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Effect of Manufacturing Method and Acidifier on the Dissolution Rate of Carvedilol from Solid Dispersion Formulations

  • Lim, Dong-Kyun;Bae, Jeong-Woo;Song, Byung-Joo;Jo, Han-Su;Kim, Hyoung-Eun;Lee, Dong-Won;Khang, Gil-Son
    • Journal of Pharmaceutical Investigation
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    • 제41권6호
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    • pp.363-369
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    • 2011
  • In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

Abnormal Behavior in Color Tracking in the Fringe-Field Switching (FFS) Liquid Crystal Display

  • Jung, Jun-Ho;Ha, Kyung-Su;Chae, Mi-Na;Cho, In-Young;Kim, Woo-Il;Kim, Dae-Hyun;Kim, Sung-Min;Lee, Seung-Hee
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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    • pp.616-619
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    • 2009
  • Color tracking behavior of in the fringe-field switching (FFS) mode using a liquid crystal with positive dielectric anisotropy has been studied. In the in-plane switching and vertical alignment devices, color chromaticity at normal direction changes from bluish to yellowish white linearly with increasing grey levels from dark to white state. Interestingly, abnormal behavior in color tracking is observed in FFS devices using a liquid crystal with positive dielectric anisotropy, that is, it changes from bluish to yellowish up to a certain middle grey level but turns over to bluish white with further increasing from a grey level to a fully white state. In this paper, we analyze this abnormal effect from the calculated and experimental results.

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분무건조와 용매증발을 이용한 Kollidon VA 64에 포접된 아세클로페낙의 개선된 용출 거동 (Improved Dissolution Behavior of Aceclofenac Loadings with Kollidon VA 64 Using Spray Drying and Rotary Evaporation Process)

  • 양재원;박진영;이천중;김혜민;이현구;장나금;고현아;조선아;양대혁;강길선
    • 폴리머
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    • 제39권1호
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    • pp.6-12
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    • 2015
  • 난용성 약물인 아세클로페낙의 용해도를 개선하기 위해 약물과 고분자의 다른 비율을 사용하여 분무건조와 용매증발의 방법으로 Kollidon VA 64의 고체분산체를 제조하였다. 아세클로페낙을 포접하는 고체분산체의 형태학적, 물리화학적 분석을 하기 위해, 전자주사현미경(SEM), 푸리에변환 적외선분광법(FTIR), 시차주사 열량측정법(DSC) 등이 사용되었다. 포접률과 인공장액에서의 용출 거동은 HPLC를 사용하여 측정하였고, 비교를 위해 원약물과 시판제 Airtal$^{(R)}$이 사용되었다. 이것은 두 가지 방법에 따라 개선된 용출 거동을 나타내었다.