• 한국수의병리학회지
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• 제7권1호
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• pp.17-21
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• 2003

From February to September in 1996, a lot of blind cattle were reported in Dangjin Area of Chungnam Province. Blindness were observed in the 143 calves of the 1,496 calves from 79 farms. Blind cattle were found only in the farms where green pasture was not fed. After administration of vitamin A as the type of feed additives and parenteral injection, the blindness cases were not occurred in those farms. Both pupils were totally dilated with the absence of pupillary light reflex in all blind cattle. In the ophthalmoscopic examination, the fundus revealed multi focal linear white mottling which was more severe in nontapetal fundus than tapetal fundus. Serum vitamin A concentration was as low as 4.1 ,$\mu\textrm{g}$/dl in the calves of the affected farms. Narrowing of optic foramen, retinal degeneration and optic disc atrophy were shown in pathological findings.

• 한국동물위생학회지
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• 제13권2호
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• pp.111-129
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• 1990

Based on the gross lesion, a survey of ulcer prevalence was carried out on pigs (3,161 heads) at a slaughterhouse in seoul from April to December in 1989. The pigs stomachs were observed anatomically and classified, according to the presence or absence of foreign bodies. Ulcer prevalence is usually classified according to size of pig farm, ages, and supplied month. The results in the studies were as follows, 1. Fundus followed the highest rate with 28.2%, esophagus with 24.5％ each of cardiac and pyloric part with 7.8% and 4.1％ in cases of gastric mucosa pathological studies examed total 3,161. In the acute ulcer prevalence, fundus follwed with 5.4%, esophagus with 2.6%, each of cardiac and pyloric part with 0.8% and 0.3%. When prevalent frequencies of fundus are compared with cardiac and pyloric part, they have meaning.(P <0.05). 2. In the survey pig of total 3,161, pathological changes of epithelium tissue foliowed 44.0%, erosion(11.5%), chronic ulcer(14.8%), acute ulcer(1.6%), scar formation (1.7%) and perforation (0.9%). 3. In general monthly prevalence rates of gastric lesion are higher in spring and fall than in summer. 4. In the size of pig farms, ulcer showed higher rate at professional farms than raising on the side. 5. When there are more fluid condition in stomach and they are old, the ulcer appeared for more. 6. Foreign bodies in stomach were sand, hairballs, and intestinal worms were detected (1%).

• 대한수의학회지
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• 제30권2호
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• pp.129-143
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• 1990

In the present paper, the distribution, relative frequences and cell types of endocrine cells in the gastrointestinal tract of the frog (Rana dybowskii) during the hibernating and the active phase were examined by light and electron microscopy. The results obtained are summarized as follow: The reactive cells for Grimelius were frequently found in the gastrointestinal tract, whereas the reactive cells for Hellman-$Hellerstr{\hat{o}}m$ were found numerous in the fundus and pylorus of stomach, a few in the duodenum and lower small intestine, and very few in the rectum during both phases. No reactive cells for Masson-Fontana were found in the gastrointestinal tract during both phases. Elecron microscopically, 4 types of endocrine cells in the fundus of the stomach, 3 types in the pylorus of the stomach and duodenum, and 1 type in the lower small intestine and rectum, respectively, were identified during the hibernating phase. In the active phase, 3 types of endocrine cell in the fundus of the stomach, 2 types in the pylorus of the stomach and duodenum, and 1 type in the lower small intestine and rectum were observed, respectively. In the hibernating phase, more cytoplasmic granules and various types of endocrine cells were generally found than in the active phase.

• 한방안이비인후피부과학회지
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• 제17권2호
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• pp.112-119
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• 2004

Objective: To carry out the oriental medical treatment on a patient with vitreous hemorrhage in the left eye caused by diabetic retinopathy and record the results of the treatment. Methods: 1. Diagnosis: Fundus photography, Colored paper, Dr. Hahn's standard test chart for 5M, Blood sugar measurement. 2. Treatment: Acupuncture, Electro-Acupuncture, Indirect moxibustion, Western medicines, Oryoungsan(Crude drug preparations) Results: Oriental treatment using Ohaeng-acupuncture, Electro-Acupuncture, Indirect moxibustion resulted in the Unaided visual acuity of 0.1 while it used to be the left eye visual acuity with only light sense I month ago. Looking from Fundus photography result, progress was achieved and diabetic retinopathy was found to be in progress in fluorescein fundus angiography to right eye also by revisiting the patient after treatment. Conclusions: 1. Vitrectomy has many advantages but there are instances where patients do not recover their visual acuity due to complications. Therefore it is necessary to prove the effect oriental medical treatment through more cases in future. 2 For diabetic retinopathy patients, diabetes must be treated together with visual acuity.

• 한국멀티미디어학회논문지
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• 제12권8호
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• pp.1082-1088
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• 2009

망막 질환의 진단에서 안저영상은 환자의 망막 상태에 대한 객관적인 평가와 기록에 중요하다. 특히 혈관의 분석은 당뇨병, 고혈압 등의 진단과 경과 관찰에 매우 중요하다. 혈관 영역을 검출하기 위해 톱-햇(Top-hat) 필터를 사용하여 균일하지 않은 배경 영상을 보상하고, 대비 제한의 적응적 히스토그램 보정(contrast limited adaptive histogram equalization) 방법을 적용하여 대비를 향상시켰다. 영상에 전처리를 한 후 헤이지안 행렬(hessian matrix)을 적용하여 혈관 성분을 검출한 결과 제안된 방법이 기존의 정합 필터(matched filter) 방법보다 약 1.3% 더 정확하였다. 결론으로 제안한 알고리즘은 안저 영상에서 혈관 영역을 검출하는데 있어서 기존 방법에 비해서 향상되었다.

• Healthcare Informatics Research
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• 제24권4호
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• pp.335-345
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• 2018

Objectives: The retinal nerve fiber layer (RNFL) is a site of glaucomatous optic neuropathy whose early changes need to be detected because glaucoma is one of the most common causes of blindness. This paper proposes an automated RNFL detection method based on the texture feature by forming a co-occurrence matrix and a backpropagation neural network as the classifier. Methods: We propose two texture features, namely, correlation and autocorrelation based on a co-occurrence matrix. Those features are selected by using a correlation feature selection method. Then the backpropagation neural network is applied as the classifier to implement RNFL detection in a retinal fundus image. Results: We used 40 retinal fundus images as testing data and 160 sub-images (80 showing a normal RNFL and 80 showing RNFL loss) as training data to evaluate the performance of our proposed method. Overall, this work achieved an accuracy of 94.52%. Conclusions: Our results demonstrated that the proposed method achieved a high accuracy, which indicates good performance.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.614-616
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• 2021

세계는 안구 질병 치료, 시력 회복 서비스, 훈련된 안과 전문의의 부족 등 안과 측면에서 어려움에 직면해 있다. 안구 병리를 조기에 발견하고 진단하면 시각 장애를 예방할 수 있다. 하지만 기존의 망막 영상 공개 데이터 세트는 임상에서 발견되는 다양한 질병으로 구성되어 있지 않기 때문에 다양한 안구 질환을 분류하는 방법을 개발하기가 어렵다. 본 연구는 2021 ISBI challenge에서 공개된 데이터 세트인 Retinal Fundus Multi-disease Image Dataset (RFMiD) 을 이용하여 안구 질환을 분류하는 방법을 제안한다. 본 연구의 목표는 망막 이미지를 정상, 비정상 범주로 선별하기 위한 강력하고 일반화 가능한 모델을 개발하는 것이다. 제안된 모델의 성능은 수신자 조작 특성 곡선 아래 면적 점수로 비공개 테스트 데이터 세트에 대해 0.9782의 값을 보여준다.

• 대한수의학회지
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• 제37권4호
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• pp.693-706
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• 1997

The present study was designed to investigate the morphological developments of the stomach in the prenatal and postnatal rats. The gastric fundus of 16- to 22-day-old fetuses, neonates, 7-day-old, 14-day-old, 21-day-old, and adult rats were observed by light and scanning electron microscopy. Light microscopic studies. 1. In the 16-day-old fetuses, the walls of the gastric fundus were differentiated into epithelium, lamina propria, muscle layer, and serosa. The lamina propria was composed of mesenchymal connective tissue cells with sparse nucleus and their fibers. 2. In the 17-day-old fetuses, the muscular layer were differentiated into the circular and longitudinal muscle layers. 3. The epithelium on the fundus of stomach was stratified columnar cells at 16-, 17- and 18-day-old fetuses, but partly converted into simple columnar epithelium at 19-day-old fetuses. 4. The mucous cells were positive by PAS reaction at the 19-day-old fetuses and then these developed rapidly within 1 or 2 days before birth. 5. In the 20-day -old fetuses, the parietal cells were distinguished from other type cells and these cells were chiefly crowded in the middle parts of the gastric glands after 7-day-old. Scanning electron microscopic studies. 6. The surface of gastric mucosa was covered with forms of the various protrusions by forming villi at the last few days before birth and these protrusion forms were fused and folded each other. 7. The mucosal surface was closely packed by polygonal mucous cells. The openings of gastric glands were seen as slit-like round invagination and were more numerous and increased gradually in depth after the postnatal life. The above findings indicate that prominent changes occurred in the pattern of cellular proliferation in the stomach fundus at the end of gestation. The gastric epithelium had well-defined glands composed of parietal, chief and mucous cells just before the birth. The stomach fundus, therefore, were developed morphologically as those of normal adult at fourteen days after birth.

• 대한안과학회지
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• 제58권11호
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• pp.1313-1316
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• 2017

목적: 학대뇌손상 영아에서 스마트폰으로 촬영한 안저소견을 보고하고자 한다. 증례요약: 생후 8개월 남아가 소파에서 떨어진 후 지속적인 발작과 의식저하를 보여 응급실로 내원하였다. 표면적인 외상이나 두개골과 긴뼈에서 골절소견은 관찰되지 않았지만, 뇌 전산화단층촬영에서 광범위한 우측 경막하출혈과 혈종, 심한 뇌부종으로 우측 뇌실과 뇌바닥수조가 소실되고 정중선이 좌측으로 치우쳐져 있었다. 두개내압을 감소시키기 위해서 즉시 머리뼈절제술을 시행하였다. 응급수술 직후 시행한 안저검사에서 망막의 여러 층에 걸친 광범위한 다발성 출혈이 양안에서 관찰되었고, 융기되어 있는 망막주름 주변에 체리모양 망막출혈이 있었다. 환아 눈에서부터 5 cm 높이에 20디옵터렌즈를, 15-20 cm 높이에 스마트폰을 두고 동영상촬영방식으로 안저를 촬영하였다. 촬영된 안저소견은 유리체망막 부착이 강한 영아에서 반복적인 가속-감속력이 안구에 가해지면 발생하는 전형적인 소견이어서, 진단과 가해자의 진술을 받는 데 중요한 역할을 하였다. 결론: 학대뇌손상 진단에서 안저검사는 매우 중요하다. 특별한 장비 없이도 시행할 수 있는 스마트폰 안저촬영이 하나의 중요한 법의학적 단서로 사용될 수 있었다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1992년도 제1회 신약개발 연구발표회 초록집
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• pp.46-46
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• 1992

항궤양약 및 진경약의 효능을 검색할 수 있는 방법을 추구하는데 목적이 있다. 항궤양약의 약효는 Shay궤양, 수침 Stress궤양, indomethacin, histamine 및 prednisolone으로 유발된 궤양에 대하여 실시하였고 진경약의 효능은 흰쥐 fundus 절편을 이용한 in vitro 방법으로 실시하였다. 그 결과 항궤양약 효능시험은 shay 궤양에 있어서 omeprazole은 10mg/kg (i.d.)의 용량에서 유의성 있는 항궤양 효과를 나타내었으며, 수침 stress궤양에서 famotidine은 0.3mg/kg(p.o.), indomethacin 궤양에서 famotidine은 3mg/kg(p.o.), histamine궤양에서 cimetidine 은 50mg/kg(p.o.), prednisolone궤양에서 cimetidine은 1mg/kg(p.o.)의 용량에서 유의성 있는 효과를 나타내었다. 또한 진경약의 약효검색에 관하여는 세신(Asarum sieboldii)의 MeOH엑스가 흰쥐 위절편(fundus) 표본에서 비상경적 진정 작용이 있음을 확인하였고, 그 작용강도는 papaverine의 1/50에 해당되나 이를 분획하였을 경우에 hexane 분획에서 papaverine의 1/2에 해당하는 강도가 있다는 결과를 얻었다.