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Bacterial meningitis in children experienced at a university hospital, 1993-2006 (서울의 한 대학병원에서 경험한 소아의 세균성 수막염: 1993-2006)

  • Cho, Sung Yoon;Kim, Tae Yeon;Lee, Hyunju;Kim, Kyung Hyo;Yoo, Eun Sun;Kim, Hae Soon;Park, Eun Ae;Ryu, Kyung Ha;Sohn, Sejung;Seo, Jeong Wan;Lee, Seung Joo
    • Clinical and Experimental Pediatrics
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    • v.51 no.10
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    • pp.1077-1084
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    • 2008
  • Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients under 18 years of age confirmed by cerebrospinal fluid (CSF) findings were retrospectively analyzed from September, 1993 to August, 2006 at Ewha Womans University Mokdong Hospital. Results : Eighty-one cases of bacterial meningitis were observed. Overall the most common organism was Streptococcus agalactiae (group B streptococcus, GBS) (30 cases, 37.0%) followed by Haemophilus influenzae (22 cases, 27.2%), Streptococcus pneumoniae (12 cases, 14.8%), Escherichia coli (3 cases, 3.7%), Neisseria meningitidis (1 case, 1.2%) and others (13 cases, 16.0%). In neonates and young infants under 2 months, the most common organism was GBS. In children between 3 months, and 5 years, the most common organism was H. influenzae. S. pneumoniae was the most common organism in children over 5 years of age. Thirty-one patients (38.3%) had complications. Of all ages, the mortality rate of bacterial meningitis markedly decreased compared with the previously reported rate. Conclusion : In neonates, GBS meningitis was most common. The frequency of H. influenzae meningitis decreased after the introduction of H. influenzae type b vaccination. A strategy for the prevention of GBS meningitis in neonates should be established. The influence of the pneumococcal conjugate vaccine on S. pneumoniae meningitis should be studied.

A Clinical Study for Gall Bladder Stones in Children (소아 담석증에 대한 임상적 연구)

  • Eun, Ho Seon;Baek, Seoung Yon;Chung, Ki Sup
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.8 no.2
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    • pp.194-201
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    • 2005
  • Purpose: Gall bladder (GB) stones in children are rarely observed, and so reports of them have been quite limited in Korea. Therefore, we tried to assess the epidemiology and clinical features of children with GB stone diagnosed at Severance Hospital. Methods: A clinical study was performed on 18 patients below 15 years of age diagnosed with GB stone by abdominal ultrasonography or CT scan at Severance hospital from January 1999 to May 2005. Results: Concerning patients' profile, their sex ratio of male to female in total 18 cases was 2 : 1 with the mean age of $6{\pm}4.3years$. 15 patients (83.3%) were asymptomatic. Inducing factors were found in 14 children (77.8%) including ceftriaxone therapy in 6 cases (33.3%), infection in 4 cases (22.2%), spherocytosis in 3 cases (16.7%), Down syndrome and abdominal operation in 1 case (5.6%) respectively. Single stone was found in 13 cases (76.5%) and multiple in 4 cases (23.5%). 15 cases (88.2%) had the stones less than 5 mm in size, and 2 cases (11.8%) between 5 and 10 mm. 17 patients received conservative treatment, and one patient had cholecystectomy due to Meckel diverticulum. Conclusion: In this report, Pediatric GB stones are predominant in male children, without typical symptoms, having inducing factors, single and small. Recently the diagnosis of them has been increased because of the development of imaging study. But the reports for them were still rare in Korea. Therefore the study for them is more necessary to find it's clinical characteristics.

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Clinical Study of Group B β-Hemolytic Streptococcal Meningitis (B군 연쇄상구균 뇌막염에 대한 임상적 고찰)

  • Lee, Seo-Young;You, Sou-Jeong;Kim, Deok-Soo;Ko, Tae-Sung
    • Clinical and Experimental Pediatrics
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    • v.46 no.12
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    • pp.1224-1229
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    • 2003
  • Purpose : Bacterial meningitis is a serious disease, especially in the neonatal period, and it carries a significant degree of mortality and morbidity. Group B streptococcus(GBS) is a common cause of neonatal bacterial meningitis. The purpose of this study was to evaluate the clinical manifestations, treatment results and complications of GBS meningitis. Methods : We analyzed 29 cases retrospectively who had been admitted to the pediatric ward or NICU in Asan Medical Center from May 1990 to January 2002. They had proven GBS in culture or latex agglutination test in CSF. Results : The male to female ratio was 1 : 1.9. There were two cases of early onset type and 27 cases of late onset type. All cases had normal birth weight with full term at delivery. The perinatal predisposing factors were premature rupture of membrane(two cases), and maternal colonization(two cases). The most common presenting symptoms were fever and irritability. Associated diseases were GBS sepsis(21 cases). There was relatively high sensitivity to penicillin derivatives. There were abnormal brain CT or MRI findings in 16 cases(64%), such as infarction, encephalomalatic change, effusion, hydrocephalus, hemorrhage and abscess. The intensive care unit admission rate and the incidence of DIC were higher in the group with complications. Two cases were discharged against advice. Conclusion : We recommend early detection and active treatment in Group B streptococcal meningitis to improve the prognosis.

Performance Analysis of Optical Transmitters with the Non-ideal Mach-Zehnder Modulator

  • Lee, Dong-Soo
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.22 no.11
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    • pp.9-14
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    • 2008
  • This paper presents the performance analysis of 10[Gb/s] optical duobinary transmitters with the non-ideal Mach-Zehnder modulator which does not have exactly 50/50 splitting/combining ratios by computer simulations. For driving voltage ratios(=driving voltage/switching voltage) with smaller than 100[%], the transmission performance has been greatly affected by extension of LPF bandwidths. Nevertheless, the performance has been degraded when the driving voltage ratio is 100[%]. The smaller driving voltage ratios has, the more sensitivity improves by extension of LPF bandwidths under the asymmetry condition. But the driving voltage ratio with 80[%] has better bit error rate(BER) than those with 50[%] and 25[%].

e-VLBI 실현을 위한 초고속 네트워크 설계

  • 송민규;김현구;김광동;노덕규;위석오;오세진
    • Bulletin of the Korean Space Science Society
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    • 2003.10a
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    • pp.79-79
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    • 2003
  • e-VLBI(electronic VLBI)는 각 관측 사이트에서 얻은 대용량의 VLBI 데이터를 영상합성처리 센터로 전송하기 위하여 네트워크를 이용하는 기술이다. 이는 전세계의 관측소에서 얻어낸 막대한 용량의 데이터를 실시간, 준-실시간 형태로서 데이터센터에 전송할 수 있는 유일한 방법으로서 초고속정보통신망을 적극적으로 활용하는 애플리케이션이라 할 수 있다. 한국천문연구원에서는 현재 2007년 완공을 목표로 연세대, 울산대, 탐라대에 건설되는 20m 안테나와 대덕전파천문대의 14m 안테나를 네트워크로 연결하는 e-KVN(Korean VLBI Network) 계획을 추진중에 있으며 이는 각 관측소에서 얻은 VLBI 데이터를 네트워크를 통하여 1024Mbps로 데이터센터까지 실시간으로 전송하는 것을 그 궁극적 목표로 하고 있다. 이러한 e-VLBI를 구현함에 있어서 첨단화된 네트워크 및 하드웨어 기술은 필수라고 할 수 있는데 본 연구에서는 e-KVN의 백본망으로서 예상되고 있는 KOREN과 10GbE으로 구성된 네트워크 토폴로지에 대해 간략히 기술하고 e-KVN의 향후 전망 및 보완해야 할 네트워크 기술에 대해 살펴보고자 한다.

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Review on the Optical tin]k Technologies for the Gigabit-per-second Wavelength-Division-Multiplexing Passive Optical Networks (WDM-PONs) (기가급 WDM-PON을 위한 광기술 분석)

  • Park Tae-Sang;Park Kun-Youl;Kim Jin-Hee;Yoon Ho-Sung
    • 한국정보통신설비학회:학술대회논문집
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    • 2006.08a
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    • pp.11-14
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    • 2006
  • This paper reviews the optical link technologies which have been developed for gigabit-per-second wavelength-division-multiplexing passive optical networks (WDM-PONs). Similarly to the 100Mb/s WDM-PON systems which have been deployed for trial services by KT, the most important requirement for 1Gb/s WDM-PON is wavelength independence (colorless feature) of its ONU/ONTs, which makes possible convenient operation and cost-effective maintenance with minimum inventory cost. Among various methods to implement such colorless feature, four promising candidates for gigabit WDM-PON are analyzed with their own development issues and their expected performances are compared.

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Systemic Review : The Study on Electroacupuncture in PubMed (Pub Med 검색(檢索)을 통한 전침(電鍼)의 최신(最新) 연구(硏究)에 관한 고찰(考察) -임상(臨床) 논문(論文) 중심(中心)으로-)

  • Seo, Dong-Min;Kang, Sung-Keel
    • Journal of Acupuncture Research
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    • v.19 no.3
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    • pp.168-179
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    • 2002
  • Objective : To research the trend of the study related to electroacupuncture and to establish the hereafter direction for the study on electroacupuncture. Methods : We have referred to PubMed, with electroacupuncture (Limits: 5 Years, only items with abstracts, English, Human) Results : 1. We have searched 67 papers in 49 journals on electroacupuncture. 2. The pattern of study was as follows: review articles-8 papers in 8 journals, RCT articles-22 papers in 16 journals, meta-analysis-2 papers in 2 journals, and clinical trials-29 papers in 14 journals. 3. How frequently each Meridians was used for electroacupuncture in the searched papers was as follows: Large Intestine Meridian-14 times, Stomach Meridian-12 times, GallBladder Meridian-5 times, Governor Vessel-4 times, Conception Vessel-3 times, Pericardium Meridian-2 times, Triple Energizer Meridian-2 times, and Liver Meridian-2 times in that order. 4. The acupoints used in the searched papers were as follows: LI4-8 times, ST36, LI11, and GB34-3 times, GV20, LR3, and PC6-2 times in that order. 5. The diseases in the searched papers were as follows: pain, stroke, and others. Conclusion : More clinical data would be needed to prove the effects of electroacupuncture for better application.

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Randomized Controlled Trial of East-West Collaborate Medical Treatment on Female Chronic Shoulder Pain Patients (여성 만성견비통 환자에 대한 동서 협진 치료의 무작위 대조군 연구)

  • Nam, Dong-Woo;Choi, Yang-Sik;Kim, Haeng-Beom;Kim, Jong-In;Lim, Sabina;Kim, Keon-Sik;Lee, Doo-Ik;Lee, Jae-Dong;Lee, Yun-Ho;Choi, Do-Young
    • Journal of Acupuncture Research
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    • v.24 no.6
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    • pp.113-122
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    • 2007
  • 목적 : 만성 견비통 환자에 대한 침 치료와 신경 차단술 병행 치료의 효과를 검증하고자 함. 방법 : 만성 견비통 환자 60명을 대상으로 동서병행치료군(EW group, n=20), 한방 침치료군(E group, n=20), 무처치 대조군(C group, n=20)으로 무작위 배정한 후 연구를 시작했다. 동서병행치료군은 먼저 견갑상 신경차단술, 견봉하 주사 및 압통점 국소 마취제를 맞은 후 5분간 휴식을 취한 후 견우($LI_{15}$), 견요($TE_{14}$), 견정(肩井)($GB_{21}$) 및 동씨침의 견중혈(肩中穴)과 신관혈(腎關穴)에 침치료를 주 2회 4주간 받았다. 한방 침치료군은 주 2회, 4주간 견우($LI_{15}$), 견요($TE_{14}$), 견정(肩井)($GB_{21}$) 및 동씨침의 견중혈(肩中穴)과 신관혈(腎關穴)에 침치료를 받았으며, 무처치 대조군은 4주간 특별한 처치를 받지 않았다. 모든 환자들은 일상생활에서 자가 운동을 실시하도록 지시 받았다. 치료 시작전과 치료 4주 후 Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI), 및 환자의 주관적 통증 평가를 Visual Analogue Scale(VAS) 로 측정하여 모인 데이터 통계를 분석하였다. 결과 : 동서병행치료군 및 한방 침치료군 모두 CSA, SPADI 및 VAS 상에서 유의한 (p<0.05) 호전을 보였다, 동서병행치료군의 CSA, SPADI, VAS는 무처치 대조군과 비교하여 유의한 우의를 나타냈으며, 한방 침 치료군과 비교하여 VAS 에서 유의한 차이를 나타냈다. 결론 : 침치료와 신경차단술 병행 치료방법은 만성 견비통을 유의하게 호전시켰다. 무처치 대조군과의 차이는 3개의 측정 도구 모두에서 유의한 차이가 있었으며, 침치료만 받은 환자들과도 주관적 통증 척도에서 유의한 차이를 보였다.

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Causative Organisms in Children with Bacterial Meningitis(1992-2002) (소아 세균성 수막염에서 원인균에 관한 고찰(1992-2002))

  • Kim, Hyun-Jung;Lee, JI-Won;Lee, Kyung-Yil;Lee, Hyung-Shin;Hong, Ja-Hyun;Hahn, Seung-Hoon;Whang, Kyung-Tai
    • Clinical and Experimental Pediatrics
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    • v.46 no.11
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    • pp.1085-1088
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    • 2003
  • Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles in Korea, in 1970s-1980s. The causative agents of the children's group were analyzed according to the stage before and after the introduction of H. influenza type b(Hib) vaccine. Results : In neonates, Group B streptococci(GBS) was the most common cause of bacterial meningitis. There was a trend in Korea that major causative agents of neonatal bacterial meningitis have changed from gram negative bacteria including E. coli to gram positive bacteria including GBS. In children, H. influenzae was isolated in six out of 11 cases(55%) in 1992-95, before the introduction of Hib vaccine, while two out of seven(29%) were isolated in 1999-2002, after the introduction of the Hib vaccine. Conclusion : Our study showed that the most common agent of neonatal bacterial meningitis was GBS. There was a trend that after the introduction of Hib vaccine, the incidence of H. influenza meningitis decreased in children.

Application and Practice of Estill Vocal Training (EVT) Through Theatrical and Musical Analysis of Musical Songs (뮤지컬 노래의 극과 음악 분석을 통한 조 에스틸 보컬 기법(EVT)의 적용과 실제)

  • Lee, Eun-Hye;Kim, Yu-Jeong
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.8
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    • pp.91-102
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    • 2020
  • The purpose of this study is to analyze musical songs from an academic perspective by applying vocal techniques that can express songs in depth in three dimensions. Singing a musical song cannot be completed with just the musical part, rather, it should be accompanied by the analysis of various aspects such as the emotional state of the scenes and the characters. To this end, this study performed a multi-dimensional analysis of fields such as theatrical structure, lyrics, musical structure, and dynamics. In addition, the study explored and applied Estill Voice Training(EVT) that actors can best express songs with the emotions of the theater and music. EVT categorizes voice into six tones: speech, sob/cry, falsetto, twang, opera, and belting. In this study, in addition to these six sounds, the positions of vocal cords and larynx were also applied to seek ways to effectively express songs using "Gar Nichts" from the musical "Elisabeth" as a case study. "Gar Nichts" is a song sung by the protagonist Elisabeth, which expresses the self and the conflict at the peak of pain. Musically, this song requires various sound and voice-changing techniques to cover the range of "G#3-Gb5." As a result, it was confirmed that in order to embody the emotions of the characters and the songs in depth, the analysis of scenes and characters as well as various singing techniques need to be applied in harmony.