• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.402-417
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• 2023

Objective: Liver fibrosis is a highly conserved wound-healing response and the final common pathway of chronic inflammatory injury. This study aimed to evaluate the potential anti-fibrotic effect of the combination of Rhei Radix et Rhizoma water extract (RW) and silymarin in a thioacetamide (TAA)-induced liver fibrosis model. Methods: The liver fibrosis mouse model was established through the intraperitoneal injection of TAA (1 week 100 mg/kg, 2-3 weeks 200 mg/kg, 4-8 weeks 400 mg/kg) three times per week for eight weeks. Animal experiments were conducted in five groups; Normal, Control (TAA-induced liver fibrosis mice), Sily (silymarin 50 mg/kg), RSL (RW 50 mg/kg+silymarin 50 mg/kg), and RSH (RW 100 mg/kg+silymarin 50 mg/kg). Biochemical analyses were measured in serum, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), malondialdehyde (MDA), and ammonia levels. Liver inflammatory cytokines and fibrous biomarkers were measured by Western blot analysis, and liver histopathology was evaluated through tissue staining. Results: A significant decrease in the liver function markers AST and ALT and a reduction in ammonia and total bilirubin were observed in the group treated with RSL and RSH. Measurement of reactive oxygen species and MDA revealed a significant decrease in the RSL and RSH administration group compared to the TAA induction group. The expression of extracellular matrix-related proteins, such as transforming growth factor β1, α-smooth muscle actin, and collagen type I alpha 1, was likewise significantly decreased. All drug-administered groups had increased matrix metalloproteinase-9 but a decreasing tissue inhibitor of matrix metalloproteinase-1. RSL and RSH exerted a significant upregulation of NADPH oxidase 2, p22^phox, and p47^phox, which are oxidative stress-related factors. Furthermore, pro-inflammatory proteins such as cyclooxygenase 2 and interleukin-1β were markedly suppressed through the inhibition of nuclear factor kappa B activation. Conclusions: The administration of RW and silymarin suppressed the NADPH oxidase factor protein level and showed a tendency to reduce inflammation-related enzymes. These results suggest that the combined administration of RW and silymarin improves acute liver injury induced by TAA.

• Convergence Security Journal
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• v.22 no.2
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• pp.131-141
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• 2022

Future battlefield domains are expanding to ground, sea, air, space, and cyber, so future military operations are expected to be carried out simultaneously and complexly in various battlefield domains. In addition, the application of convergence technologies that create innovations in all fields of economy, society, and defense, such as artificial intelligence, IoT, and big data, is being promoted. However, since the current Korean military C4I system manages warfighting function DBs in one DB server, the efficiency of combat performance is reduced utilization and distribution speed of data and operation response time. To solve this problem, research is needed on how to apply the 4th industrial revolution technologies such as AI, IoT, 5G, big data, and cloud to the Korean military C4I system, but research on this is insufficient. Therefore, this paper analyzes the problems of the current Korean military C4I system and proposes to apply the 4th industrial revolution technology in terms of operational mission, network and data link, computing environment, cyber operation, interoperability and interlocking capabilities.

• Journal of Dental Rehabilitation and Applied Science
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• v.38 no.4
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• pp.222-232
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• 2022

Purpose: This study was to investigate the dentists' experience and awareness of foreign body ingestion and aspiration during dental prosthetic treatment. Materials and Methods: A survey of 157 dentists working at 108 dental institutions in Daejeon and Chungcheong provinces was carried out and frequency analysis was conducted. Chi-square test was conducted to find out the difference between the sociodemographic data and experience of foreign body ingestion and aspiration of patients and independent sample t-test was conducted to find out the difference in awareness depending on whether receiving related education. Results: The percentage of dentists experiencing dropping foreign body into patients' oral cavity was 99.4% and the percentage of dentists experiencing foreign body ingestion and aspiration of patients was 53.5%. There were more dentists who experienced foreign body ingestion and aspiration of patients in male than female, longer working career, and general practitioners than specialists (P < .05). 50.3% of the respondents received related education. When they receive related education, they had low degree of concern, high confidence in coping with situations, and low willingness to receive education in the future (P < .05). Conclusion: The percentage of foreign body dropping was 16% higher in prosthetic treatment than general treatment. The percentage of dentists with experience of foreign body ingestion and aspiration of patients was 53.5%. Among them, 92.9% experienced foreign body ingestion of patients and 7.1% of them experienced foreign body aspiration of patients.

• Journal of Service Research and Studies
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• v.11 no.1
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• pp.31-44
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• 2021

The net function of the domestic medical insurance system is highly regarded, but due to the problem of incomplete coverage, the public wants to secure coverage through private medical insurance subscription. As a result, the subscription rate of private medical insurance has recently increased, and the billing rate has also increased. As the number of people seeking private medical insurance increased, workers at private medical insurance companies are experiencing increased job stress and side effects, especially for insurance reviewers who are in charge of paying insurance, such as communicating with customers who claimed insurance and contributing to the company's profit. In response, this study analyzed the effects of job stress on mental health of insurance reviewers and conducted a descriptive survey study to reduce job stress of insurance reviewers and promote mental health. The analysis shows that job stress for insurance reviewers has a significant impact on mental health (+). In detail, job stress has a significant impact on all four factors: social performance and self-confidence, depression, sleeping disturbance and anxiety, and general well-being and vitality. This study showed that job stress in insurance reviewers has a significant (+) impact on mental health. Job stress can cause side effects in organizational aspects, such as reducing enthusiasm for job performance and increasing turnover and resignation rates, but it can also worsen individual physical health and cause diseases such as depression and anxiety, causing mental health to be impoverished. Therefore, in order to prevent this, appropriate work stress prevention methods and countermeasures should be provided to help reduce work stress and improve mental health.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5D
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• pp.821-829
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• 2006

Traffic load comprise primary input to pavement design causing pavement damage. therefore it should be proceeded suitable traffic load distribution modeling for pavement design and analysis. Traffic load have been represented by equivalent single axle loads (ESALs) which convert mixed traffic stream into one value for design purposes. But there are some limit to apply ESALs to other roads because it is empirical value developed as part of the original AASHO(American Association of State Highway Officials) road test. There have been many efforts to solve these problems. Several leading country have implemented M-E(Mechanistic-Empirical) design procedures based on mechanical concept. As a result, they established traffic load quantification method using load distribution model known as Axle Load Spectra. This paper details Axle Load Spectra and presents axle load distribution model based on normal mixture distribution function using truck load data collected by WIM system installed in national highway. Axle load spectra and axle load distribution model presented in this paper could be useful for basic data when making traffic load quantification plan for pavement design, overweight vehicle permit plan and pavement maintenance cost plan.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3D
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• pp.425-433
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• 2006

The presented work provided a predictive equation for dynamic modulus of hot mix asphalt, which showed higher reliability and more simplicity. Lots of test result by UTM at laboratory has been used to develop the precise predictive equation. Evaluation of dynamic modulus for 13mm and 19mm surface course and 25mm of base course of hot mix asphalt with granite aggregate and two asphalt binders (AP-3 and AP-5) were carried out. Superpave Level 1 Mix Design with gyrator compactor was adopted to determine the optimum asphalt binder content (OAC) and the measured ranges of OAC were between 5.1% and 5.4% for surface HMA, and around 4.2% for base HMA. The dynamic modulus and phase angle were determined by testing on UTM, with 5 different testing temperature (-10, 5, 20, 40, & $55^{\circ}C$) and 5 different loading frequencies (0.05, 0.1, 1, 10, 25 Hz). Using the measured dynamic modulus and phase angle, the input parameters of Sigmoidal function equation to represent the master curve were determined and these will be adopted in FEM analysis for asphalt pavements. The effect of each parameter for equation has been compared. Due to the limitation of laboratory tests, the reliability of predictive equation for dynamic modulus is around 80%.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.4A
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• pp.373-384
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• 2009

For the first step on the quantitative evaluation of shrinkage reduction and differential shrinkage analysis of lightweight aggregate concrete, this study sets the moisture transport model of concrete by pre-absorbed water of porous lightweight aggregates and measured effective moisture diffusion coefficient, moisture capacity, degree of humidity supply and degree of humidity consumption by water binder ratio and aggregate type. The effective moisture diffusion coefficient in steady state caused by humidity difference between inside and outside of concrete had low value as low water-binder ratio. And in case of same water-binder ratio, effective moisture diffusion of mixtures used normal aggregates were lower than those used lightweight aggregates. To determine moisture store capability of concrete - moisture capacity, moisture contents were measured in 9 humidity conditions. As a result moisture contents of mixtures used lightweight aggregates was higher than mixtures used normal aggregates in all humidity conditions. This study measured lightweight aggregates' degree of humidity supply that applicable to normal atmospheric environment (above RH 50%) and made it quantitatively. Also amount of moisture release was set as a exponential function that represents a clear trend proportion to time and inverse proportion to humidity of the surroundings. As the result of measurement about degree of moisture consumption inside concrete following the internal consumption caused by cement hydration self-drying, it was showed that rapid decrease of humidity, around 10%, at early ages (7~10 days) when water-binder ratio is 0.3 and slow decrease around 5% and 1% when water-binder ratio is 0.4 and 0.5.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3B
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• pp.259-267
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• 2009

Generalized Extreme Value (GEV) distribution is recommended for flood frequency and extreme rainfall distribution in many country. L-moment method is the most common estimation procedure for the GEV distribution. In this study, the relationships between the cross-site correlations between extreme events and the cross-correlation of estimators of L-moment ratios (L-moment Coefficient of Variation (L-CV) and L-moment Coefficient of Skewness (L-CS)) for data generated from GEV distribution were derived by Monte Carlo simulation. Those relationships were fit to the simple power function. In this Monte Carlo simulation, GEV+ distribution were employed wherein unrealistic negative values were excluded. The simple power models provide accurate description of the relationships between cross-correlation of data and cross-correlation of L-moment ratios. Estimated parameters and accuracies of the power functions were reported for different GEV distribution parameters combinations. Moreover, this study provided a description about regional regression approach using Generalized Least Square (GLS) regression method which require the cross-site correlation among L-moment estimators. The relationships derived in this study allow regional GLS regression analyses of both L-CV and L-CS estimators that correctly incorporate the cross-correlation among GEV L-moment estimators.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.4C
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• pp.145-151
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• 2009

In general, a drilled shaft embedded in weathered rock has a large load bearing capacity. Therefore, most of the load tests are performed only up to the load level that confirms the pile design load capacity, and stopped much before the ultimate load of the pile is attained. If a reliable ultimate load value can be extracted from the premature load test data, it will be possible to greatly improve economic efficiency as well as pile design quality. The main purpose of this study is to propose a method for judging the reliability of the ultimate load of piles that is obtained from extrapolated load test data. To this aim, ten static load test data of load-displacement curves were obtained from testing of piles to their failures from 3 different field sites. For each load-displacement curve, loading was assumed as 25%, 50%, 60%, 70%, 80%, and 90% of the actual pile bearing capacity. The limited known data were then extrapolated using the hyperbolic function, and the ultimate capacity was re-determined for each extrapolated data by the Davisson method (1972). Statistical analysis was performed on the reliability of the re-evaluated ultimate loads. The results showed that if the ratio of the maximum-available displacement to the predicted displacement exceeds 0.6, the extrapolated ultimate load may be regarded as reliable, having less than a conservative 20% error on average. The applicability of the proposed method of judgment was also verified with static load test data of driven piles.

• Journal of Korea Entertainment Industry Association
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• v.13 no.7
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• pp.183-192
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• 2019

This study studied five major films from the 1980s to the 2000s when Philip Glass's minimal music was used, and studied the aesthetic and functional meaning of the minimal music. Minimal music has a repetitive rhythm and is understood to be aesthetically monotonous, to avoid a particular purpose, or as an expression of moveless. On the one hand, it can mean infinite persistence by repetitive rhythms, or sometimes repetition with subtle changes. The functions of film music were applied as the function of film music common to many theorists. As a result of the analysis of the music in five films, the aesthetic meaning of Philip Glass's minimal music was most relevant to the characteristics of the film story, and the functional meaning of the film music was determined by the structure, form, and genre of the film. Therefore, the theme of the film and the contents of the story played an important role in the aesthetic interpretation of film music with repetitive rhythm characteristics. And the elements of the plot such as the structure, form, and genre of the film are thought to have had a significant effect on the functional interpretation of the film music. The aesthetic value of the film music is closely related to the story of the film, and the functional meaning of the film music is interpreted as determined by the formal elements of the film.