• Journal of Microbiology and Biotechnology
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• 제28권2호
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• pp.236-245
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• 2018

Ingredients of soy and fermented soy products have been widely utilized as food supplements for health-enhancing properties. The aim of this study was to evaluate the effects of fermented soymilk (FSM) and soymilk (SM) on free fatty acid-induced lipogenesis in the hepatocellular steatosis model. HepG2 cells were incubated with palmitic acid (PA) for 24 h to induce lipogenesis and accumulation of intracellular lipid contents. The PA-treated cells were co-incubated with FSM, SM, genistein, and estrogen, respectively. Lipid accumulation in the PA-treated HpG2 cells was significantly decreased by co-incubation with FSM. Treatment of HepG2 cells with PA combined with genistein or estrogen significantly increased the expression of SREBP-1. However, FSM co-incubation significantly attenuated SREBP-1 expression in the PA-treated HepG2 cells; in addition, expression of NRF-2 and phosphorylation of ERK were significantly increased in the PA and FSM co-incubated cells. PA-induced ROS production was significantly reduced by FSM and SM. Our results suggested that the bioactive components of FSM could protect hepatocytes against the lipid accumulation and ROS production induced by free fatty acids. These effects may be mediated by the inhibition of SREBP-1 and the activation of NRF-2 via the ERK pathway in HepG2 cells.

• 한국미생물·생명공학회지
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• 제42권3호
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• pp.307-311
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• 2014

폴리우레탄 담체가 혼합폐기물을 이용한 연속식수소생산에 미치는 영향을 조사하였다. 당밀폐수와 하수슬러지를 혼합하여 연속 회분식 공정에서 발효시켰다. 담체를 넣지 않고 12 h의 수리학적 체류시간으로 운전하였을 때, 대부분의 바이오매스가 외부로 유실된 반면, 담체를 반응조에 투입하였을 때에는 미생물 유실이 현저히 저감하였다. 또한, 담체를 이용한 경우, 수소생산속도 $0.4L-H_2L^{-1}d^{-1}$로 높게 나타났다. 반응조 내 부유 바이오매스에 의한 비수소생산속도가 $241{\pm}4ml-H_2g-VSS^{-1}d^{-1}$로서 담체 표면 부착바이오매스($133{\pm}10ml-H_2g-VSS^{-1}d^{-1}$) 및 담체 내부 부착 바이오매스에 의한 값($95{\pm}14ml-H_2g-VSS^{-1}d^{-1}$)보다 높게 나타났다.

• 한국미생물·생명공학회지
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• 제49권1호
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• pp.120-129
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• 2021

Rotavirus A (RVA) is recognized as a major etiology responsible for the development of acute gastroenteritis in children worldwide. The purpose of the present study was to perform the molecular characterization of RVA. A total of 323 stool specimens collected from hospitalized children with acute gastroenteritis in Chiang Rai, Thailand, in 2016-2018 were identified for G- and P-genotypes through RT-PCR analysis. RVA was more prevalent in 2017-2018 (37.8%) than in 2016-2017 (23.2%). The seasonal peak of RVA occurred from March to April. G3P[8] was predominant in 2016-2017 (90.6%) and 2017-2018 (58.6%). Other genotypes including G1P[8], G8P[8], G9P[8], and mixed infections were also identified. G3P[8] strains clustered together in the same lineage with other novel human equine-like G3P[8] strains previously identified in multiple countries and presented a genotype 2 constellation (G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2). Several amino acid differences were observed in the antigenic epitopes of the VP7 and VP8* capsid proteins of the equine-like G3P[8] compared with those of the RVA vaccine strains. The homology modeling of the VP7 and VP8* capsid proteins of the equine-like G3P[8] strains evidently exhibited that these residue differences were present on the surface-exposed area of the capsid structure. The emergence of the equine-like G3P[8] strains in Thailand indicates the rapid spread of strains with human and animal gene segments. Continuous surveillance for RVA is essential to monitor genotypes and genetic diversity, which will provide useful information for selecting rotavirus strains to develop a safe and effective RVA vaccine that is efficacious against multiple genotypes and variants.

• 화훼연구
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• 제16권2호
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• pp.107-111
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• 2008

규산질 비료가 국화의 발근과 생육에 미치는 영향을 알아보기 위해 절화용 국화 'Backwang'과 분화용 국화 'Pink Pixie Time'을 실험작물로 하여 1차 실험은 규소가 국화의 삽목 발근에 미치는 영향을 알아보고자 수행하였고 2차 실험은 규소가 국화의 생육에 미치는 영향을 알아보고자 수행하였다. 1차 실험에서는 'Pink Pixie Time'을 실험작물로 하여 토실이 상토 3L에 규산질비료 0, 30, 60, 90g을 첨가하여 국화의 발근을 조사하였다. 2차 실험에서는 'Backwang'을 실험작물로 하여 피트모스와 펄라이트가 혼합된 배지 20L에 규산질비료 0, 60, 90, 120g, 240g 을 첨가하여 발근된 삽수를 정식하여 국화의 생육을 조사하였다. 1차 실험에서는 배지에 혼합된 규소 함량이 많아질수록 초장과 근장이 길어졌다. 뿌리의 생체중과 건물중은 처리간에 차이를 보이지 않았다. 2차 실험에서는 분지수, 초장, 마디수, 경경을 조사한 결과 규산질비료 첨가구가 무첨가구보다 생육이 우수하였고 건물률에서는 처리간의 유의성이 없었다. 잎, 줄기, 뿌리의 생체중의 경우에도 무첨가구에 비해 첨가구가 높게 나왔다. 흰가루병은 규산질 비료의 시용에 상관없이 모두 발생했다.

• Industrial Engineering and Management Systems
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• 제13권3호
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• pp.258-266
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• 2014

This paper proposes a management system for the educational program of production managers on the basis of value co-creation by the learner and the instructor. The program combines an intelligent knowledge-based approach with the kaizen activity program. The program helps individuals acquire knowledge and skills to ensure the total rather than the partial optimization of processes and operations facilitating continuous improvement in the workplace. To achieve these goals, the program uses models of a learning process and a swing of enlightenment. In addition, the program is supported by a framework of academic, business people, consultants, and government officers. The program was developed using an instructional design approach. This paper discusses the process of developing and managing the educational program between 2006 and 2012 as well as the results obtained.

• 천문학회보
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• 제30권1호
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• pp.39.1-39.1
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• 2005

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2008년도 Asian Magnetics Conference
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• pp.244.1-244.1
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• 2008

• 한국정보통신학회논문지
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• 제25권9호
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• pp.1234-1243
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• 2021

본 연구에서는 한국 방산분야에서 정부분야 경쟁력 향상을 위하여 미국의 FMS 제도를 모델로 하여 한국형 G to G 방위산업협력을 위한 국제국방산업협력제도 도입 시, 국방산업협력국가 확산이 어떻게 이루어질 것인지를 Bass 모델을 통해 예측한다. 이를 위해 미국의 FMS에 참여한 국가 데이터를 기반으로 수요국가 확산을 설명할 수 있는 확산계수와 모방계수를 추정하였다. 또한 이 계수들에 대하여 미국과 한국의 정부분야 경쟁력 차이와 종합적인 방산 경쟁력 차이를 적용하여 한국의 상황을 고려한 확산 패턴을 예측하였고, 조기에 확산을 이룰 수 있는 방안을 제시한다. 한국은 국제방산시장에서 모방구매자들에게 상대적인 우위를 점할 수 있을 것으로 보이며, 확산을 조기화하기 위해서는 Medium-High급 무기체계에서의 경쟁력을 High급까지 확장시켜야 하며, 미국의 FMS에서 정부가 주도하지 않는 절충교역 분야인 산업협력을 포함한 대안 제공을 강화하여야 한다.

• 대한간호학회지
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• 제34권7호
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• pp.1362-1371
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• 2004

Purpose: This study was to examine the effect of an obesity management program on the body weight, body-mass index, and physiological index of obese female high school students. Method: Students from one school were selected as the experimental group, and students from another school as a control group so the latter group wasn't exposed to the experiment. The experimental group and the control group were each organized with 20 students. The experimental group received 60 minutes of behavior modification once a week, for eight weeks. Result: The Body weight, and Body mass-Index of the experimental group significantly decreased after the obesity management program. Total-cholesterol, T-G, and LDL-C significantly decreased and HDL-C increased in the experimental group. Total-cholesterol, T-G, LDL-C and HDL-C between the experimental group and control group showed significant differences. Conclusion: These results indicate that the obesity management program had a great effect on decreasing the body weight and body-mass index of the female obese high school students, normalizing their physiological index. In conclusion, this program turned out to be one of the safest and most effective obesity-management methods that could be applied to female high school students.

• Journal of Nutrition and Health
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• 제33권8호
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• pp.901-908
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• 2000

The study was carried out to assess whether the nutritional management program by dietician at child center can affect nutritional status of children at child care center. The diet intakes were measured by mother\`s record at home and by direct weighing at child care centers, and the hight and weight of children were measured before and after nutritional management program for 3months to see the effects. The energy intakes were significantly increased 56.29 Kcal after program, and protein 3.61g, lipid 3.12 g, calcium 49.71mg, iron 0.39 mg, vitamin B$_1$ 0.084 mg, vitamin B$_2$ 0.116 mg, and vitamin C 10.10 mg, respectively, except vitamin A and niacin. the significant changes of nutrient intakes were more at higher age group compared to at the lower age group, and more at girls compared to boys, Although the significant increase fo nutrient intakes at child care center, most nutrient intakes at home were not significantly changed, except energy, lipid, iron, vitamin A. The changes at changes of fat and calcium intakes for 3 months were positively correlated to the change of Z-score for weight, and the change of A-score for weight was positively correlated to changes of Z-score for height. The results showed that the nutritional management program for 3 month at child care center can increase nutrient intakes significantly and the incresed nutrient intakes can enhance children\`s growth. (Korean J Nutrition 33(8) : 901-908, 2000)