• Journal of Internet Computing and Services
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• v.8 no.2
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• pp.95-103
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• 2007

Many techniques have been proposed for mapping from XML to relations, but most techniques did not negotiate the semantics of XML data. The semantics is important to validate storage, query optimization, modification anomaly in process of schema design. Specially, functional dependencies are an important part of database theory, also it is basis of normalization for relational table in BCNF. This paper propose a new technique that reflect functional dependencies to store relation mapped from XML based on XML Schema. The technique can reduce storage redundancy and can keep up content and structure with constraint described by functional dependencies.

• Journal of Ginseng Research
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• v.34 no.1
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• pp.59-67
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• 2010

Response surface methodology was used to predict the optimum conditions of explosive puffing process for ginseng. A central composite design was used to monitor the effect of moisture content and puffing pressure on dependent variables such as functional compounds (extract yield, crude saponin, acidic polysaccharide, and total phenolic content) and sensory properties. Correlation coefficients $(R^2)$ of models for crude saponin, acidic polysaccharide, and total phenolic content were 0.9176 (p<0.05), 0.9494 (p<0.05), and 0.9878 (p<0.001), respectively. Functional compounds increased with decreasing moisture content and increasing puffing pressure. Overall palatability was high at 15-20% moisture content and 98-294 kPa of puffing pressure. On the basis of superimposed contour maps for functional compounds and overall palatability of puffed ginseng, the optimum ranges of puffing conditions were 10-17% moisture content and 294-392 kPa puffing pressure.

• Molecules and Cells
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• v.27 no.2
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• pp.225-235
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• 2009

Antibody phage display provides a powerful and efficient tool for the discovery and development of monoclonal antibodies for therapeutic and other applications. Antibody clones from synthetic libraries with optimized design features have several distinct advantages that include high stability, high levels of expression, and ease of downstream optimization and engineering. In this study, a fully synthetic human scFv library with six diversified CDRs was constructed by polymerase chain reaction assembly of overlapping oligonucleotides. In order to maximize the functional diversity of the library, a ${\beta}$-lactamase selection strategy was employed in which the assembled scFv gene repertoire was fused to the 5'-end of the ${\beta}$-lactamase gene, and in-frame scFv clones were enriched by carbenicillin selection. A final library with an estimated total diversity of $7.6{\times}10^9$, greater than 70% functional diversity, and diversification of all six CDRs was obtained after insertion of fully randomized CDR-H3 sequences into this proofread repertoire. The performance of the library was validated using a number of target antigens, against which multiple unique scFv sequences with dissociation constants in the nanomolar range were isolated.

• Food Science and Biotechnology
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• v.18 no.3
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• pp.793-798
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• 2009

The objectives of this present study were to compare the contents and determine optimum extraction conditions for the rosmarinic acid (RA) and caffeic acid (CA) from leaves of Korean Perilla frutescens varieties. RA and CA from leaves of cv. Bora, a breeding line of P. frutescens were isolated and elucidated using various spectroscopic data. On the basis of 2 phenolic acids, optimum extraction conditions were obtained by employing 50% EtOH for 60 min at $25^{\circ}C$. We reported for the first time on the contents of RA and CA from leaves of 32 Korean varieties. Among them, leaves of P. frutescens Brit. var. acuta Kudo I exhibited the highest RA content ($8.53{\pm}0.57$ mg/g) and CA content ($2.33{\pm}0.11$ mg/g) showed the highest in the P. frutescens Brit. var. viridis Makino. Interestingly, average RA content ($2.66{\pm}0.17$ mg/g) showed a markedly higher than that of CA ($1.98{\pm}0.16$ mg/g) in Korean varieties. These results suggest that concentrations of the RA and CA in P. frutescens leaves could be a key factor in the selection process of a high quality species.

• Journal of the Korean Society of Food Science and Nutrition
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• v.38 no.2
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• pp.235-243
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• 2009

This study was performed to find the optimum ratio of ingredients in the Chinese radish jam. The experiment was designed according to the RSM (response surface methodology), which included 18 experimental points with 4 replicates for three independent variables (sugar $45{\sim}70%$, pectin $0.5{\sim}2.0.%$, citric acid $0.2{\sim}0.5%$). The compositional and functional properties of the prepared products were measured, and these values were applied to the mathematical models. By use of F-test, sweetness, color values (L, a, b), and firmness were expressed by a linear model, while the sensory characteristics (color, smell, taste, texture and overall acceptance) were by a quadratic model. In the numeric optimization, the optimal ingredient amounts were 53.7% sugar, 1.0% pectin, and 0.3% citric acid. And in the graphical optimization, 53.9% sugar, 1.0% pectin, and 0.3% citric acid; these data were equivalent to 0.6985 desirability, indicating that the values were almost equivalent to the numerical optimization points. The above results demonstrate the feasibility of Chinese radish jam, and therefore, the commercialization of a Chinese radish jam marketed as a functional food is deemed possible.

• Fisheries and Aquatic Sciences
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• v.2 no.1
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• pp.105-111
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• 1999

In order to produce functional chitin oligosaccharides, a chitinolytic bacterium was newly screened from the viscera of Korean bony fishes, and identified as Bacillus sp. LJ-25. For the production of chitinolytic enzymes, $1.0\%$ nutrient broth and $0.3\%$ colloidal chitin were used as nitrogen and carbon source, respectively. The optimal temperature, initial pH and concentration of NaCl for the enzyme production by Bacillus sp. LJ-25 were $30^{\circ}C$ 6.5-7.0 and $1.0\%$, respectively. The enzyme activity of Bacillus sp. LJ-25 increased until the incubation time of 168 hr, followed by a decrease in activity.

• Journal of the Korean Mathematical Society
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• v.57 no.5
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• pp.1079-1101
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• 2020

This work is concerned with a geometric inverse problem in fluid mechanics. The aim is to reconstruct an unknown obstacle immersed in a Newtonian and incompressible fluid flow from internal data. We assume that the fluid motion is governed by the Stokes-Brinkmann equations in the two dimensional case. We propose a simple and efficient reconstruction method based on the topological sensitivity concept. The geometric inverse problem is reformulated as a topology optimization one minimizing a least-square functional. The existence and stability of the optimization problem solution are discussed. A topological sensitivity analysis is derived with the help of a straightforward approach based on a penalization technique without using the classical truncation method. The theoretical results are exploited for building a non-iterative reconstruction algorithm. The unknown obstacle is reconstructed using a levelset curve of the topological gradient. The accuracy and the robustness of the proposed method are justified by some numerical examples.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.633-636
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• 2006

In order to determine new settings of key process variables optimally, a new rule induction method through a historical data is proposed without using an explicit functional model between process and quality variables. First, a partial least square is used to reduce the dimensionality of the process variables. Then new process settings that yield the best quality variable are identified by sequentially partitioning the reduced latent variable space using a patient rule induction method. The proposed method is illustrated with a case study obtained from steel-making processes. We also show, through simulation, that the proposed method gives more stable results than estimating an explicit function even when the form of the function is known in advance.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.890-894
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• 2003

This paper discuss basic functional construction and plant layout of a ELV dismantling system that can maximize the reusability of tarts and the recoverability of materials by dismantling ELV rationally and efficiently. "Island" type was selected for the system configuration considering processing amount, economical efficiency, and effectiveness. The system is supported by the information system, and composed of dismantling stations and handling equipments. The layout of the stations was determined after simulation and optimization using commercial software package, Arena and OptQuest. The objective of the optimization was maximum profit while the system capacity is considered as constraint. The environmental load of ELV can be minimized when the composition and function of each station are embodied in detail and the system is interfaced with shredding operation.

• Journal of Korean Society for Quality Management
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• v.23 no.3
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• pp.84-92
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• 1995

A method is proposed for the simultaneous optimization of several response functions that depend on the same set of controllable variables and are adequately represented by a response surface model (polynomial regression model) with the same degree and with constraint that the individual responses have the target values. First, the multiple responses data are checked for linear dependencies among the responses by eigenvalue analysis. Thus a set of responses with no linear functional relationships is used in developing a function that measures the distance estimated responses from the target values. We choose the optimal condition that minimizes this measure. Also, under the different degree of importance two step procedures are proposed.