• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4775-4778
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• 2013

The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. In the present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87 and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interfering RNA oligos inhibits cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing GPR48. Therefore, our results indicated that GPR48 activates Wnt/${\beta}$-catenin signaling to regulate cancer cell proliferation.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.1
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• pp.48.1-48.1
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• 2021

Gaussian process regression (GPR) is a powerful method used for model-independent analysis of cosmological observations. In GPR, it is important to decide an input mean function and hyperparameters that affect the reconstruction results. Depending on how the input mean function and hyperparameters are determined in the literature, I divide into four main applications for GPR and compare their results. In particular, a zero mean function is commonly used as an input mean function, which may be inappropriate for reconstructing cosmological observations such as the distance modulus. Using mock data based on Pantheon compilation of type Ia supernovae, I will point out the problem of using a zero input and suggest a new way to deal with the input mean function.

• Biomolecules & Therapeutics
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• v.30 no.1
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• pp.48-54
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• 2022

GPR43 (also known as FFAR2), a metabolite-sensing G-protein-coupled receptor stimulated by short-chain fatty acid (SCFA) ligands is involved in innate immunity and metabolism. GPR43 couples with Gα_i/o and Gα_q/11 heterotrimeric proteins and is capable of decreasing cyclic AMP and inducing Ca²⁺ flux. The GPR43 receptor has additionally been shown to bind β-arrestin 2 and inhibit inflammatory pathways, such as NF-κB. However, GPR43 shares the same ligands as GPR41, including acetate, propionate, and butyrate, and determination of its precise functions in association with endogenous ligands, such as SCFAs alone, therefore remains a considerable challenge. In this study, we generated novel synthetic agonists that display allosteric modulatory effects on GPR43 and downregulate NF-κB activity. In particular, the potency of compound 187 was significantly superior to that of pre-existing compounds in vitro. However, in the colitis model in vivo, compound 110 induced more potent attenuation of inflammation. These novel allosteric agonists of GPR43 clearly display anti-inflammatory potential, supporting their clinical utility as therapeutic drugs.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.1
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• pp.42-48
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• 2017

Characteristics of ground-penetrating radar(GPR) signals for detecting buried pipes are investigated numerically. Transmitting and receiving parts of a GPR system, a subsurface soil and a plastic pipe filled with a dielectric material are modeled by using the finite-difference time-domain(FDTD) method. FDTD simulations for observing aspects of GPR signals are performed as a function of the diameter of the pipe and the permittivity of the filling material in the pipe. GPR signals scattered by a dielectric filled pipe appear as a superposition of two waves, such as the specular wave from the front convex surface of the pipe and the axial wave from the rear concave surface of the pipe. We show that the amplitude, the polarity, the delay time of two waves depend on the size of the pipe and the permittivity of the filling material in the pipe.

• Korean Journal of Heritage: History & Science
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• v.48 no.4
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• pp.74-93
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• 2015

Geophysical survey of Korea was introduced in Nara National Research Institute of Cultural Heritage in 1995. At that time, it has been activated geophysical survey of architecture and civil engineering in Korea. But there was no exploration experts to be combined the archaeology. For this reason, National Research Institute of Cultural Heritage has introduced the physical exploration. Through the expert exchanges South Korea and Japan carried out joint exploration. And it has increased the reliability of the exploration method and exploration results. It is GPR the most method commonly in geophysical exploration. There are many usability before excavation because of good resolution. However, the shallow GPR penetration depth has limitations in large mounds. We were able to take advantage of the resistivity analysis program to study the underground structure to deep through the experts exchange. We was able to get a good result that overcomes the limitations of GPR exploration in a number of burial mounds including Naju bokamri by the resistivity analysis program. In particular, we confirmed the location of the burial main body by compares the results of exploration and excavation results. In the future we will perform a convergence research of exploration and archaeology through a variety of joint research. In addition we will have to build a new network of archaeological science.

• 한국도로학회지:도로
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• v.16 no.3
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• pp.48-53
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• 2014

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.12
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• pp.3-12
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• 2016

This paper describes the development of the ground penetrating radar (GPR) system using UWB impulse radar with 48 Channel array. GPR is an effective alternative technology to resolve th disadvantages of metal detectors. Metal detectors have a very low detection probability of non-metallic landmine and high false alarm rates caused by metallic materials under the ground. In this paper, we use the mono-cycle pulse waveform with about 600 ps pulse width to obtain high resolution landmine microwave images. In order to analyze performances of this system, we utilize indoor test facility that made up of rough sandy loam which representative Korean soil. The mimic landmine models of metal/non-metal and anti-tank/anti-personnel landmines buried in DMZ (demilitarized zone) of Korea are used to analyze the detection depth and the shape of the mines using microwave image.

• 한국지구물리탐사학회:학술대회논문집
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• 2004.08a
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• pp.25-48
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• 2004

Structures show the phehomena of deformation and lowering of function with time-lapse by artificial environments and changes of geotechnical conditions or accumulation of initial deformation elements. This study aims the structural assessment of cultural property, Chum-Sung-Dae, located in Kyeongju city, Korea. It was built about 1,300 years ago, and has undergone deformation and ground-subsidence with time-lapse. Non-destructive evaluation techniques were applied to the Chum-Sung-Dae, to protect it from survey Because of this reason, 3D precise laser scanning surveying system was applied to measure the exact size of Chum-Sung-Dae, displacement and declining angles. Geophysical exploration also was applied to study the subsurface distribution of geotechnical parameters or physical properties. Natural frequencies were measured from real and model of Chum-Sung-Dae to study the dynamic characteristics of vibration and/or earthquake load and stiffness of structures.