Browse > Article
http://dx.doi.org/10.5668/JEHS.2007.33.3.202

The Effect of Petasites japonicus Extract on Hepatotoxicity in Rats  

Park, Ji-Young (Department of Oriental Medicine Resources, Hyechon College)
Publication Information
Journal of Environmental Health Sciences / v.33, no.3, 2007 , pp. 202-206 More about this Journal
Abstract
Petasites japonicus (Compositae) is a perennial herb which has been used as treatment of antitussive, expectorant, sedatives, paralysis, diurectics in folk remedies. The pharmacological studies of this natural drug have not yet estabilished. So, we examined anti-lipid peroxidative effects and liver protective effect on $CCl_4$ induced lipid peroxidation and hepatotoxicity in rats. In vivo liver lipid, MeOH Ex. revealed significant increase of anti-lipid peroxidative effects according to concentration dependently. In chemical parameters obtained from serum analysis, MeOH Ex. as a increase of medicine concentration (0.25 g/kg, 0.5 g/kg, 1.0 g/kg), GOT, GPT, AlP decreased. In 0.5 g/kg GPT administered group, there was relative in GOT, AlP. Cholesterol decreased in 1.0 g/kg and 1.0 g/kg administered group, BUN decreased relatively in 1.0 g/kg administered group.
Keywords
Petasites japonicus; anti-lipid peroxidation; hepatotoxicity;
Citations & Related Records
Times Cited By KSCI : 5  (Citation Analysis)
연도 인용수 순위
1 Kim, J.G. : Illustrated Natural Drugs Encyclopedia(I), Seoul, Namsandang Press, 44, 1984
2 Yaoita, Y. and Kikuchi, M. : Eremopetasidione, a nor-sesquiterpenoid from the rhizomes of Petasites japonicus. Phytochemistry, 37(6), 1765-1766, 1994   DOI   ScienceOn
3 Yaoita, Y., Nagata, K. and Suzuki, N. : The structure of eremophilenolides isolated from the P. japonicus. Chemical and Pharmaceutical Bulletin (JPN), 40(12), 3277-3282, 1992   DOI   ScienceOn
4 John D. Bauer : Clinical laboratory methods, nine edition, The C.V. Mosby Co. S.C.L. 535-538, 1982
5 Lee, C.G. and Kim, N.J. : Anti lipid peroxidation and liver protective effects of polygonum aviculare L. Korean Journal of Pharmacognosy, 25(1), 59-66, 1994
6 Xu, J. and Hu, Q. : Effect of foliar application of selenium on the antioxidant activity of aqueous and ethanolic extracts of selenium-enriched rice. Journal of Agriculture Food Chemistry, 52, 1759-1768, 2004   DOI   ScienceOn
7 Basu, S., Smedman, S. and Vessby, B. : Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Letters, 468, 33-36, 2000   DOI   ScienceOn
8 Lee, S.L. and Kim, J.G. : Anti-microbial activity of soybean extract against oral microbes. Korean Journal of Environmental Health, 32(2), 192-197, 2006   과학기술학회마을
9 Park, J.Y. and Kim, E.K. : The effect of Cichorium intybus extract on hepatotoxicity in rats. Korean Journal of Environmental Health, 32(3), 235-239, 2006   과학기술학회마을
10 Stanley L. Robbins. Ramzis S. Cotran, Vinay Kumar : Pathologic Basis of Disease, third edition, W. B. S Saunders Company, 12, 1984
11 Han,Y.N. and Oh, H.K. : Antioxidant components of gardenia fruit. Korean Journal of Pharmacognosy, 25(3), 226-232, 1994   과학기술학회마을
12 Lim, W.G. : The wild plants for food and medicine, Seoul. Five Star Press, 115, 1990
13 Seo, B.G. and Kim, Y.B. : Effects of aralia elata on lipid peroxidation. Yakhak Hoeji, 37, 270-275, 1993
14 Zhou, K., Laux, J.J. and Yu, L. : Comparision of Swiss red wheat grain and fractions for their antioxidant properties. Journal of Agriculture Food Chemistry, 52, 1118-1123, 2004   DOI   ScienceOn
15 Chae, Y.B. and Kim, H.J. : The research of Korean utilized plants. Korea Research Institute of Chemical Technology, Daejeon, 254-261, 1988
16 Chance, B., Sies, H. and Boveris, A. : Hydroperoxide metabolism mammalian organs. Physiol. Rev., 59, 527-536, 1979   DOI
17 Kim, C.M. : The Encyclopedia of Orietal Herbal Medicine (II), Seoul, Chungdam Press, 1815-1816, 1997
18 Lee, T.B. : Illustrated flora of Korea, Seoul, Hyangmoon Press, 742, 1994
19 Mun, S.I. and Ryu, H.S. : Further screening for antioxidant activity of vegetable plants and its active principles from Zanthoxylum Schinifolium. Journal of the Korean Society of Food and Nutrition, 23(3), 466-472, 1994
20 Yagik : A simple fluormetric assay for lipid peroxide in blood plasma. Biochem. Med., 15, 212-219, 1976   DOI   ScienceOn
21 Shahina, A. Ghazanfar : Handbook of Arabian medicinal Plants, 42-49 CRC Press, U.S.A., 1994
22 Lee, S.L. and Kim, J.G. : Inhibitory effect of Doenjang (Korean Fermented Soybean Paste) and soybean extracts on the growth of KB cells. Korean Journal of Environmental Health, 31(5), 444-450, 2005   과학기술학회마을
23 Park, J.Y. and Kim, N.J. : The effects of chelidonii herba extract on the cell mediate and humoral immune responses in mice. Korean Journal of Environmental Health, 31(1), 66-72, 2005   과학기술학회마을