• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2006년도 추계학술대회
• /
• pp.65-74
• /
• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• 한국정보통신학회논문지
• /
• 제16권12호
• /
• pp.2762-2770
• /
• 2012

본 논문에서는 서브영상(sub-image)에 MSE(mean square error)기반의 블록정합 알고리즘인 TSS (three-step search)와 FS (full search)를 복합적으로 적용함으로써 물체움직임을 고속, 정밀하게 추정 보상하고, 차 영상 기법을 통해 공간적 중복데이터를 제거한 잔여영상(residual image)을 고속 압축할 수 있는 새로운 기법을 제시하였다. 즉, 제안된 기법에서는 픽업된 영상 간의 유사성을 향상시키기 위하여 픽업된 요소영상으로부터 서브영상을 재합성한 뒤, TSS 기반의 MSE 알고리즘을 사용하여 전 물체영역을 대상으로 가능한 물체영역 만을 고속으로 찾은 다음, 그 가능한 물체영역에 정밀한 FS 탐색 알고리즘을 적용하여 물체영상의 정확한 움직임 벡터를 추정하여 보상하게 된다. 또한, 움직임이 보상된 물체영상에 차 영상(difference image) 기법을 적용하여 서브영상 간의 공간적 중복 데이터를 제거한 잔여영상을 얻게 되고 이는 MPEG-4 알고리즘을 통해 최종적으로 압축되게 된다. 실험결과, 제안된 기법은 기존방식에 비해 영상 압축률은 그대로 유지하면서 프레임 당 압축시간이 214% 향상됨을 보임으로써 제안된 기법의 실제 응용 가능성을 제시하였다.

• 한국콘텐츠학회논문지
• /
• 제20권1호
• /
• pp.1-15
• /
• 2020

본 연구는 기업 내 협업 프로젝트에서 창의적 성과에 영향을 주는 요인들을 살펴보았다. 구체적으로 팀의 협업 촉진을 위해 조직학습 커뮤니케이션의 중요 요인 중 하나인 스캐폴딩과 더불어 협업도구이자 매개체인 바운더리 오브젝트 변수가 성과에 영향을 끼치는지 확인하였다. 203명의 협업프로젝트를 경험한 직장인을 대상으로 설문을 수집하였으며, 탐색적 요인분석(exploratory factor analysis)을 거쳐 3단계 매개효과 분석(three-step mediated regression analysis)을 시행하였다. 즉, 스캐폴딩이 창의적 협업 성과에 끼치는 영향관계에서 바운더리 오브젝트의 매개효과를 살펴보았다. 분석 결과, 인지적 스캐폴딩이 창의적 성과에 미치는 영향 관계에서 바운더리 오브젝트는 매개효과가 유의하지 않았으나, 정서적 스캐폴딩은 창의적 성과에 미치는 영향관계에서 완전매개효과가 있었고 유효성 성과에 미치는 영향관계에서도 완전매개효과가 있는 것으로 나타났다. 이러한 결과를 감안하면 조직학습 차원에서 스캐폴딩이 유용하며, 바운더리 오브젝트 역시 프로젝트의 협업을 촉진하는 매개체로써 일부 효과가 있으므로 이를 활성화하기 위해 비전을 공유하고 팀원 간 개인적 친분을 형성하는 것이 필요하다고 볼 수 있다.

• 한국해양공학회지
• /
• 제15권3호
• /
• pp.120-127
• /
• 2001

The potential pollution problems resulting from tanker collision necessitate the requirement for an effective structural design and the development of relevant safety regulations. During a few decades, the great effort has been made by the international Maritime Organization and the Administration, etc, to reduce oil spillage from collision accidents. However there is still a need for investigation in the light of structural evaluation method for the experiments and rational analysis, and design development for an operational purpose of ships. This study aims for investigating a complicated structural response of bow structures of simplified models and oil carriers for assessing the energy dissipation and crushing mechanics of the striking vessels through a methodology of the numerical analysis for the various models and its design changes. Through these study an optimal bow construction absorbing great portion of kinetic energy at the least penetration depth prior to reach to the cargo area and an effective location of collision bulkhead are investigated. In order to obtain a rational results in this study, three stages of collision simulation procedures have been performed step by step as follows; 1) 16 simplified ship models are used to investigate the structural response against bow collision with variation of primary and secondary members. Mass and speed are also varied in four conditions. 2) 21 models consisted of 5 sizes of the full scaled oil carriers are used to perform the collision simulation with the various sizes and deadweight delivered in a recent which are complied with SOLAS and MARPOL. 3) 36 models of 100l oil carrier are used to investigate the structural response and its influence to the collision bulkhead against bow collision in variation with location of collision bulkhead, primary members, framing system and colliding conditions, etc. By the first study using simplified models the response of the bow collision is synthetically evaluated for the parameters influencing to the absorbed energy, penetration depth and impact force, etc.

• 구강회복응용과학지
• /
• 제33권2호
• /
• pp.154-162
• /
• 2017

노인 환자 구강의 생리적 변화 중 하나인 생리적 치아 마모는 일반적으로 치료를 필요로 하지 않으나 교합 부조화, 저작기능의 저하, 치수 노출 등 구강 내 문제 발생 시 보철 수복을 필요로 한다. 마모된 치열을 지닌 환자의 보철 수복 시 우선적으로 고려되는 사항들 중 하나가 바로 수직고경에 대한 고려이다. 이에 정확한 진단 및 분석과 예지성 있는 치료계획을 위한 악간관계에 대한 올바른 판단이 요구되며, 노인 환자의 치과 치료를 감안한 단계별 치료접근을 필요로 한다. 본 증례는 93세 남자 환자로 전반적인 치아 마모 및 기존 고정성 보철물의 동요도를 보이고 있었다. 진단 및 평가 후 수직교합 고경을 유지한 상악 구강회복술을 시행하였으며, 기능 및 형태적으로 만족할만한 결과를 보여 보고하는 바이다.

• 대한원격탐사학회:학술대회논문집
• /
• 대한원격탐사학회 1999년도 Proceedings of International Symposium on Remote Sensing
• /
• pp.80-83
• /
• 1999

An efficient modeling and management of a large amount of surface data for a wide rage of geographic information play an important role in determining the functionality of 3D geographic information system. It has been put many efforts to design and manage an effective way to enhence the manipulation of the data by considering geometry type and data structures. Recently, DEM(Data Elevation Model) and TIN(Triangulated Irregular Network) are used for representing surface data. In this paper, we propose a 3D data processing method. The method utilizes the major properties of DEM and TIN, respectively. Furthermore, by approximating DEM with a TIN of an appropriate resolution, we can support a fast and realistic surface modeling. We implement the structure with the following 4 level stages. The first is an optimal resolution of DEM which represent all of wide range of geographic data. The second is the full resolution DEM which is a subarea of original data generated by user's selection in our implemeatation. The third is the TIN approximation of this data with a proper resolution determined by the relative position with the camera. And the last step is multi-resolution TIN data whose resolution is dynamically decided by considering which direction user take notice currently. Specially, the TIN of the last step is designed for realtime camera navigation. By using the structure we implemented realtime surface clipping, efficient approximation of height field and the locally detailed surface LOD(Level of Detail). We used the initial 10-meter sampling DEM data of Seoul, KOREA and implement the structure to the 3D Virtual GIS based on the Internet.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 1991년도 하계학술대회 논문집
• /
• pp.102-105
• /
• 1991

In recognition of the transportation problems of the present and to prepare for the ever increasing demands of the future, government decided to develop the magnetically levitated train domestically and started R&D program office in Korea Institute of Machinery and Metals(KIMM). This office since has established three step by step goals : first to develop a 40 passenger exhibition vehicle for Daejon EXPO'93, second to develop the low to mid-speed maglev system for urban public transportation by 1997 and finally the high speed inter-city maglev train by year 2001. The first two maglev systems will use attractive levitation-LIM driven technologies and these technologies are the ones currently being developed by this office and others. The maglev train system is a product of wide range of technologies from electro-technologies to civil engineering technologies. Some of the technologies are currently available but more have to be developed in the near future and these technologies are owned by or to be developed by various institutions within the science & technology community. The level of the technologies available at the present time are still very rudimentary and their basis are very narrow. Recently we have made a few successes in terms of levitation and propulsion but they are only with small scale modules and results are very qualitative at best. A great deal of development work has yet to be done to refine the technologies and to gain confidence. Full scale levitation/propulsion modules will be tested on the curved guideway within 6 months by this office and another institution. This paper reviews the current status of the maglev technologies in Korea and discuss the development strategies. The Korean maglev program is very ambitious and the schedule is even more so. A steady financial support and strong system engineering and integration are essential to the success of this program.

• Korean Journal of Acupuncture
• /
• 제28권3호
• /
• pp.1-12
• /
• 2011

Objectives : The purpose of this study is to review laser acupuncture studies to find possibility for applying high intensity laser to acupuncture and moxibustion treatment. Methods : Searching papers was performed using search engines of five electronic databases, including Pubmed, Thomson ISI, EMBASE, Sciencedirect, and EBSCO, from inception to May 2011 without language limitation. Inclusion criteria were clinical studies with human, randomized controlled trials (RCTs), case-control studies, and case reports. Selecting papers was performed with titles and abstracts in first step, scrutinize full text in second step, and then the extrated data was analyzed by two authors independently. The methodological quality for RCTs was evaluated using Jadad's scale. Results : Total 8 papers, (3 RCTs, 5 controlld studies, and 1 case reports), were finally selected. The study dealt with surgical laser, argon and $CO_2$ laser was one for each, with GaAs laser was two, and with new semiconductor laser, GaN, were four. The output range was from 110 mW to 15 W. The study diseases were alcohol addiction, knee osteoarthritis, bronchopneumonia and asthma for children, and circulation. All studies reported positive effect. The methodological quality in all RCTs was low because of below 3 points and all studies had few subject numbers. Conclusions : We suggest that high intensity laser can be applied to acupuncture and moxibustion. Further rigorous and well-designed study will be needed for various disease. The oriental medical society needs to take active measures to study and clinical application of acupuncture and moxibustion treatment with high intensity laser.

• 한국항공우주학회지
• /
• 제31권9호
• /
• pp.88-93
• /
• 2003

본 논문은 헬리콥터용 시뮬레이션 프로그램 개발에 관한 연구이다. 일반적으로 헬리콥터 비행시뮬레이션에 사용되는 수학모델은 고 충실도를 가져야 한다. 그러므로 시뮬레이션을 실행할 때 보다 정교하 공력 모델이 필요하게 되며, 계산시간이 많이 걸린다. 어떠한 특수 목적을 수행하는 UAV 비행제어시스템에서는 제어기를 설계할 때 사용되는 선형모델을 비선형모델로부터 얻는 시간을 최소화 하는 것이 중요하다. 이와 같은 목적을 달성하기 위한 첫 번째 단계는 실제로 헬리콥터 동특성을 잘 나타내는 비선형 모델을 완성하는 일이다. 두 번째 단계는 비선형방정식으로부터 특정 비행조건에 맞는 트림값을 계산하는 것이다. 그리고 나서 수치적인 방법으로 안정미계수와 조종미계수를 계산하여 특정 비행 상태 조건에 부합하는 선형모델을 구한다. 이러한 과정을 편리하게 처리하는 프로그램을 MATLAB GUI를 사용해서 개발하였다. 이 논문에서 제안된 방법은 기존의 실물크기 모델헬리콥터 시뮬레이션 방법에 비해 간략화된 것이다. 따라서 선형모델을 얻기까지의 연산시간이 짧아서 무인헬리콥터의 비행제어시스템을 설계하는데 유용할 것이다.

• 대한가정학회지
• /
• 제44권12호
• /
• pp.9-18
• /
• 2006

A case study was conducted on the development of patient clothes designs at the Korea University Medical Center, in order to provide an example of patient clothes designs which meet the hospital identity and the demands of patients and nurses. In this study, we focused on general patient pajamas and one-piece gowns worn in the obstetrics and gynecology department. A scientific and systematic design approach consisting of the following four steps was conducted in the designing process: needs assessment, design direction establishment, design presentation, and final decision. For the first step, focused group interviews and a survey were conducted to identify the needs of the patients and nurses. According to the results of the first step, 3 fabric patterns with light, modern, rhythmic, modest and ordinary images were designed utilizing the university and hospital symbols and logotypes. Fixed forms with realistic and geometric characteristics and colors, including white, yellow, blue, grey, and pink were selected to deliver the preferred image. Each fabric pattern was made in male and female versions of the color sets. The following styles of patient clothes were made with the 3 fabric samples: general patient pajamas with a U-neckline, 9/10-length sleeves and ankle-length pants, a full-length sleeved gown with openings for breast-feeding, and a gown with a deep back-neckline and button fastening. Different sizing systems for males and females were recommended for the production.