• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.104-104
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• 2001

Purpose： In this study, we investigated the possible motor pathways of hemiplegic stroke patients usin combined TMS and BOLD fMRI approach and evaluated the correlation between TMS a fMRI methods. Method： Four subjects, who demonstrated left hemiplegia after stroke, are included. TMS was performed using a Dantec Mag2 stimulator (Dantec Company, USA) in single puls mode with figure eight-shaped coil. Following TMS localization, The BOLD T2＊-weight images were acquired with echo planar imaging sequence (TR = 1.2 sec, TE = 60 msec, and flip angle = 90). Motor activation was studied by means of a repetitive fing flexion-extension task. The stimulation protocol comprised 10 cycles of alternating activati and rest (10 images per cycle). Total 60 cycles were performed and each cycle take abou 1.5 sec. The resulting images were then analyzed with STIMULATE (CMRR, U, o Minnesota) to generate functional maps using a student t-test (p < 0.0005) and cluste analysis.

• The Korean Journal of Nuclear Medicine
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• v.36 no.1
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• pp.80-86
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• 2002

Presently, PET is widely used in oncology, but suffers from limitations of poor anatomical information. To compensate for this weakness, a combined PET/CT has been developed by Professor Townsend at the University of Pittsburgh Medical Center. The prototype was designed as PET and CT components combined serially in a gantry. The CT images provide not only accurate anatomical location of the lesions but also transmission map for attenuation correction. More than 300 cancer patients have been studied with the prototype of PET/CT since July, 1998. The PET/CT studies affected the managements in about $20{\sim}30%$ of cancer patients. These changes are a consequence of the more accurate localization of functional abnormalities, and the distinction of pathological from normal physiological uptake. Now a variety of combined PET/CT scanners with high-end PET and high-end CT components are commercially available. With the high speed of multi-slice helical CT, throughput of patient's increases compared to conventional PET. Although some problems (such as a discrepancy in breathing state between the two modalities) still remain, the role of PET/CT in oncology is very promising.

• Nuclear Medicine and Molecular Imaging
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• v.42 no.2
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• pp.137-144
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• 2008

Positron emission tomography-computed tomography (PET/CT) provides both functional and anatomical images of high quality non-invasively with better precision in localization than PET alone. Increase in the use of PET/CT, coupled with increasing concerns about the quality of medical services accrued the demands for accurate evaluation of system performance and quality assurance. Thus, well designed programs for performance evaluation and quality assurance are needed. Widely used protocols for performance evaluation of PET are the methods proposed by National Electrical Manufacturers Association (NEMA) in 1994 and 2001. In addition, in order to maintain high quality of PET/CT images, quality assurance programs including periodic (daily, monthly, and yearly). Therefore, in this article, the methods and present state of performance evaluation and quality assurance of PET/CT are reviewed.

• Nuclear Engineering and Technology
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• v.19 no.1
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• pp.42-50
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• 1987

Through a project "Development of Nuclear Safety Parameter Monitoring System", a nuclear data link system was established between Kori nuclear unit 2 and Nuclear Safety Center. We present in this paper the selected parameter sets, a description of the developed pseudo-network software and the functional descriptions of the equipments involved. We also include the conceptual design of the Kori four unit ERF/SPDS system, along with the localization direction for the related software and hardware. hardware.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.492-500
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• 2004

The purpose of this study is localization of safety relief valves fur Nuclear Service through technical development with overall design, fabrication, inspection, capacity certification test and functional qualification test of safety relief valves in accordance with KEPIC MN Code(or ASME Sec.III ). The safely relief valve is the important equipment used to protect the pressure vessel, the steam generator and the other pressure facility from overpressure by discharging the operating medium when the pressure of system is reaching the design pressure of the system. But we're depending on technology of the other country up to the present time. Because we don't have our own technologies, we have been spent the great time and money on installing and repairing safety relief valve at nuclear power plant. Therefore we have to achieve the development of safety relief valves for Nuclear Service with our own technologies.

• Animal cells and systems
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• v.15 no.3
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• pp.197-202
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• 2011

The present study demonstrates the first-ever characterization of cell types that express the vanilloid receptor 1 (VR1) in the taste buds of rat circumvallate papillae. We performed electron microscopy to identify the subcellular location. The VR1 immunoreactivity was associated with the endoplasmic reticulum, cytoplasmic vesicles, and plasma membrane of taste cells. These results demonstrate the localization of the VR1 in membranous structures of the taste cells. We used double immunofluorescence histochemistry with taste cell type-specific markers to identify the cell types that express the VR1. The VR1 was detected in all functional taste cell types (Type I, Type II, and Type III cells). Together, our data suggest that the VR1 might play different roles according to the cell types within a taste bud.

• YAKHAK HOEJI
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• v.49 no.3
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• pp.205-211
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• 2005

The 3' UTR (3' untranslated region) plays important roles in controlling gene expression through regulating 3' polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3' UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3' UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD 15 + myeloid progenitor cells. Wide-spread differential usage of the 3' UTR was observed from the genes expressed during this cellular transition. This study implies that the 3' UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.

• Journal of the Korean Institute of Rural Architecture
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• v.3 no.3
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• pp.11-21
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• 2001

This study is intended to clarify the ideologies and principles applied to the formative expression of church architecture which is contained both the God and human. From the result of study of modern architectural movement, all of architectural ideology have not been developed with the church architecture. Some of architectural concept have been the foundation of modern church architecture. From the point of view of theological aspects of Christianism, in church architecture which is hard to overcome the adherence of historical characteristics, especially nationalism which contain all the concepts and try the localization of church architecture play multi-functional roles to form expressional characteristics of the modern church architecture show harmonize to the modern architecture trend. The study is intended to clarify the nationalism-church architecture and to know the capability of our cases.

• 한국전기화학회:학술대회논문집
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• 2004.06a
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• pp.287-292
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• 2004

In order to understand the relationship between molecular structure of Metal-Organic Framework(MOF) and capacity of hydrogen absorption, quantum mechanical calculations and grand canonical Monte Carlo simulations have been carried out on a series of MOF-5 having various organic linkers. The calculation results about specific surface area and electron density for various frameworks indicated that the capacity of the hydrogen storage is largely dependent on effective surface area rather than the free volume. Based on the iso-electrostatic potential surface from density functional calculation and the amount of adsorbed hydrogens from grand canonical Monte Carlo calculation, it was also found that the electron localization ground organic linker plays an important role in hydrogen capacity of MOFs.

• Molecules and Cells
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• v.46 no.1
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• pp.48-56
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• 2023

Genomic information stored in the DNA is transcribed to the mRNA and translated to proteins. The 3' untranslated regions (3'UTRs) of the mRNA serve pivotal roles in post-transcriptional gene expression, regulating mRNA stability, translation, and localization. Similar to DNA mutations producing aberrant proteins, RNA alterations expand the transcriptome landscape and change the cellular proteome. Recent global analyses reveal that many genes express various forms of altered RNAs, including 3'UTR length variants. Alternative polyadenylation and alternative splicing are involved in diversifying 3'UTRs, which could act as a hidden layer of eukaryotic gene expression control. In this review, we summarize the functions and regulations of 3'UTRs and elaborate on the generation and functional consequences of 3'UTR diversity. Given that dynamic 3'UTR length control contributes to phenotypic complexity, dysregulated 3'UTR diversity might be relevant to disease development, including cancers. Thus, 3'UTR diversity in cancer could open exciting new research areas and provide avenues for novel cancer theragnostics.