• 한국잠사학회:학술대회논문집
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• 한국잠사학회 2003년도 제46회 춘계 학술연구 발표회
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• pp.53-53
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• 2003

Alpha-glucosidase inhibitor, 1-deoxynojirimycin, has been shown to eliminate the production of ER-budding viruses in the ER of host cell. This glucose-derived iminosugar derivative, 1-DNJ, has been largely purified from midgut of silkworm, Bombyx mori, Here, we have screened the antiviral activity in the GBV-B infected marmoset hepatocyte cell line. (omitted)

• 방송공학회논문지
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• 제20권4호
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• pp.489-496
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• 2015

본 논문에서는, 밝기 변화가 존재하는 영상에서의 부호화 효율을 향상하기 위해 새로운 가중치 예측 기술이 제안된다. 종래의 가중치 예측 기술은 참조 영상 단위로 지원되고 하나의 가중치 예측 계수 세트만을 사용하기 때문에 전체적 밝기 변화가 존재하는 영상에서만 효율적이다. 이러한 문제를 해결하기 위해 제안하는 알고리즘은 상황에 따라 세 가지 종류의 가중치 예측을 사용한다. 제안한 방법의 실험 결과는 기존 기술 대비 BD-rate 기준으로 최대 -10.2%의 성능 향상을 가져오며 인코더의 복잡도는 163%, 디코더의 복잡도는 약 101% 변화가 존재한다.

• Asian-Australasian Journal of Animal Sciences
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• 제31권5호
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• pp.628-635
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• 2018

Objective: To determine the effects of genomic breeding values (GBV) and single nucleotide polymorphisms (SNP) on the total number of piglets born (TNB) in 3 pig breeds (Berkshire, Landrace, and Yorkshire). Methods: After collecting genomic information (Porcine SNP BeadChip) and phenotypic TNB records for each breed, the effects of GBV and SNP were estimated by using single step best linear unbiased prediction (ssBLUP) method. Results: The heritability estimates for TNB in Berkshire, Landrace, and Yorkshire breeds were 0.078, 0.107, and 0.121, respectively. The breeding value estimates for TNB in Berkshire, Landrace, and Yorkshire breeds were in the range of -1.34 to 1.47 heads, -1.79 to 1.87 heads, and -2.60 to 2.94 heads, respectively. Of sows having records for TNB, the reliability of breeding value for individuals with SNP information was higher than that for individuals without SNP information. Distributions of the SNP effects on TNB did not follow gamma distribution. Most SNP effects were near zero. Only a few SNPs had large effects. The numbers of SNPs with absolute value of more than 4 standard deviations in Berkshire, Landrace, and Yorkshire breeds were 11, 8, and 19, respectively. There was no SNP with absolute value of more than 5 standard deviations in Berkshire or Landrace. However, in Yorkshire, four SNPs (ASGA 0089457, ASGA0103374, ALGA0111816, and ALGA0098882) had absolute values of more than 5 standard deviations. Conclusion: There was no common SNP with large effect among breeds. This might be due to the large genetic composition differences and the small size of reference population. For the precise evaluation of genetic performance of individuals using a genomic selection method, it may be necessary to establish the appropriate size of reference population.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제3권12호
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• pp.547-552
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• 2014

플리커, 페이스북과 같은 대용량 소셜 미디어 공유 사이트의 발전으로 이미지 정보가 매우 빠르게 증가하고 있다. 이에 따라 소셜 이미지를 정확하게 검색하기 위한 다양한 연구가 활발히 진행되고 있다. 이미지 태그들의 의미적 연관성을 이용하여 태그기반의 이미지 검색의 정확도를 높이고자 하는 연구를 비롯하여 이미지 단어집(Bag of Visual Words)을 기반으로 웹 이미지를 분류하는 연구도 다양하게 진행되고 있다. 본 논문에서는 이미지에서 배경과 같은 중요도가 떨어지는 정보를 제거하여 중요부분을 찾는 GBVS(Graph Based Visual Saliency)모델을 기존 연구에 사용할 것을 제안한다. 제안하는 방법은 첫 번째, 이미지 태그들의 의미적 연관성을 이용해 1차 분류된 데이터베이스에 SIFT알고리즘을 사용하여 이미지 단어집(BoVW)을 만든다. 두 번째, 테스트할 이미지에 GBVS를 통해서 이미지의 관심영역을 선택하여 테스트한다. 의미연관성 태그와 SIFT기반의 이미지 단어집을 사용한 기존의 방법에 GBVS를 적용한 결과 더 높은 정확도를 보임을 확인하였다.

• Journal of Microbiology
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• 제45권5호
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• pp.431-440
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• 2007

A silkworm (Bombyx mori L.) extract known to contain naturally occurring iminosugars, including 1-deoxynojirimycin (1-DNJ) derived from the mulberry tree (Morus alba L.), was evaluated in surrogate HCV and HBV in vitro assays. Antiviral activity of the silkworm extract and one of its purified constituents, 1-DNJ, was demonstrated against bovine viral diarrhea virus (BVDV) and GB virus-B (GBV-B), both members of the Flaviviridae family, and against woodchuck hepatitis virus (WHV) and hepatitis B virus (HBV), both members of the Hepadnaviridae family of viruses. The silkworm extract exhibited a 1,300 fold greater antiviral effect against BVDV in comparison to purified 1-DNJ. Glycoprotein processing of BVDV envelope proteins was disrupted upon treatment with the naturally derived components. The glycosylation of the WHV envelope proteins was affected largely by treatment with the silkworm extract than with purified 1-DNJ as well. The mechanism of action for this therapy may lie in the generation of defective particles that are unable to initiate the next cycle of infection as demonstrated by inhibition of GBV-B in vitro. We postulate that the five constituent iminosugars present in the silkworm extract contribute, in a synergistic manner, toward the antiviral effects observed for the inhibition of intact maturation of hepatitis viral particles and may complement conventional therapies. These results indicate that pre-clinical testing of the natural silkworm extract with regards to the efficacy of treatment against viral hepatitis infections can be evaluated in the respective animal models, in preparation for clinical trials in humans.

• Bulletin of the Korean Chemical Society
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• 제23권8호
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• pp.1073-1077
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• 2002

Binding of dodecyl trimethylammonium bromide (DTAB) to human and bovine hemoglobin and globin samples has been investigated in 50 mM glycine buffer pH = 10, I = 0.0318 and 300 K by equilibrium dialysis and temperature scanning spectrophotometry techniques and method for calculation of average hydrophobicity. The binding data has been analyzed, in terms of binding capacity concept $({\theta})$, Hill coefficient (nH) and intrinsic Gibbs free energy of binding $({\Delta}Gbv).$ The results of binding data, melting point (Tm) and average hydrophobicity show that human hemoglobin has more structural stability than bovine hemoglobin sample. Moreover the results of binding data analysis represent the systems with two and one sets of binding sites for hemoglobin and globin, respectively. It seems that the destabilization of hemoglobin structure due to removal of heme group, is responsible of such behavior. The results indicating the removal of heme group from hemoglobin caused the depletion of first binding set as an electrostatic site upon interaction with DTAB and exposing the hydrophobic patches for protein.

• 생명과학회지
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• 제8권3호
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• pp.279-284
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• 1998

한국인 환자의 혈청에서 분리한 HGV 5'-UTR영역의 염기서열을 결정하였다. 이들 염기서열을 이미 보고된 서열들과 비교한 결과, 한국 분리주들은 일본 분리주들과 더 높은 상동성을 나타내어 지리적 격리에 의해 HGV의 염기서열의 변이가 축적되었음을 알 수 있다. 흥미롭게도 동일 지역에서 분리된 HGV 분리주들 간에는 고도로 보존되어 있어 HGV의 분류에 이용가능한 세 개의 영역이 5'-UTR에서 발견되었다. 이들 그룹-특이적 영역에 기초하여, 24 HGV 분리주들을 5개의 그룹으로 분류할 수 있었다.