• Polymer(Korea)
• /
• 제37권6호
• /
• pp.702-710
• /
• 2013

Zaltoprofen loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method like oil-in-water (O/W) for sustained release of zaltoprofen. The influence of several preparation parameters such as fabrication temperature, stirring speed, intensity of the sonication, initial drug ratio, molecular weight ($M_w$) of POX, concentration of POX and concentration of emulsifier has been investigated on the zaltoprofen release profiles. Physicochemical properties and morphology of zaltoprofen loaded POX microspheres were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). Through the analyzed results, it was demonstrated that the characteristics of the microspheres greatly affected by the prepared condition. The releases behavior of zaltoprofen was investigated for 10 days in vitro. It was confirmed that the release behavior of zaltoprofen can be controlled by the manufacturing factor of solvent-evaporation/extraction method.

• Journal of Pharmaceutical Investigation
• /
• 제37권6호
• /
• pp.339-347
• /
• 2007

SMEDDS is mixture of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle agitation and digestive motility that would be encountered in the gastro-intestinal(GI) tract. The main purpose of this work is to prepare self-microemulsifying drug delivery system(SMEDDS) for oral bioavailability enhancement of a poorly water soluble drug, atorvastatin calcium. Solubility of atorvastatin calcium was determined in various vehicles. Pseudo-ternary phase diagrams were constructed to identity the efficient self-emulsification region and particle size distributions of the resultant micro emulsions were determined using a laser diffraction sizer. Optimized formulations for in vitro dissolution and bioavailability assessment were $Capryol^{(R)}$ 90(50%), Tetraglycol(16%), and $Cremophor^{(R)}$ EL(32%). The release rate of atorvastatin from SMEDDS was significantly higher than the conventional tablet ($Lipitor^{(R)}$), 2-fold. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin calcium by the oral route.

• 핵융합뉴스레터
• /
• 통권36호
• /
• pp.1-16
• /
• 2007

KSTAR 진공용기 제 1차 진공시운전 성공/핵융합 연구 소식/KSTAR 사업소식/ITER 사업 소식/KSTAR 10대 기술 성과/세계 핵융합 연구 동향/국내외 핵융합 협력 소식/NFRC 이모저모/

• 핵융합뉴스레터
• /
• 통권35호
• /
• pp.1-8
• /
• 2007

ITER 협정 비준동의안 통과/핵융합&플라즈마 연구개발 성과/김우식 부총리 축사/KSTAR 10대 기술성과/KSTAR TF·PF 전류전송계 진공배기 시험 성공/핵융합 연구동향/국제협력/워크샵.세미나/내방인사/대중과 함께하는 핵융합/NFRC 이모저모/

• Journal of Pharmaceutical Investigation
• /
• 제38권2호
• /
• pp.119-126
• /
• 2008

Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). The solid dispersion form transformed the drug into an amorphous state and dramatically improved its dissolution rate. These data suggest that the solid dispersion technique is an effective approach for developing the appetite depressant drug products and various pharmaceutical excipients are able to control the release behaviors.

• Nonlinear Functional Analysis and Applications
• /
• 제28권1호
• /
• pp.37-56
• /
• 2023

In this paper, we introduced the notions of ∗ - g-fusion frame and ∗ - K - g-fusion frame in Hilbert C^*-modules, we gives some properties and study the tensor product of ∗ - g-fusion frame. Non-trivial examples are further provided to support the hypotheses of our results.

• Proceedings of the SAREK Conference
• /
• 대한설비공학회 2006년도 하계학술발표대회 논문집
• /
• pp.596-601
• /
• 2006

Because of insufficiency of energy resources and pollution of environment, it is necessary to develop alternative energy sources. Nuclear fission energy is used widely for source of electric Power but being restricted due to radioactivity problem. Nuclear fission is highlighted as the new generation of nuclear energy and researched worldwide because of low risk of radiation effect. The representatives of fusion research is China's EAST, KSTAR of Korea and ITER of world. Korea Superconducting Tokamak Advanced Research(KSTAR) project is on progress for the completion in August, 2007. In this study, the research of utility system for KSTAR be carried out. The utility system of KSTAR is consist of water cooling & heating system, $N_2$ gas system, DI water system, service water system and instrument air & auto control system. The progress of KSTAR utility system is under commissioning state after construction completion. The optimal operation scenario will be verified during commissioning and adopted to the KSTAR operation.

• Journal of Korean Neurosurgical Society
• /
• 제54권4호
• /
• pp.344-346
• /
• 2013

A 55-year-old female patient presented with lower back pain and neurogenic intermittent claudication and underwent L3-L4 posterolateral fusion. To prepare the bone fusion bed, the transverse process of L3 and L4 was decorticated with a drill. On the 9th post-operative day, the patient complained of a sudden onset of severe abdominal pain and distension. Abdominal computed tomography revealed retroperitoneal hematoma in the right psoas muscle and iatrogenic right L3 transverse process fracture. Lumbar spinal angiography showed the delayed hematoma due to rupture of the 2nd lumbar artery pseudoaneurysm and coil embolization was done at the ruptured lumbar artery pseudoaneusyrm. Since then, the patient's postoperative progress proceeded normally with recovery of the hemodynamic parameters.

• 핵융합뉴스레터
• /
• 통권37호
• /
• pp.3-4
• /
• 2007

• 핵융합뉴스레터
• /
• 통권37호
• /
• pp.5-26
• /
• 2007