• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.163.1-163.1
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• 2000

• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2585-2591
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• 2012

A series of heterocyclic chalcone derivatives bearing heterocycles such as thiophene or furan ring as an isostere of benzene ring were carefully prepared, and the influence of heterocycles on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities was systematically investigated. Structure-activity relationships (SAR) analysis showed that the activities of thiophene ring-containing chalcones were higher than those of furan ring-containing chalcones, and the presence of methyl substituent of heterocyclic ring distinctly affected the activities compared with non-substituted heterocycles in an opposite manner, with the 4'-methyl group of thiophene ring increasing activity and the 3'-methyl group of the furan ring decreasing activity. The distinct isosteric effect of heterocycles (i.e., thiophene or furan ring) on radical scavenging activities of heterocyclic chalones was distinctly demonstrated in our work.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2000년도 봄 학술발표회 논문집
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• pp.419-426
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• 2000

The purpose of this study is to present the application of WFS co-mixtures for retaining wall as flowable backfill. The fly ash, generated at the Tae-An thermoelectric power plant, was used in this research and was classified as Class F. Green Sand, Furane Sand, and Coated Sand, which had been used at a foundry located in Pusan, were used. Couple of laboratory tests and small scale retaining wall tests were performed to obtain the physical properties of the WFS co-mixtures and the possibility of backfill materials of retaining wall. The range of permeability for all the co-mixtures was from 3.0${\times}$10$\^$-3/ cm/s to 6.0${\times}$10$\^$-5/ cm/s. The unconfined strength of the 28-day cured specimens reached around 550kPa. Results of the consolidated-undrained triaxial test showed that the internal friction angle is between 33.5$^{\circ}$ and 41.8$^{\circ}$. The lateral earth pressure against wall decreased up to 80% of initial pressure within a 12 hours and the total lateral earth pressure is less than that of typical granular soil. It was enough to construct the backfill for the standard retaining of 6m with just two steps, like fill the co-mixtures for half of retaining wall, and then fill the others after 1 day. The stability of retaining wall for overturning and sliding increased as the curing time elapsed.

• 한국식품과학회지
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• 제25권6호
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• pp.593-595
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• 1993

마늘의 건조방법에 따른 향기성분의 비교를 위하여 마쇄-열풍건조, 세절-열풍건조, 세절-동결건조후 Soxhlet를 이용하여 용매 추출하였으며 이들 시료를 GC/MS로 향기성분을 비교 분석한 결과, 열풍건조법 보다는 동결건조법에서, 마쇄한것 보다는 세절하여 건조한 경우가 더 많은 마늘 향기성분의 종류가 확인되었다. 즉, 세절하여 동결건조한 시료에서는 allyl propyl disulfide, 2-vinyl-1,3-dithian 3-vinyl-〔4H〕-1,2-dithiin, 1,2-Bis(allyl)disulfane 등이, 세절하여 열풍건조한 시료에서는 methyl allyl trisulfide, 2,4-dimethylfuran 등이, 마쇄하여 열풍건조한 시료에서는 disulfide 등이 확인되었다.

• 한국연초학회지
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• 제24권2호
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• pp.113-120
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• 2002

This study was conducted to determine the smoke component changes by adding oriental, reconstituted, and expanded tobacco leaves. 7 different cigarette brands which were mixed with flue-cured, burley, oriental, reconstituted and expanded tobacco leaves were used for this study. 64 kinds of smoke components which were 6 of general components, 34 of semi-volatile and volatile components, 9 of acid components, and 15 of phenolic components were analyzed. All smoke components of mainstream smoke were changed by the different branding. As Tar, nicotine, ammonia, pH, all of acid compounds(except lacatic and glycolic acid) were decreased; HCN, levoglucosame, 4-vinyl phenol, 4-vinyl catechol, quinic acid-r-lactone, acetaldehyde, 2,3-butadiene, stylene were increased by adding oriental tobacco leaves. When the reconstituted tobaccos were added to 20%, the concentration of nicotine, all of acid compounds(except lactic. glycolic, palmitic acid) and all of phenol compounds were reduced; the concentration of ammonia, HNC, CO, aeconitrile, benzene, 2-butanone, moth-acrolene, butyronitrile, stylene, o-xylene were increased. As decreasing ammonia, pH, nicotine, all of acid compounds, all of phenol compounds, Isoprene, acetonitrile, 2-methyl-2-butene, 1,3-pentadiene, 2-nlethyl furane, ethylene cyclopentanone, ethyl bezene; increasing CO concentration were followed by adding expanded tobacco leaves.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1999년도 봄 학술발표회 논문집
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• pp.489-496
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• 1999

The objective of this study is to present engineering properties required in use of co-mixtures of fly ash and WFS(Waste Foundry Sand)'s, which are Presently used as fill or (lovable backfill. The fly ash, generated at the Tae-An thermoelectric power plant was used in this research and was classified as Class F. Green Sand, Furane Sand, and Coated Sand, which had been used at a foundry located in Pusan, were used. Laboratory experiments were peformed to obtain the physical properties of the co-mixture of fly ash and WFS. The range of permeability for all the co-mixtures was from 3.0×10/sup -3/㎝/s to 6.0×10/sup -5/㎝/s. The unconfined strength of the 7-day cured specimens composed of Green Sand reached 94% of that of 28-day cured specimens but for the 7-day cured specimens composed of, respectively, Furnace Sand and Coated Sand, only 64% and 66% of the strength of the 28-day cured specimens were reached. Results of the consolidated-untrained triaxial test showed that the specimens composed of Furnace Sand showed a distinct increase of the internal friction angle, while the other specimens showed negligible increase. In the case of 28-day cured specimens, specimens composed of Furnace Sand showed an internal friction angle of 41.8°, while specimens of Green and Coated Sand showed those of 33.5° and 35.0°, respectively. From the shrinkage test, the shrinkage ratios of all specimens did not exceed 0.25%.

• Reproductive and Developmental Biology
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• 제30권3호
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• pp.169-174
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• 2006

돼지 페르몬성 분자를 탐색하기 위하여 일련의 green odorant로서 기질 분자인 2-(Cyclohexyloxy)tetrahydrofurane 유도체들의 정량적인 구조와 수용체인 porcine odorant binding protein(pOBP) 사이의 결합 친화력 상수($p(Od)_{50}$)에 대한 비교 분자 유사성 지수 분석(CoMSIA)을 실행하였다. 가장 양호한 CoMSIA 모델(I-AI)은 기질 분자내 입체 중심의 절대 배열이 $I:\;C_{1'}(R),\;C_2(S)$인 분자를 atom based fit 정렬하였을 경우의 입체장 조건에서 유도되었으며 PLS 분석 결과, 예측성이 ${r^2}_{cv.}(q^2)=0.856)$ 그리고 적합성이 ${r^2}_{ncv.}=0.964)$ 이었다. 모델의 CoMSIA 등고도 상, pOBP와 냄새 분자 사이의 상호작용으로부터 가장 높은 결합 친화력을 나타내는 분자의 구조적 특정들을 이해할 수 있었다.

• 대한방사성의약품학회지
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• 제1권2호
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• pp.118-122
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• 2015

Suicidal gene therapy is based on the transduction of tumor cells with "suicide" genes encoding for prodrug-activating enzymes that render target cells susceptible to prodrug treatment. Suicidal gene therapy results in the death of tumor with the expression of gene encoding enzyme that converts non-toxic prodrug into cytotoxic product. Cytochrome P450 4B1 (CYP4B1) activates 4-ipomeanol (4-IPO) or 2-aminoanthracene (2-AA) to cytotoxic furane epoxide and unsaturated dialdehyde intermediate.In this study, therapeutic effects of suicidal gene therapy with rabbit CYP4B1/2-AA or 4-IPO system were evaluated in HT-29 (human colon cancer cell). pcDNA-CYP4B1 vector was transfected into HT-29 by lipofection and stable transfectant was selected by treatment of hygromycin ($500{\mu}g/mL$) for 3 weeks. Reverse transcription polymerase chain reaction (RT-PCR) analysis was performed for confirmation of CYP4B1 expression in CYP4B1 gene transduced cell. The cytotoxic effects of CYP4B1 transduced cell were determined using dye-exclusion assay after treatment of 2-AA or 4-IPO for 96 hrs. Dye-exclusion assay showed that $IC_{50}$ of HT-29 and CYP4B1 transduced HT-29 was 0.01 mM and 0.003 mM after 4-IPO or 2-AA treatment at 96 hrs exposure, respectively. In conclusion, CYP4B1 based prodrug gene therapy probably have the potential for treatment of colorectal adenocarcinoma.