• Title/Summary/Keyword: Functional dyspepsia (FD)

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Pattern Identification of 97 Functional Dyspepsia Patients and the Characteristics of Each Pattern Type (기능성 소화불량 환자 97명의 변증유형별 특성)

  • Han, Ga-Jin;Kim, Jin-Sung;Park, Jae-Woo;Ryu, Bong-Ha
    • The Journal of Korean Medicine
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    • v.32 no.2
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    • pp.42-62
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    • 2011
  • Objective: This study was designed to identify and explore the pathological patterns of functional dyspepsia (FD) patients. We also evaluated the usefulness of the Pattern Identification Questionnaire by comparing it with other assessment tools for FD. Methods: We recruited 97 FD patients based on the Rome III criteria for FD diagnosis. The pathological patterns of the subjects were determined by the Pattern Identification Questionnaire. Their dyspepsia-related symptoms were assessed using the Gastrointestinal Symptom Questionnaire (GIS) and the Pyeongwi-san (Pingwei-san) Patternization Questionnaire. Depressive symptoms were evaluated with the Beck Depression Inventory (BDI) and quality of life with the Functional Dyspepsia-Related Quality of Life (FD-QoL) Questionnaire. Tongue coating was measured by the Digital Tongue Diagnosis System (DTDS). Results: The male to female ratio was 1:1.1, and the forties and fifties age groups were largest in number. The spleen deficiency and phlegm-dampness pattern was the most common pattern found among the FD patients. No significant differences in the GIS, BDI, FD-QoL, and DTDS scores were found among the five pattern types. All pattern types showed significant correlation with GIS, Pyeongwi-san Patternization Questionnaire, and FD-QoL scores. Conclusions: Pattern Identification Questionnaire can not only identify the pathological pattern types of FD patients but also evaluate the severity of their symptoms. Compared to conventional assessment tools for FD, it could enable a more dynamic evaluation of FD patients reflecting the severity of dyspeptic symptoms and the quality of life. Further studies on the Pattern Identification of FD patients are anticipated in order to improve the diagnosis and therapy for Korean FD patients.

Development of a Food Retention Questionnaire for Functional Dyspepsia and the Analysis of Its Reliability and Validity (기능성소화불량의 식적설문지 개발과 신뢰도 및 타당도 검정)

  • Hwang, Mi-ni;Ha, Na-yeon;Ko, Seok-jae;Park, Jae-woo;Kim, Jin-sung
    • The Journal of Internal Korean Medicine
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    • v.40 no.3
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    • pp.390-408
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    • 2019
  • Objectives: Several pattern diagnosis questionnaires have been developed to objectify the process of pattern diagnosis in Korean medicine. In this context, this study aimed to develop a food retention questionnaire for functional dyspepsia (FRQ-FD) by modifying the previously developed food retention questionnaire (FRQ) and to verify its reliability and validity. Furthermore, this study aimed to identify the optimal cut-off value of the FRQ-FD for standardization and use in clinical situations. Methods: To develop the FRQ-FD, we extracted the major symptoms of food retention pattern for functional dyspepsia from Chinese/Korean medicine textbooks and requested an importance survey from experts using the Delphi method. The first draft of the FRQ-FD was composed of 25 questions comprising 8 questions from the textbooks and the Delphi method and 17 questions from the FRQ already developed in 2013. To analyze its reliability, validity, and optimal cut-off value, 60 subjects were enrolled in this study from June 25 to August 13, 2018. Thirty patients were diagnosed as both functional dyspepsia and food retention pattern, and 30 healthy participants were not. All participants were requested to fill up the FRQ-FD, Stomach Qi Deficiency Questionnaire (SQDQ), Scale for Stomach Qi Deficiency pattern (SSQD), visual analog scale (VAS) for dyspepsia, Nepean Dyspepsia Index-Korean version (NDI-K), and functional dyspepsia-related quality of life (FD-QoL). Results: No statistically significant differences were found in sex distribution, age, and body mass index between the patient group and the control group. As five questions affected the reliability negatively and three questions affected the clinical validity negatively, we decided to exclude the eight questions upon further investigation. The Cronbach's ${\alpha}$ coefficient of the revised FRQ-FD (17 items) was 0.899, and its clinical validity was verified. Construct validity was analyzed by factor analysis and produced five factors. Statistically significant positive correlations were found between the revised FRQ-FD and the other dyspepsia scales, namely, SQDQ, SSQD, VAS, NDI-K, and FD-QoL. VAS and NDI-K especially had strong positive correlations with FRQ-FD. Conclusions: The FRQ-FD developed in this study can provide fundamental reliability and validity for a pattern diagnosis questionnaire. FRQ-FD can help to diagnose food retention pattern in functional dyspepsia patients. Further studies are required to inspect several statistical factors.

Development of a Phlegm Pattern Questionnaire for Functional Dyspepsia and Analysis of Its Reliability and Validity (기능성소화불량에 대한 담음 변증설문지 개발과 신뢰도 및 타당도 검정)

  • Baek, So-young;Ha, Na-yeon;Ko, Seok-jae;Park, Jae-woo;Kim, Jin-sung
    • The Journal of Internal Korean Medicine
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    • v.41 no.4
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    • pp.563-582
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    • 2020
  • Objectives: The aim of this study was to develop a Phlegm Pattern Questionnaire for Functional Dyspepsia (PPQ-FD) by modifying a previously developed Phlegm Pattern Questionnaire (PPQ) and to verify its reliability and validity. Further objectives were to obtain the optimal cut-off value for the PPQ-FD for standardization and for clinical use. Methods: The PPQ-FD was developed by extracting the major symptoms of the phlegm pattern in functional dyspepsia and by using the Delphi method to administer a requested importance survey to experts. The reliability, validity, and optimal cut-off value of the PPQ-FD were analyzed by enrolling a total of 60 subjects in this study. Thirty patients were diagnosed with both functional dyspepsia and phlegm pattern and thirty patients were diagnosed with only functional dyspepsia. All participants were requested to fill out the PPQ-FD. Results: No statistically significant differences were detected in the two groups for sex distribution, age, or body mass index. Five of the survey questions negatively affected its reliability; therefore, we decided to exclude those five questions on further inspection. The Cronbach's α coefficient of the revised PPQ-FD was 0.853, and clinical validity was verified. Construct validity was analyzed by factor analysis and identified four factors. Statistically significant positive correlations were found between the revised PPQ-FD and other dyspepsia scales, such as the SQDQ, SSQD, VAS, NDI-K, and FD-QoL scales. The VAS had particularly strong positive correlations with the PPQ-FD. Conclusions: The PPQ-FD developed in this study has fundamental reliability and validity for use as a pattern-diagnosis questionnaire. The PPQ-FD can help to diagnose the phlegm pattern in patients with functional dyspepsia.

Investigation on evaluation of functional dyspepsia by using Digital Infrared Thermal Images (기능성 소화불량증에 대한 적외선 체열검사(DITI)의 임상 지표적 의의 연구)

  • Jeong, Seung-Hwan;Im, In-Hwan;Um, Eun-Jin;Lee, Beom-Jun;Na, Byong-Jo
    • Journal of Oriental Medical Thermology
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    • v.6 no.1
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    • pp.56-62
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    • 2008
  • Objective: To investigate the significance of temperature differences on two different acupuncture points between functional dyspepsia(FD) group and non-functional dyspepsia(non-FD) group respectively. Methods: We performed this research on 40 patients who came and took D.I.T.I in Kang-nam korean hospital kyung-hee university. We analyzed the averaged temperature of Zhongwon(CV12), Indang(HN1) and, also, investigated the significance of subtraction from Indang to Zhongwon temperature statistically. Results: The temperature differences from Indang to Zhongwon between functional dyspepsia group and non-functional dyspepsia group was significant, it meant that patients who have functional dyspepsia have more significant temperature difference from Indang(HN1) to Zhongwon(CV12). The direct comparisons of mean temperature between Indang and Zhongwon in the FD group and non-FD group were not significant. Conclusion: The study provide hypothesis on the temperature difference from Indang(HN1) to Zhongwon(CV12) and its association with functional dyspepsia. This study can provide a foundation for future studies on the evaluation of functional dyspepsia by using D.I.T.I.

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Skin Color Measurement of LU10; Comparison between Functional Dyspepsia Patients and Healthy Controls (기능성 소화불량증 환자와 건강인의 어제혈 색택 비교 연구)

  • Kim, Min-ji;Ko, Seok-Jae;Park, Jae-Woo
    • The Journal of Korean Medicine
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    • v.37 no.3
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    • pp.27-38
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    • 2016
  • Objectives: According to Korean Medicine theory, the skin color of LU10 serves as a diagnostic clue to dyspeptic symptoms. The aims of this study were (1) to find the difference of skin color in LU10 region between functional dyspepsia (FD) and healthy control (HC) and (2) to examine the relationship between LU10 skin color parameters and dyspeptic symptoms. Methods: 39 participants (29 FD and 10 HC) have participated in this study. They were asked to complete gastrointestinal scale (GIS), gastrointestinal symptom rating scale (GSRS), Nepean dyspepsia index (NDI), functional dyspepsia-related quality of life (FD-QoL), visual analogue scale (VAS) for dyspeptic symptoms, food retention questionnaire (FRQ) and cold heat questionnaire (CHQ). $L^*$ (luminance), $a^*$ (red-green balance) and $b^*$ (yellow-blue balance) values of LU10 region were calculated through digital images of the participant's hand. Then we evaluated test-retest reliability of $L^*$, $a^*$ and $b^*$ values of LU10 region. Additionally, we compared $L^*$, $a^*$ and $b^*$ values of LU10 between FD and HC, and examined the relationship between LU10 color parameters and seven questionnaires scores. Results: Only $L^*$ values in LU10 region were significantly higher in FD compared with HC. GIS scores and the subset scores of NDI had a positive correlation with $L^*$ values significantly. Correlation coefficients of test-retest reliability of skin color measurement of LU10 ranged from 0.871 to 0.936 representing very strongly statistically significant (P<0.001). Conclusions: We confirmed the difference of skin color in LU10 region between FD and HC, and relationship between LU10 skin color parameters and dyspeptic symptoms.

Fungiform Papillae and its Correlation with Rome III Classification and Spleen Qi Deficiency in Functional Dyspepsia (기능성 소화불량증 환자에서 로마기준 III 아형분류 및 脾氣虛證과 심상유두 수의 상관성 분석)

  • Choi, Jane;Kim, Jin-sung
    • The Journal of Internal Korean Medicine
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    • v.36 no.3
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    • pp.308-322
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    • 2015
  • Objectives: Whether there exists a distinct pathogenesis in subgroups of functional dyspepsia (FD), the classification of epigastric pain syndrome (EPS), and postprandial distress syndrome (PDS) remains controversial. We aimed to investigate the number of fungiform papillae (FP) in the subgroups of FD and its correlation with the severity of dyspepsia symptoms and spleen qi deficiency. Methods: Patients with FD were enrolled from August to November 2014. All patients were evaluated using a questionnaire and divided into 2 groups according to the Rome III criteria for FD. The severity of dyspepsia symptoms and spleen qi deficiency were separately assessed by Nepean Dyspepsia Index-Korean (NDI-K) version and Spleen qi deficiency questionnaire (SQDQ). The number of FP was measured on the anterior part of tongue, within an area of 9 mm 2, using a digital cam Results: The NDI-K score, SQDQ score, and number of FP in the EPS group were significantly greater than those in the PDS group. Also, the EPS group had more patients diagnosed with spleen qi deficiency. The number of FP showed a significant positive correlation with epigastric pain and burning. Furthermore, the number of FP was significantly associated with the score of some items in NDI-K and SQDQ, even though not with the total score. Conclusions: Thus, measurement of the number of FP could be a new evaluation indicator for allocation into FD subtypes and to investigate the severity of dyspepsia symptoms and spleen Qi deficiency reflecting visceral hypersensitivity.

Perception Difference between Korean Medicine Doctors, Western Medicine Doctors, and Patients on the Collaborative and Integrated Medicine for the Functional Dyspepsia (기능성 소화불량의 의한 협진과 통합의료에 대한 한의사, 의사, 환자의 인식도 차이)

  • Kim, Keumji;Jeon, Hye-jin;Ko, Seok-jae;Cha, Jae Myung;Park, Jae-Woo
    • The Journal of Internal Korean Medicine
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    • v.42 no.6
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    • pp.1285-1302
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    • 2021
  • Objectives: The aim of this study was to investigate the perception difference between Korean Medicine doctors, Western Medicine doctors, and functional dyspepsia (FD) patients on the 'Collaborative and Integrated Medicine (CIM)' for FD management. Methods: Between February and April 2021, 545 Korean Medicine doctors, 121 Western Medicine doctors, and 186 FD patients were invited to participate in this survey. A questionnaire was developed by both the Korean and Western Medicine doctors and consisted of questions about general perceptions of FD and perceptions of CIM for FD. Results: Responses from 424 Korean Medicine doctors, 113 Western Medicine doctors, and 153 FD patients were analyzed for the CIM of FD. Significant perceptional differences were noted between Korean Medicine doctors, Western Medicine doctors, and FD patients on the CIM for FD, including necessity, effectiveness, safety, cost, and reliability of CIM for the management of FD (p<0.001). The FD patients also more strongly supported the necessity of developing CIM for FD than did the Korean and Western Medicine doctors (p<0.001), and 87.6% of the FD patients strongly agreed or agreed with the use of CIM for FD. Conclusions: A significant perception difference was detected between Korean Medicine doctors, Western Medicine doctors, and FD patients regarding the use of CIM for FD. Patients with FD favored the necessity and were more willing to accept CIM for FD than were the doctors. Therefore, more efforts may be warranted for doctors to promote CIM for FD.

Correlation Analysis between Gastric Emptying Measured by Ultrasonography and Spleen Qi Deficiency Pattern in Patients with Functional Dyspepsia (기능성 소화불량 환자에서 초음파로 측정한 위 배출능과 비기허증(脾氣虛證)간의 상관성 분석)

  • Baek, Seung-hwan;Kim, Jin-sung
    • The Journal of Internal Korean Medicine
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    • v.36 no.4
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    • pp.527-546
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    • 2015
  • Objectives The purpose of this study was to investigate the correlation between gastric emptying measured by ultrasonography and Korean medical instruments of diagnosis and assessment in functional dyspepsia (FD) patients. Among the subgroups of FD, postprandial distress syndrome (PDS) is related to gastric motility disorder.Methods Ten patients with FD and particularly with PDS as well as 10 healthy controls were enrolled in the study from September to November 2015. The gastric emptying shown as the half-life of gastric volume (T1/2) was measured by ultrasonography. The severities of spleen qi deficiency and dyspepsia symptoms were assessed by a spleen qi deficiency questionnaire (SQDQ) and the Nepean Dyspepsia Index-Korean version (NDI-K), respectively. In addition, a food retention questionnaire (FRQ), a damum questionnaire (DQ), a cold and heat questionnaire (CHQ), a deficiency and excess questionnaire (DEQ), and a visual analogue scale (VAS) of distention and fullness were completed by every participant.Results In comparison with the control group, the FD group showed significantly higher scores for the SQDQ, NDI-K, FRQ, DQ, DEQ, and VAS of distention and fullness. T1/2 was also significantly higher in the FD group than in the control group. There were significant correlations between T1/2 and the SQDQ score. However, there were no significant correlations between T1/2 and other questionnaire scores except for one item of the NDI-K.Conclusions According to these findings, it was determined that measuring gastric emptying using ultrasonography could be a quantitative indicator to diagnose spleen qi deficiency in FD patients.

Clinical Observation of Changes in Subjective Evaluation Index and Electrogastrography Parameters of Patients with Functional Dyspepsia before and after Oriental Medical Interventions (기능성 소화불량 환자의 한방치료 전후의 주관적 평가지표와 Electrogastrography Parameters를 이용한 객관적 지표의 변화 관찰)

  • Han, Ga-Jin;Kim, Jin-Sung;Ryu, Bong-Ha
    • The Journal of Internal Korean Medicine
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    • v.32 no.4
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    • pp.584-598
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    • 2011
  • Objectives : Functional dyspepsia is a type of disease characterized by bothersome postprandial fullness, early satiation, epigastric pain and burning without structural gastrointestinal disease. The aim of this study was to analyze the characteristics of functional dyspepsia patients and evaluate changes in symptoms, quality of life, and electrogastrography parameters before and after oriental medical interventions. Methods : We recruited forty-six functional dyspepsia patients who visited gastroenterology clinic in the oriental medicine hospital of Kyung Hee University between November 2009 and February 2011. Patients were assessed for their frequency of dyspepsia (based on short form-Leeds Dyspepsia Questionnaire: SF-LDQ), quality of life (based on functional dyspepsia-related quality of life questionnaire: FD-QoL), gastric motility (based on electrogastrography: EGG) on the first visit. Then, the effect of oriental medical interventions was evaluated using EGG on the second visit. Results : The majority of patients had symptoms of nausea and indigestion. The largest decrease in EGG parameters was found in the indigestion group. The frequency of regurgitation and postprandial EGG power % bradygastria showed a significant correlation. Also, significant correlations were found between some items of FD-QoL and some EGG parameters. Compared to the EGG parameters before oriental medical interventions, some parameters after treatment had positive results, implying the improvement of gastric motility disorder. We also found improvement of EGG parameters in both digestant medicinal group and digestant combined with qi-tonifying medicinal group. Conclusions : The results of this study suggest that clinical application of EGG can be an objective diagnostic tool in functional dyspepsia patients visiting oriental medical hospital.

Effect of Herb Medicine Treatment for Functional Dyspepsia: A Randomized Placebo-Controlled and Compared Standard Treatment Trial (기능성 소화불량증 환자에 대한 한약복합제의 치료 효과: 무작위배정 표준치료제 위약 대조군 연구)

  • Kim, Yeon-Mi;Park, Yang-Chun;Jo, Jeong-Hyo;Kang, Wee-Chang;Son, Mi-Won;Hong, Kwon-Eui
    • The Journal of Korean Medicine
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    • v.31 no.1
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    • pp.1-13
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    • 2010
  • Objective: Functional dyspepsia is a prevalent disease. It impedes subjective quality of life. The purpose of this study was to examine the equivalent effect of herb medicine treatment (DA-9701) for functional dyspepsia. Methods: In this randomized, single-blinded, placebo-controlled study, we compared a herb medicine (DA-9701) with standard treatment (mosapride) and placebo for the treatment of functional dyspepsia. 42 volunteers who satisfied the requirements were enrolled in study. Severity of dyspepsia was measured by Nepean Dyspepsia Index (NDI) and Functional Dyspepsia Quality of Life (FD-QOL) before and after treatments. Results: 1. In the DA-9701 group, total key symptoms score was significantly lower and improve rate of key symptoms was higher than in the mosapride and placebo groups, but there were no statistically significant differences between three groups. 2. In the DA-9701 and mosapride groups, "nausea" and "bad breath" were significantly lower compared with the placebo group. 3. In the DA-9701 group, NDI Quality of Life scores were significantly higher, but there were no [other] statistically significant differences between the three groups. 4. In the DA-9701 and mosapride groups, FD-QOL scores were higher compared with the placebo group, but there were no statistically significant differences between the three groups. Conclusion: Herb medicine treatment (DA-9701) is effective to improve the symptoms and quality of life in patients with functional dyspepsia.