• 기술혁신연구
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• 제15권2호
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• pp.123-152
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• 2007

The striking characteristic of the contemporary global security environment is that the nature of threats has become diverse and complex. For example, transnational and non-military threats including terrorism and proliferation of weapon of mass destruction has increased. In this security environment, Advanced countries funnel their investments for defense budgets into the assurance of key force capability and R&D of cutting-edge core technologies, in consideration of future battlefield environments so as to get an edge on not only defense science and technology but also intelligence capabilities. As shown by past practices of the korea's defense acquisition, the ministry of national defense has tried to enhance its force capabilities in the short-term by purchasing foreign weapon systems rather than by investing in domestic R&D. Accordingly, the technological gaps between the korea and advanced countries were widened due to both insufficient investment in development of domestic technologies and avoidance of technological transfer by advanced countries. Thus, for the effective execution of the R&D budget and the successful performance of the projects, the importance of selection, management and evaluation of the R&D projects is emphasized. So, The objective of this study is that the analysis of the proposal-selection evaluation system for the realization of the successful defense core technology R&D projects. This study focused on the improvement of the proposal-selection evaluation model which can be applicable to the national defense core R&D projects. Using the improved proposal-selection evaluation system, we propose a model to enhance the reliability of the national defense core technology R&D project evaluation system.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2917-2922
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• 2014

Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

• 대한기계학회논문집A
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• 제27권3호
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• pp.432-439
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• 2003

Inconel 690 for nuclear steam generator tube has more Chromium than the conventionally used Inconel 600 in order to increase the corrosion resistance. To evaluate the tribological characteristics of Inconel 690 under fretting condition the fretting tests were carried out in air and elevated temperature water. Fretting tests of the cross-cylinder type were done under various vibrating amplitudes and applied normal loads in order to measure the friction forces and wear volumes. From the results of fretting wear tests. the wear of Inconel 690 can be predictable using the work rate model. The amounts of friction forces were proportional to relative movement between two fretting surfaces. The friction coefficients were decreased as increasing the normal loads and deceasing the vibrating amplitudes. Depending on fretting environment, distinctively different wear mechanisms and often drastically different wear rates can occur It was found that the fretting wearfactors in air and water at 2$0^{\circ}C$, 5$0^{\circ}C$, and 8$0^{\circ}C$ were 7.38 $\times$ $10^{-13}$$Pa^{-1}$, 2.12 $\times$$10^{-13}$$Pa^{-1}$, 3.34$\times$$10^{-13}$$Pa^{-1}$and 5.21$\times$$10^{-13}$$Pa^{-1}$, respectively flexibility to model response data with multiple local extreme. In this study, metamodeling techniques are adopted to carry out the shape optimization of a funnel of Cathode Ray Tube, which finds the shape minimizing the local maximum principal stress. Optimum designs using two metamodels are compared and proper metamodel is recommended based on this research.

• 한국치위생학회지
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• 제20권3호
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• pp.269-279
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• 2020

Objectives: Previous studies have reported inconsistent findings in the association between dental diagnostic X-ray exposure and thyroid cancer. This study was a meta-analysis of case-control studies evaluating the association between exposure to dental radiation and the thyroid cancer risk. Methods: We searched the PubMed and EMBASE databases to identify studies on dental radiation and thyroid cancer risks that were published up to September 2018. Quality of studies was assessed using the Newcastle-Ottawa scale. A fixed-effects model was used to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs) using STATA 14.0. Potential publication biases were evaluated using Egger's test and Begg's funnel plot. Results: From the literature search, we included six case-control studies in this meta-analysis. The meta-analysis using the fixed-effects model found that dental X-ray exposure was associated with 2.34 times increased risk for thyroid cancer (OR=2.34, 95% CI=1.79-3.21). There was no heterogeneity in the data (p=0.662, I² =0%). Egger's test showed that there was no publication bias (p=0.532). Conclusions: This meta-analysis confirmed the association of dental X-ray exposure and thyroid cancer risk. The current results underscore the importance of applying safety regulations at dental clinics to protect thyroid glands during dental radiography examinations.

• Journal of Preventive Medicine and Public Health
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• 제55권1호
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• pp.37-48
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• 2022

Objectives: Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis. Methods: PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I² statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias. Results: Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I² = 87%). Conclusions: Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.

• 한국철도학회논문집
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• 제11권1호
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• pp.7-12
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• 2008

본 연구에서는 경사각에 다른 임계속도 변화를 파악하기 위하여 축소모형 실험을 수행하였다. Froude 상사를 사용하여 1/20 축소모델 시험을 수행하였고, 화원은 메탄올, 아세톤, 헵탄을 연료로하여 Akinson과 Wu가 사용한 가스버너가 아닌 배연속도에 따라 달라지는 정사각형 풀을 사용하였으며, 터널의 각도는 $0^{\circ}$, $2^{\circ}$, $4^{\circ}$, $6^{\circ}$, $8^{\circ}$에 관하여 실험을 수행하였다. 발열량과 온도는 로드셀과 K-type 열전대를 사용하여 측정하였다. 실험결과 발열량 변화를 고려하지 않은 Atkinson과 Wu의 실험결과 보다 배연속도에 따른 발열량이 변화하는 풀화재를 사용한 경우가 더 큰 기울기 값을 얻었다. 따라서 배연속도는 화원의 연소율 변화에 직접적으로 영향을 미치기 때문에 경사터널화재 발생시 연소율의 변화에 따른 임계속도의 영향을 고려하는 것이 중요하다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7583-7588
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• 2014

Background: Colorectal cancer (CRC) is a major cause of cancer-related death and cancer-related incidence worldwide. The potential of microRNA-21 (miR-21) as a biomarker for CRC detection has been studied in several studies. However, the results were inconsistent. Therefore, we conducted the present meta-analysis to systematically assess the diagnostic value of miR-21 for CRC. Materials and Methods: Using a random-effect model, the pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to evaluate the diagnostic performance of miR-21 for CRC. A summary receiver operating characteristic (SROC) curve and an area under the curve (AUC) were also generated to assess the diagnosis accuracy of miR-21 for CRC. Q test and I2 statistics were used to assess between-study heterogeneity. Publication bias was evaluated by the Deeks' funnel plot asymmetry test. Results: A total of 986 CRC patients and 702 matched healthy controls from 8 studies were involved in the meta-analysis. The pooled results for SEN, SPE, PLR, NLR, DOR, and AUC were 57% (95%CI: 39%-74%), 87% (95%CI: 78%-93%), 4.4 (95%CI: 2.4-8.0), 0.49 (95%CI: 0.32-0.74), 9 (95%CI: 4-22), and 0.83 (95%CI: 0.79-0.86), respectively. Subgroup analyses further suggested that blood-based studies showed a better diagnostic accuracy compared with feces-based studies, indicating that blood may be a better matrix for miR-21 assay and CRC detection. Conclusions: Our findings suggest that miR-21 has a potential diagnostic value for CRC with a moderate level of overall diagnostic accuracy. Hence, it could be used as auxiliary means for the initial screening of CRC and avoid unnecessary colonoscopy, which is an invasive and expensive procedure.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5149-5153
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• 2014

Background: Chlorophenols (CPs) and related phenoxyacetic acids (PAs) are pesticide groups contaminated with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) during production. PAs and CPs exposure is associated with risk of cancer, but the situation regarding lung cancer has not been clearly defined. We proposed a meta-analysis of published researches to evaluate relationship between chronic exposure to PAs and CPs in pesticide production workplaces and the risk of lung cancer. Materials and Methods: After searching PubMed, Scopus, Scholar Google, Web of Sciences until August 2013, the association between chronic PAs and CPs exposure in production workplace and lung cancer was studied in 15 cohort studies. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were collected from the papers. We used random or fixed-effects models, Egger test, funnel plot and meta regression in our analysis. Results: Five papers with six reports were included in the final analysis. The standardized mortality rate for lung cancer from the random model was 1.18 (95% CI: 1.03-1.35, p=0.014) with moderate heterogeneity. Publication bias was not found for included studies in meta-analysis (p=0.9). Conclusions: Our findings has strengthen the evidence of lung cancer from chronic exposure to chlorophenol related compounds (PAs, CPs).

• Journal of Preventive Medicine and Public Health
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• 제46권1호
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• pp.10-18
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• 2013

Objectives: We investigated the association between particulate matter less than $10{\mu}m$ in aerodynamic diameter ($PM_{10}$) exposure and non-accidental mortality in Asian populations by meta-analysis, using both time-series and case-crossover analysis. Methods: Among the 819 published studies searched from PubMed and EMBASE using key words related to $PM_{10}$ exposure and non-accidental mortality in Asian countries, 8 time-series and 4 case-crossover studies were selected for meta-analysis after exclusion by selection criteria. We obtained the relative risk (RR) and 95% confidence intervals (CI) of non-accidental mortality per $10{\mu}g/m^3$ increase of daily $PM_{10}$ from each study. We used Q statistics to test the heterogeneity of the results among the different studies and evaluated for publication bias using Begg funnel plot and Egger test. Results: Testing for heterogeneity showed significance (p<0.001); thus, we applied a random-effects model. RR (95% CI) per $10{\mu}g/m^3$ increase of daily $PM_{10}$ for both the time-series and case-crossover studies combined, time-series studies relative risk only, and case-crossover studies only, were 1.0047 (1.0033 to 1.0062), 1.0057 (1.0029 to 1.0086), and 1.0027 (1.0010 to 1.0043), respectively. The non-significant Egger test suggested that this analysis was not likely to have a publication bias. Conclusions: We found a significant positive association between $PM_{10}$ exposure and non-accidental mortality among Asian populations. Continued investigations are encouraged to contribute to the health impact assessment and public health management of air pollution in Asian countries.

• Journal of Gastric Cancer
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• 제15권4호
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• pp.256-261
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• 2015

Purpose: Gastric cancer is the third leading cause of cancer-related mortality, with the incidence and mortality being higher in men than in women. Various studies have shown that eating carrots may play a major role in the prevention of gastric cancer. We conducted a meta-analysis to determine the relationship between carrot consumption and gastric cancer. Materials and Methods: We searched multiple databases including PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx. The following search terms were used: stomach or gastric, neoplasm or cancer, carcinoma or tumor, and carrot. Statistical analyses were performed using Comprehensive Meta Analysis/2.0 software. Results: We retrieved 81 articles by searching the databases. After considering the inclusion and exclusion criteria, 5 articles were included in this study. The odds ratio (OR) obtained by fixed effects model showed that a 26% reduction in the risk of gastric cancer has been associated with the consumption of carrots) OR=0.74; 95% confidence interval=0.68~0.81; P<0.0001). According to funnel graph, the results showed that the possibility of a publication bias does not exist in this study. Conclusions: The findings of this study showed an inverse relationship between the consumption of carrots and the risk of gastric cancer.