• 전자공학회논문지SC
• /
• 제41권5호
• /
• pp.9-18
• /
• 2004

본 논문에서는 펄스레이더를 이용한 차량검지 알고리즘을 제안하였다. 제안된 알고리즘은 likelihood개념을 이용한 likelihood ration를 통해 하나의 펄스신호에서 분류위치를 추출하고 추출된 분리점을 기준으로 신호를 분리, 간략화 하였다. 이렇게 처리 된 펄스신호에서 연속된 신호의 유클리드거리를 이용하여 단순 군집 탐색 알고리즘에 의해 차량을 검지하였고, 실험을 통해 제안된 알고리즘의 유용성을 확인하였다.

• 대한한방내과학회지
• /
• 제36권3호
• /
• pp.217-227
• /
• 2015

Objectives: The primary aim of this study was to identify bioactive compounds in Dangnyo-hwan, a Korean herbal medicine, through instrumental analysis using LC-MS/MS and ICP, and investigate its potential use in diabetes treatment. Methods: The extract of Dangnyo-hwan has 12 medicinal herbs; these were compared with 18 marker substances selected from literature survey. Results: LC-MS/MS analysis could detect 9 of the 18 bioactive compounds: citruline, catalpol, berberine, ginsenoside Rb1, ginsenoside Rg1, oleanolic acid, β-sitosterol, mangiferin, and schizandrin. While harmful heavy metals such as As, Pb, Cd, Hg, Ni, and Cu were not present in high concentrations, Zn concentration was 4.2 mg in 100 g Dangnyo-hwan. Conclusions: Instrumental analysis such as LC-MS/MS and ICP was successfully used to identify bioactive compounds in Dangnyo-hwan. Detection of 9 bioactive substances and Zn from the herb medicine is a valuable finding, and suggests that Dangnyo-hwan is a candidate medicine for diabetes. Further investigations like in vitro assay, percent GPR 119 activity, and percent human DGAT-1 inhibition are underway.

• 식품보건융합연구
• /
• 제4권4호
• /
• pp.18-25
• /
• 2018

Proteins play a key role in many functions such as metabolic activity, differentiation, as cargos and cell fate regulators. It is necessary to know about the markers involved in male fertility in order to develop remedies for the treatment of male infertility. But, the role of the proteins is not limited to particular function in the biological systems. Some of the proteins act as ion channels such as catsper and proteins like Nanos acts as a translational repressor in germ cells and expressed in prenatal period whose role in male fertility is uncertain. Rbm5 is a pre mRNA splicing factor necessary for sperm differentiation whose loss of function results deficit in sperm production. DEFB114 is a beta defensin family protein necessary for sperm motility in LPS challenged mice where as TEX 101 is a plasma membrane specific germ cell protein whose function is not clearly known u to now. Gpr56 is another adhesion protein whose null mutation leads to arrest of production of pups in rats. Amyloid precursor protein role in Alzheimer's disease is already known but it plays an important role in male fertility also but its function is uncertain and has to be considered while targeting APP during the treatment of Alzheimer's disease. The study on amyloid precursor protein in male fertility is a novel thing but requires further study in correlation to alzheimer's disease.

• 지질공학
• /
• 제18권2호
• /
• pp.127-136
• /
• 2008

지반의 수분량 분포 및 강우에 의한 침윤선 거동과 지하수 수위 분포조사와 같이 광역지역을 대상으로 한 물리탐사기법인 지하투과 레이다탐사(ground penetrating radar, GPR) 및 전기비저항탐사(electrical resistivity survey)등을 이용해 광역조사가 이루어지며, 이에 반해 지반의 유전 반응(dielectric responses)을 이용한 유전율 측정법(permittivity method)은 협소한 지점에 대한 보다 정확한 지반의 물성 파악을 위해 다양한 연구분야에서 적용되어 왔다. 본 연구에서는 불포화 지반에 인공강우를 내려 침윤선의 침투거동을 파악하기 위하여 토층의 수분량 변화를 frequency domain reflectometry 시험법을 적용하여 측정하고, 간극수압과 간극 공기압의 변화는 간극수압계로 측정하였다. 이들 측정센서는 일정 깊이의 불포화 화강풍화토 공시체 몰드에 매설하고, 상단부에서부터 강우의 침투수 거동을 계측하여 물성치 변화로부터 수분분포 및 침윤선 분포특성을 평가하는 기법을 제안하였다. 지반 변형을 효율적으로 평가하기 위해 지반의 체적함수비, 간극수압 및 간극공기압의 측정 기술을 기존의 측정법과 비교해 신속하고 정량적으로 파악할 수 있는 측정방법에 대한 연구를 진행할 예정이다.

• 한국지반신소재학회논문집
• /
• 제18권3호
• /
• pp.79-88
• /
• 2019

본 연구에서는 도로노면 하부 지반에서 발생한 공동의 확장특성을 평가하기 위하여, 지하수주입 실험을 수행하였다. 즉, 공동체적에 비례한 일정량의 물을 단계별로 주입하고, 주입한 물이 배출됨에 따라 확대되는 공동을 모니터링 함으로써, 공동의 체적변화를 확인하였다. 실험결과, 지하수 주입에 따른 공동의 체적은 증가하다 수렴 또는 감소하는 경향을 나타냈다. 이는 지하수 주입 시, 공동이 확장되는 과정에서 주변의 이완된 지반이 일부 붕괴되거나 세립토가 주변 지반의 간극을 채우기 때문인 것으로 분석되었다. 또한 지하수 주입 단계에 따른 공동의 체적변화와 확장특성을 분석한 결과, 실험대상 공동은 횡방향으로 확장되는 것을 확인할 수 있었다. 그리고 지하수 유동에 따라 이완된 공동 주변지반이 붕괴되고, 붕괴된 토사가 공동하부의 지중으로 유실되는 과정이 반복됨으로써 공동이 확장되는 것으로 평가되었다.

• 대한한의학방제학회지
• /
• 제24권2호
• /
• pp.80-99
• /
• 2016

Objectives : Instrumental chemical analysis was utilized to investigate the effect of Add-Omit-Saenghyeoryunbu-eum(AO-SHU) on diabetic treatment. One of the most exciting, yet also controversial, arguments is the safety and biological mechanisms of the natural medicine on human body. Therefore, the aim of this study is to provide a better understanding on bioactive chemical components, hazards of heavy metal contamination and biological mechanism of the diabetic medicine composed of 12 different natural herbs. Methods : To study bioactive compound and metallic component in the diabetic medicine in detail, LC-MS/MS (Liquid Chromatography-Mass/Mass), GC (Gas Chromatography) and ICP (Inductively Coupled Plasma) were utilized to characterize the extract of the diabetic medicine and the result was compared with 18 marker substances selected from literature survey. In addition, in vitro assay experiments including GPR 119 activity and human DGAT-1 inhibition, and OGTT (Oral Glucose Tolerance Test) were performed to verify the effectiveness of this medicine on diabetic treatment. Results : Out of 18 marker substances, 9 bioactive compounds were identified from LC-MS/MS analysis which include Citruline, Catalpol, Berberine, Ginsenoside Rb1, Ginsenoside Rg1, Oleanolic acid, β-Sitosterol, Mangiferin, and Schizandrin. ICP study on 245 residual pesticides revealed that 239 species were not detected but 6 species, Dimethomorph, Trifloxystrobin, Pyraclostrobin, Isoprocarb, Carbaryl and Flubendiamide, while the amounts are trace levels, below permitted concentrations. The biological activity was observed in vitro assay and Oral Glucose Tolerance Test(OGTT), which are consistent with a preliminary clinical test result, a drop in blood sugar level after taking this herbal medicine. Conclusions : Instrumental chemical analysis using LC-MS/MS, GC, and ICP was conducted successfully to identify bioactive compounds in AO-SHU for the treatment of diabetes, finding 9 bioactive compounds. Furthermore, in vitro assay experiments and OGTT show that AO-SHU has its biological activities, which imply that it can be a candidate for the future diabetes remedy.