• Physical Therapy Rehabilitation Science
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• 제13권2호
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• pp.213-222
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• 2024

Objective: Stroke is a leading cause of disability worldwide, often leaving survivors with significant cognitive and motor impairments. Dual-task (DT), which involves performing cognitive and motor tasks simultaneously, can influence brain activation patterns and functional recovery in stroke patients. Design: A systematic review Methods: Following PRISMA guidelines, databases including MEDLINE, CINAHL, Embase, and Web of Science were searched for studies assessing cortical activation via functional near-infrared spectroscopy (fNIRS) during DT performance in stroke patients. Studies were selected based on predefined eligibility criteria, focusing on changes in hemodynamic responses and their correlation with task performance. Results: Eight studies met the inclusion criteria. Findings indicate that DT leads to increased activation in the prefrontal cortex (PFC), premotor cortex (PMC), and posterior parietal cortex (PPC), suggesting an integrated cortical response to managing concurrent cognitive and motor demands. However, increased activation did not consistently translate to improved functional outcomes, highlighting the complex relationship between brain activation and rehabilitation success. Conclusions: DT interventions may enhance cortical activation and neuroplasticity in post-stroke patients, but the relationship between increased brain activity and functional recovery remains complex and requires further investigation. Tailored DT programs that consider individual neurophysiological and functional capacities are recommended to optimize rehabilitation outcomes.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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• pp.105-105
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• 2001

Purpose： The activation of the Brocas and the Wernickes area in the language functional MR (fMR) well-known phenomena. We want to evaluate correlation of that activation with langua lateralization. So we evaluate the lateralization using the activation of the Brocas and t Wernickes area comparing with total cortical activation amount of cerebral hemisphere in t functional MR for measuring language lateralization based on Wada test.

• 대한물리의학회지
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• 제14권2호
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• pp.41-51
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• 2019

PURPOSE: This study was conducted to investigate the effects of combined Joint Mobilization and Functional Electrical Stimulation on Muscle Activation and Mobility of ankle joints in stroke patients and their Modified Functional Reach Test (MFRT) results. METHODS: A total of 26 patients with stroke were randomly selected for enrollment in this study. (1) Functional Electrical Stimulation (FES) (2) combined Joint Mobilization and FES. An EMG system was used to measure tibialis anterior and gastrocnemius activities. Range Of Motion (ROM) of Ankle Joint and MFRT for Dynamic Balance. Pre and post intervention results were compared by paired-t-tests and differences in changes after intervention between groups were identified by the independent t-test. RESULTS: The muscle activation, ROM, and MFRT differed significantly in the experimental group (p<.05). The ROM was significantly different for the active dorsiflexion pre and post intervention in the group that received FES alone (p<.05). CONCLUSION: The results of this study suggest use of a systematic program of proactive posture control to prevent dysfunction when planning interventions for ankle joints can help stroke patients walk efficiently.

• Journal of Korean Neurosurgical Society
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• 제50권3호
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• pp.209-215
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• 2011

Objective : The authors investigated the changes of cortical sensorimotor activity in functional MRI (fMRI) and functional recovery in spinal cord injury (SCI) patients who had been treated by bone marrow cell transplantation. Methods : Nineteen patients with SCI were included in this study; ten patients with clinical improvement and nine without. The cortical sensorimotor activations were studied using the proprioceptive stimulation during the fMRI. Results : Diagnostic accuracy of fMRI with neurological improvement was 70.0% and 44.4% for sensitivity and specificity, respectively. Signal activation in the ipsilateral motor cortex in fMRI was commonly observed in the clinically neurological improved group (p-value=0.002). Signal activation in the contralateral temporal lobe and basal ganglia was more commonly found in the neurological unimproved group (p-value<0.001). Signal activation in other locations was not statistically different. Conclusion : In patients with SCI, activation patterns of fMRI between patients with neurologic recovery and those without varied. Such plasticity should be considered in evaluating SCI interventions based on behavioral and neurological measurements.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3405-3409
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• 2013

The activation of heat shock factor 1 (HSF1) can be induced by the changes in environmental pH, but the mechanism of HSF1 activation by acidification is not completely understood. This paper reports that a low pH (pH~6.0) can trigger human HSF1 activation. Considering the involvement of the imidazole group of histidine residues under acid pH stress, an in vitro EMSA experiment, Trp-fluorescence spectroscopy, and protein structural analysis showed that the residue, His83, is the essential for pH-dependent human HSF1-activation. To determine the roles of His83 in the HSF1-mediated stress response affecting the cellular acid resistance, mouse embryo fibroblasts with normal wild-type or mutant mouse HSF1 expression were preconditioned by heating or pH stress. The results suggest that His83 is essential for HSF1 activation or the HSF1-mediated transcription of heat shock proteins, in protecting cells from acid pH stress.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 B
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• pp.656-658
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• 1999

This paper presents musculotendon model to show the decline in muscle force during functional electrical stimulation (FES). It represent muscle activation and contraction concepts including muscle fatigue. A muscle fatigue term in activation dynamics as a function of the intracellular acidification and the pulsewidth of stimulation pulses change activation to decline muscle force. The computer simulation shows that muscle force decline in stimulation time.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 춘계학술대회
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• pp.208-208
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• 1996

In this work we investigated coupling of the m2 and m4 subtypes of muscarinic acetylcholine receptors expressed in chinese hamster ovary (CHO) cells to activation of neuronal nitric oxide synthase (nNOS). Stimulation of guanylate cyclase activity in detector neuroblastoma cells was used as an index of generation of nitric oxide (NO) in CHO cells. The agonist carbachol induced marked time and concentration-dependent enhancement of the activity of nNOS at m2 receptors. In sharp contrast, the response in CHO cells transfected with the m4 receptor gene was similar in magnitude to that observed in non-transfected cells, suggesting lack of significant coupling of m4 muscarinic receptors to NO signaling. This novel observation of functional divergence of the two muscarinic receptor subtypes at the level of activation of nNOS is quite intriguing, in light of the currently accepted dogma that they belong to the same functional class. This functional selectivity was not due to differential effects on intracellular Ca$\^$2+/ concentration, since activation of both subtypes of muscarinic receptors produced a comparable, albeit quite small, Ca$\^$2+/ signal. Taken together, our present data strongly suggest that the generally assumed functional equivalence of m2 and m4 muscarinic receptors should be carefully reexamined. These data also suggest the presence of alternate mechanisms of activation of nNOS, which might be operative in the absence of large changes in the concentration of cellular Ca$\^$2+/. The latter mechanisms are expected to be activated by m2, but not m4 muscarinic receptors. Both sets of findings are quits important in regards to refining the functional classification of muscarinic receptor subtypes and the cellular mechanisms of activation of NOS.

• Investigative Magnetic Resonance Imaging
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• 제10권1호
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• pp.26-31
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• 2006

목적 : 감각 및 운동기능에 대한 기능적 자기공명영상에서 데이터 분석 시 global scaling이 뇌 활성화 영상에 미치는 영향을 알아보고자 하였다. 대상 및 방법 : 신경학적 병력이 없는 정상 성인 피검자 4명을 대상으로 하였다. 운동기능은 오른쪽 상지를 구부렸다가 폈다가를 반복하는 운동을 시행하였고 청각기능은 1 KHz 순음자극을 시행하였다. 기능적 자기공명영상은 3.0T 자기공명영상기기(GE, Milwaukee, USA)에서 BOLD-EPI 기법을 사용하였고 데이터 분석은 SPM2를 사용하였다. 데이터 분석 시 움직임 보정, 통계적 유의 수준 등은 동일하게 한 상태에서 global scaling의 시행 전후의 뇌 활성화 영상을 획득하였다. 결과 : 오른쪽 상지운동에 대한 기능영상에서 global scaling 효과를 고려하지 않은 경우와 고려한 경우의 뇌 활성화 영상의 차이는 크지 않았다 (p<0.000001). 청각기능 검사에서는 global scaling 효과를 고려한 경우에서 고려하지 않은 경우에 비해 뇌 활성화 영상이 훨씬 크게 나타났다 (p<0.05). 결론 : 국소적 BOLD 신호의 변화가 작은 기능영상 검사에서는 데이터 분석 시 global scaling이 뇌 활성화 결과에 큰 영향을 미칠 수 있으므로 주의가 요구된다.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.55-63
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• 2022

Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to exert protective effects against several neurological diseases through its anti-oxidative and anti-inflammatory activities. The goal of the present study was to evaluate the therapeutic potential of OA against acute and chronic brain injuries after ischemic stroke using a mouse model of transient middle cerebral artery occlusion (tMCAO, MCAO/reperfusion). OA administration immediately after reperfusion significantly attenuated acute brain injuries including brain infarction, functional neurological deficits, and neuronal apoptosis. Moreover, delayed administration of OA (at 3 h after reperfusion) attenuated brain infarction and improved functional neurological deficits during the acute phase. Such neuroprotective effects were associated with attenuation of microglial activation and lipid peroxidation in the injured brain after the tMCAO challenge. OA also attenuated NLRP3 inflammasome activation in activated microglia during the acute phase. In addition, daily administration of OA for 7 days starting from either immediately after reperfusion or 1 day after reperfusion significantly improved functional neurological deficits and attenuated brain tissue loss up to 21 days after the tMCAO challenge; these findings supported therapeutic effects of OA against ischemic stroke-induced chronic brain injury. Together, these findings showed that OA exerted neuroprotective effects against both acute and chronic brain injuries after tMCAO challenge, suggesting that OA is a potential therapeutic agent to treat ischemic stroke.

• 한국대기환경학회지
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• 제21권4호
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• pp.471-478
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• 2005

The objective of this research is to improve adsorption efficiency of adsorbent made from MSWI (Municipal Solid Waste Incinerator) ny ash by $HNO_3$ activation. The acidity and the basicity were determined by Boehm's method and the surface structure was studied by BET method with N2 adsorption. The adsorption properties were investigated with benzene and MEK (Methylethylketone). $HNO_3$ activation can modify the surface property of an adsorbent such as specific surface area, pore volume, and functional group. According to the results, the specific surface area of the adsorbent was increased from $309.2m^2/g\;to\;553.2 m^2/g$ by activation. Also oxygen-containing functional groups were formed on it.