• 제목/요약/키워드: GIN

검색결과 370건 처리시간 0.027초

감마선 및 화학적 돌연변이원 처리가 스테비아 (Stevia rebaudiana Bert.)의 종자 발아 및 초기 생장에 미치는 영향 (Effects of Gamma-ray and Chemical Mutagens on the Germination and Seedling Growth in Stevia rebaudiana Bert.)

  • 윤태영;김이엽;김영호;최진수;현경섭;성윤희;조한직;김동섭;강시용;고정애
    • 방사선산업학회지
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    • 제6권2호
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    • pp.189-197
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    • 2012
  • This study was carried out to develop the improved useful mutants for yield or composition of stevia plants using the gamma ray or chemical mutagens treatments. The seeds of stevia 'Suwon No. 11' were irradiated up to 400 Gy of gamma ray. Chemical mutagens were treated on the seeds of the 'Suwon No. 11' using 0.07% colchicine, 10 mM sodium azide, or 10 mM NMU for various durations. The germination rate, and shoot and root growth of seedling were estimated at 30 days after gamma ray irradiation or chemical mutagen treatment, and the plant height, the number of branches, and leaf length and width were examined at 3 months after mutagenesis treatments. In the case of gamma ray treatments, the germination rate and early-stage growth were decreased as the increase of radiation dose, and the 50% lethal dose was found to be 200 Gy. the plant height was decreased as the increase of radiation dose, while the number of branches per plant and leaf length were increased. Leaf shape was modified to the relatively longer one compared to the control, which was identified more apparently at the treatments of higher than 150 Gy. In the treatment of chemical mutagens, the rate of germination and survival were decreased as the increase of incubation time. The 50% lethal dose for germination rate were identified as the conditions of the 15 hours incubation in 0.07% colchicine, the 4 hrs in 10 mM sodium azide, and the 2 hrs in 10 mM NMU, in the three chemical mutagens treatments. Chemical mutagens had no influence on shoot growth, while root growth was increased, especially as the incubation time was extended. The highest root growth occurred in the NMU treatment at 6 hrs incubation time. The plant height was decreased as the increase of incubation time in the chemical mutagens treatments. Among the chemical mutagens, NMU was the most effective to induce the mutants with long-shaped or the least lobed leaves.

Linac 기반 VMAT 정위적 수술 뇌 병변 연구와 기존의 정위적 방사선 수술 비교 (Comparison of Linac-based VMAT Stereotatic Radiosurgery and Conventional Stereotatic Radiosurgery for Multiple Brain Lesions)

  • 장은성;장보석
    • 한국방사선학회논문지
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    • 제15권2호
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    • pp.239-246
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    • 2021
  • 기존 연구인 선량평가의 임상 적용 및 신뢰도 확보를 위하여 EPID를 이용하여 Portal Dosimetry를 검증하였다. 뇌정위방사선수술 2.5 cm cone을 장착하여 360° 회전조사에 의한 측정치와 Geant4의 선량분포를 비교하였다. 뇌전이 환자의 선량분포를 확인하기위해 두부인체 팬톰에 Gafchromic EBT필름을 삽입하여 조사한 선량분포와 VMAT을 이용한 두부인체 팬톰에서 얻은 선량분포를 비교하여 실제 환자에 적용하고자 한다. 분석결과 beam center와 couch의 center가 정확하게 일치하는가를 pin ball을 통해 QA한 결과 1 mm 이내의 오차로 정밀함을 확인할 수 있었다. 또한 EBT3 Film에 다양한 선량조사에 따라 0 ~ 10 Gy영역까지 우수한 선형성임을 확인할 수 있었다. 두경부 팬텀과 같은 설정에서 광자 빔을 사용한 Geant4에 기반한 선량 계산 도구의 구현과 시뮬레이션 결과 계산치는 치료계획용적(PTV)내에서 실험 데이터와 일치함을 확인하였다. 따라서 체적변조 아크치료(VMAT) 360° 회전 조사를 실시하여 회전조사에 의한 등선량분포 분석결과 가상 종양을 포함하기에 적절함을 확인하였다.

순차치료에 병합 투여된 Ecabet Sodium이 Helicobacter pylori 제균에 미치는 효과 (Efficacy of Ecabet Sodium for Helicobacter pylori Eradication with Sequential Therapy)

  • 소설;안지용;나희경;정기욱;이정훈;김도훈;최기돈;송호준;이진혁;정훈용
    • 대한상부위장관⦁헬리코박터학회지
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    • 제18권3호
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    • pp.180-185
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    • 2018
  • Background/Aims: We aimed to compare the outcomes of Helicobacter pylori eradication in patients receiving sequential therapy (ST) depending on the use of ecabet sodium (ES). Materials and Methods: Between January to December 2015, 176 patients randomly received either ST alone (n=72) or 10-day ES therapy combined with ST (n=104). After applying the exclusion criteria, 56 patients were finally assigned to the ST-only group and 84 to the ST with ES group. We retrospectively reviewed and analyzed the H. pylori eradication rate and adverse events between the two groups. Results: Among the 140 patients, 121 (86.4%) achieved successful H. pylori eradication and 24 (17.1%) had adverse events. Eradication was achieved in 50 patients (89.3%) in the ST-only group and in 71 patients (84.5%) in the ST with ES group (P=0.420). No significant difference in the incidence of adverse events was found between the ST-only and ST with ES groups (12.5% vs. 20.2%, respectively; P=0.234). However, the ST with ES group tended to have a higher prevalence of nausea or vomiting than the ST-only group (11.9% vs. 1.8%; P=0.050). Conclusions: ST showed a good H. pylori eradication rate without deteriorating the adverse events regardless of adding ES.

지진감시를 위한 국내 해안지역 시추공 내 단열계 변화 특성 (Characterizing Fracture System Change at Boreholes in a Coastal Area in Korea for Monitoring Earthquake)

  • 정재열;함세영;옥순일;조현진;김수진;윤설민
    • 지질공학
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    • 제29권1호
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    • pp.1-12
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    • 2019
  • 지진은 진원지 주변의 지반의 응력상태를 변화시키고, 암반의 단열계에 영향을 미칠 수 있다. 국내에서 2016년 9월 12일과 2017년 11월 15일에 각각 발생한 지진규모 5.8의 경주지진과 지진규모 5.4의 포항지진은 양산단층대와 관련되며, 양산단층대 및 인근 지역 암반의 단열계에 영향을 미쳤을 가능성이 있다. 본 연구에서는 동해안 지역에 위치하는 중 저준위 방사성폐기물 처분장 부지 내 암반의 단열계 특성(방향성, 주향에 따른 절리개수, 절리간격, 절리간극, 경사각, 심도 구간별 절리빈도, 상대 암반강도)이 경주지진 및 포항지진에 의해서 영향을 받았는지를 분석하기 위하여 부지내 감시공에서 2005년과 2018년에 실시한 초음파 주사검층자료를 비교 분석하였다. 초음파 주사검층 분석 결과, 주향에 따른 절리개수, 절리간극, 심도 구간별 절리빈도는 2005년보다 2018년에 대체로 증가하였다. 이러한 증가는 지진의 영향으로 인한 단열체계의 변화로 인한 영향이거나, 2005년 감시공 설치 이후 10년 이상의 오랜 기간 나공 상태에서 공벽의 풍화로 인한 것일 수도 있다. 또한 KB-14공에서 전체 절리의 방향성과 절리의 평균 간격이 2005년과 2018년 사이에 다소 차이를 보이고 있으나, 절리면 경사와 상대 암반강도는 전반적으로 2005년과 2018년이 유사하게 나타났다.

작용 . 반작용과 전기회로 학습과제에서 인지갈등과 결과예측에 따른 대학생의 응답특성 (Undergraduate Students' Response Characteristics by Cognitive Conflict Levels and Result Predictions on Action-Reaction and Electric Cireuits Learning Tasks)

  • 홍정인;김연수;권재술
    • 한국과학교육학회지
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    • 제27권4호
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    • pp.354-365
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    • 2007
  • 이 연구는 작용 반작용 과제와 전기회로 과제에서 인지갈등 정도와 실험결과 예측에 따른 대학생의 인지갈등 특성을 알아보는 데 목적이 있다. 연구대상은 일반물리실험을 수강중인 공과 대학 학생 147명이었다. 인지갈등 정도와, 예측이 실험결과와 일치하는가를 기준으로 학생들을 네 집단으로 나누어 학생들의 응답을 분석하였다. 첫째, 작용 반작용 과제에서는 실험결과를 의심하고 오류를 찾아내려고 하는 경향을 나타내었으나, 전기회로 과제에서는 현상을 그대로 인정하는 경향이 나타났다. 둘째, 인지갈등 정도에 따라 인지갈등 요인별 응답 원인이 다르다. 학생의 인지갈등은 학생의 과거 지식, 경험, 학습습관, 학습동기, 인식론적 신념 등의 영향을 받는다. 인지갈등 점수가 높은 학생은 불일치 상황을 잘 인식하고 자신이 모르는 것을 지각하고 있었고, 재평가의 의지가 높았다. 반면에 인지갈등 점수가 낮은 학생들은 상황을 의심 없이 받아들이는 경향이 있었고 물리에 대한 관심이 적었다. 결론적으로, 이 연구는 이러한 응답특성을 근거로 학생과 과제의 특성을 파악하고 그에 따른 적절한 인지갈등 전략이 마련될 필요가 있음을 제안하였다.

Cardiac Phenotyping of SARS-CoV-2 in British Columbia: A Prospective Echo Study With Strain Imaging

  • Jeffrey Yim;Michael Y.C. Tsang;Anand Venkataraman;Shane Balthazaar;Ken Gin;John Jue;Parvathy Nair;Christina Luong;Darwin F. Yeung;Robb Moss;Sean A Virani;Jane McKay;Margot Williams;Eric C. Sayre;Purang Abolmaesumi;Teresa S.M. Tsang
    • Journal of Cardiovascular Imaging
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    • 제31권3호
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    • pp.125-132
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    • 2023
  • BACKGROUND: There is limited data on the residual echocardiographic findings including strain analysis among post-coronavirus disease (COVID) patients. The aim of our study is to prospectively phenotype post-COVID patients. METHODS: All patients discharged following acute COVID infection were systematically followed in the post-COVID-19 Recovery Clinic at Vancouver General Hospital and St. Paul's Hospital. At 4-18 weeks post diagnosis, patients underwent comprehensive echocardiographic assessment. Left ventricular ejection fraction (LVEF) was assessed by 3D, 2D Biplane Simpson's, or visual estimate. LV global longitudinal strain (GLS) was measured using a vendor-independent 2D speckle-tracking software (TomTec). RESULTS: A total of 127 patients (53% female, mean age 58 years) were included in our analyses. At baseline, cardiac conditions were present in 58% of the patients (15% coronary artery disease, 4% heart failure, 44% hypertension, 10% atrial fibrillation) while the remainder were free of cardiac conditions. COVID-19 serious complications were present in 79% of the patients (76% pneumonia, 37% intensive care unit admission, 21% intubation, 1% myocarditis). Normal LVEF was seen in 96% of the cohort and 97% had normal right ventricular systolic function. A high proportion (53%) had abnormal LV GLS defined as < 18%. Average LV GLS of septal and inferior segments were lower compared to that of other segments. Among patients without pre-existing cardiac conditions, LVEF was abnormal in only 1.9%, but LV GLS was abnormal in 46% of the patients. CONCLUSIONS: Most post-COVID patients had normal LVEF at 4-18 weeks post diagnosis, but over half had abnormal LV GLS.

Predicting Helicobacter pylori infection from endoscopic features

  • Jun-young Seo;Ji Yong Ahn;Seonok Kim;Hee Kyong Na;Jeong Hoon Lee;Kee Wook Jung;Do Hoon Kim;Kee Don Choi;Ho June Song;Gin Hyug Lee;Hwoon-Yong Jung
    • The Korean journal of internal medicine
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    • 제39권3호
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    • pp.439-447
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    • 2024
  • Background: Helicobacter pylori infection, prevalent in more than half of the global population, is associated with various gastrointestinal diseases, including peptic ulcers and gastric cancer. The effectiveness of early diagnosis and treatment in preventing gastric cancer highlights the need for improved diagnostic methods. This study aimed to develop a simple scoring system based on endoscopic findings to predict H. pylori infection. Methods: A retrospective analysis was conducted on 1,007 patients who underwent upper gastrointestinal endoscopy at Asan Medical Center from January 2019 to December 2021. Exclusion criteria included prior H. pylori treatment, gastric surgery, or gastric malignancies. Diagnostic techniques included rapid urease and 13C-urea breath tests, H. pylori culture, and assessment of endoscopic features following the Kyoto gastritis classification. A new scoring system based on endoscopic findings including regular arrangement of collecting venules (RAC), nodularity, and diffuse or spotty redness was developed for predicting H. pylori infection, utilizing logistic regression analysis in the development set. Results: The scoring system demonstrated high predictive accuracy for H. pylori infection in the validation set. Scores of 2 and 3 were associated with 96% and 99% infection risk, respectively. Additionally, there was a higher prevalence of diffuse redness and sticky mucus in cases where the initial H. pylori eradication treatment failed. Conclusions: Our scoring system showed potential for improving diagnostic accuracy in H. pylori infection. H. pylori testing should be considered upon spotty redness, diffuse redness, nodularity, and RAC absence on endoscopic findings as determined by the predictive scoring system.

한국 제주도 남부 해역에서 출현한 참서대과(Cynoglossidae) 어류 1미기록종, Symphurus longirostris 치어의 분자동정 및 형태기재 (Molecular Identification and Morphological Description of Juvenile of the Previously Unrecorded Species Long-snout Tonguefish, Symphurus longirostris (Cynoglossidae) from the Southern Sea of Jeju Island, Korea)

  • 서연주;김진구;유효재;명세훈
    • 한국어류학회지
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    • 제36권3호
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    • pp.288-294
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    • 2024
  • 2023년 8월 한국 제주도 남부 해역에서 참서대과에 속하는 Symphurus longirostris의 치어 1개체가 채집되었다. Mitochondrial DNA 16S rRNA 영역의 염기서열 475 base pairs를 분석한 결과, 이 표본은 일본의 S. longirostris 완모식표본과 일치하였으며(Kimura-2-parameter distance, d=0.002), 동속의 보섭서대, S. orientalis (d=0.199)와는 잘 구분되었다. 이 종의 치어는 등지느러미와 뒷지느러미 기저부에 1열의 흑색소포를 가지며, 등지느러미 기저의 흑색소포는 등지느러미 13~14번째 기조 부근에서 끊어져 있다. 또한, 복강의 가장 등쪽은 청흑색을 띤다. 국내 분포하는 보섭서대와는 지느러미 기조 수, 척추골 수 등의 계수형질과 유안측 복강 위쪽의 흑색소포군의 유무에서 잘 구분된다. 본 종은 일본의 Wakasa Bay 및 Tosa Bay에서 보고되었으며, 이번 연구를 통해 한국 제주 남부 해역에서도 출현하는 것을 확인할 수 있었다. 본 연구는 우리나라에서 처음으로 확인된 S. longirostris의 기록이며, 본 종에 대한 새로운 국명으로 "긴코보섭서대"를 제안한다.

이비인후, 안, 치아 및 피부증상의 민간요법에 관한 고찰 (Study on the Herb Remedies of ENT, Eyes, Teeth and Skin Problems)

  • 조결자;강현숙
    • 동서간호학연구지
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    • 제1권1호
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    • pp.50-71
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    • 1997
  • The intention of this study is to apprehend the con. tents and methods of herb remedies that are commonly conducted when there are health-problem cases of ENT, eyes, teeth and skin. Methods of this study are divided into two stages : 1) For a period of six months from December 1994 to June 1995, some 40 persons who are believed to be well versed with herb remedies have been randomly chosen, and we made a survey on herb remedies by symptoms: and 2) we have endeavored to make their grounds evident through the studies on literatures with the focus on the basic data collected. Their results are as follows: 1) When one feels a pain in ears, such herb remedies are employed as pouring the vapor into ears, which is made by steaming Alaska pollack, or as applying or wiping with the juices of radish or the ginkgo, or' alum. Applying the radish juice is effective for sterilization and fever removal: and applying the ginkgo juice is effective for cleanliness. But, plastering alum, sesame oil or castor oil, or pouring the vapor of Alaska pollack into ears are perhaps effective but do not have any pharmacologic grounds. 2) When one bleeds at the nose, such kinds of herb remedies are applied as stimulating nose or head with cold water, pressing nose or ridge of nose, or filling up nares with mashed mugworts. In addition, they have utilized garlic or leeks. Such methods as stimulating with cold water or just pressing nose and ridge of nose is based on reasonable grounds, i.e. vasoconstriction and vascular compression ; and applying mashed garlic on the sole of foot is good for the circulation of Qui ; and the use of mugworts and leeks is based upon the pharmacological function of hemostasis. 3) When one feels a sore throat such kinds of herb remedies are employed as gargling or rinsing throat with brine, drinking hot gruel or water, or drinking the juice of mugwort, radish, ginger or Chinese quince. Gargling with brine or drinking the juice of mugwort, radish or ginger is based upon the pharmacological function of pain alleviation, fever removal, and detoxication. 4) When a boil is formed in mouth, such herb remedies are applied as spreading honey, brine or alum water, and taking gall nut, Chinese matrimony vine, lotus root, etc, for drugs. Spreading honey, brine or water that is made by infusing gallnut, Chinese matrimony vine, lotus root is based upon such functions as hematosis, astriction, antibacterial, and antiphlogistic, Alum, eggplant and licorice are said to be effective, but their pharmacological effects have no grounds. 5) When one has conjunctivitis such herb remedies are commonly applied as irrigation with brine and dropping breast milk in eyes. Moreover, such other drugs are used as plantain. shepherd's purse, and purslane, etc. The use of brine, breast milk, plantain, shepherd's purse and purslane is based upon such functions as sterilization, antiphlogistic, disinfection and pain relieving. Eriocaulon sieboldianum, bean stem, bean pod and narcissus leaves are said to be effective, but their pharmacological action have no basis. When one has a stye, such herb remedies are applied as extracting eyelashes, stimulating by a massage of middle finger, third finger or big toe, as well as sear ing with a heated bamboo comb that is fine-toothed. Other than these, plantain and nightshade's nuts are used as drugs for it. Extracting eyelashes corresponds with exclusing suppurative node and draining the stye of pus ; and the use of plantain is based upon disinfection: and nightshade's nuts are said to be effective, however, their pharmacological action has no grounds. 6) For a treatment of toothache, such herb remedies are commonly employed as rinsing mouth with brine and holding cold water or gasoline in the mouth ; and as the drugs that are believed to be effective have been Welsh onion, ginger and castor-oil, plant, etc. The use of Welsh onion is based upon pain killing, antiinflammatory actions, and the use of ginger is based upon detoxication and disinfection ; and seeds of castor-oil plants are said to be effective, but they have no pharmacological basis. 7) When one has hives, such herb remedies are commonly applied as rubbing burned straw in affected parts, exposing to its smoke, rubbing with salt, sweeping down with a broom, and spreading and drinking boiled water of trifoliate orange. The use of cassia tora seeds, walnut, aloe and radish is said to be effective. The use of cassia tor a seeds has the functions of intestinal order, anti-paralysis, etc. The use of walnut has resulted in an increase of blood by invigorating spirits ; and the use of aloe is based upon disinfection, antibiotic, anti-salt, antihistamine and detoxication action. But, the effects of radish juice and straw's smoke have no pharmacological grounds. 8) When one gets a boil, such herb remedies are commonly used as applying a plaster, paste of flour mixed with yolk, soy sauce or honey, as well as spreading pounded elm tree. Other remedies that have been said to be effective are ; heating with mugwort, brine, wild rocambole, aloe, onion, squid's bone, etc. The use of mugwort is based upon pain killing, astringent antiinflammatory and tranquility. Wild rocambole is based upon the generation and maintenance functions of cell-joining textures ; elm tree upon antiphlogistic ; aloe upon fever removal and antiphlogistic ; onion on pain killing, fever removal, antiphlogistic and tranquility ; squid's bone on astriction: and brine or vinegar on sterilization. Pine resin and gardenia seed are said to be effective, but they have no pharmacological basis. 9) When one cuts his skin, such herb remedies are commonly employed as spreading mugwort's juice or squid's bone powder, or pressing the wounds. In addition, kalopanax, onion and fine soil are employed. The use of mugwort, kalopanax and squid's bone is based upon such functions as hemostasis, sedation, pain killing, antibacterial ; and fine soil is said to be effective, but it has no pharmacological basis. 10) When one suffers from whitlow, such herb remedies are commonly utilized as heating with boiled soy sauce, spreading soybean paste, or dipping into eggs, etc. Other drugs that have been employed are onion root, brine, eggplant, potato, loach, etc. The use of onion is based upon pain killing and antiphlogistic functions ; and that of brine upon antiphlogistic function. The use of soy sauce or soybean paste, fomentation, eggplant, potato and loach is said to be effective, but it has no pharmacblogic ground. 11) For the treatment of frostbite, such herb remedies are commonly used as dipping the affected part into frozen soybean sack, using boiled water of eggplant stem, garlic caulis, onion, hot pepper, caulis. Onion is based upon antiphlogistic and tranquility actions garlic upon disintection, metabolic exacerbation, tonic and aphrodisiac actions and the use of eggplant and hot pepper is based upon help blood circulation, dissolution and excretion of waste matters in vein. 12) For the treatment of burn, such herb remedies or drugs are commonly used as cleansing with Korean gin, spreading eggs, cleansing with cold water and soap water ; and as brine, cactus, moss, soybean paste, oil, etc. The cleansing with Korean gin, cold water, soap water, brine, vinegar is based upon cleaning and sterilizing functions ; and the use of cucumber is based upon nu. trition provision, and strengthening of resisting power by adjustment of metabolism. The use of potato, cactus, moss, oil and eggs is said to be effective, but their phamacological functions are not clarified. In view of the above results, we can realize that the drugs that have been employed in herb remedies are quite diverse. However, in regard to majority of herb remedies that have been employed by symptoms, the pharmacological functions of their drugs have not been clarified, and they are merely known as effective. Furthermore, they have not been recorded in the literature as yet ; and we confirm that there have been many herb remedies that were executed without the proper knowlege of their effects. It is now our view that the results of this survey may be utilized for consulting data in regard to the use of herb remedies.

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경골 내염전 환아에서 경비골 역회전 교정장치(TCR)의 치료 효과 (Usefulness of tibia counter rotator (TCR) for treatment of tibial internal torsion in children)

  • 송동호;이윤;은백린;이광재;강상국;박성진;유성;신정빈;김봉옥
    • Clinical and Experimental Pediatrics
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    • 제50권1호
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    • pp.79-84
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    • 2007
  • 목 적 : 우리나라와 일본 같이 전통적으로 좌식생활을 많이 하는 동아시아 국가에서는 경골 내염전이 많은 것으로 알려져 있다. 또한 경골 내염전이나 지나친 외염전은 미용적인 문제, 기능인 문제, 정신적인 문제 외에도 나이 들어서 퇴행성 관절염의 발생과도 관련이 있다. 본 연구는 경골 내염전 환아에서 경비골 역회전 교정장치(Tibia Counter Rotator, TCR)를 이용한 치료 효과를 알아보고자 하였다. 방 법 : 2002년 4월부터 2006년 9월까지 고대안암병원 소아과 소아족부클리닉과 충남의대 소아재활의학과 신발클리닉, 국민보험공단 일산병원 재활의학과를 방문하여 경골 내염전으로 진단 받고 보조기 치료를 하여, 추적관찰 기간이 1년 이상된 환아, 또는 2006년 9월 현재 치료가 완료된 환아 149명(274하지)을 대상으로 하였다. 환자군은 치료 시작시 연령을 기준으로 만 2세미만, 만 2세 이상 3세 미만, 만 3세 이상 4세 미만, 만 4세 이상 5세 미만, 만 5세 이상 6세 미만, 만 6세 이상 9세 미만, 만 9세 이상의 7개의 연령군으로 나누었으며, 환아들의 복사 통과 각도를 치료 시작 시점과 치료 시작 후 1, 3, 6, 9, 12개월에 순차적으로 측정하여 비교하였다. 결 과 : 복사 통과 각도 $0^{\circ}$ 이하의 경골 내염전을 보이는 신경학적인 이상이 없는 12세 이하의 환아에서 경비골 역회전 교정장치를 이용한 경골내염전의 교정을 통해 전 연령군에서 복사통과 각도가 2차 곡선 형태로 증가하는 경향을 보였으며, 복사통과 각도의 초기 값과 교정후의 값간에도 유의한 차이를 보였다(P<0.001). 결 론 : 경비골 역회전 교정장치는 경골 내염전을 교정하는 효과적인 방법이 될 수 있을 것으로 판단된다.