• 산업경영시스템학회지
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• 제27권2호
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• pp.1-9
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• 2004

This study aims to examine the relationship between total quality management(TQM) practices and operational performance perceived by employees who are in different functional organization types, R&D function and Non-R&D function organization in manufacturing companies. Operational performance is defined as the degree of operation efficiency in the perspective of quality, delivery, and cost. Our study showed that the significant elements of TQM practice were different depending on functional organization types. In case of R&D organization, the categories of customer focus and process management were the strongest significant predictors of operational performance. Therefore, the optimal TQM practices for R&D organization can be obtained in consideration of customer focus and process management.

• Genomics & Informatics
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• 제19권1호
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• pp.3.1-3.12
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• 2021

Functional interpretation of noncoding genetic variants associated with complex human diseases and traits remains a challenge. In an effort to enhance our understanding of common germline variants associated with lung cancer, we categorize regulatory elements based on eight major cell types of human lung tissue. Our results show that 21.68% of lung cancer-associated risk variants are linked to noncoding regulatory elements, nearly half of which are cell type-specific. Integrative analysis of high-resolution long-range chromatin interactome maps and single-cell RNA-sequencing data of lung tumors uncovers number of putative target genes of these variants and functionally relevant cell types, which display a potential biological link to cancer susceptibility. The present study greatly expands the scope of functional annotation of lung cancer-associated genetic risk factors and dictates probable cell types involved in lung carcinogenesis.

• 정보관리학회지
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• 제15권2호
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• pp.119-136
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• 1998

본 연구는 대학도서관의 효율적인 조직구조의 형성방안을 위하여 조직구조의 상황변수, 기본변수, 구조형태 및 조직유효성 간에 상호영향을 미치는 용인을 규명하고자 한 것으로서 연구모형을 설계하고 실증적인 검증을 시도하였다. 이 검증을 위하여 대학 도서관 조직구조의 상황변수로 환경, 기술, 규모, 전략유형, 권력유형을 채택하고, 기본변수로 복잡화, 공식화, 집권화를 채택하였으며, 구조형태는 단순조직, 기능별조직, 분관조직, 주제별 조직(I), (II)로 구분하였다. 그리고 조직유효성 변수는 능률성, 유연성, 정보자료관리 및 만족성을 채택하였고, 만족성은 조직몰입과 직무만족으로 세분하였다. 연구결과, 조직구조의 상황변수, 기본변수 및 구조형태는 상호간에 영향을 주며, 궁극적으로 조직유효성에 영향을 주지만 그 내용은 극히 미약한 것으로 나타났으며, 모든 측면에서 조직유효성이 높은 조직은 없는 것으로 분석되었다.

• Advances in aircraft and spacecraft science
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• 제10권6호
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• pp.545-554
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• 2023

The widespread introduction of unmanned aircrafts has led to the understanding of the need to organize a common information space for manned and unmanned aircrafts, which is reflected in the Russian Unmanned aircraft system Traffic Management (RUTM) project. The present article deals with the issues of spatial information database (DB) organization, which is the core of RUTM and provides storage of various data types (spatial, aeronautical, topographical, meteorological, vector, etc.) required for flight safety management. Based on the analysis of functional capabilities and types of work which it needs to ensure, the architecture of spatial information DB, including the base of source information, base of display settings, base of vector objects, base of tile packages and also a number of special software packages was proposed. The issues of organization of these DB, types and formats of data and ways of their display are considered in detail. Based on the analysis it was concluded that the optimal construction of the spatial DB for RUTM system requires a combination of different model variants and ways of organizing data structures.

• 한국실내디자인학회논문집
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• 제15권6호
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• pp.178-187
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• 2006

The purpose of this study was analyze the space organizational characteristics of heath facilities for the elderly in Japan, in order to refer them in establishing the planning direction in Korea. Therefore the 79 architectural drawings, which was gathered through mailed self-reported questionnaires in Japan and standard of heath facilities for the elderly have been analysed for this study. The results of the study were following: The spatial composition was categorized into living space, public use space, nursing, medical treatment, management, provision, and home assistance, and daycare. Moreover, coupling method of respective space was diversity according to inmate satisfaction measurement and form of service. In order to do that, this study has classified type of health facilities into 6 types on the basis of the space of position and space organization characteristics. Therefore study shows the functional relationships of spaces, the proportions of departmental areas in each type.

• Genomics & Informatics
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• 제17권4호
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• pp.36.1-36.6
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• 2019

The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.

• 한국식품과학회지
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• 제45권2호
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• pp.174-179
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• 2013

본 연구에서는 동양배에 함유된 유용성분을 분자수준에서 밝히고자, 우리나라에서 가장 많이 섭취되고 있는 품종 중의 하나인 추황배를 대상으로 배 과피의 MeOH 추출물을 해리성을 이용하여 용매분획하였다. 얻어진 획분들을 대상으로 항산화 활성에 초점을 맞추어 open column chromatography와 high performance liquid chromatography를 행하여 3종의 항산화 화합물을 단리하였다, 그 결과, BuOH 획분으로부터 화합물 1을, EtOAc-산성 획분으로부터 화합물 2를, 그리고 EtOAc-페놀성 획분으로부터 화합물 3을 단리하고, 각각 NMR 및 MS 분석을 행하여 구조해석을 행하였다. 그 결과, 화합물 1-3은 각각 2-carboxyl 4(1H)-quinolinone (kynurenic acid, 화합물 1), cis-coumaric acid (화합물 2), 그리고 vanillin(화합물 3)으로 동정되었다. 이 3종의 화합물 모두 본 연구에 의해 배로부터 처음 동정되었다. 본 연구결과가 배의 유용성 및 기능성 연구를 위한 기초자료로 활용되길 기대한다.

• Genomics & Informatics
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• 제20권1호
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• pp.6.1-6.15
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• 2022

Litorilituus sediminis is a Gram-negative, aerobic, novel bacterium under the family of Colwelliaceae, has a stunning hypothetical protein containing domain called von Hippel-Lindau that has significant tumor suppressor activity. Therefore, this study was designed to elucidate the structure and function of the biologically important hypothetical protein EMK97_00595 (QBG34344.1) using several bioinformatics tools. The functional annotation exposed that the hypothetical protein is an extracellular secretory soluble signal peptide and contains the von Hippel-Lindau (VHL; VHL beta) domain that has a significant role in tumor suppression. This domain is conserved throughout evolution, as its homologs are available in various types of the organism like mammals, insects, and nematode. The gene product of VHL has a critical regulatory activity in the ubiquitous oxygen-sensing pathway. This domain has a significant role in inhibiting cell proliferation, angiogenesis progression, kidney cancer, breast cancer, and colon cancer. At last, the current study depicts that the annotated hypothetical protein is linked with tumor suppressor activity which might be of great interest to future research in the higher organism.

• 한국식품과학회지
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• 제45권5호
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• pp.557-564
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• 2013

본 연구에서는 배의 유용성 증명을 위한 일환으로 배의 화학성분을 분자수준에서 밝히고자 하였다. 이에 배 과피 MeOH 추출물을 용매분획하여 얻은 EtOAc-산성 분획과 EtOAc-중성분획을 대상으로 Sephadex LH-20, silica gel, 그리고 ODS colmn chromatography와 HPLC를 이용하여 정제 및 단리하였다. 그 결과, EtOAc-산성 분획과 EtOAc-중성 분획으로부터 각각 2종씩의 화합물을 단리하였다. 단리된 화합물 1-4는 $^1H$- 및 $^{13}C$-NMR 분석을 통하여 각각 (S)-(+)-2-cis-abscisic acid O-${\beta}$-D-glucopyranosyl ester (화합물 1), 1-[4-O-${\beta}$-D-glucopyranosyl]phenyl ethanone (piceoside, 화합물 2), ${\beta}$-sitosterol (화합물 3), 그리고 ${\beta}$-sitosteryl 3-O-${\beta}$-D-glucopyranoside (화합물 4)로 동정되었다. 단리된 3종의 배당체 화합물(화합물 1, 2, 4)들은 본 연구에 의해 배로부터 처음 동정되었으며, 화합물 3은 추황배로부터 처음 동정되었다. 본 연구결과가 배 함유 성분연구는 물론 배의 기능성 해명 연구에도 추후 중요한 기초자료로 활용되길 기대한다.

• 한국실내디자인학회논문집
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• 제23권4호
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• pp.257-266
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• 2014

This study has been performed to come up with any rational way for responding to the functions of fire-fighting spaces newly required by the changing social paradigms and to seek for the approach to designing fire-fighting spaces by taking into account the psychological and behavioral factors of fire-fighters who are exposed stress of operations. In particular, it is to satisfy any physical and functional requirements as special working-spaces and to reflect the psychological and behavioral approach to the workers who are forced to be at standby for a long time, which is the characteristic of their operation, to designing. Accordingly, for fundamental appreciation of whether or not such space programs as space organization needed for operational function are being practiced actively, the fire-fighting headquarters of Incheon City has been selected for the research. First, in the process of assessing the trend of organizing the space at safety centers for the recent 20 years, those built more than 20 years ago were left out from the space selection for the research. Second, those with less than 20 operators also were excluded. Third, among those completed in the same year, only one was selected, which was to avoid overlapping, with the consideration its regional representative nature for applying the safety centers in the jurisdiction of the headquarters equally. The study was performed through the visits to and the actual inspections by surveys at the selected 119 Safety Centers as well as the reviews of literature based on case studies. And for the assessment of significance, surveys and analysis of reliability and factors were carried out. The actual users of Safety Centers were picked as objects for the assessment of significance of space factors at 119 Safety Centers, which revealed that there are five types of dimensions for factor-analyzing standard with which users estimate any significance, which are "Area of Mobilization Preparation and Return" "Area of Standby" "Area of Working Activities" "Area of Employ Welfare" and "Area of Support".