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http://dx.doi.org/10.7314/APJCP.2013.14.8.4775

GPR48 Promotes Multiple Cancer Cell Proliferation via Activation of Wnt Signaling  

Zhu, Yong-Bin (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine)
Xu, Lin (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine)
Chen, Ming (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine)
Ma, Hai-Na (Department of Otolaryngology, Second Affiliated Hospital, Zhejiang University School of Medicine)
Lou, Fang (Department of Oncology, Run Run Shaw Hospital, Zhejiang University School of Medicine)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.8, 2013 , pp. 4775-4778 More about this Journal
Abstract
The key signaling networks regulating cancer cell proliferation remain to be defined. The leucine-rich repeat containing G-protein coupled receptor 48 (GPR48) plays an important role in multiple organ development. In the present study, we investigated whether GPR48 functions in cancer cells using MCF-7, HepG2, NCI-N87 and PC-3 cells. We found that GPR48 overexpression promotes while its knockdown using small interfering RNA oligos inhibits cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing GPR48. Therefore, our results indicated that GPR48 activates Wnt/${\beta}$-catenin signaling to regulate cancer cell proliferation.
Keywords
GPR48; Wnt/${\beta}$-catenin; cancer cell; cell proliferation;
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