• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 추계종합학술대회
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• pp.830-833
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• 2007

본 논문에서는 두 개의 17비트 오퍼랜드를 radix-4 Booth's algorithm을 이용하여 곱셈 연산을 수행하는 곱셈기에 대한 효율적인 풀커스텀 디자인에 대한 테스트 방법을 제안하였다. 클럭 속도를 빠르게 하기 위하여 2단 파이프라인 구조로 설계하였고 Wallace tree 부분의 레이아웃을 규칙적으로 하기 위해서 4:2 CSA(Carry Save Adder)를 사용하였다. 회로는 하이닉스반도체의 0.6-um 3-Metal N-well CMOS 공정을 사용하여 칩으로 제작되었다. 제안된 테스트 방법을 사용하여 관찰해야 하는 노드의 수를 약 88% 줄여 효율적으로 고장 시뮬레이션을 수행하였다. 설계된 곱셈기는 9115개의 트랜지스터로 구성되며 코어 부분의 레이아웃 면적은 약 $1135^*1545$ um2 이다. 칩은 전원전압 5V에서 약 24MHz의 클럭 주파수로 동작한다. 제안된 테스트 방법은 풀커스텀 방식의 곱셈기를 비롯한 대부분의 커스텀 설계 회로에 적용이 가능하다.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2007년도 추계종합학술대회
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• pp.518-521
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• 2007

TinyOS기반의 u-헬스케어를 위한 무선센서노드 어플리케이션을 구현하였으며 이를 이용하여 기존의 지속적인 데이터 전송방식과 성능 비교를 하였다. 무선센서노드에서 QRS-complex 넓이와 R-R간격을 이용하여 비정상적인 ECG를 감지하였다. 사용된 ECG 데이터는 MIT/HIB Database 100, 112, 119번을 이용하였다. 정상적인 ECG 데이터를 가지고 있는 100레코드를 기준으로 지속적인 데이터 전송 시 발생되는 패킷량과 전원 소모율을 측정 후, 본 연구에서 구현된 문선센서노드 어플리케이션을 이용하여 각각의 ECG데이터를 이전과 같은 방법으로 성능 평가하여 비교분석 하였다. 비교분석 결과, ECG 데이터 발생량, 전원 소모율이 획기적으로 감소된 것을 알 수 있었다.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.735-743
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• 2017

본 논문은 통합설계교육 방법론에 대한 연구로서 1990년대 물질조직화의 개념으로 작업하였던 건축가들 중 특히 FOA에 집중하여 건축관과 설계방법론을 고찰하고 이를 적용한 수업사례를 중심으로 통합설계교육 방법론으로서의 가능성을 고찰하는 것을 목적으로 한다. FOA의 설계방법론은 프로토타입에서 출발하여 건물을 구성하는 요소를 물질로서 다루고 다이어그램의 위상학적 변환의 과정으로 이들을 조정하고 통합하여 하나의 건물로 일관성 있게 조직화하는 방법이다. 이를 실제 본인이 지도하였던 통합설계스튜디오의 설계방법론으로 적용하여 학생들의 설계과제를 진행하고 이를 분석하였다. 통합설계스튜디오는 대지의 문화적, 역사적 맥락의 이해를 바탕으로 한 설계개념의 추출에서 시작하여, 기본법규사항과 무장애 설계에 대한 이해와 적용을 거쳐, 필요한 기술적 요소들을 적용하고 조정하면서 상세설계까지 발전시키는 것을 교육목표로 삼아 진행되었으며, 학생들은 물질조직화의 방법으로 여러 관련 이론과목에서 배운 지식들을 통합한 설계안을 도출하고자 하였다. 이 과정에서 학생들은 구조, 대지의 역사, 극장 시야각 등을 주요 물질 요소로 삼아 형태를 형성하며 학습한 지식과 설계안을 일관성 있게 통합할 수 있음을 보여주었으며, 이에 FOA의 물질조직화를 기반으로 한 설계방법론은 통합설계방법론으로서의 의의를 갖는다고 판단된다.

• 대한물리치료과학회지
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• 제24권2호
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• pp.45-52
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• 2017

Purpose : Most of the moderns have been spent sedentary life style in front of desk or on the chairs, so that their hamstring muscles are shorted commonly and the shortness of hamstring muscles are caused to some problems in functional activities. The purpose of this study was to compare the effectiveness of thermotherapy with hot-pack and ultrasound on the tightness of hamstring muscles in individuals with hamstring tightness. Method : Twenty-eight persons with hamstring tightness participated in this study. They were randomly assigned to three exercise groups: stretching group(n=10), hot-pack group(n=9), and ultrasound group(n=9). Before experiment, this study measured the angle of hip flexion using a inclinometer in all participants. Stretching group conducted actively stretching on their shorted leg for 30 seconds, 3 times, and rest for 10 seconds between each exercises. Hot-pack group have applied hot-pack($70{\sim}75^{\circ}C$) on shorted hamstring muscles for 20 minutes before stretching exercise. Ultrasound group have applied therapeutic ultrasound(1 MHz and 1.5W/cm2) on shorted hamstring muscles for 10 minutes before stretching exercise. All data was analysed using one-way repeated ANOVA. Result : The results revealed that ultrasound therapy before stretching is more effective to the flexibility on hamstring muscles than hot-pack before stretching and stretching only. Conclusion : The results of this study show that thermotherapy with therapeutic ultrasound will be effective on the shortness of hamstring muscles before stretching exercise.

• 한국응용과학기술학회지
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• 제31권4호
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• pp.759-770
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• 2014

평택시는 우리나라 도시 중에서 가장 역동적으로 변모하고 있는 지역이다. 평택시가 도 농복합도시에서 향후 10년 이내에 인구 100만 명에 이르는 최첨단산업도시로 육성 발전 될 것으로 기대됨으로써 그에 따른 많은 환경오염문제가 발생할 것으로 예상된다. 본 연구에서는 환경인식 설문조사를 통하여 평택시민들의 자연환경에 대한 인식과 자연보존에 대한 태도를 알아보고자 한다. 환경인식 설문조사는 평택시의 22개 읍 면 동(3읍, 6면, 13동) 단위의 주민 자치 단체를 통해 주민 700명을 대상으로 실시하였으며, SPSS 12.0을 사용하여 주민들의 환경문제에 대한 제반 인식을 조사 하였다. 설문조사 결과 평택시민들은 대부분이 환경에 대해 많은 관심을 가지고 있었으며, 자연환경을 훼손하지 않고 잘 보전되는 가운데 조화로운 발전을 이루기를 기대하고 있었다. 이러한 설문조사를 기반으로 본 연구에서는 평택시민들이 갖는 환경현안 중에서 가장 심각하고 중요하게 생각하고 있는 분야에 대해서 그 현황을 기술하고 평택지역의 지속가능한 환경보전을 이루기 위해 그 대안을 제시하고자 한다.

• 대한치과보철학회지
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• 제36권5호
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• pp.701-720
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• 1998

Research advances in dental implantology have led to the development of several different types of materials and it is anticipated that continued research will lead to advanced dental implant materials. Currently used pure titanium has relatively low hardness and strength which may limit its ability to resist functional loads as a dental implant. Ti-6Al-4V also has potential problems such as corrosion resistance. osseointegration properties and neurologic disorder due to aluminium and vanadium, known as highly toxic elements, contained in Ti-6Al-4V. Newly developed titanium based alloys(Ti-20Zr-3Nb-3Ta-0.2Pd-1In, Ti-20Zr-3Nb-3Ta-0.2Pd) which do not contain toxic metallic components were designed by the Korea Institute of Science and Technology (KIST) with alloy design techniques using Zr, Nb, Ta, Pd, and In which are known as non-toxic elements. Biocompatibility and osseointegration properties of these newly designed alloys were evaluated after implantation in rabbit femur for 3 months. The conclusions were as follows : 1. Mechanical properties of the new designed Ti based alloys(Ti-20Zr-3Nb-3Ta-0.2Pd-1In, Ti-20Zr-3Nb-3Ta-0.2Pd) demonstrated close hardness and tensile strength values to Ti-6Al-4V. 2. New desinged experimental alloys showed stable corrosion resistance similar to the pure Ti but better than Ti-6Al-4V. However, the corrosion rate was higher for the new alloys. 3. Cell culture test showed that the new alloys have similar cell response compared with pure Ti and Ti-6Al-4V with no cell adverse reaction. 4. New designed alloys showed similar bone-metal contact ratio and osseointegration properties compared to pure Ti and Ti-6Al-4V after 3 months implantation in rabbit femur. 5. Four different surface treatments of the metals did not show any statistical difference of the cell growth and bone-metal contact ratio.

• Journal of Microbiology and Biotechnology
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• 제27권11호
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• pp.1932-1941
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• 2017

DFC-2, a methyl 5-[2-(dimethylamino)ethoxy]-7,12-dioxo-7,12-dihydrodinaphtho[1,2-b:2',3'-d]furan-6-carboxylate, is reported to have antitubercular effects against Mycobacterium tuberculosis. At concentrations ranging from 0.19 to $0.39{\mu}g/ml$, DFC-2 inhibited both drugusceptible and -resistant strains of M. tuberculosis. Microarray analyses were employed to gain insights into the molecular mechanisms of DFC-2's action in M. tuberculosis. The most affected functional gene category was "lipid biosynthesis," which is involved in mycolic acid synthesis. The decrease in transcription of genes related to mycolic acid synthesis was confirmed by RT-PCR. Furthermore, we found that DFC-2 triggered a reduction in mycolic acid levels, showing a similar pattern to that of mycolic acid synthesis inhibitor isoniazid. These results may explain how this compound kills mycobacteria efficiently by inhibiting mycolic acid synthesis.

• 한국작물학회지
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• 제60권1호
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• pp.97-106
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• 2015

Platycodon grandiflorum, commonly known as Doraji in Korea, has a wide range of pharmacologic properties, such as reducing adiposity and hyperlipidemia, and antiatherosclerotic effects. However, the mechanisms underlying these effects remain unclear. In order to profile proteins from the nodal segment, callus, root and shoot, high throughput proteome approach was executed in the present study. Two dimensional gels stained with CBB, a total of 84 differential expressed proteins were confirmed out of 839 protein spots using image analysis by Progenesis SameSpot software. Out of total differential expressed spots, 58 differential expressed protein spots (${\geq}$ 2-fold) were analyzed using MASCOT search engine according to the similarity of sequences with previously characterized proteins along with the UniProt database. Out of 58 differential expressed protein, 32 protein spots were up-regulated such as ribulose-1,5-bisphosphate carboxylase, endoplasmic oxidoreductin-1, heat stress transcription factor A3, RNA pseudourine synthase 4, cysteine proteinase, GntR family transcriptional regulator, E3 xyloglucan 6-xylosyltransferase, while 26 differential protein spots were down-regulated such as L-ascorbate oxidase precursor, late embryogenesis abundant protein D-34, putative SCO1 protein, oxygen-evolving enhancer protein 3. However, frequency distribution of identified proteins using iProClass databases, and assignment by function based on gene ontology revealed that the identified proteins from the explants were mainly associated with the nucleic acid binding (17%), transferase activity (14%) and ion binding (12%). In that way, the exclusive protein profile may provide insight clues for better understanding the characteristics of proteins and metabolic activity in various explants of the economically important medicinal plant Platycodon grandiflorum.

• Journal of Microbiology and Biotechnology
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• 제16권2호
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• pp.312-317
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• 2006

The chromosomal sprD gene encoding Streptomyces griseus protease D (SGPD), a chymotrypsin-like protease, was disrupted in Streptomyces griseus by insertion of the neomysin-resistance gene. The production of chymotrypsin activity of sprD disruptant was not completely abolished, but delayed by 24 h, compared with that of wild-type strain. The aerial mycelial formation of sprD disruptant was retarded, and specifically the formation of spores was not observed in the central region of colonies. However, normal morphological development into spores was observed in the marginal region of colonies. In addition, the production of yellow pigment that might be dependent on A-factor was also decreased in the sprD disruptant, compared with that of the wild-type strain. Introduction of the sprD gene, which was placed on a high copy-numbered plasmid into S. griseus ${\Delta}sprD$, partially restored the ability of morphological development, and a significant level of sporulation was observed. When the overexpression vector for sprD, pWHM3-D, was introduced in S. griseus, there was no significant change in the chymotrypsin activity or colonial morphology, in contrast to Streptomyces lividans, indicating the presence of a tight regulation system for the overexpression of the sprD gene in S. griseus.

• 식물병연구
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• 제23권1호
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• pp.82-87
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• 2017

During 2012 to 2014, a survey for the presence of viral diseases in yam plants was carried out in a field of the Institute for Bioresources Research in Gyeongsangbuk-do, Korea. A total of 88 leaf samples were collected and tested by reverse transcription polymerase chain reaction using specific primer sets. Eighty-one samples were positive for Broad bean wilt virus 2 (BBWV2), Chinese yam necrotic mosaic virus (ChYNMV), Cucumber mosaic virus (CMV), Japanese yam mosaic virus (JYMV), and Yam mild mosaic virus (YMMV), whereas Yam mosaic virus (YMV) was not detected. Additionally, seven samples were negative for all viruses. Several samples exhibited mixed (double and triple) infections. Three viruses (CMV, JYMV, and YMMV) were detected for the first time in yam plants in Korea. A BLAST search showed that three viruses shared nucleotide identities with CMV-Ca (98%), JYMV-O2 (91%), and YMMV-TG_NH_1 (86%). Thus, our findings confirmed that yam plants cultivated in Korea were infected with multiple viruses with three of these viruses reported for the first time in Korea.