• 디지털융복합연구
• /
• 제20권1호
• /
• pp.191-202
• /
• 2022

본 연구의 목적은 고등학교 남자 축구선수 24명을 대상으로 10주간 신체안정화운동 프로그램 중재 후 기술체력에 미치는 영향을 규명하는 것이다. 블레이즈포드로 시각반응속도 검사를 시행한 결과 위팔, 왼발, 오른발의 15초간 반응횟수와 반응시간(p<0.001)은 유의하게 증가하였다. 기능적 움직임 평가하기 위해 7가지 동작의 향상 여부 평가결과 허들건너기(p<0.001), 능동적폄다리올리기(p=0.022) 동작이 유의하게 향상되었다. 균형능력을 평가하기 위해 와이발런스 평가결과 양쪽 복합점수(p<0.001)가 유의하게 향상하였다. 기동력과 근지구력을 평가하기 위해 폐활량 측정결과 노력성폐활량(p<0.001)과 1초간 강제날숨량(p=0.003)이 유의하게 향상되었다. 10주간 신체안정화운동 중재 후, 경기에 필요한 기술 체력인 순발력, 민첩성, 다리 근력, 다리의 안정성, 기동력, 근지구력을 효과적으로 향상할 수 있다는 결론을 얻었고, 이러한 기술체력의 향상은 축구선수들의 부상을 방지할 수 있으며, 경기력을 향상할 수 있을 것이다.

• PNF and Movement
• /
• 제6권2호
• /
• pp.51-57
• /
• 2008

Purpose : Mechanical stress activates signaling cascades and leading to a specific response of a network of signaling pathways. The purpose of this study is to review the effect of mechanical stress-induced adaptation in skeletal muscle involves a biological mechanisms. Methods : This is literature study with Pubmed, Medline and books. Results : Skeletal muscle tissue demonstrates a malleability and may adjust its metabilic response, vascularization and neuromuscular characteristic makeup in response to alteration in functional demands. The adaptation in skeletal muscle involoves a multitude of signalling mechanisms related with insuline-like growth factor, vascular endothelial growth factor, neurotrophins. Conclusions : The identification of the basic relationships underlying the malleability of skeletal muscle tissue is likely to be of relevance for our understanding with PNF technique.

• 소성∙가공
• /
• 제10권6호
• /
• pp.493-499
• /
• 2001

An optimal robust design methodology has been developed to minimize warpage in injection-molded pats. The response surface methodology was applied to obtain a functional relationship between design variables and warpage value, and the modified complex method was used as an optimization tool to search for an optimal design solution over prescribed design region. To attain robustness against process variations, Taguchi's SN ratio was introduced as the design metric. The proposed optimal design procedure was applied to an actual part, the Guide-ASF model of a fax machine, and the usefulness of the methodology was shown through the CAE simulation using a commercial injection molding software package.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2009년도 춘계학술대회 논문집
• /
• pp.616-620
• /
• 2009

Modern wind turbines have been mainly erected in region where earthquake are rare or normally weak, especially Korea was thought as safety zone from earthquake. But recently, the earthquake occurs more and more frequently. So, the wind turbine design is required the structural and functional stability under the earthquake. The earthquake can influence normal operation, even if a weak earthquake. There are two ways to review the design under earthquake using Computer Applied Engineering (CAE). One is the Response Spectrum Analysis (RSA) the other is Time History Analysis (THA). In this research, dynamic response on time is obtained under the earthquake by taking into account ground accelerogram consistent with the relevant standards applied to the turbine foundation.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권12호
• /
• pp.5947-5954
• /
• 2012

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal, either by symmetric or asymmetric cell division, and have the exclusive ability to reproduce malignant tumors indefinitely. Current systemic cancer therapies frequently fail to eliminate advanced tumors, which may be due to their inability to effectively target CSC populations. It has been shown that embryonic pathways such as Wnt, Hedgehog, and Notch control self-renewal and cell fate decisions of stem cells and progenitor cells. These are evolutionary conserved pathways, involved in CSC maintenance. Targeting these pathways may be effective in eradicating CSCs and preventing chemotherapy or radiotherapy resistance.

• 품질경영학회지
• /
• 제23권3호
• /
• pp.84-92
• /
• 1995

A method is proposed for the simultaneous optimization of several response functions that depend on the same set of controllable variables and are adequately represented by a response surface model (polynomial regression model) with the same degree and with constraint that the individual responses have the target values. First, the multiple responses data are checked for linear dependencies among the responses by eigenvalue analysis. Thus a set of responses with no linear functional relationships is used in developing a function that measures the distance estimated responses from the target values. We choose the optimal condition that minimizes this measure. Also, under the different degree of importance two step procedures are proposed.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• 제18권4호
• /
• pp.317-335
• /
• 2014

In this work, we investigate the global stability analysis of a viral infection model with antibody immune response. The incidence rate is given by a general function of the populations of the uninfected target cells, infected cells and free viruses. The model has been incorporated with two types of intracellular distributed time delays to describe the time required for viral contacting an uninfected cell and releasing new infectious viruses. We have established a set of conditions on the general incidence rate function and determined two threshold parameters $R_0$ (the basic infection reproduction number) and $R_1$ (the antibody immune response activation number) which are sufficient to determine the global dynamics of the model. The global asymptotic stability of the equilibria of the model has been proven by using Lyapunov theory and applying LaSalle's invariance principle.

• Molecules and Cells
• /
• 제25권4호
• /
• pp.553-558
• /
• 2008

Essential aspects of the innate immune response to microbial infection appear to be conserved between insects and mammals. In order to identify new Drosophila melanogaster genes involved in the immune response, we performed gene expression profiling of Drosophila SL2 cells stimulated with bacterial (LPS/PGN) or fungal (curdlan) components using a cDNA microarray that contained 5,405 Drosophila cDNAs. We found that some genes were similarly regulated by LPS/PGN and curdlan. However, a large number, belonging to the functional classes of cell organization, development, signal transduction, morphogenesis, cell cycle, and DNA replication, displayed significant differences in their transcription profiles between the two treatments, demonstrating that bacterial and fungal components induce different immune response even in an in vitro cell system.

• Smart Structures and Systems
• /
• 제15권5호
• /
• pp.1177-1202
• /
• 2015

The present paper is concerned with the optimal control and/or design of symmetric and antisymmetric composite laminate with two piezoelectric layers bonded to the opposite surfaces of the laminate, and placed symmetrically with respect to the middle plane. For the optimal control problem, Liapunov-Bellman theory is used to minimize the dynamic response of the laminate. The dynamic response of the laminate comprises a weight sum of the control objective (the total vibrational energy) and a penalty functional including the control force. Simultaneously with the active control, thicknesses and the orientation angles of layers are taken as design variables to achieve optimum design. The formulation is based on various plate theories for various boundary conditions. Explicit solutions for the control function and controlled deflections are obtained in forms of double series. Numerical results are given to demonstrate the effectiveness of the proposed control and design mechanism, and to investigate the effects of various laminate parameters on the control and design process.

• Mycobiology
• /
• 제39권4호
• /
• pp.249-256
• /
• 2011

Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators have studied various fungal species to define conserved pH-responsive signaling pathways. One of these pathways, known as the Pal/Rim pathway, is activated in response to alkaline pH signals, ultimately targeting the PacC/Rim101 transcription factor. Although the central signaling components are conserved among divergent filamentous and yeast-like fungi, there is some degree of signaling specificity between fungal species. This specificity exists primarily in the downstream transcriptional targets of this pathway, likely allowing differential adaptation to species-specific environmental niches. In this review, the role of the Pal/Rim pathway in fungal pH response is discussed. Also highlighted are functional differences present in this pathway among human fungal pathogens, differences that allow these specialized microorganisms to survive in the various micro-environments of the infected human host.