 향상됨을 확인하였다