• Genomics & Informatics
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• v.5 no.4
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• pp.152-160
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• 2007

Most common diseases are caused by multiple genetic and environmental factors. Among the genetic factors, single nucleotide polymorphisms (SNPs) are common DNA sequence variations in individuals and can serve as important genetic markers. Recently, investigations of gene-based and whole genome-based SNPs have been applied to association studies for marker discovery. However, SNPs are so population-specific that the association needs to be verified. Fifty-five genes and 384 SNPs were selected based on association with disease. Genotypes of 337 SNPs in candidate genes were determined using Illumina Sentrix Array Matrix (SAM) chips by an allele-specific extension method in 364 unrelated Korean individuals. Allelic frequencies of SNPs were compared with those of other populations obtained from the International HapMap database. Minor allele frequencies, linkage disequilibrium blocks, tagSNPs, and haplotypes of functional candidate SNPs in 55 genetic disease-associated genes were provided. Our data may provide useful information for the selection of genetic markers for gene-based genetic disease-association studies of the Korean population.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.63 no.7
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• pp.976-986
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• 2014

In this paper, the problem of reliable control of linear systems with time-varying delays, randomly occurring disturbances, and actuator failures is investigated. It is assumed that actuator failures occur when disturbances affect to the systems. Firstly, by using a suitable Lyapunov-Krasovskii functional and some recent techniques such as Wirtinger-based integral inequality and reciprocally convex approach, stabilization criterion for nominal systems with time-varying delays is derived. Secondly, the proposed method is extended to the reliable $H_{\infty}$ controller design for linear dynamic systems with time-varying delays, randomly occurring disturbances, and actuator failures. Since nonlinear matrix inequalities (NLMIs) are involved in proposed results, the cone complementarity algorithm will be introduced. Finally, two numerical examples are included to show the effectiveness of the proposed criteria.

• Journal of Electrical Engineering and Technology
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• v.11 no.1
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• pp.200-214
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• 2016

This paper investigates the problem of stability analysis and robust H_∞ controller for time-delayed systems with parameter uncertainties and stochastic disturbances. It is assumed parameter uncertainties are norm bounded and mean and variance for disturbances of them are known. Firstly, by constructing a newly augmented Lyapunov-Krasovskii functional, a stability criterion for nominal systems with time-varying delays is derived in terms of linear matrix inequalities (LMIs). Secondly, based on the result of stability analysis, a new controller design method is proposed for the nominal form of the systems. Finally, the proposed method is extended to the problem of robust H_∞ controller design for a time-delayed system with parameter uncertainties and stochastic disturbances. To show the validity and effectiveness of the presented criteria, three examples are included.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.79-79
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• 2013

Quantum-structures with nanoparticles have been attractive for various electronic and photonic devices [1,2]. In recent, nonvolatile memories such as nano-floating gate memory (NFGM) and resistance random access memory (ReRAM) have been studied using silicides, metals, and metal oxides nanoparticles [3,4]. In this study, we fabricated nonvolatile memories with silicides (WSi2, Ti2Si, V2Si) and metal-oxide (Cu2O, Fe2O3, ZnO, SnO2, In2O3 and etc.) nanoparticles embedded in polyimide matrix, and photovoltaic device also with SiC nanoparticles. The capacitance-voltageand current-voltage data showed a threshold voltage shift as a function of write/erase voltage, which implies the carrier charging and discharging into the metal-oxide nanoparticles. We have investigated also the electrical properties of ReRAM consisted with the nanoparticles embedded in ZnO, SiO2, polyimide layer on the monolayered graphene. We will discuss what the current bistability of the nanoparticle ReRAM with monolayered graphene, which occurred as a result of fully functional operation of the nonvolatile memory device. A photovoltaic device structure with nanoparticles was fabricated and its optical properties were also studied by photoluminescence and UV-Vis absorption measurements. We will discuss a feasibility of nanoparticles to application of nonvolatile memories and photovoltaic devices.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.645-645
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• 2013

Applying a first-principles computational approach combining density-functional theory and matrix Green's function calculations, we have studied the effects [2+2] cycloaddition olligormerization of fullerene $C_{60}$ chains on their junction charge transport properties. Analyzing first the microscopic mechanism of the switching realized in recent scanning tunneling microscope (STM) experiments, we found that, in agreement with experimental conclusions, the device characteristics are not significantly affected by the changes in electronic structure of $C_{60}$ chains. It is further predicted that the switching characteristics will sensitively depend on the STM tip metal species and the associated energy level bending direction in the $C_{60}-STM$ tip vacuum gap. Considering infinite $C_{60}$ chains, however, we confirm that unbound $C_{60}$ chains with strong orbital hybridizations and band formation should in principle induce a much higher conductance state. We demonstrate that a nanoelectromechanical approach in which the $C_{60}-STM$ tip distance is maintained at short distances can achieve a metal-independent and drastically improved switching performance based on the intrinsically better electronic connectivity in the bound $C_{60}$ chains.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 2000.04a
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• pp.212-217
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• 2000

The purpose of this study was to develop a design process for a functional and sensible brassiere for muddle - aged women. As a methodology, an engineering design process QFD (Quality Function Deployment) was adopted to translate the consumer's needs into product design parameters. the customer needs for the wear comfort of brassieres were extracted from a survey of 100 women aged 30 - 40. To select which items were critical and which could be traded off for other attributed or benefits. the importance ratings for the customer needs were determined. Customer needs were translated into technical language by various physical test methods and wear tests. The customer competitive assessment was generated by wear tests of 10 commercial brassieres under controlled environmental conditions of 28${\pm}$1$^{\circ}C$, 65${\pm}$3% RH. The relationship matrix between the customer needs and the means of delivering the needs was developed. Using the QFD methodology, design elements for developing a brassiere for middle-aged women could be analyzed and organized efficiently.

• Journal of Powder Materials
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• v.16 no.2
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• pp.85-90
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• 2009

Magnesium and its alloys are attractive as light weight structural/functional materials for high performance application in automobile and electronics industries due to their superior physical properties. In order to obtain high quality products manufactured by the magnesium powders, it is important to control and understand the densification behavior of the powders. The effect of the sheath surrounding the magnesium powders on the plastic deformation and densification behavior during equal channel angular pressing was investigated in the study by experimental and the finite element methods. A modified version of Lee-Kim's plastic yield criterion, notably known as the critical relative density model, was applied to simulate the densification behavior of magnesium powders. In addition, a new approach that extracts the mechanical characteristics of both the powder and the matrix was developed. The model was implemented into the finite element method, with which powder compaction under equal channel angular pressing was simulated.

• International Journal of Aeronautical and Space Sciences
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• v.11 no.2
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• pp.126-130
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• 2010

This paper presents the conceptual design of a multi-rotor unmanned aerial vehicle (UAV) based on an axiomatic design. In most aerial vehicle design approaches, design configurations are affected by past and current design tendencies as well as an engineer's preferences. In order to design a systematic design framework and provide fruitful design configurations for a new type of rotorcraft, the axiomatic design theory is applied to the conceptual design process. Axiomatic design is a design methodology of a system that uses two design axioms by applying matrix methods to systematically analyze the transformation of customer needs into functional requirements (FRs), design parameters (DPs), and process variables. This paper deals with two conceptual rotary wing UAV designs, and the evaluations of tri-rotor and quad-rotor UAVs with proposed axiomatic approach. In this design methodology, design configurations are mainly affected by the selection of FRs, constraints, and DPs.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2187-2191
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• 2015

Background: Protrusive structures formed by migrating and invading cells are termed lamellipodia, filopodia, invadopodia and podosomes. Lamellipodia and filopodia appear on the leading edges of migrating cells and function to command the direction of the migrating cells. Invadopodia and podosomes are special F-actin-rich matrix-degrading structures that arise on the ventral surface of the cell membrane. Invadopodia are found in a variety of carcinomatous cells including squamous cell carcinoma of head and neck region whereas podosomes are found in normal highly motile cells of mesenchymal and myelomonocytic lineage. Invadopodia-associated protein markers consisted of 129 proteins belonging to different functional classes including WASP, NWASP, cortactin, Src kinase, Arp 2/3 complex, MT1-MMP and F-actin. To date, our current understanding on the role(s) of these regulators of actin dynamics in tumors of the orofacial region indicates that upregulation of these proteins promotes invasion and metastasis in oral squamous cell carcinoma, is associated with poor/worst prognostic outcome in laryngeal cancers, contributes to the persistent growth and metastasis characteristics of salivary gland adenoid cystic carcinoma, is a significant predictor of increased cancer risk in oral mucosal premalignant lesions and enhances local invasiveness in jawbone ameloblastomas.

• Macromolecular Research
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• v.15 no.4
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• pp.343-347
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• 2007

Novel composite membranes, which delivered high separation performance for propylene/propane mixtures, were developed by coating inert poly(ethylene-co-propylene) rubber (EPR) onto a porous polyester substrate, followed by the physical distribution of $AgBF_4$. Scanning electron microscopy-wavelength dispersive spectrometer (SEM-WDS) revealed that silver salts were uniformly distributed in the EPR layer. The physical dispersion of the silver salts in the inert polymer matrix, without specific interaction, was characterized by FT-IR and FT-Raman spectroscopy. The high separation performance was presumed to stem from the in-situ dissolution of crystalline silver ionic aggregates into free silver ions, which acted as an active propylene carrier within a propylene environment, leading to facilitated propylene transport through the membranes. The membranes were functional at all silver loading levels, exhibiting an unusually low threshold carrier concentration (less than 0.06 of silver weight fraction). The separation properties of these membranes, i.e. the mixed gas selectivity of propylene/propane ${\sim}55$ and mixed gas permeance ${\sim}7$ GPU, were stable for several days.