• 한국고분자학회:학술대회논문집
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• 한국고분자학회 2006년도 IUPAC International Symposium on Advanced Polymers for Emerging Technologies
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• pp.54-55
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• 2006

Polymeric micelles, supramolecular assemblies of block copolymers, are useful nanocarriers for the systemic delivery of drugs and genes. Recently, novel polymeric micelles with various functions such as the targetability and stimuli-sensitivity have been emerged as promising carriers that enhance the efficacy of drugs and genes with minimal side effects. This presentation focuses our recent approach to the preparation of functional block copolymers that are useful for constructing smart micellar delivery systems in advanced therapeutics, including chemo-gene therapy. Particular emphasis is placed on the characteristic behaviors of intracellular environment-sensitive micelles that selectively exert drug activity and gene expression in live cells.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.140-141
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• 2006

Most PM components are exposed to cyclic loading over long periods of time, yet, the fatigue performance is often at best characterized by a fully reversed bending strength. The effects of density, deviating loading modes, external notches or mean stresses must usually be estimated. The amount of available data is nowadays sufficient to come to fact-based estimates.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2002년도 제1차워크샵
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• pp.5-23
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• 2002

Motivation: Protein-protein interaction plays a critical role in the biological processes. The identification of interacting proteins by bioinformatical methods can provide new lead In the functional studies of uncharacterized proteins without performing extensive experiments. Results: Protein-protein interactions are predicted by a computational algorithm based on the weighted scoring system for domain interactions between interacting protein pairs. Here we propose potential interaction domain (PID) pairs can be extracted from a data set of experimentally identified interacting protein pairs. where one protein contains a domain and its interacting protein contains the other. Every combinations of PID are summarized in a matrix table termed the PID matrix, and this matrix has proposed to be used for prediction of interactions. The database of interacting proteins (DIP) has used as a source of interacting protein pairs and InterPro, an integrated database of protein families, domains and functional sites, has used for defining domains in interacting pairs. A statistical scoring system. named "PID matrix score" has designed and applied as a measure of interaction probability between domains. Cross-validation has been performed with subsets of DIP data to evaluate the prediction accuracy of PID matrix. The prediction system gives about 50% of sensitivity and 98% of specificity, Based on the PID matrix, we develop a system providing several interaction information-finding services in the Internet. The system, named PreDIN (Prediction-oriented Database of Interaction Network) provides interacting domain finding services and interacting protein finding services. It is demonstrated that mapping of the genome-wide interaction network can be achieved by using the PreDIN system. This system can be also used as a new tool for functional prediction of unknown proteins.

• Bulletin of the Korean Chemical Society
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• 제31권11호
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• pp.3212-3216
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• 2010

A new rhodamine-based sensor 1 was designed and synthesized by incorporating rhodamine B and benzimidazole moieties. Sensor 1 exhibits high selectivity and sensitivity to $Cu^{2+}$ in $CH_3CN$-water solution (HEPES buffer, pH = 7.0) with an obvious color change from colorless to pink. Other metal ions such as $Hg^{2+}$, $Ag^+$, $Pb^{2+}$, $Sr^{2+}$, $Ba^{2+}$, $Cd^{2+}$, $Ni^{2+}$, $Co^{2+}$, $Fe^{2+}$, $Mn^{2+}$, $Cu^{2+}$, $Zn^{2+}$, $Ce^{3+}$, $Mg^{2+}$, $K^+$ and $Na^+$ had no such color change and have no significant influence on $Cu^{2+}$ recognition process. The interaction of $Cu^{2+}$ and sensor 1 was proven to adopt a 1:1 binding stoichiometry and the recognition process is reversible.

• Journal of Magnetics
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• 제14권1호
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• pp.42-46
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• 2009

The measurement of external magnetic field orientation using Giant Magneto Impedance (GMI) sensors has been performed. A soft magnetic alloy of $Co_{30}Fe_{34}Ni_{36}$ was electroplated on a Si wafer with a CoFeNi seed layer. V-shaped microwire patterns were formed using a conventional photolithography process. An external magnetic field was generated by a rectangular AlNiCo permanent magnet. The reference direction was defined as the external magnetic field direction oriented in the middle of 2 GMI devices. As the orientation of the magnetic field deviated from the reference direction, variation in the field component along each device introduced voltage changes. It was found that, by taking the voltage difference between the left and right arms of the Vshaped device, the nonlinearity of each device could be significantly reduced. The fabricated angle sensor had a linear range of approximately $70^{\circ}$ and an overall sensitivity of approximately 10 mV.

• 한국응용과학기술학회지
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• 제40권6호
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• pp.1445-1453
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• 2023

In 2022, the domestic production performance of functional cosmetics in South Korea reached 4.6 trillion won, accounting for 33.85% of the total cosmetics production. The number of functional cosmetics reviewed increased by about 7.5% from the previous year, totaling 974 items. Especially with the increasing importance of the skin barrier function due to skin sensitivity caused by various environmental pollutants, domestic cosmetic companies are showing interest in the development of new ingredients and products related to this area. This study aims to analyze academic research trends related to in vitro experiments for the development of cosmetics improving the skin barrier, to provide practical information for the cosmetic industry. The findings are as follows: Academic research mainly focused on the efficacy of natural ingredients in improving the skin barrier, but there is a significant lack of quantitative accumulation of research. For the development of skin barrier-improving cosmetic ingredients, efficacy evaluation indicators were set, including hyaluronic acid production, expression of filaggrin gene, loricrin, formation of cornified envelope (CE), and expression of ceramide synthesis enzyme genes. Moreover, effective cosmetic ingredients for improving the skin barrier included lemongrass and perilla leaf extracts, flavonoids, Lactococcus lactis subsp. lactis, Exosomelike Nanovesicles derived from apple callus, Eleutherococcus sessiliflorus, Acanthopanax sessiliflorus, Eleutherococcus gracilistylus, Acer okamotoanum extracts, Aloe vera adventitious root extract, ethanol extract of Aruncus dioicus, and organic solvent fraction of Dracocephalum argunense.

• 경영과정보연구
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• 제33권3호
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• pp.1-19
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• 2014

본 연구는 비영리기관에 대한 기부행위에 영향을 주는 여러 가지 요인들 중에서 기존의 많은 선행연구들에서 강조되어온 기부동기와 기부행위간의 관계에 대한 새로운 시각을 제시하고자 하며, 이는 기존의 기부동기와 기부행위간의 상황적 갭에 따른 문제제기를 바탕으로 한다. 이러한 갭을 구체화하기 위하여 비영리 단체에 대한 개인 기부자의 기부동기와 기부행위간의 보다 더 정교한 심리적 요인을 탐색적으로 살펴보고, 아울러 그러한 심리적 요인의 실체가 무엇인지를 규명하고자 하는 것이 본 연구의 주된 연구 목적이라 할 수 있다. 이에 본 연구는 관련 선행연구를 바탕으로 기부동기와 기부행위간의 관계를 충동적 관점에서 자선적 기부 충동이라 명명하고, 이에 대한 구체적인 측정도구를 개발하고자 한다. 연구결과 소비자의 자선적 기부 충동성은 구체적으로 평가민감 충동성, 기능적 충동성, 보상민감 충동성, 무계획적 충동성 등의 4가지 요인들로 구분되었으며, 향후 소비자의 자선적 충동성과 관련된 연구를 수행하는 데 있어 기초자료로 활용될 수 있을 것으로 기대된다.

• 한국안광학회지
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• 제14권1호
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• pp.39-45
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• 2009

목적: 본 연구는 약도의 근시성 난시안의 토릭 소프트 렌즈와 다른 교정 방법의 효과를 알아보기 위해 대비감도 검사와 눈부심 장애 검사를 이용하여 시력의 질을 비교하였다. 방법: 1.50D이하의 경도 난시의 근시안인 남녀 대학생 20명(40안)을 대상으로 5가지 다른 방법(소프트렌즈 등가구면, 토릭 소프트 렌즈, RGP 렌즈, 난시교정 안경, 안경 등가구면)으로 교정하였다. 모든 대상자는 교정시력이 20/20(1.0) 이상이었다. 대비감도 검사와 눈부심 장애 검사는 OPTEC$^{(R)}$ 6500을 이용하여 밝은 조도과 어두운(글레어) 조도에서 실시하였다. 결과: 밝은 조도 하에서 난시교정 안경이 모든 공간주파수에서 가장 높은 대비감도를 나타내었고, 토릭 소프트 렌즈, RGP 렌즈, 안경 등가구면, 소프트 콘택트렌즈 등가구면 처방 순으로 대비감도가 낮아지는 것으로 나타났다. 그러나 모두 정상 범위의 대비감도 영역에 포함되었다. 어두운 조도(글레어) 하에서는 토릭 소프트 렌즈 착용자가 가장 높은 대비감도를 나타내었고, RGP렌즈, 안경 등가구면, 난시교정 안경, 소프트 렌즈 등가구면 처방 순으로 대비감도가 낮아지는 것으로 나타났다. 구면 소프트렌즈 착용자는 어두운 조도(글레어) 하에서 정상 영역보다 낮은 대비감도 값을 보였다. 결론: 약도의 근시성 난시안의 교정으로 토릭 소프트 렌즈 교정이 구면 소프트렌즈보다 좋은 시력의 질(대비감도)을 보인 것으로 나타났다. 어두운 조명에서 콘택트렌즈를 착용해야할 경우에는 토릭 소프트렌즈가 우수한 것으로 사료된다.

• Journal of Microbiology and Biotechnology
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• 제18권2호
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• pp.263-269
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• 2008

Hydrazinocurcumin (HC), a synthetic derivative of curcumin, has been reported to inhibit angiogenesis via unknown mechanisms. Understanding the molecular mechanisms of the drug's action is important for the development of improved compounds with better pharmacological properties. A genome-wide drug-induced haploinsufficiency screening of fission yeast gene deletion mutants has been applied to identify drug targets of HC. As a first step, the 50% inhibition concentration $(IC_{50})$ of HC was determined to be $2.2{\mu}M$. The initial screening of 4,158 mutants in 384-well plates using robotics was performed at concentrations of 2, 3, and $4{\mu}M$. A second screening was performed to detect sensitivity to HC on the plates. The first screening revealed 178 candidates, and the second screening resulted in 13 candidates, following the elimination of 165 false positives. Final filtering of the condition-dependent haploinsufficient genes gave eight target genes. Analysis of the specific targets of HC has shown that they are related to septum formation and the general transcription processes, which may be related to histone acetyltransferase. The target mutants showed 65% growth inhibition in response to HC compared with wild-type controls, as shown by liquid culture assay.

• Journal of Korean Neurosurgical Society
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• 제45권4호
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• pp.219-223
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• 2009

Objective : Functional magnetic resonance imaging (fMRI) is frequently used to localize language areas in a non-invasive manner. Various paradigms for presurgical localization of language areas have been developed, but a systematic quantitative evaluation of the efficiency of those paradigms has not been performed. In the present study, the authors analyzed different language paradigms to see which paradigm is most efficient in localizing frontal language areas. Methods : Five men and five women with no neurological deficits participated (mean age, 24 years) in this study. All volunteers were right-handed. Each subject performed 4 tasks, including fixation (Fix), sentence reading (SRI. pseudoword reading (PR), and word generation (WG). Fixation and pseudoword reading were used as contrasts. The functional area was defined as the area(s) with a t-value of more than 3.92 in fMRI with different tasks. To apply an anatomical constraint, we used a brain atlas mapping system, which is available in AFNI, to define the anatomical frontal language area. The numbers of voxels in overlapped area between anatomical and functional area were individually counted in the frontal expressive language area. Results : Of the various combinations, the word generation task was most effective in delineating the frontal expressive language area when fixation was used as a contrast (p<0.05). The sensitivity of this test for localizing Broca's area was 81 % and specificity was 70%. Conclusion : Word generation versus fixation could effectively and reliably delineate the frontal language area. A customized effective paradigm should be analyzed in order to evaluate various language functions.