• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3805-3809
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• 2014

Background: In Mexico, breast cancer (BCa) is the leading type of cancer in women. Cytochrome P450 (CYP450) is a superfamily of major oxidative enzymes that metabolize carcinogens and many antineoplastic drugs. In addition, these enzymes have influence on tumor development and tumor response to therapy. In this report, we analyzed the protein expression in patients with BCa and in healthy women. Links with some clinic-pathological characteristic were also assessed. Materials and Methods: Immunohistochemical analyses were conducted on 48 sets of human breast tumors and normal breast tissues enrolled in Hospital Militar de Especialidades de la Mujer y Neonatologia and Hospital Central Militar, respectively, during the time period from 2010 to 2011. Informed consent was obtained from all participants. Statistical analysis was performed using ${\chi}^2$ or Fisher exact tests to estimate associations and the Mann Whitney U test for comparison of group means. Results: We found a significant CYP3A4 overexpression in BCa stroma and gland regions in comparison with healthy tissue. A significant association between protein expression with smoking, alcoholism and hormonal contraceptives use was also observed. Additionally, we observed estrogen receptor (ER) and progesterone receptor (PR) positive association in BCa. Conclusions: We suggest that CYP3A4 expression promotes BCa development and can be used in the prediction of tumor response to different treatments. One therapeutic approach may thus be to block CYP3A4 function.

• Proceedings of the Korea Contents Association Conference
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• 2005.05a
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• pp.107-111
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• 2005

As Internet grows rapidly and next electronic commerce applications increase, the security is getting more important. Information security to provide secure and reliable information transfer is based on cryptography technique. The proposed ISEED(Improved SEED) algorithm based on block cryptography algorithm which belongs to secret-key algorithm. In terms of efficiency, the round key generation algorithm has been proposed to reduces the time required in encryption and decryption. The algorithm has been implemented as follow. 128-bit key is divided into two 64-bit group to rotate each of them 8-bit on the left side and right side, and then basic arithmetic operation and G function have been applied to 4-word outputs. In the process of converting encryption key which is required in decryption and encryption of key generation algorithm into sub key type, the conversion algorithm is analyzed. As a result, the time consumed to encryption and decryption is reduced by minimizing the number of plain text required differential analysis.

• Journal of Korean Neurosurgical Society
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• v.39 no.2
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• pp.130-135
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• 2006

Objective : After ischemic stroke, partial recovery of function frequently occurs and may depend on the plasticity of axonal connections. Here, we examine whether blockade of the Nogo/NogoReceptor[NgR] pathway might enhance axonal sprouting and thereby recovery after focal brain infarction. Methods : Adult male Sprague Dawley rats weighing $250{\sim}350g$ were used. Left middle cerebral artery occlusion[MCAO] was induced with a intraluminal filament. An osmotic mini pump [Alzet 2ML4, Alza Scientific Products, Palo Alto, CA] for the infusion of NgR-Ecto[310]-Fc to block Nogo/NgR pathway was implanted 1 week after cerebral ischemia. Prior to induction of ischemia, all animals received training in the staircase and rotarod test. Two weeks after biotin dextran amine injection, animals were perfused transcardially with PBS, followed by 4% paraformadehyde/PBS solution. Brain and cervical spinal cord were dissected. Eight coronal sections spaced at 1mm intervals throughout the forebrain of each animal with cresyl violet acetate for determination of infarction size. Images of each section were digitized and the infarct area per section was measured with image analysis software. Results : Histological examination at 11 weeks post-MCAO demonstrates reproducible stroke lesions and no significant difference in the size of the stroke between the NgR[310]Ecto-Fc protein treated group and the control group. Behavioral recovery is significantly better and more rapid in the NgR-Ecto[310]-Fe treated group. Blockade of NgR enhances axonal sprouting from the uninjured cerebral cortex and improves the return of motor task performance. Conclusion : Pharmacological interruption of NgR allows a greater degree of axonal plasticity in response this is associated with improved functional recovery of complicated motor tasks.

• Korean Journal of Microbiology
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• v.38 no.4
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• pp.203-203
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• 2002

Cytomegalovirus (CMV), a beta-herpesvirus with worldwide distribution, exhibits host persistence, a distinguishing characteristic of all herpesviruses. This persistence is dependent upon restricted gene expression in infected cells as well as the ability of productively infected cells to escape from normal cell-mediated anti-viral immunosurveillance. Type I (IFN-α/β) and type II (IFN-γ) interferons are major components of the innate defense system against viral infection. They are potent inducers of MHC class I and II antigens and of antigen processing proteins. Additionally, IFNS mediate direct antiviral effects through induction effector molecules that block viral infection and replications such as 2′, 5-oligoadenylate synthetase (2, 5-OAS). IFNS function through activation of well-defined signal transduction pathways that involve phosphorylation of constituent proteins and ultimate formation of active transcription factors. Recent studies have shown that a number of diverse viruses, including CMV, EBV, HPV mumps and Ebola, are capable of inhibiting IFN-mediated signal transduction through a variety of mechanisms. As an example, CMV infection inhibits the ability of infected cells Is transcribe HLA class I and II antigens as well as the antiviral effector molecules 2, 5-OAS and MxA I. EMSA studies have shown that IFN-α and IFN-γ are unable to induce complete signal transduction in the presence of CMV infection, phenomena that are associated with specific decreases in JAKl and p48. Viral inhibition of IFN signal transduction represents a new mechanistic paradigm for increased viral survival, a paradigm predicting widespread consequences in the case of signal transduction factors common to multiple cytokine pathways.

• Journal of the Institute of Convergence Signal Processing
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• v.2 no.2
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• pp.13-19
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• 2001

The conventional fractal decoding was required a vast amount computational complexity, since every range blocks was implemented to IFS(iterated function system). In order to improve this, it has been suggested that each range block was classified to iterated and non-iterated regions. Non-iterated regions is called data dependency region, and if data dependency region extended, IFS regions are contractive. In this paper, a searched region of the domain is limited to the range regions that is similar with the domain blocks, and the domain region is more overlapped. As a result, data dependency region has maximum region, that is IFS regions can be minimum region. The minimizing method of domain region is defined to minimum domain(MD) which is minimum IFS region. Using the minimizing method of domain region, there is not influence PSNR(peak signal-to-noise ratio). And it can be performed a fast decoding by reducing the computational complexity for IFS in fractal image decoding.

• Journal of Information Management
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• v.21 no.2
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• pp.9-23
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• 1990

CD-ROM technique, not more than 10 years after development, goes through rapid growth, has been taken advantage of several practical application parts. Needless to say about bibliographic data, numeric value, the phonetics, an image and a picture data that are recorded as abstract or full text, and offered and applied to industry, information service including library, it can be used for library staffs, information retrieval. Escape from the need of one disc drive and one computer to access one disc, now we organize an ideal system that can be retrieved several CD-ROM used only one drive, several users can access several information, so networking is possible through LAN. In this article, we studied the function and type, characteristics, system, structure, data block, production procedure, standardization of CD-ROM LAN.

• Journal of Biomedical Engineering Research
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• v.20 no.6
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• pp.573-581
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• 1999

Although phonocardiography by auscultation has been used in diagnosis long time ago, recognition of heart sound was tried only restricted fields such as the first heart sound, the second heart sound, and specific valve operation for the purpose of analyzing local function or operation of heart and developments of heart sound recognition in full cycle are quite insignificant. in this paper, we proposed a recognition method which extracts features of heart sound in full cycle and classllies heart sounds This proposed recognition algorithm is based on detecting the first and second heart sounds in thme domain. The algorithm classifics heart sound into several classes by extracting the important time blocks and analyzing the peak position, integration values and statistical variables. Heart sounds are classified into normal, early systolic murmur, late systolic mumur, early diastolic murmur, late diastolie murmur, continuous murmur. We can verify our algorithm is useful from the results which show the average recognition rate of heart sounds is 88 perecnt. Recognition error was occurred mainly in early systolic murmur.

• Archives of Plastic Surgery
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• v.37 no.1
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• pp.95-98
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• 2010

Purpose: One of the most common cause of upper extremity lymphedema is breast cancer surgery. We experienced the nerve entrapment syndrome which was associated with postmastectomy lymphedema. To the best of our knowledge, this is the first case report of lymphedema induced nerve entrapment syndrome on upper extremity in Korea. Methods: A 54-year-old woman presented with a tingling sensation on her right hand, which had been present for 1 year. On her history, she had a postmastectomy lymphedema on her right upper extremity for 20 years. Initial electromyography (EMG) showed that the ampulitude of the median, ulnar, and dorsal ulnar cutaneous nerve were decreased, and conduction block was also seen in median nerve across the wrist. In needle EMG, incomplete interference patterns were observed in the muscles innervated by median and ulnar nerves. In conclusion, electrophysiologic study and clinical findings suggested right median and ulnar neuropathy below the elbow. Therefore, we performed surgical procedures, which were release of carpal tunnel, Guyon's canal, and cubital tunnel. Results: The postoperative course was uneventful until the first two years. The tingling sensation and claw hand deformity were improved, however, the motor function decreased progressively. In 7 years after the operation, patient could not flex her wrist and thumb sufficiently. EMG which was performed recently showed that ulnar motor response was of low ampulitude. Moreover, median, ulnar, dorsal ulnar cutaneous, lateral antecubital cutaneous and median antebrachial cutaneous sensory response were unobtainable. Abnormal spontaneous activities were observed in upper arm muscles. In conclusion, multiple neuropathies were eventually developed at above elbow level. Conclusion: On treating nerve entrapments associated with lymphedema, medical professionals should be fully aware of the possibility of unpredictable results after the surgery, because of the pathophysiologic traits of chronic lymphedema.

• Applied Chemistry for Engineering
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• v.21 no.5
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• pp.570-574
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• 2010

The main function of conventional insulation materials is only to block the heat transfer and reduce heat loss from the building. On the other hand, thermal storage materials can work as an energy saver by absorbing or emitting heat within a specific temperature range. Thermal storage materials for building can maintain a constant temperature by effectively regulating the cycle of indoor temperature. As a result, we can enhance the performance of a cooling and heating system efficiently. In this study, phase change materials (PCMs) were added as thermal storage materials into gypsum boards which are extensively used for building material and we found out the thermal environmental characteristics. In addition, we checked out some problems when applying the thermal storage materials to buildings. Finally, This study set out to examine the degree of environmental-friendly characteristics of thermal storage building materials by analyzing the amount of TVOC and HCHO contents with the possibility of pollutants emission.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.24 no.4
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• pp.172-179
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• 1988

A cartridge type hydraulic logic valve consists of simple two port valve whose poppet is closed or opened by means of pressure signal of a pilot line. Accordingly, the logic valve can be used not only for direction, flow and pressure control purpose but also for versatile function valve which enables all above mentioned functions. In addition, the valve has little internal leakage and pressure loss, superior response characteristics and easiness in making small block type valve. The above mentioned good performances being recognized recently, the logic valve has been used widely in the large scale hydraulic system such as a hydraulic press system, for the performance requirements of high speed operation and precise control characteristics. However, there are scarce reports until now, except for a few ones from Aachen Institute of Technology in West Germany, so it is necessary to be studied on development and investigation for practical application. This paper showed that the static and dynamic characteristics of a logic valve when the logic valve is used for directional control, to investigate the relations between the valve operating characteristics and the valve design conditions. From the above mentioned procedure, it was ascertained that the valve operation characteristics obtained by numerical analysis showed good agreements with experimental results. The representative results obtained are as follows; 1. During the valve is closing, the poppet velocity is almost constant in the logic valve. 2. The pilot pressure P sub(3) and the resistance R in the pilot line have much influences on the valve operation time. 3. Spring strength have not such a severe influence on the valve operating time. 4. The operation characteristics of the logic valve can be estimated with good accuracy comparatively by numerical analysis with the equations describing poppet motion.