• Archives of Plastic Surgery
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• 제34권2호
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• pp.243-249
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• 2007

Purpose: Posttraumatic nasal deformities might not be corrected adequately by conventional osteotomy techniques when the configuration of the nasal bone has been changed due to malunion. To consistently obtain good aesthetic and functional results, the anatomic reduction of malunion sites of the nasal bone is important. The purpose of this study is to present an osteotomy technique, including refracture along malunion sites and anatomical reduction of a malformed nasal bone, for the correction of a posttraumatic deviated nose. Methods: From March of 2003 to May of 2004, 27 patients, who underwent corrective rhinoplasty for the correction of bony pyramid deviation, were included in this study. Postoperative results of the technique were evaluated objectively at 1 year after surgery regarding nasal midline location, nose symmetry, and nasal contour. Results were rated as excellent, good, fair, or poor. All patients were also evaluated subjectively for cosmetic improvement, changes in breathing, and overall satisfaction. Results: Objective analysis of the outcomes revealed an excellent result in 17 patients(63%), good in 9(33%), and fair in 1 patient(4%). No case evaluated had a poor result. Regarding subjective analysis, 19 patients(70%) evaluated the cosmetic outcome as perfect. Among the 21 patients with preoperative airway problems, 19 patients(90%) reported improved breathing post-operatively. Patients' overall satisfaction levels were also very positive. No postoperative complications occurred during the 14 month mean follow-up period. Conclusion: The osteotomy technique presented in this study is simple, effective, and safe for correcting posttraumatic nasal deviation, and also produces consistent results.

• 정보처리학회논문지D
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• 제16D권4호
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• pp.571-582
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• 2009

본 논문은 구성원들 사이의 자원공유를 원천적으로 봉쇄하는 일반적 협업개발 지원도구의 한계를 극복하고, 조직의 여러 사용자들에게 자원 공유의 기회를 제공함과 동시에 자원공유에서 발생하는 버전관리와 충돌문제를 해결하기 위한 방법을 제시한다. 개발된 소프트웨어 협업개발 지원도구는 전통적인 낙관적 기법을 적용하되 충돌해결에 드는 비용과 노력의 절감을 위한 개선된 알고리즘을 사용한다. 시스템의 구조는 전통적인 Client/Server 방식에 개인간 정보교환을 지원하는 P2P(peer-to-peer) 방식이 결합된 형태로 이루어져 있으며, 공개 소프트웨어인 CVS(Concurrent Version System)를 기반으로 구현되었다. 이를 바탕으로 대표적인 기존 협업개발 지원도구들과의 유용성 비교를 통해 기능적 효율성을 확인하였다.

• Experimental and Molecular Medicine
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• 제50권12호
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• pp.5.1-5.15
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• 2018

Targeting hair follicle regeneration has been investigated for the treatment of hair loss, and fundamental studies investigating stem cells and their niche have been described. However, knowledge of stem cell metabolism and the specific regulation of bioenergetics during the hair regeneration process is currently insufficient. Here, we report the hair regrowth-promoting effect of a newly synthesized novel small molecule, IM176OUT05 (IM), which activates stem cell metabolism. IM facilitated stemness induction and maintenance during an induced pluripotent stem cell generation process. IM treatment mildly inhibited mitochondrial oxidative phosphorylation and concurrently increased glycolysis, which accelerated stemness induction during the early phase of reprogramming. More importantly, the topical application of IM accelerated hair follicle regeneration by stimulating the progression of the hair follicle cycle to the anagen phase and increased the hair follicle number in mice. Furthermore, the stem cell population with a glycolytic metabotype appeared slightly earlier in the IM-treated mice. Stem cell and niche signaling involved in the hair regeneration process was also activated by the IM treatment during the early phase of hair follicle regeneration. Overall, these results show that the novel small molecule IM promotes tissue regeneration, specifically in hair regrowth, by restructuring the metabolic configuration of stem cells.

• 대한원격탐사학회지
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• 제18권1호
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• pp.53-59
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• 2002

The MSC is a payload on the KOMPSAT-2 satellite to perform the earth remote sensing. The instrument images the earth using a push-broom motion with a swath width of 15 km and a GSD(Ground Sample Distance) of 1 m over the entire FOV(Field Of View) at altitude 685 km. The instrument is designed to haute an on-orbit operation duty cycle of 20% over the mission lifetime of 3 years with the functions of programmable gain/offset and on-board image data compression/storage. The MSC instrument has one channel for panchromatic imaging and four channel for multi-spectral imaging covering the spectral range from 450nm to 900nm using TDI(Time Belayed Integration) CCD(Charge Coupled Device) FPA(Focal Plane Assembly). The MSC hardware consists of three subsystem, EOS(Electro Optic camera Subsystem), PMU(Payload Management Unit) and PDTS(Payload Data Transmission Subsystem) and each subsystems are currently under development and will be integrated and verified through functional and space environment tests. Final verified MSC will be delivered to spacecraft bus for AIT(Assembly, Integration and Test) and then COMSAT-2 satellite will be launched after verification process through IST(Integrated Satellite Test). In this paper, the introduction of MSC, the configuration of MSC electronics including electrical interlace and design of CEU(Camera Electronic Unit) in EOS are described. MSC Operation parameters induced from the operation concept are discussed and analyzed to find the influence of system for on-orbit operation in future.

• 한국철도학회논문집
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• 제20권3호
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• pp.349-355
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• 2017

철도시스템의 고장은 운행지연 또는 철도사고의 원인이 될 수 있으며, 철도안전을 확보하기 위하여 높은 신뢰성이 요구된다. 철도시스템은 신뢰도 및 가용도를 높이기 위하여 동일 시스템을 다중으로 구성하여 동작 중인 시스템에 고장이 발생한 경우에 대기 시스템이 정상 동작을 수행하도록 설계한다. 일반적으로 시스템의 신뢰도는 시스템을 구성하는 각 요소의 신뢰도를 사용하여 분석하며, 시스템간의 물리적, 기능적, 프로세스적 독립이 보장되지 않는 다중 시스템의 경우는 다중 시스템에 동시에 고장을 유발하는 공통원인고장을 고려하여야 한다. 본 논문에서는 철도 시스템에서 사용되고 있는 대기 이중계 시스템에 대하여 각 시스템이 독립일 경우와 공통원인고장을 고려한 종속일 경우에 대한 신뢰도를 분석하였다. 신뢰도 분석을 위하여 다중계 구조의 다양성과 시스템 상태 전이별로 모델링이 가능한 마코브 모델을 사용하였으며, 공통고장모드의 분석 유무의 차이점 평가를 통해 시스템 신뢰도평가의 정확도 향상 방안을 제시한다.

• The Korean Journal of Physiology and Pharmacology
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• 제23권3호
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• pp.191-201
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• 2019

The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic receptor activation and extracellular pH change and inhibited by the protein kinase C pathway. Recent studies have also suggested that TRPC5 is extracellularly activated by englerin A (EA), but the mechanism remains unclear. The purpose of this study is to identify the EA-interaction sites in TRPC5 and thereby clarify the mechanism of TRPC5 activation. TRPC5 channels are over-expressed in human embryonic kidney (HEK293) cells. TRPC5 mutants were generated by site-directed mutagenesis. The whole-cell patch-clamp configuration was used to record TRPC5 currents. Western analysis was also performed to observe the expression of TRPC5 mutants. To identify the EA-interaction site in TRPC5, we first generated pore mutants. When screening the mutants with EA, we observed the EA-induced current increases of TRPC5 abolished in K554N, H594N, and E598Q mutants. The current increases of other mutants were reduced in different levels. We also examined the functional intactness of the mutants that had no effect by EA with TRPC5 agonists, such as carbachol or $GTP{\gamma}S$. Our results suggest that the three residues, Lys-554, His-594, and Glu-598, in TRPC5 might be responsible for direct interaction with EA, inducing the channel activation. We also suggest that although other pore residues are not critical, they could partly contribute to the EA-induced channel activation.

• 한국소프트웨어감정평가학회 논문지
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• 제17권1호
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• pp.67-73
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• 2021

본 논문에서는 리눅스 기반 프로그래밍 언어를 온라인으로 실습할 수 있는 시스템의 구성 방법을 제시하였다. 제시한 시스템은 리눅스 운영체제의 가장 큰 특징인 웹-서버 기능을 활용하며, 방화벽이나 기타 보안적 제약을 받지 않으면서 telnet과 FTP 기능을 모사하여 실제 리눅스 콘솔과 유사한 실습이 가능하다. 이를 위해 웹 상에서 프로그래밍 도구가 가져야 할 기능적 요소들을 분석하고 이를 구현하기 위한 알고리즘을 정립하였으며, 특히 사용자의 실수에 의한 오류 메시지 등이 실재 telnet 화면과 동일한 형태로 나타날 수 있는 방법을 구현하였다. 구현된 학습 시스템을 학생들을 대상으로 수업에 활용한 결과 온라인으로 리눅스 프로그래밍 언어의 실습이 가능함은 물론 교수자가 학습자들의 모든 사항들을 직접 점검하고 지도할 수 있어 학습자의 만족도가 오프라인 수업 때와 유사한 결과를 확인하였다.

• Structural Engineering and Mechanics
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• 제85권3호
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• pp.289-304
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• 2023

The main objective of this paper is to study the effect of porosity on the buckling behavior of thick functionally graded sandwich plate resting on various boundary conditions under different in-plane loads. The formulation is made for a newly developed sandwich plate using a functional gradient material based on a modified power law function of symmetric and asymmetric configuration. Four different porosity distribution are considered and varied in accordance with material propriety variation in the thickness direction of the face sheets of sandwich plate, metal foam also is considered in this study on the second model of sandwich which containing metal foam core and FGM face sheets. New quasi-3D high shear deformation theory is used here for this investigate; the present kinematic model introduces only six variables with stretching effect by adopting a new indeterminate integral variable in the displacement field. The stability equations are obtained by Hamilton's principle then solved by generalized solution. The effect of Pasternak and Winkler elastic foundations also including here. the present model validated with those found in the open literature, then the impact of different parameters: porosities index, foam cells distribution, boundary conditions, elastic foundation, power law index, ratio aspect, side-to-thickness ratio and different in-plane axial loads on the variation of the buckling behavior are demonstrated.

• Archives of Plastic Surgery
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• 제50권6호
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• pp.578-585
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• 2023

An artificial sphincter implanted in the bulbous urethra to treat severe postprostatectomy urinary incontinence is effective, but embedding-associated complications can occur. We assessed the feasibility, efficacy, and safety of urethral graciloplasty cross-innervated by the pudendal nerve. A simulation surgery on three male fresh cadavers was performed. Both ends of the gracilis muscle were isolated only on its vascular pedicle with proximal end of the obturator nerve severed and transferred to the perineum. We examined whether the gracilis muscle could be wrapped around the bulbous urethra and whether the obturator nerve was long enough to suture with the pudendal nerve. In addition, surgery was performed on a 71-year-old male patient with severe urinary incontinence. The postoperative 12-month outcomes were assessed using a 24-hour pad test and urodynamic study. In all cadaveric simulations, the gracilis muscles could be wrapped around the bulbous urethra in a γ-loop configuration. The length of the obturator nerve was sufficient for neurorrhaphy with the pudendal nerve. In the clinical case, the postoperative course was uneventful. The mean maximum urethral closure pressure and functional profile length increased from 40.7 to 70 cm H₂O and from 40.1 to 45.3 mm, respectively. Although urinary incontinence was not completely cured, the patient was able to maintain urinary continence at night. Urethral graciloplasty cross-innervated by the pudendal nerve is effective in raising the urethral pressure and reducing urinary incontinence.

• 대한치과보철학회지
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• 제46권1호
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• pp.1-11
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• 2008

현대 치의학에서는 환자의 심미적 만족을 충족시키기 위한 지속적인 관심으로 완전 도재관의 발전을 가져왔다. 최근의 연구 결과들은 완전 도재관의 물리적 성질과 마모 저항성, 색조의 안정성 등을 보고하고 있다. 이와 같이 여러 장점이 많음에도 불구하고 아직 파절에 대한 저항성에는 많은 의문점을 내포하고 있다. 구강 내에서 기능적인 교합력은 수복물의 변연에 응력을 주게된다. 이러한 응력은 주변 조직으로 잘 분산되어져야 하는데, 수복물의 변연 형태에 따라 다른 양상을 보여주게 된다. 변연 형태는 수복물의 부피와 모양, 그리고 변연에서의 적합도에도 영향을 주게 된다. 본 연구에서는 완전 도재관에서의 변연 형태에 따른 응력 분포를 3차원 유한 요소 분석법을 이용하여 조사하였다. 상악 중절치가 기본 모델로 사용되었고, 완전 도재관을 재현하였다. 변연 형태로는 $90^{\circ}$ shoulder, $110^{\circ}$ shoulder, $135^{\circ}$ shoulder형태를 부여하고, 100N의 힘을 치축에 $45^{\circ}$ 방향으로 가하였다. 그 결과 도재 내부의 응력 분포는 $90^{\circ}$, $110^{\circ}$ 모델에 비해 변연 각도가 $135^{\circ}$인 모델의 경우가 응력의 분포가 고르게 나타났다. 그러나 변연에서는 $90^{\circ}$와 $110^{\circ}$ 모델의 응력보다 조금 더 집중되었다. $90^{\circ}$와 $110^{\circ}$ 모델의 비교시는 대체로 비슷했다. 알루미나 코아 내부의 응력 분포에서도 또한 $135^{\circ}$인 모델이 $90^{\circ}$와 $110^{\circ}$ 모델의 응력분포보다 더 잘 분포되었다. $90^{\circ}$와 $110^{\circ}$ 모델의 비교시는 $110^{\circ}$가 $90^{\circ}$ 모델에 비해 더 좋은 응력분포를 보였다. 알루미나 코아와 접착제 사이의 계면에서는 응력이 변연으로 갈수록 감소하고, 알루미나 코아와 도재 사이의 계면에서는 변연으로 갈수록 응력이 점차 증가하였다. $135^{\circ}$ shoulder는 고른 응력분포임에도 변연에서의 응력 집중이 나타나므로 완전 도재관의 변연으로는 적절하지 못하며, $90^{\circ}$ shoulder보다 상대적으로 좋은 응력분포와 변연 형성의 용이성이 우세한 $110^{\circ}$ shoulder가 완전 도재관의 변연에 추천될 수 있겠다.