• Journal of Korean Neurosurgical Society
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• v.56 no.5
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• pp.405-409
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• 2014

Objective : To determine the efficacy of endoscopic surgery in combination with long-acting somatostatin analogues (SSAs) in treating patients with growth hormone (GH)-secreting pituitary tumor. Methods : We performed retrospective analysis of 133 patients with GH producing pituitary adenoma who underwent pure endoscopic transsphenoidal surgery in our center from January 2007 to July 2012. Patients were followed up for a range of 3-48 months. The radiological remission, biochemical remission and complication were evaluated. Results : A total of 110 (82.7%) patients achieved radiological complete resection, 11 (8.2%) subtotal resection, and 12 (9.0%) partial resection. Eighty-eight (66.2%) patients showed nadir GH level less than 1 ng/mL after oral glucose administration. No mortality or severe disability was observed during follow up. Preoperative long-acting SSA successfully improved left ventricle ejection fraction (LVEF) and blood glucose in three patients who subsequently underwent success operation. Long-acting SSA (20 mg every 30 days) achieved biochemical remission in 19 out 23 (82.6%) patients who showed persistent high GH level after surgery. Conclusion : Endoscopic transsphenoidal surgery can biochemically cure the majority of GH producing pituitary adenoma. Post-operative use of SSA can improve biochemical remission.

• Research in Plant Disease
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• v.10 no.3
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• pp.183-187
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• 2004

Black spot disease on sweet persimmon (Diospyros kaki cv. Fuyu) was found from the farmer's refregerated ware house located in Dong-eup, Changwon city, Gyeongnam province, Korea, 2002. The typical symptoms of the disease was appeared black spot on surface of fruits. Colonies of causal fungus were developed velvety and later turned olivaceous black to sooty black in color on PDA. Conidia were pale brown to golden brown in color and ovoid, obclavate to obpyriform, rarely ellipsoid in shape. and were 12∼46 ${\times}$ 6∼12 ${\mu}{\textrm}{m}$ in size. Septa were 3∼5 transvers, 1∼2 longitudinal or oblique. Conidia were mostly beakless and generated chains by means of secondary conidiophores. Conidiophores were pale to mid brown in color and 42∼95 ${\times}$ 3∼5 ${\mu}{\textrm}{m}$ in size. The optimum temperature for growth of the fungus was about 25∼3$0^{\circ}C$. This is the first report on the black spot of sweet persimmon caused by Alternaria alternata (Fr.) Keissler in Korea.

• Applied Biological Chemistry
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• v.25 no.4
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• pp.201-205
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• 1982

As a series of study on the removal of astringency and production of tannin substances, this experiment was conducted to investigate changes of tannin contents and microscopic observation on leaves of persimmon(Diospyros kaki L.). Changes of tannin contents of leaves and fruits in Daegu Bansi(astringent variety) were of similar tendency in content of total and soluble tannin during growth. It seemed therefore that tannin contents of leaves in astringent variety were closely concerned with tannin of fruits. But Fuyu(sweet variety) was different from each other during its growth. Histological form of leaves in microscopic observation had similar tendency between astringent and sweet varieties. It was observed that tannin substances were contained in epidermis cells of levels, that tannin substances were transfered in phloems of nerves system, and that tannin cell existed too in the vicinity of nerves system.

• Nuclear Engineering and Technology
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• v.52 no.7
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• pp.1443-1451
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• 2020

The objective of this study is to design a robust power control system for a small pressurized water reactor (PWR) to achieve stable power operations under conditions of external disturbances and internal model uncertainties. For this purpose, the multiple-input multiple-output transfer function models of the reactor core at five power levels are derived from point reactor kinetics equations and the Mann's thermodynamic model. Using the transfer function models, five local reactor power controllers are designed using an H infinity (H_∞) mixed sensitivity method to minimize the core power disturbance under various uncertainties at the five power levels, respectively. Then a multimodel approach with triangular membership functions is employed to integrate the five local controllers into a multimodel robust control system that is applicable for the entire power range. The performance of the robust power system is assessed against 10% of full power (FP) step load increase transients with coolant inlet temperature disturbances at different power levels and large-scope, rapid ramp load change transient. The simulation results show that the robust control system could maintain satisfactory control performance and good robustness of the reactor under external disturbances and internal model uncertainties, demonstrating the effective of the robust power control design.

• Korean Journal of Food Science and Technology
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• v.52 no.4
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• pp.363-368
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• 2020

This study was conducted to evaluate several physiological activities of 4 sweet persimmon cultivar leaf water extracts. One new cultivar ('Hongchu' (HC)]) and three traditional cultivars ('Sangseojosaeng' (UW), Japanese Uenishiwase; 'Seochonjosaeng' (NW), Japanese Nishimurawase; and 'Buyu' (FY), Japanese Fuyu) were used in this study. The HC extract showed significantly higher DPPH and ABTS radical scavenging activities, tyrosinase inhibitory activity, and acetaldehyde dehydrogenase activity than the other extracts, while the FY extract exhibited a relatively higher alcohol dehydrogenase activity. The HC extract contained higher amount of phenolics and ascorbic acid. These results suggest the possibility of high-quality persimmon leaf tea development using the new sweet persimmon cultivar, HC.

• Korean Journal of Organic Agriculture
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• v.22 no.3
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• pp.413-421
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• 2014

This study was conducted into the effects of cover crops among the hairy vetch, red clover, rye, and hairy vetch+rye on the soil chemical and physical properties, and fruit yield in mature 'Fuyu' persimmon (Diospyros${\times}$kaki Thunb.) trees. The shallow-rooted red clover had poor dry matter production, resulting in the lowest coverage (66%) on the orchard floor. In contrast, the highest dry matter production observed in rye and hairy vetch+rye. Estimated N, P and K production from the cover crops were the highest on the hairy vetch+rye plots, increasing soil chemicals at a depth of 0-30 cm soil. Rye or hairy vetch+rye treatments decreased the soil bulk density and solid phase. As the hairy vetch+rye treatment increased fruit yield and sugar contents, it could be proposed as an suitable cover crop for improving productivity of persimmon trees.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.5
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• pp.949-953
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• 2001

Persimmon has been considered to have a therapeutic value diseases in Korea, Dried, persimmon was applied to a wounded part for an anti-inflammatory and analgesic activities, Anti-coagulating activity has been detected in persimmon by a thrombin-induced clotting assay using human plasma. The anti-coagulating activity was detectible in stem, pulp, core, leaf, and seed of persimmon The stem part of persimmon contains maximal anti-coagulating activity after-size-fractionation. Both of an anticoagulant and its denaturating factor were present in persimmon pulp. The concentration of anti-coagulating activity was determined and compared in different harvesting time, species, and available foods. The level of anti-coagulating activity was highest in persimmon(Fuyu)harvested in November. The anti-coagulating activity was decreased significantly in its processed foods. Persimmon could be expected to be effective in prevention of diseases induced by excess coagulation.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.5
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• pp.665-674
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• 2019

Objective: In tropical regions, as in temperate regions where seasonality of forage production occurs, well-preserved forage is necessary for animal production during periods of forage shortage. However, the unique climate conditions (hot and humid) and forage characteristics (high moisture content and low soluble carbohydrate) in the tropics make forage preservation more difficult. The current study used natural ensiling of tropical forage as a model to evaluate silage characteristics under different temperatures ($28^{\circ}C$ and $40^{\circ}C$). Methods: Four tropical forages (king grass, paspalum, white popinac, and stylo) were ensiled under different temperatures ($28^{\circ}C$ and $40^{\circ}C$). After ensiling for 30 and 60 days, samples were collected to examine the fermentation quality, chemical composition and microbial community. Results: High concentrations of acetic acid (ranging from 7.8 to 38.5 g/kg dry matter [DM]) were detected in silages of king grass, paspalum and stylo with relatively low DM (ranging from 23.9% to 30.8% fresh material [FM]) content, acetic acid production was promoted with increased temperature and prolonged ensiling. Small concentrations of organic acid (ranging from 0.3 to 3.1 g/kg DM) were detected in silage of white popinac with high DM content (50.8% FM). The microbial diversity analysis indicated that Cyanobacteria originally dominated the bacterial community for these four tropical forages and was replaced by Lactobacillus and Enterobacter after ensiling. Conclusion: The results suggested that forage silages under tropical climate conditions showed enhanced acetate fermentation, while high DM materials showed limited fermentation. Lactobacillus and Enterobacter were the most probable genera responsible for tropical silage fermentation.

• Korean Journal of Environmental Agriculture
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• v.38 no.2
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• pp.89-95
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• 2019

BACKGROUND: Liquid pig manure (LPM) has been used as an alternative for conventional fertilizers on some gramineous crops. However, its chemical properties varied widely depending on the degree of the digestion. A pot experiment was conducted to determine the responses of persimmon trees to immature (not well-digested) LPM application. METHODS AND RESULTS: Ten application levels of immature LPM, consisted of a total of 3 to 30 L in 3-L increment, were applied during summer to 5-year-old 'Fuyu' trees grown in 50-L pots. Increasing the LPM application rate caused defoliation, wilting, and chlorosis in leaves. When applied with the rate of 3 L during summer, the tree produced small fruits with low soluble solids and bore few flower buds the following season, indicating insufficient nutritional status. In trees applied with the LPM rates of 6~12 L, both fruit characteristics and above-ground growth of the trees appeared normal but some roots were injured. However, application of higher LPM rates than 27 L resulted in small size, poor coloration, or flesh softening of the fruits the current season. Furthermore, the high LPM rates caused severe cold injury in shoots during winter and weak shoot growth the following season. It was noted that the application of higher LPM rate than 9 L damaged the root, even though above-ground parts of the tree appeared to grow normally. CONCLUSION: The results indicated that an excessive immature LPM application could cause various injuries on leaves, fruits, and the roots in both the current and the following season.

• Molecules and Cells
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• v.45 no.6
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• pp.365-375
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• 2022

Long non-coding RNAs (lncRNAs) may be important regulators in the progression of ankylosing spondylitis (AS). The competing endogenous RNA (ceRNA) activity of lncRNAs plays crucial roles in osteogenesis. We identified the mechanism of the differentially expressed lncRNA MALAT1 in AS using bioinformatic analysis and its ceRNA mechanism. The interaction of MALAT1, microRNA-558, and GSDMD was identified using integrated bioinformatics analysis and validated. Loss- and gain-of-function assays evaluated their effects on the viability, apoptosis, pyroptosis and inflammation of chondrocytes in AS. We found elevated MALAT1 and GSDMD but reduced miR-558 in AS cartilage tissues and chondrocytes. MALAT1 contributed to the suppression of cell viability and facilitated apoptosis and pyroptosis in AS chondrocytes. GSDMD was a potential target gene of miR-558. Depletion of MALAT1 expression elevated miR-558 by inhibiting GSDMD to enhance cell viability and inhibit inflammation, apoptosis and pyroptosis of chondrocytes in AS. In summary, our key findings demonstrated that knockdown of MALAT1 served as a potential suppressor of AS by upregulating miR-558 via the downregulation of GSDMD expression.