• 대한두개안면성형외과학회지
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• 제21권1호
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• pp.7-14
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• 2020

Background: It is difficult to completely fix nasal bone fractures with closed reduction, as it is often accompanied by septal cartilage damage, and this often results in postoperative secondary deformities. Thus, patients are often reluctant to undergo closed reduction surgery. The present study aimed to evaluate aesthetic and functional satisfaction, as well as satisfaction with and complications of closed reduction, according to nasal bone fracture type. Methods: The subjects were patients who underwent closed reduction under general anesthesia from January 2017 to December 2018. Based on the modified Murray classification, patients were classified into five groups according to the fracture site, septal fracture, and deviation. A total of 211 patients were sent a web-based survey on postoperative satisfaction and complications, as well as intention for revision and cosmetic surgery. Sixty-one patients (28.9%) responded. Results: There were no significant differences in aesthetic and functional satisfaction or satisfaction with closed reduction according to the fracture type, site, or severity. Postoperative functional complications developed in 14 of 61 patients (22.95%). With 10 out of 24 (41.67%) patients (p = 0.044), the bilateral fracture with septal fracture or prominent septal deviation type had a higher incidence of complications than the other types. Conclusion: The incidence of complications is higher for bilateral fracture with septal fracture or prominent septal deviation compared to the other nasal bone fracture types. Therefore, long-term follow-up after closed reduction surgery for this fracture type can aid in establishing additional postoperative treatment plans and improving patient satisfaction.

• Archives of Plastic Surgery
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• 제44권1호
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• pp.48-52
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• 2017

Background The ideal vaginoplasty must be successful functionally as well as have a natural appearance, and also must retain its functionality and appearance over the long term. Conventional vaginoplasty techniques have functional limitations and are associated with recurrent complications, but rectosigmoid vaginoplasty is known to have a high satisfaction rate due to its functional similarity with the vagina. We conducted the present study to assess the usability of rectosigmoid vaginoplasty over the course of long-term follow-up. Methods From March 1992 to February 2014, 84 patients were treated with rectosigmoid vaginoplasty; 44 had gender identity disorder, 29 had vaginal agenesis, 8 had female pseudohermaphroditism, and 3 had gynecologic malignancies after radical pelvic surgery. This retrospective study was based on a review of the patients' records, clinical examinations, complications, and questionnaires about appearance, function, and sexual intercourse. Results All patients who underwent rectosigmoid vaginoplasty were discharged within 2 weeks without surgical flap loss. The early complications were partial flap necrosis, difficulty in defecation, mucous hypersecretion, and postoperative ileus. The late complications were vaginal introitus contracture, vaginal prolapse, and difficulty in urination. The mean length and diameter of the neovagina 3.4 years after rectosigmoid vaginoplasty were 13.2 cm and 3.8 cm, respectively. On questionnaires about satisfaction, 70% of patients reported excellent satisfaction, 11% good, 12% fair, and 7% poor. Conclusions Rectosigmoid vaginoplasty is useful, safe, and well-accepted operative method with good functional and cosmetic results, such as natural lubrication and adequate vaginal length and width obtained without requiring the use of a dilator.

• 융합정보논문지
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• 제10권2호
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• pp.89-95
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• 2020

아로니아 비가식 부위(잎, 송이가지, 가지)를 바이오 기능성 소재로 활용하기 위하여 부위별, 용매별 추출물의 총 폴리페놀 함량과 생리활성을 분석하였다. 잎과 가지 추출물의 폴리페놀 함량은 열매와 송이가지 추출물보다 더 높은 값을 나타냈고, 아로니아의 부위별 항산화능(DPPH 래디컬과 ABTS 래디컬 소거능)을 분석한 결과, 열수추출물과 메탄올추출물 두 경우에서 가지, 잎, 열매, 송이가지의 순으로 활성을 나타냈다. Tyrosinase 저해활성을 평가한 결과, 열수추출물은 열매, 잎, 가지, 송이가지의 순으로 높은 저해활성을 보였으며, 메탄올추출물의 경우 가지, 잎, 열매, 송이가지의 순으로 저해활성을 갖는 것으로 나타났다. Nitric oxide 저해활성은 열수추출물과 메탄올 추출물 두 경우에서 열매, 잎, 가지, 송이가지의 순으로 높았다. 결론적으로 아로니아 가지와 잎은 항산화, 미백 및 항염증 활성을 갖고 있는 것으로 확인하였고, 추가적인 연구를 통하여 화장품 등의 바이오 헬스케어 제품의 기능성 바이오소재로 개발할 수 있을 것으로 기대된다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.38.1-38.9
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• 2018

Background: Fibrous dysplasia (FD) is a benign bone lesion characterized by the progressive replacement of normal bone with fibro-osseous connective tissue. The maxilla is the most commonly affected area of facial bone, resulting in facial asymmetry and functional disorders. Surgery is an effective management option and involves removing the diseased bone via an intraoral approach: conservative bone shaving or radical excision and reconstruction. Case presentation: This case report describes a monostotic fibrous dysplasia in which the patient's right midface had a prominent appearance. The asymmetric maxillary area was surgically recontoured via the midfacial degloving approach under general anesthesia. Follow-up photography and radiographic imaging after surgery showed the structures were in a stable state without recurrence of the FD lesion. Furthermore, there were no visible scars or functional disability, and the patient reported no postoperative discomfort. Conclusions: In conclusion, the midfacial degloving approach for treatment of maxillary fibrous dysplasia is a reliable and successful treatment option. Without visible scars and virtually free of postoperative functional disability, this approach offers good exposure of the middle third of the face for treatment of maxillary fibrous dysplasia with excellent cosmetic outcomes.

• Journal of the Korean Data and Information Science Society
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• 제25권6호
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• pp.1273-1281
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• 2014

현대사회에서는 다양한 산업 기술의 고도화와 함께 여러 가지 재료와 집적기술의 발전으로 화장품 산업 전반에도 많은 종류의 화장품이 출시되고 있는 실정이다. 이와 함께 화장품법의 독립과 화장품의 전 성분 표시제가 도입되었다. 웰빙시대인 요즈음에는 질 좋은 삶의 추구를 위해 생활관리, 생체리듬, 올바른 자세, 스트레스 증상과 같은 생활패턴에도 많은 관심을 갖게 되었다. 이들 생활패턴은 삶의 질과 건강뿐만 아니라 피부 관리와도 관련이 있을 것으로 판단하여 기능성 화장품의 인지도와 생활패턴과의 관계를 알아보기 위하여 설문조사를 하였다. 그 결과는 화장품 인지도 관련 16문항 중 문항 3, 문항 5, 문항 6 및 문항 11은 대학교 간 응답에 유의한 차이가 있음을 보였다. 또한, 생활패턴과의 교차분석 결과는 응답연도와 스트레스 증상 간, 응답연도와 올바른 자세 간에는 응답에 유의한 차이가 있음을 보였다. 끝으로, 성별과 생체리듬, 성별과 올바른 자세 및 성별과 스트레스 증상 간에는 응답에 유의한 차이가 있음을 알 수 있었다. 향후 과제로는 일반인을 대상으로도 동일한 조사를 하여 이들간의 차이를 조사해 볼 필요성이 있는 것으로 생각된다.

• 산업경영시스템학회지
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• 제38권4호
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• pp.184-192
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• 2015

Korea has already entered into an aging society. In recent decades, the health problems for seniors has received considerable interest. We often see the elderly who have been struggled from discomfort or illness of the foot. Those foot related problems mainly cause from the use of improper shoes. Recently, shoe makers sell the shoes for seniors, so called comfort shoes, but the shoes are too expensive for seniors to buy easily. In this paper, we develop cheap insoles for seniors as an alternative of the comfort shoes and suggest the systematic process for the insoles development. This systematic process is as follows: 1) Survey the literature about the market of insole, 2) Investigate the standard size of body and foot for the seniors in Korea, 3) Analyze the customer needs by survey, 4) Study the walking pattern by experiments, and 5) Develop the novel insole for the seniors to relieve the inconveniences related with foot. From the newly developed insoles, the company B gains the sales increasing effect approximately 30% over through the increase in consumer satisfaction and company reputation and secures for intellectual property rights. Using the database from Korea Research Institute of Standards and Science, the reliability of developing technology of the functional insole has been obtained. The seniors are also enable to choose an alternative of comfort shoes for foot health. In the future, the insoles developed from this study have wide applications in the medical, cosmetic fields, and leisure sports fields. Accordingly, it seems to require more systematic studies utilizing Walk Analyzer and Foot Pressure Meter.

• 대한화장품학회지
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• 제23권3호
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• pp.134-146
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• 1997

Consumers have recently preferred to purchase extensive UV intercepting products, which are waterproof and free from side effects on skin. Testing Cytoroxicity in SR method, cell survivial ratio of UV-B interceptors decreased above 0.08W/V%, and so did that of UV-A interceptors above 0.06W/V%. Also, Patch-test of inorganic UV interceptors resulted in no skin irritation even below 10.0 and 11.25. UV interceptors in the sunlight showed yellowish discoloration in 5 to 14 days. In absorption curves, UV-B was most suitable for Octyl methoxycinnamate and UV-A for Butyl methoxy dibenzoylmethane. Fro this reason, Nylonpoly UVA/UVB the material of OMC and BMDM coated with Nylon & polyethylene, was used as the organic UV interceptor. And zinc oxide and titanium dioxide was used as inorganic UV ibterceptors. The appropriate mixture ratio of ZnO and TiO2 was 6 to 4.6% of ZnO, 4% of TiO2 and 5% of Nylonpoly UVA/UVB were all combined with our sunscreen cream. The SPF value of in-vivo applied to a guinea pig was 34.9 and that of in-vivo was 38.5. Cyclomerhicone and dimerthicone were used in water-in-Silicone system. Ceryl diverhicone and sorbitan sesquioleate were used as emulsifiers and MgSO4, 7H2O, Mg-stearate/Mg-Al-stearate copolymer as emulsification stabilizers. In practical application, each SPF duration of O/W type and W/S type containing sunscreen cream of the same content showed that W/S type of sunscreen cream was 5 times as durable as the other. This product is fit for using in swimming, climbing or skiing. This research is to minimize skin trouble used by UV interceptors and to make one with proper softness, skin safety and UV intercepting efficiency.

• 대한화장품학회지
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• 제42권4호
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• pp.311-320
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• 2016

카바(Piper methysticum, P. methysticum)는 비뇨생식기 질환, 류머티즘, 위장 장애, 호흡기 자극 및 폐 통증에 대해 전통적으로 사용되는 것으로 알려져 있다. 본 연구에서는 카바에서 분리된 flavokavain C (FKC)가 염증성 유전자의 발현에 관여하는 전사인자인 핵요소-${\kappa}B$ (NF-${\kappa}B$) 의존성 산화 질소(NO) 생산 및 산화 질소 합성 효소(iNOS)의 발현에 리포폴리사카라이드(LPS) 처리된 대식세포에서 항 염증 활성을 나타낸다는 것을 확인하였다. FKC는 과산화수소와 같은 반응성 산소 종(ROS)의 축적을 억제하고, LPS로 유도된 NO 생성 및 각종 염증 관련 유전자(iNOS, IL-$1{\beta}$, IL-6)의 발현을 NF-${\kappa}B$ 및 MAPKs (ERK 및 JNK)의 억제를 통해 농도 의존적으로 줄일 수 있었다. 결론적으로, 이러한 결과는 FKC가 NF-${\kappa}B$ 경로와 MAPKs 포함한 염증 프로세스를 억제하는 능력을 가지고 있음을 나타내며, 이는 항 염증 및 항산화 효능 기반 기능성 화장품에 적용될 수 있음을 암시한다.

• 농업과학연구
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• 제45권3호
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• pp.499-508
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• 2018

To use mountain ginseng adventitious roots (MGAR), which is superior in functionality compared to ginseng, and to mass produce raw materials as a functional cosmetic material, the antioxidant and cosmeceutical activities of the extracts of MGAR at different ethanol concentrations (0, 20, 40, 60 and 80%) were compared and analyzed. At first, different ethanol concentrations were compared to determine the best solvent for the extraction of phenolic compounds from MGAR. An 80% ethanol extract with 10.07 mg of gallic acid equivalents/g sample and 0.94 mg of quercetin equivalents/g sample was the best solvent in the extraction of phenolic compounds. However, the 60% ethanol extract had the highest antioxidant activity, evident by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Trolox equivalent antioxidant capacity (35.01 mM Trolox/g sample) and ferric reducing antioxidant power (460.94 mM $FeSO_4/g$ sample). However, the inhibitory activities of the 80% ethanol extract from the MGAR against tyrosinase and elastase were higher than those of the other extracts. The results of this study show that the extract of MGAR can be used as an easily accessible source of natural antioxidant and as a possible cosmetic ingredient in the cosmeceutical industry. However, the components responsible for the antioxidant and cosmeceutical activities of the MGAR extracts are currently unclear. Therefore, it is suggested that further studies should be carried out to isolate and identify the antioxidant and cosmeceutical components in MGAR.

• Applied Biological Chemistry
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• 제50권3호
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• pp.217-223
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• 2007

화장품에 폴리페놀을 다량 첨가 시 색소가 문제시 될 수 있어 이를 제거하기 위하여 폴리페놀을 첨가한 토너와 에센스에 방사선을 5, 10, 20 kGy로 조사하고, 조사량에 따른 암세포증식 억제능을 검토하였다. 암세포 증식 억제능 측정 결과 모든 세포주(B16F10, G361, A549, HT-29)에 대하여 폴리페놀이 첨가된 토너와 에센스는 500 ppm에서 80% 이상의 증식 억제능을 나타내었으며, 특히 human melanoma(G361)에서는 100 ppm에서 80% 이상의 뛰어난 암세포 증식 억제 효과를 나타내었으며, 방사선 조사량이 증가해도 폴리페놀의 활성이 유지되었다. 또한, 방사선 조사량이 증가 할수록 색이 점차적으로 옅어짐을 확인할 수 있었다. 이와 같은 결과로 미루어 보아 녹차 폴리페놀을 토너와 에센스에 첨가했을 때 암세포증식 억제능이 우수하였으며, 화장품에 첨가 시 나타나는 색소문제는 방사선 조사를 이용하여 개선이 될 것으로 사료된다.