• Journal of Pharmaceutical Investigation
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• v.14 no.2
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• pp.86-91
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• 1984

A ginseng preparation (GP) consisting of ginseng ex., lycium fructus ex., four kinds of vitamines and caffein was evaluated for acute toxicity and general pharmacology. Average lethal doses $(LD_{50})$ of GP in male mice were 2,988mg/kg (i.p.) and more than 3g/kg (p.o.). In dosage of 300 and 900mg/kg (p.o.) showed no analgesic activity in both tests of the writhing method induced by acetic acid and of tail pressure method and no effect on the pentetrazole-induced convulsion. However, it appeared to have a hypothermic action only in dose of 900mg/kg. The duration of hypnosis induced by hexobarbital sodium in mice was shortened by GP, being probably due to caffein. GP Produced no marked contraction of isolated ileum and uterus in high concentrations of up to $1{\pm}10^{-3}g/ml$. These results suggested that GP did not show any considerable central nervous depressant activity and exhibited very weak actue toxicity in mice.

• Spatial Information Research
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• v.14 no.2 s.37
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• pp.211-221
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• 2006

GLONASS(Global NAvigation Satellite System) using the satellite information on 19,100km altitude supplies the location information similar method with GPS. Therefore, many researches study in combination GPS and GLONASS. This research compares with deciding coordination of one unit parcel using RTK-GPS and RTK-GPS/CLONASS. Then we examine the possibility of RTK-GPS/GLONASS for determining parcel coordinate.

• Korean Journal of Microbiology
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• v.29 no.1
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• pp.1-7
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• 1991

Human immunodeficiency virus type 1 (HIV-1) causes a deadly infectious disease, Acquired Immunodeficiency Syndrome (ADIS). As a first step to develop a reliable and fast diagnostic procedure for HIV-1 infection, we cloned various immunodominant epitopes of HIV-1 in bacterial expression vectors containing tac or trp promoter. While the protein level of direct expression of gp160 was low, trp E fused gp120, gp41 and p17-p24 were produced at high levels (15-30% of total bacterial proteins) in E. coli. Since gp120 and gp41 contain relatively conserved regions which can react with antibodies in the plasma from most of HIV-1 infected individuals, these expression clones were used for large preparations of HIV-1 antigens.

• Proceedings of the Korean Biophysical Society Conference
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• 1996.07a
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• pp.33-33
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• 1996

An ectodomain of gp41, the transmembrane fusion protein of HIV, without the fusion peptide region was expressed using pET system in E. coli. The expressed protein gp41core, was isolated as inclusion body and was purified by ion-exchange chromatography after solubilized in 6M urea. The purified denatured protein was renaturated and the folded domain of gp41core was identified by the presence of the proteolysis resistence domain and a high content of ${\alpha}$-helical secondary structure. (omitted)

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2001.10a
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• pp.71-82
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• 2001

인공위성을 이용한 범 지구 위치결정시스템인 GPS(Global Positioning System)는 수 밀리의 정밀도로 정적, 동적 위치측정이 가능한 시스템으로 교량, 건축물, 댐 등 각종 구조물의 미세한 변위를 측정하는데 이용되고 있다. 최근 국내에서도 대형구조물의 변위 측정에 GPS를 활용하려는 시도가 부분적으로 이루어지고 있으나 초보적인 단계이며 체계적인 연구가 이루어지지 못하고 있는 실정이다. 본 연구에서는 RTK(Real Time Kinematic) GPS로 구조물의 변위를 실시간 측정하고 모니터링 할 수 있는 시스템을 개발하였다. 먼저 예비실험으로 반송파의 차분에 의해서 증폭되는 수신기의 측정잡음 오차, 다중경로 오차, GDOP(Geometric Dilution of Precision)가 RTK GPS의 위치정확도에 미치는 영향을 분석하였다. 그리고, RTK GPS를 이용하여 마포대교를 관측한 결과, 수 센티미터 정도 발생하는 구조물의 변위를 3차원으로 정밀 관측할 수 있었으며, 본 연구에서 개발한 모니터링프로그램을 이용하여 구조물의 거동을 실시간으로 모니터링 할 수 있었다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.1125-1129
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• 2005

In this study, for suggesting the development of GPS navigation in the naval vessels, the test of GPS error is conducted for analyzing the precision of GPS installed in the naval vessels. And the reliability and utilization of GPS are verified throughout interview and questionnaire with the workers in the naval vessels.

• Journal of Information Technology Application
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• v.3 no.3
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• pp.1-24
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• 2001

This paper introduces the genetic programming algorithm(GP), which can approximate highly nonlinear functions, as a tool for the modeling of response surfaces. When the response surfaces is approximated, the very small or minimal teaming set should be used, and thus it is almost certain that GP trees will show overfilling that must be avoided at all costs. We present a novel method, calledDDBS(DirectionalDerivative-Based Smoothering), which very effectively eliminates the unwanted behaviors of GP trees such as large peaks, oscillations, and also overfitting. Four illustrative numerical examples are given to demonstrate the performance of the genetic programming algorithm that adopts DDBS.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.10a
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• pp.339-342
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• 2010

최근 프로세서가 클럭 향상의 한계에 부딪힘에 따라, 프로세서의 성능을 향상시키기 위해 멀티 코어 기반의 병렬처리를 이용한 방법들이 제안 되고 있다. 본 논문은 여러개의 연산기를 한 명령어 사이클에 동시에 사용할 수 있는 MIMD(Multiple Instruction, Multiple Data) 구조를 가지며, Scratch Counter를 이용해 멀티 코어와 멀티 스레드의 작업을 할당하는 구조의 GP-GPU(General Purpose - Graphics Processing Unit)를 활용해 멀티 코어, 멀티 스레드 환경에서의 효율적인 픽셀 셰이딩 방법을 설계 하였다. 선형 안개 픽셀 셰이딩의 경우 싱글코어에서 18.3 FPS이며 4개의 멀티코어 GP-GPU에서는 4배가 증가한 73.2 FPS 결과를 얻었다.

• Journal of Integrative Natural Science
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• v.5 no.3
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• pp.190-194
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• 2012

Human P-gp is one of the protein responsible for the multidrug resistance (MDR) develpment. MDR is a major cause of the cancer chemotherapy. In this paper, we performed homology modeling, docking study of papayriferic acid into the P-gp nucleotide binding domain (NBD2). For human P-gp, X-ray crystal structure is not known yet. We developed homology model for human NBD2 using HlyB ABC transporter structure (PDB code: 1XEF, resolution 2.5 ${\AA}$). Docking study was performed using Autodock. Docking result was analyzed, which shows that ligand docks into steroid binding site and interacts through hydrophobic and hydrophilic interactions.

• Journal of Integrative Natural Science
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• v.5 no.1
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• pp.18-21
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• 2012

The resistance of tumour cells against cytotoxic drug is significant limitation in successful chemotherapeutic treatment of cancer. To date, no crystal structure is available for human P-gp. We developed homology model for human P-gp NBD2 by using coordinates of transporter associated protein (TAP1). Docking study was performed for 8-geranyl-chrysin (Flavonoids) inhibitor in the NBD2 model. Ligand-protein interactions were determined which indicates that the 8-geranyl chrysin shares two overlapping sites in the cytosolic domains of P-gp, the ATP site and a hydrophobic steroid-binding site.