• 컴퓨터교육학회논문지
• /
• 제7권5호
• /
• pp.9-21
• /
• 2004

인터넷이라는 새로운 IT기술을 교육현장에서 적극적으로 활용해야 한다는 강한 요구에도 불구하고 웹기반 교육의 정착은 미흡한 실정이다. 그 원인은 현재 웹기반 교육이 전통적 교실수업과 질적으로 다르지 않고 웹기반 교육에 적합한 설계모형들이 충분히 개발되지 않았기 때문이다. 본 연구자들은 구성주의 학습관에 기반한 GBS 설계모형을 이용하여 도서관 이용에 관한 웹기반 교육용 컨텐츠를 개발함으로써 웹기반 교육을 개발하거나 활용하고자 하는 교사와 교육실천가들에게 구체적인 개발사례를 제공하고자 한다. 3개월 간 요구분석, 학습내용분석, 학습자 및 학습환경분석을 통해서 GBS모형을 적용한 웹기반 교육용 컨텐츠를 설계하고 GBS의 7가지 구성요소들에 충실하게 개발하였다. 본 연구의 결과들은 학교와 기업에서 새로운 형태의 웹기반 교육을 개발하고자 하는 실천가들에게 구체적인 가이드를 제공해줄 것이다.

• 대한물리치료과학회지
• /
• 제6권3호
• /
• pp.9-24
• /
• 1999

Guillain-Barre syndrome(GBS) is one of the common motor unit diseases and defined as acute postinfectious polyneuropathy, It is not known most effective medical intervention for GBS, but generally benefits from an intensive physical therapy program. In this report, hydrotherapy was applied for a patient with GBS to improve muscle power and functional abilities. Two weeks later, the patient's functional abilities, muscle power, and physical endurance were improved without complications. Since the hydrotherapy does not load maximally to the patient with GBS, the patient can exercise himself actively for the maximal tolerance. It is the reason of fast recovery. In summary, the hydrotherapy is important to the patient with GBS and it must apply to these patients more frequently.

• Annals of Clinical Neurophysiology
• /
• 제22권1호
• /
• pp.13-18
• /
• 2020

The electrodiagnostic findings in Guillain-Barré syndrome (GBS) play important roles in both understanding its pathophysiology and its diagnosis. Only demyelinating neuropathies were thought to be present when GBS patients were first diagnosed in Western countries, but the concept changed when many axonal GBS patients were reported in Asia. Reversible conduction failure was subsequently revealed, and it was recognized as a pathophysiologic continuum of axonal GBS. Thus, the electrodiagnostic findings in GBS have had a profound effect on the history of this disease.

• Advances in concrete construction
• /
• 제5권5호
• /
• pp.437-450
• /
• 2017

The present work investigates about the development of a novel construction material by utilizing Granulated Blast Furnace Slag (GBS), an industrial waste product, as substitution of natural fine aggregates. For this, experimental work has been carried out to determine the influence of GBS on the properties of concrete such as compressive strength (CS), modulus of elasticity, ultrasonic pulse velocity (UPV), chloride penetration, water absorption (WA) volume of voids (VV) and density. Concrete mixes of water/cement (w/c) ratios 0.45 and 0.5, and incorporating 20%, 40% and 60% of GBS as partial replacement of natural fine aggregate (sand) are designed for this study. The results of the experimental investigation depict that CS of concrete mixes increases with the increasing percentages of GBS. Moreover, the decrease in chloride penetration, WA and VV, and improvement in the modulus of elasticity, UPV, density of concrete is reported with the increasing percentage of GBS in concrete.

• Structural Engineering and Mechanics
• /
• 제88권3호
• /
• pp.251-262
• /
• 2023

This paper presents a method for assessing the dynamic responses of gravity-based structures (GBS) under various seismic loads, with a focus on fluid-structure-ground interactions. Models of GBSs and their surrounding environments were developed, incorporating interaction effects among the structure, seawater, and seabed. Dynamic responses of the GBS subjected to three seismic loads-Chi-Chi, Northridge01, and Northridge02-were calculated, with consideration of both horizontal and vertical accelerations, as well as displacements. Parametric studies indicated that the primary factors affecting the dynamic responses of GBS were seismic loads characterized by significant input forces and accelerations. The frictional force on the ground had minimal impact on the horizontal and vertical displacements of the GBS. Weight emerged as a critical factor in anchoring the GBS to the ground and minimizing vertical accelerations and displacements.

• 대한한방내과학회지
• /
• 제39권1호
• /
• pp.76-83
• /
• 2018

Objectives: This case study reports on one patient presenting atypical and chronic disorders after being diagnosed with $Guillain-Barr{\acute{e}}$ Syndrome (GBS). Methods: One patient was treated by Yeongseonjetong-eum-gami, Taklisodok-eum-gami, electroacupuncture, and physical therapy. Any improvement in symptoms was assessed by measuring changes in the motor grade of upper limb weakness, the numerical rating scale (NRS) of lower limb numbness, and GBS scores. Results: After 24 days of treatment, the patient's symptoms of GBS showed little improvement. Conclusions: Traditional Korean medical treatment appeared to be effective in reducing GBS symptoms, but more research is required to confirm these results. When treating GBS patients, the clinician should put effort into distinguishing GBS from other nervous disorders, such as acute onset Chronic Inflammatory Demyelinating Polyneuropathy (CIDP).

• Annals of Clinical Neurophysiology
• /
• 제4권2호
• /
• pp.119-124
• /
• 2002

Background : Guillain-$Barr{\acute{e}}$ syndrome(GBS) is a neurologically emergent condition, leading to respiratory insufficiency without an early and appropriate treatment. Thus, the treatment of GBS requires early diagnosis but it is difficult due to the low sensitivity of laboratory tools in the initial stage. Hoffman reflex (H-reflex) and its facilitation by Jendrassik maneuver (JM) are sensitive tools evaluating the central circuit of motor system on the spinal cord level. The aim of this study is to test whether the change of H-reflex and F-wave under the JM is able to detect the early stage of GBS and whether GBS involves the central nervous system (CNS). Material and Methods : All 7 GBS patients who showed normal or nearly normal nerve conduction study were included. The facilitation of H-reflex and changes of F-wave were calculated by measuring the percent difference of H-reflex or F-wave amplitude under JM compared to basal H-reflex of F-wave amplitude. The changes of F-wave and H-reflex in the GBS patients were compared with them of 8 healthy controls. Results : The F-wave amplitudes of both healthy controls and GBS patients did not changed under the influence of JM ($102.4{\pm}24.9%$, $108.7{\pm}29.0%$ respectively). However, the facilitation of H-wave by JM in the GBS patients was absent ($98.8{\pm}5.8%$), even though the H-reflex amplitude I the healthy controls increased under the influence of JM ($124.8{\pm}12.1%$). Conclusions : The loss of H-reflex facilitation in GBS implies that this phenomenon might be the most early change detected in the electrophysiological study and support the early diagnosis, and that GBS might include lesion in the spinal motor CNS.

• 농업과학연구
• /
• 제44권4호
• /
• pp.495-503
• /
• 2017

Genotyping-by-sequencing (GBS) is an outstanding technology for genotyping and single nucleotide polymorphism (SNP) discovery compared to next generation sequencing (NGS) because it can save time when analyzing large-scale samples and carries a low cost per sample. Recently, studies using GBS have been conducted on major crops and, to a greater extent, on fruit crops. However, many researchers have some problems due to low GBS efficiency resulting from low quality GBS libraries. To overcome this limitation, we developed an efficient GBS library construction method that regulates important conditions such as restriction enzymes (RE) digestion and a PCR procedure for grapevine. For RE digestion, DNA samples are digested with ApeKI (3.6U) at $75^{\circ}C$ for 5 hours and adapters are ligated to the ends of gDNA products. To produce suitable PCR fragments for sequencing, we modified the PCR amplification conditions; temperature cycling consisted of $72^{\circ}C$ (5 min), $98^{\circ}C$ (30 s), followed by 16 cycles of $98^{\circ}C$ (30 s), $65^{\circ}C$ (30 s), $72^{\circ}C$ (20 s) with a final extension step. As a result, we had obtained optimal library construct sizes (200 to 400 bp) for GBS analysis. Furthermore, it not only increased the mapping efficiency by approximately 10.17% compared to the previous method, but also produced mapped reads which were distributed equally on the19 chromosomes in the grape genome. Therefore, we suggest that this system can be used for various fruit crops and is expected to increase the efficiency of various genomic analysis performed.

• Annals of Clinical Neurophysiology
• /
• 제4권1호
• /
• pp.60-62
• /
• 2002

Two separate cranial nerve variants of Guillain-Barre syndrome(GBS) have been reported. One is Miller-Fisher syndrome, the other is polyneuritis cranialis. Involvement of the extraocular muscles in variants of GBS is well recognized, but complete external and internal opthalmoplegia is rare. Optic neuritis remains the only consistent, albeit very uncommon, evidence of inflammation of central nervous system myelin in GBS. This propose that GBS is part of a spectrum of central and peripheral inflammation. This case is an unusual clinical variant who had ptosis, opthalmoplegia, areflexia, ataxia, optic neurritis, marked oropharyngeal, and neck and shoulder weakness. This combined regional from is able to misdiagnose initially as botulism or diphtheria and less so, myasthenia. So if we were consider variant from of GBS, it is possible for make a correct diagnosis more easily and treatment without delay.

• 농업과학연구
• /
• 제44권3호
• /
• pp.318-324
• /
• 2017

With the development of next-generation sequencing (NGS), a cutting-edge technology, genotype-by-sequencing (GBS) became available at a low cost per sample. GBS makes it possible to customize the process of library preparation to obtain high-quality single nucleotide polymorphisms (SNPs) in the most efficient way. However, a GBS library is hard to construct due to fine-tuning of concentration of each reagent and set-up. The major reason for this is the presence of undigested genomic DNA (gDNA) owing to the efficiency of different restriction enzymes for different species with unknown reasons. Therefore, this proof-concept study is to demonstrate the unpredictable patterns of enzyme digestion from various plants in order to make the reader aware of the caution needed when choosing restriction enzymes for their GBS library preparations. Indeed, no pattern was found for the digestibility of gDNA samples and restriction enzymes in the current study. We suggest that more data should be accumulated on this matter to help researchers who want to apply GBS technologies in a variety of genetic approaches.