• 한국전산유체공학회:학술대회논문집
• /
• 한국전산유체공학회 2004년도 추계 학술대회논문집
• /
• pp.53-59
• /
• 2004

A general purpose program NUFLEX for the analysis of 3-D heat/fluid flow in complex geometry with pre/post processor have been developed, which consists of a flow solver based on FVM and a dedicated pre/post processor. The program employs a general non-orthogonal grid system and solve laminar and turbulent (lows with standard and RNG $\kappa-\epsilon$ turbulence models. NUFLEX is capable of analysing two-phase flow with topologically complex interface, turbulent diffusion combustion, solidification problems and magnetic flow. For the purpose of verification of the program and testing the applicability, several practical problems are solved and compared with the available data. Comparison of the NUFLEX results with that by the STAR-CD program has been also made for the same flow configuration and grid structure.

• 한국전기전자재료학회논문지
• /
• 제14권12호
• /
• pp.953-958
• /
• 2001

The antifuse is a semi-permanent memory device like a ROM which shows the open or short state, and a switch device connecting logic blocks selectively in FPGA. In addition, the antifuse has been used as a logic device to troubleshoot defective memory cells arising from SDRAM processing. In this study, we have fabricated ONO antifuses consisted of PIP structure. The antifuse shows a high resistance more than several G Ω in the normal state, and shows a low resistance less than 500 Ω after program. The program resistance variation according to temperature shows the very stable value of $\pm$20 Ω. At this time, its program voltage shows 6.7∼7.2 V and the program is performed within 1 second. Therefore this result shows that the PIP antifuse is a very stable and programmable logic device.

• 한국약용작물학회지
• /
• 제24권1호
• /
• pp.14-20
• /
• 2016

Background : This study aimed to investigate the antioxidant and antiproliferative activities of extract from different parts of water chestnut (Trapa japonica Flerow). Methods and Results : The total polyphenol content of pericarp and seed extract was 438.31 mg/g and 25.32 mg/g respectively. DPPH radical scavenging assay showed that the half maximal inhibitory concentration ($IC_{50}$ values) of pericarp and seed extract were $5.28{\mu}g/m{\ell}$ and $355.51{\mu}g/m{\ell}$ respectively. In addition, the pericarp extract showed strong reducing power. In the MTT assay, the pericarp extract significantly inhibited the viability of A549, AGS, HeLa, PC-3, HCT116, HT29 and SW620 cell lines compared with the seed extract. Conclusions : These results suggest that T. japonica Flerow extracts have significant antioxidant and antiproliferative activity.

• 화약ㆍ발파
• /
• 제14권2호
• /
• pp.71-80
• /
• 1996

본 고에서는 터널 신공법으로 건설되고 있는 Iran 철도터널의 지진에 대한 안정성을 검토하기 위하여 수행한 일련의 과정 즉, 설계지진 가속도의 산출과정과 이를 FEM 해석에 도입한 과정을 소개하고 FEM 해석결과를 분석하여 지진이 터널에 미치는 영향을 고찰하였다. Iran 지역의 지진기록 및 경험식을 통하여 지진의 최대설계가속도로서 수평가속도 $a_h=0.34g$ 와 수직 가속도 $a_v=0.23g$을 산출하였고, 이를 지진의 영향에 가장 취약한 갱구부근 터널의 FEM 해석에 적용한 결과, 설계지진강도 이내에서 터널구조체의 변위와 응력은 증가하나 터널구조체에 손상은 주지 않는 것으로 나타났다.

• 대한지역사회영양학회지
• /
• 제7권6호
• /
• pp.814-823
• /
• 2002

This study was conducted to evaluate the nutritional status of the elderly women, who attended the Health Promotion Program of the Seogu Health Center in Daegu. The study subjects were 158 elderly women in an urban community. The general characteristics, dietary behavior (nutritional knowledge, nutritional attitudes and dietary habits), food and nutrient intake were surveyed by an individual interview. The average age of the study subjects was 70.9 $\pm$ 2.3 years of the subject group 79.1% ranged in age from 65 to 74 years and 20.9% were over 75 years. Their average score for nutritional knowledge, nutritional attitudes and dietary habits was 7.3 (total mark of 10), 7.2 (total mark of 10) and 9.1 (total mark of 22) respectively. Specifically, the level of the dietary habits of the study subjects was very low. In relation to food group intake of the study subjects according to age, their food intake was low. The total, plant. and animal food intake were 1078.9 g, 954.4 g (88.5%), and 244.4 g (11.5%), respectively. The mean daily energy intake and nutrient intake according to percentage of the Korean RDA were higher in the from 65 to 74 year group than in those people over 75 years. The average calories and the mean percentage of nutrient intake, except for vitamin C and phosphorus. were below 75% of the Korean RDA. It seems that the nutrient intake was very low. The mean nutrient adequacy ratio (MAR) was 0.59. Nutritional status of age over 75 years old was significantly lower than that of 6574 years old group (Mar ＝ 0.60 VS 0.54, p ＜ 0.05) The correlation coefficients between their dietary behavior (nutritional knowledge, nutritional attitudes, dietary habit) and their mean nutrient adequacy ratio (MAR) showed significant linear relations. In conclusion, if nutritional education is to affect the dietary behavior of elderly women, it should be included in a Program to Promote their nutrition and health status.

• Journal of Microbiology and Biotechnology
• /
• 제25권4호
• /
• pp.526-536
• /
• 2015

Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira, a genus of which more than 250 serovars have been identified. Commercial bacterin vaccines are limited in that they lack both cross-protection against heterologous serovars and long-term protection. This study investigated in mice the immunogenicity of an anti-leptospirosis vaccine, using the outer membrane proteins LipL32 and Loa22 as antigens. The immunogenicity of this vaccine formulation was compared with those induced by vaccines based on LipL32 or Loa22 alone. A DNA-encapsulated chitosan nanoparticle was used for in vivo DNA delivery. Using a unique DNA plasmid expressing both lipL32 and loa22 for vaccination, higher antibody responses were induced than when combining plasmids harboring each gene separately. Therefore, this formulation was used to test the immunogenicity when administered by a heterologous prime (DNA)-boost (protein) immunization regimen. The specific antibody responses against LipL32 (total IgG and IgG1) and Loa22 (IgG1) were higher in mice receiving two antigens in combination than in those vaccinated with a single antigen alone. Although no significant difference in splenic CD4⁺ T cell proliferation was observed among all groups of vaccinated mice, splenocytes from mice vaccinated with two antigens exhibited higher interferon-γ and IL-2 production than when using single antigens alone upon in vitro restimulation. Taken together, the immunogenicity induced by LipL32 and Loa22 antigens in a heterologous primeboost immunization regimen using chitosan as a DNA delivery system induces higher immune response, and may be useful for developing a better vaccine for leptospirosis.

• 한국전기전자재료학회논문지
• /
• 제13권11호
• /
• pp.914-920
• /
• 2000

When the charge-trap type SONOS(polysilicon-oxide-nitride-oxide-semiconductor) cells are used to flash memory, the tunneling program/erase condition to minimize the generation of interface traps was investigated. SONOSFET NVSM(Nonvolatile Semiconductor Memory) cells were fabricated using 0.35 ㎛ standard memory cell embedded logic process including the ONO cell process, based on retrograde twin-well, single-poly, single metal CMOS(Complementary Metal Oxide Semiconductor) process. The thickness of ONO triple-dielectric for the memory cell is tunnel oxide of 24 $\AA$, nitride of 74 $\AA$, blocking oxide of 25 $\AA$, respectively. The program mode(V$\_$g/=7, 8, 9 V, V$\_$s/=V$\_$d/=-3 V, V$\_$b/=floating) and the erase mode(V$\_$g/=-4, -5, -6 V, V$\_$s/=V$\_$d/=floating, V$\_$b/=3 V) by MFN(Modified Fowler-Nordheim) tunneling were used. The proposed programming condition for the flash memory of SONOSFET NVSM cells showed less degradation(ΔV$\_$th/, S, G$\_$m/) characteristics than channel MFN tunneling operation. Also, the program inhibit conditins of unselected cell for separated source lines NOR-type flash memory application were investigated. we demonstrated that the phenomenon of the program disturb did not occur at source/drain voltage of 1 V∼12 V and gate voltage of -8 V∼4 V.

• 대한간호학회지
• /
• 제33권5호
• /
• pp.643-650
• /
• 2003

Purpose: This study was conducted to examine the effect of a posture training program, including posture education and spinal exercise as implemented on the elementary school students with scoliosis. Method: The design of this study is nonequivalent sample control group pretest-posttest design. The study subjects were elementary school students attending 7 elementary schools located in G city in Gyungsangbuk-Do. Among them, those who had the Cobb angle between 4～10$^{\circ}$ in spine x-ray who agreed to participate in the study program were selected as the study subjects. The research instruments included the degree of spinal scoliosis(cobb angle), the level of knowledge on posture, and an evaluation following the posture training program. The data were collected from March 1, 2002 to July 30, 2002. The collected data were analyzed by frequency, percentile, mean, standard deviation, t-test, i test and Mann-Whitney U test were using SPSS WIN10.0 program. Result: The elementary school students with scoliosis who received the posture training program have a lower Cobb angle and higher level of knowledge of posture than the elementary school students with scoliosis who did not receive the posture training program. Conclusion: The posture training program was effective on the on Cobb angle and Knowledge of posture in the elementary school students with scoliosis in this study. Therefore, the program training program can be usefully utilized for the students with mild scoliosis in the field of school health.

• 한국약용작물학회지
• /
• 제17권2호
• /
• pp.133-138
• /
• 2009

Nelumbo nucifera (lotus) is known to be a useful medicinal plant and leaf extract contains several flavonoids and alkaloids. To analyze the effect of Nelumbo nucifera leaves extract (NNL) on the HBsAg production, we treated NNL on HepG2.2.15 cells which contain the hepatitis B viral genome and secrete surface antigen into media. NNL suppressed the production of hepatitis B surface antigen as a dose-dependent manner. To analyze the effect of NNL on HBV DNA replication, PCR analysis was performed. NNL was not affected the HBV DNA replication and HBsAg mRNA expression. To understand the effect of NNL on the production of HBsAg, we carried out the analysis of lipid-metabolizing gene expression using one-step RT-PCR. NNL reduced the gene expression of FASN and SREBP2 and increased the expression of LDLR. Triglyceride content of HepG2.2.15 cells was not decreased by treatment of NNL. This result suggests a possibility that NNL may have an effect for the inhibition of hepatitis B surface antigen by modulation of lipid and cholesterol metabolism.

• 지역사회간호학회지
• /
• 제29권1호
• /
• pp.120-132
• /
• 2018

Purpose: This study is a systematic review and meta-analysis designed to investigate effects of alcohol management programs for Korean university students. Methods: Research results published until October 14, 2016 were systematically collected in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). A total of 12 papers were selected for the meta-analysis. To estimate the effect size, meta-analysis of the studies was performed with the Comprehensive Meta-Analysis 3.0. Results: The mean effect size of 12 studies in total (Hedges' g=-0.36; 95% Confidence Interval [CI]: -0.76~0.05) was not significant statistically. In a study of college students classified as problematic drinking (total of 9), the drinking program showed a median effect size of Hedges' g=-0.57(95% CI: -0.96~-0.18). Results of the drinking-related outcome variables showed a significant effect size (Hedges' g=-0.61; 95% CI: -1.10~-0.13), but psychosocial related outcome variables were not significant (Hedges' g=-0.50; 95% CI: -1.24~0.23). Conclusion: It can be seen that the alcohol management program for college students has a significant effect on controlling the problem drinking of college students. In addition, application of a differentiated drinking program with problem drinkers selected as a risk group will be effective in controlling drinking and drinking related factors.