• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2007.12a
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• pp.125-126
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• 2007

In this paper, the floating body with vertical plate is introduced with a study on the flow patterns and characteristics in around the floating body by using 2 frame particle tracking method. This paper introduce an analysis method to predict the characteristics if flow around the neighboring fields if Floating Body with vertical plate in order to investigate a high performance model. Flow visualization has conducted in a drcu1ating water channel by a high speed camera and etc. Flow phenomena according to turbulence intensity distribution and flow separation around the floating body with vertical plate were obtained by two-dimensional PIV system.

• Herbal Formula Science
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• v.23 no.1
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• pp.101-110
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• 2015

Objectives : The purpose of this study was to investigate the anti-cancer effects of Oldenlandia diffusa extract on WiDr human colorectal adenocarcinoma cells. Methods : We examined cell death by (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) MTT assay and the caspase 3 and 9 activity assay with Oldenlandia diffusa extract. To examine the inhibitory effects of Oldenlandia diffusa extract, we performed a cell cycle (sub-G1) analysis and mitochondrial membrane potential for the WiDr cells after 24 hours with Oldenlandia diffusa extract. Results : 1. Oldenlandia diffusa extract induced cell death in WiDr cells. 2. The sub-G1 peak was increased by Oldenlandia diffusa extract in WiDr cells. 3. Oldenlandia diffusa extract leads to increase the mitochondrial membrane depolarization in WiDr cells. 4. Oldenlandia diffusa extract increases caspase 3 and 9 activities in WiDr cells. 5. Oldenlandia diffusa extract combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) markedly inhibited the growth of WiDr cells compared to Oldenlandia diffusa extract and anti-cancer drugs alone. Conclusions : Oldenlandia diffusa extract has an apoptotic role in human colorectal cancer cells and a potential role in developing therapeutic agents against colorectal cancer.

• Toxicological Research
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• v.31 no.3
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• pp.307-312
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• 2015

Trans fat is a unsaturated fatty acid with trans configuration and separated double bonds. Analytical methods have been introduced to analyze trans fat content in foods including infrared (IR) spectroscopy, gas chromatography (GC), Fourier transform-infrared (FT-IR) spectroscopy, reverses-phase silver ion high performance liquid chromatography, and silver nitrate thin layer chromatography. Currently, FT-IR spectroscopy and GC are mostly used methods. Trans fat content in 6 vegetable oils were analyzed and processing effects including baking, stir-frying, pan-frying, and frying on the formation of trans fat in corn oil was evaluated by GC. Among tested vegetable oils, corn oil has 0.25 g trans fat/100 g, whereas other oils including rapeseed, soybean, olive, perilla, and sesame oils did not have detectable amount of trans fat content. Among cooking methods, stir-frying increased trans fat in corn oil whereas baking, pan-frying, and frying procedures did not make changes in trans fat content compared to untreated corn oils. However, the trans fat content was so low and food label can be declared as '0' trans based on the regulation of Ministry of Food ad Drug Safety (MFDS) (< 2 g/100 g edible oil).

• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.129-136
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• 2016

Objectives: The crude extracts of Scutellaria barbata D. Don (SB) have traditionally demonstrated inhibitory effects on numerous human cancers both in vitro and in vivo. Gastric cancer is one of the most common types of cancer on world. The authors investigated the effects of an ethanol extract of Scutellaria barbata D. Don (ESB) on the growth and survival of MKN-45 cells (a human gastric adenocarcinoma cell line). Methods: The MKN-45 cells were treated with different concentrations of ESB, and cell death was examined using an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Analyses of sub-G1 peaks, caspase-3 and -9 activities, and mitochondrial membrane depolarizations were conducted to determine the anti-cancer effects of SB on MKN-45 cells. Also, intracellular reactive oxygen species (ROS) generation was investigated. Results: ESB inhibited the growth of MKN-45 cells, caused cell cycle arrest, and increased the sub-G1 population. In addition, ESB markedly increased mitochondrial membrane depolarization and the activities of caspase-3 and -9. ESB exerted anti-proliferative effects on MKN-45 cells by modulating the mitogen-activated protein kinase (MAPK) signaling pathway and by increasing the generation of ROS. Furthermore, combinations of anti-cancer drugs plus ESB suppressed cell growth more than treatments with an agent or ESB, and this was especially true for cisplatin, etoposide, and doxorubicin. Conclusion: ESB has a dose-dependent cytotoxic effect on MKN-45 cells and this is closely associated with the induction of apoptosis. ESB-induced apoptosis is mediated by mitochondria-, caspase- and MAPK dependent pathways. In addition, ESB enhances ROS generation and increases the chemosensitivity of MKN-45 cells. These results suggest that treatment with ESB can inhibit the proliferation and promote the apoptosis of human gastric adenocarcinoma cells by modulating the caspase-, MAPK- and ROS-dependent pathway.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.4
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• pp.352-359
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• 2012

An experiment was carried out to figure out the turbulence flow characteristics in the wake of the transom stern's 2-dimensional section by 2-frame grey level cross correlation PIV method at Re= $3.5{\times}10^3$, Re= $7.0{\times}10^3$. The angles of transom stern are $45^{\circ}$(Model "A"), $90^{\circ}$(Model "B") and $135^{\circ}$(Model "C") respectively. The depth of wetted surface is 40mm from free surface. Strong turbulence intensity appears at the interaction between the flow separation of the bottom of a model and the free surface. This study provides statistic flow information such as turbulence intensity, Reynolds stress and turbulence kinetic energy. Model C type (Raked transom) has low Reynolds stress and turbulence kinetic energy.

• Journal of the Korean Society of Marine Environment & Safety
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• v.18 no.4
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• pp.371-377
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• 2012

This paper presents an experimental investigation to figure out slamming impact pressure and flow characteristics of a rectangular Marine structure($800{\times}250{\times}50mm^3$) in free fall. The flow field has been obtained by 2-frame grey level cross correlation PIV(Particle Image Velocimetry) method, the impact pressure of the free fall model by a pressure acquisition system(Dewatron). The angles between a model and the free surface are adapted $10^{\circ}$ and $20^{\circ}$ respectively. Velocity field of water exit has higher better than water entry. The highest point, P2 of impact pressure under the bottom of the model has been appeared about 6 % higher values at 20 degrees than 10 degrees.

• Journal of Korean Physical Therapy Science
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• v.20 no.1
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• pp.61-67
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• 2013

Purpose : The purpose of this paper is to figure out the effects of the Powerball exercise on grip strength, tip pinch and key pinch. Methods : Twenty subjects participated in this experiment. Spin right wrist counterclockwise for five minutes holding Powerball after making main joint of right hand -predominant hand- into elbow flexion and forearm pronation. Results : 1. Before and after Powerball exercise, when we compared the grip strength of men and women, there was a significant difference. 2. Before and after Powerball exercise, when we compared tip pinch of men and women, there was a significant difference. 3. Before and after Powerball exercise, when we compared key pinch of men and women, there was a significant difference. 4. Before and after Powerball exercise, there was no significant difference between men and women. Conclusion : From what using Powerball exercise influenced grip strength, tip pinch and key pinch positively, we assume that it will be considered a great expectation to improve grip strength, tip pinch and key pinch in the future and it would be better to conduct this experiment in depth to a lot of people.

• Journal of Biosystems Engineering
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• v.36 no.5
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• pp.303-313
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• 2011

This study was conducted to investigate the effects of axle weight distribution and inflation pressure of tire on the fuel economy of tractors as well as operational range of tractor engine in terms of engine speed and power when a 4WD tractor of 38.2 kW rated power at 2500 rpm is used for plowing and flooded-field rotavating in paddy fields. (1) Plowing operation required an average engine power of 9.6~13.5 kW which equals 25~35% of rated PTO power. Engine speed ranged from 1,320.4 to 1,737.4 rpm, work velocity from 3.4 to 4.8 km/h, and fuel consumption from 3.2 to 4.2 L/h, respectively. (2) Flooded-field rotavating required an average engine power of 11.5~18.5 kW which equals 30~48.4% of rated PTO power. Out of this 6.2~12.2 kW was used for PTO power. Engine speed ranged from 1,557 to 2,067 rpm, work velocity from 2.5~5.4 km/h and fuel consumption from 3.2~5.5 L/h, respectively. (3) Axle weight distribution, inflation pressure of tire and moisture content of soil did not affect significantly the specific volumetric fuel consumption but affected significantly the fuel consumption per unit area of operation. Fuel savings amounted to 65% in plowing operation and 20% in flooded-field rotavating when the axle weight distribution and inflation pressure of tire were optimally adjusted. (4) Optimal adjustment of axle weight distribution and inflation pressure of tire are expected to save fuel consumption by 10~65% per unit area of operation in plowing and 10~20% in flooded-field rotavating.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.48 no.7
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• pp.523-528
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• 2020

A lateral type MEMS inertial switch was designed on the same principle as spring-mass system. The MEMS switch is used for arming mechanism of the arm-fire device by sensing the applied acceleration. We analyzed the switching capability of the MEMS switch under various acceleration conditions via performance model. Simulation results showed that the MEMS switch works very well at 10 g when the applied acceleration slope does not exceed 10 g/msec. On the other hand, the threshold operating acceleration level simulation exceeded the requirement (10±2 g) due to the width and length of the spring by considering 10% tolerance of the design values. Design modification of doubling the width of the spring, which is difficult to reduce less than 10% tolerance in fabrication process, was proposed after confirming the simulation results comply the requirement.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.11a
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• pp.599-602
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• 2011

A propulsion controller for one-time flight vehicles should be designed robustly so that it can complete its missions even in case sensor failures. These vehicles improve their fault tolerance by back-up sensors prepared for the failure of major sensors, which raises the total cost. This paper presents the NARX model which substitutes vehicles' velocity sensors, and detects failure of sensor signals by using model based fault detection. The designed NARX model and fault detection algorithm were optimized and installed in TI's TMS320F2812 so that they were linked to HILS instruments in real-time. The designed propulsion controller made the vehicle to have better fault tolerance with fewer sensors and to complete its missions under a lot of complicated failure situations. The controller's applicability was finally confirmed by tests under the HILS environment.