• Archives of design research
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• v.15 no.4
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• pp.177-188
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• 2002

A thousands of chairs have designed from the Victorian era to the present. Thonet's Nol4 chair in 1859, Wright's high-back chair in 1904, Ritveld's red/blue chair in 1917, Breuer's Wassily chair in 1925, Aalto's Paimio chair in 1932, Eames's DAR chair in 1948, Piero Gatti's Sacco chair in 1969, Starck's Von Volgelsang chair in 1984, Stumpf's Aeron Chair in 1992, Little's 'Coat of arms' chair in 1994 - the list of architects who have seized the opportunity to express their theories in the design of a chair is seemingly endless. Architects such as Machintosh(1868-1928), Wright(1807-1959), Aalto(1898-1976) included chairs within their artistic schemes for interiors and buildings. But as the manufacture of chairs moved away from the domain of the craftsman towards that of the industrial process, architects were also ideally positioned, with their background knowledge of engineering, to pioneer innovative chair design within the constraints of modern manufacturing technology. Beyond matters of function and structure, the fundamental worth of chairs, past or present, lies in their communication of attitudes, ideas and values. The persuasiveness of a chair depend on the clarity of its rhetoric. Chair has become an ideal medium for designers to make their visual statements and construct their individual manifestos. In chair design there is a ping-pong game played out between absurd and useful design, and this game is one way in which the design profession explores itself.

• Journal of Korea Technology Innovation Society
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• v.17 no.1
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• pp.95-123
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• 2014

Recently, as the role of science and technology in social domain is more increased and the creative economy becomes a important matter in national development strategy, it is necessary that the improvement of legal system on science and technology for efficiently responding to paradigm shift into Innovation driven science and technology policy. Especially, The Framework Act On Science And Technology as a general and basic norm on science and technology policy is necessary to revise in systematic and substantial aspect in order to correspond with changed environment and current of the times. The Framework Act On Science And Technology was established in 2001 and revised several times, but substantial amendment reflecting the political facts as the need to demand was insufficient because it was revised only related with restructuring the government organization and changing the S&T Policy Coordinating Committee system. And therefore, this paper aims to review the problems and complementary factors and suggest the improvement draft on The Framework Act On Science And Technology. According to study, the revision methodologies are following : first, the Chapter and Paragraph of the law should be restructured to improve the systemicity, next the comprehensiveness, effectiveness, connections with related special laws and compatibility of the law should be complemented by adding the new provision or amending the inadequate provision to improve the position and function as a general and basic norm.

• KIPS Transactions on Computer and Communication Systems
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• v.6 no.6
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• pp.281-288
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• 2017

In Smart-cities, various types of integrated services must be linked to provide services to applications. Therefore, flexibility must be ensured between services so that various services can be efficiently provided. In order to secure the flexibility among services, it is very important to have a function to dynamically discover and invoke a desired service by searching for a semantic service by reflecting a recognized context through real-time context-aware in smart-cities. To date, quite a number of semantic service discovery techniques have been developed. However, they have not been verified as suitable for use in the smart-city domain. In this study, we tried to verify the existing ones to use a suitable one. We tested most of existing semantic service discovery techniques, but we found that none of them is suitable to our research. Therefore, we developed our own semantic service discovery technique. This paper introduces our work and presents the performance evaluation results that demonstrate that our developed works well and show good performance. For the performance evaluation, the experimental system was actually constructed and the real performance was measured. In the experiment, we implemented the semantic service discovery scenario that dynamically searches and calls the services needed to provide fire accident management services in smart cities.

• IMMUNE NETWORK
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• v.6 no.4
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• pp.192-198
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• 2006

Background: Investigating strategy to enhance efficiency of gene transfer via adenovirus is critical to sustain gene expression in targeted cells or tissues to regulate immune responses. However, the use of adenovirus as a gene delivery method has been limited by the native tropism of the virus. In this study, the critical parameter is to improve the efficient binding of viral particles to the plasma membrane prior to cellular uptake. Methods: Human immunodeficiency virus (HIV-1) trans-acting activator of transcription (TAT), a protein transduction domain, was fused to the ectodomain of the coxsackie-adenovirus receptor (CAR). The CAR-TAT protein was produced from a Drosophila Schneider 2 cells (S2) transfected with CAR-TAT genes. The function of CARTAT was analyzed the efficiency of adenoviral gene transfer by flow cytometry, and then immunizing AdVGFP with CAR-TAT was transduced on dendritic cells (DCs). Results: S2 transfectants secreting CAR-TAT fusion protein has been stable over a period of 6 months and its expression was verified by western blot. Addition of CAR-TAT induced higher transduction efficiency for AdVGFP at every MOI tested. When mice were vaccinated with DC of which adenoviral transduction was mediated by CAR-TAT, the number of IFN-${\gamma}$ secreting T-cells was increased as compared with those DCs transduced without CAR-TAT. Conclusion: Our data provide evidence that CAR-TAT fusion protein enhances adenoviral transduction and immunogenecity of transgenes on DCs and may influence on the development of adenoviral-mediated anti-tumor immunotherapy.

• Journal of the Korean Magnetics Society
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• v.1 no.2
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• pp.60-68
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• 1991

In compacting the melt-spun $Nd_{14}Fe_{76}Co_{4}B_{6}$ and $Nd_{10.5}Fe_{79}Co_{2}Zr_{15}B_{7}$ magnetic powders. the difference in composition induces a different behavior of closed packing rate as a function of aspect ratio of the powders. The $Nd_{10.5}Fe_{79}Co_{2}Zr_{1.5}B_{7}$ alloy having a low Co/Fe ratio (low density) shows the better green density to have an enhanced closed packing rate. An empirical power equation relating the green density with the compacting pressure was obtained such as ${\phi}(g/cm^{2})=5.2~5.6{\times}P^{0.045~0.065}(ton/cm^{2})$. The $Nd_{14}Fe_{76}Co_{4}B_{6}$ alloy having a high Nd/Fe ratio possesses much finer grain size(50~60 nm) than that of $Nd_{10.5}Fe_{79}Co_{2}Zr_{1.5}B_{7}$ alloy and shows the higher coercivity($iH_{c}=14~15kOe$). The higher Nd/Fe ratio in the melt-spun Nd-Fe-Co-B alloy, where the domain wall pinning mechanism was found to be predominant, assists the formation of Nd-rich grain boundary phase acting as a pinning site. The grain boundary ranges over $12~16\;{\AA}$ thick in the Nd-Fe-Co-B alloy while it ranges over $8~12\;{\AA}$ thick in the Nd-Fe-Co-Zr-B alloy.

• Journal of the Korean Geotechnical Society
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• v.27 no.5
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• pp.85-92
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• 2011

The dynamic behavior of piles becomes very complex due to soil-pile dynamic interaction, soil non-linearity, resonance phenomena of soil-pile system and so on. Therefore, the proper numerical simulation of the pile behavior needs much effort and calculation time. In this research, a new modeling method, which can be applied to the conventional finite difference analysis program FLAC 3D, was developed to reduce the calculation time. The soil domain in this method is divided into a near-field region and a far-field region, which is not influenced by the soil-pile dynamic interaction. Then, the ground motion of the far-field is applied to the boundaries of the near-field instead of modeling the far-field region as finite meshes. In addition, the soil non-linearity behavior is modeled by using the hysteretic damping model, which determines the soil tangent modulus as a function of shear strain and the interface element was applied to simulate the separation and slip between the soil and pile. The proposed method reduced the calculation time by as much as one third compared with a usual modeling method and maintained the accuracy of the calculated results. The calculated results by the proposed method showed a good agreement with the prototype pile behavior, which was obtained by applying a similitude law to the 1-g shaking table test results.

• Journal of Environmental Science International
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• v.19 no.11
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• pp.1423-1436
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• 2010

The effects of meteorological and reclaiming conditions on the reduction of suspended particles are investigated using a computational fluid dynamics (CFD) model with the k-$\varepsilon$ turbulence closure scheme based on the renormalization group (RNG) theory. Twelve numerical experiments with different meteorological and reclaiming conditions are performed. For identifying the meteorological characteristics of the target area and providing the inflow conditions of the CFD model, the observed data from the automatic weather station (AWS) near the target area is analyzed. Complicated flow patterns such as flow distortion, horse-shoe vortex, recirculation zone, and channeling flow appeared due to the topography and buildings in the domain. Specially, the flow characteristics around the reclamation area are affected by the reclaiming height, reclaiming size and windbreak height. Reclaiming height affected the wind speed above the reclaiming area. Windbreak induces more complicated flow patterns around the reclaiming area as well as within the reclaiming area. In front of the windbreak, flow is distorted as it impinges on the windbreak. As a result, upward flow is generated there. Behind the windbreak, a secondary circulation, so called, a recirculation zone is generated and flow is reattached at the end of the recirculation zone (reattachment point). At the lower part of the recirculation zone, there is a reverse flow toward the windbreak. Flow passing to the reattachment point starts to be recovered. Total amounts of suspended particles are calculated using the frictional and threshold frictional velocities, erosion potential function, and the number of surface disturbance. In the case of a 10 m-reclaiming and northerly wind, the amount of suspended particles is largest. In the presence of 5 m windbreak, the friction velocity above the reclaiming area is largely reduced. As a result, the total amount of the suspended particles largely decreases, compared to the case with the same reclaiming and meteorological conditions except for the windbreak The calculated suspended particle amounts are used as the emission rate of the dispersion model simulations and the dispersion characteristics of the suspended particles are analyzed.

• Journal of Korea Game Society
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• v.9 no.5
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• pp.25-41
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• 2009

The objective of this study is to develop an analytic framework to code systematically the gamer's behaviour in MMO(Massively Multi-player Online) gameplay experience, to explore their gameplay as a problem solving procedure empirically. Previous studies about model human processor, content based protocol, and procedure based protocol are reviewed in order to build the outline of the analytic framework related to MMO gameplay. The specific gameplay actions and contents were derived by using concurrent protocol analysis method through the empirical experiment executed in MMORPG gameplay. Consequently, gameplay are divided into six actions : kinematics, perception, function, representation, simulation, and rule (heuristics, following, and transcedence). The analytic framework suitable for MMO gameplay was built. As a result of this study, we found three rule spaces in the problem solving domain of gameplay that are an heuristics, a following of the rule, and a transcendence of the rule. 'Heuristics' denotes the rule action that discovers the rule of game through trial-and-error. 'Following' indicates the rule action that follows the rule of game embedded in game by game designers. 'Transcendence' presents the rule action that transcends that. The new discovered rule spaces where 'Following' and 'Transcendence' actions occur and the gameplay pattern in them is provided with the key basis to determine the level design elements of MMO game, such as terrain feature, monster attribute, item, and skill et cetera. Therefore, this study is concludes with key implications to support game design to improve the quality of MMO game product.

• BMB Reports
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• v.47 no.10
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• pp.569-574
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• 2014

Heme oxygenase-1 (HO-1) degrades heme to carbon dioxide, biliverdin, and $Fe^{2+}$, which play important roles in various biochemical processes. In this study, we examined the protective function of HO-1 against oxidative stress in SH-SY5Y cells and in a Parkinson's disease mouse model. Western blot and fluorescence microscopy analysis demonstrated that PEP-1-HO-1, fused with a PEP-1 peptide can cross the cellular membranes of human neuroblastoma SH-SY5Y cells. In addition, the transduced PEP-1-HO-1 inhibited generation of reactive oxygen species (ROS) and cell death caused by 1-methyl-4-phenylpyridinium ion ($MPP^+$). In contrast, HO-1, which has no ability to transduce into SH-SY5Y cells, failed to reduce $MPP^+$-induced cellular toxicity and ROS production. Furthermore, intraperitoneal injected PEP-1-HO-1 crossed the blood-brain barrier in mouse brains. In a PD mouse model, PEP-1-HO-1 significantly protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced toxicity and dopaminergic neuronal death. Therefore, PEP-1-HO-1 could be a useful agent in treating oxidative stress induced ailments including PD.

• Journal of Digital Convergence
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• v.15 no.8
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• pp.455-463
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• 2017

Background/Objectives: The purpose of the study is to derive a goal usable in the field by exploring the case management success experiences of case managers. Civil case managers state that what is still important in case management practice is qualitative change made in the practice process. Therefore, the study will deal with detailed contents about case management that civil domain case managers consider to be important. Methods/Statistical analysis: For data collection, the study used focus group interview on 20 professional case management social workers and used Grounded theory method by Glaser for data analysis. The analysis of collected data consisted of a process of finding the categories and characteristics of the research problem. Findings: As a result of analysis, 4 categories, 10 subcategories, and 25 elements were derived for success experiences of case management practice. The categories were divided into satisfaction and ability improvement of client, case manager ability improvement, establishment of organization and environment function, and multilateral trust relationship strengthening. Improvements/Applications: The results of this study further clarified the goal of field case management practice and it was suggested as a plan to reflect on future case management related institutions evaluation.