• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.24 no.5
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• pp.413-422
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• 2021

Intestinal lymphangiectasia is a rare disease which is causing protein-losing enteropathy. Treatment of intestinal lymphangiectasia can be a challenge for clinicians because of the lack of specific guidelines regarding pharmacological indications. We sought to introduce a diagnostic approach and suggest guidelines for treatment. After exclusion of secondary intestinal lymphangiectasia, magnetic resonance lymphangiography is a promising tool for the assessment of abnormal lymphatic lesions in primary intestinal lymphangiectasia. Determining the extent of the lesion provides direction for treatment options. Focal short-segment intestinal lymphangiectasia can be treated via intestinal resection or radiologic embolization after dietary therapy failure. Diffuse intestinal lymphangiectasia and extensive lymphangiectasia should be treated with several drugs with a full understanding of their mechanisms.

• The Plant Pathology Journal
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• v.20 no.3
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• pp.212-219
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• 2004

Three isolates of Cucumber mosaic virus (CMV) from lily plants showing mosaic and distortion symptoms were detected by reverse-transcriptase polymerase chain reaction (RT-PCR) using primers specific to Cucumovirus genus namely, LK-CMV, LK4-CMV, and LKS-CMV. Restriction enzymes patterns of the RT-PCR products revealed that the lily isolates belonged to subgroup IA of CMV. In terms of biological properties, the lily isolates have highly similar but distinct pathogenicity as reported in other lily strains and ordinary strains of CMV. To characterize the molecular properties, cDNAs containing coat protein (CP) gene and 3' non-coding region (NCR) of RNA3 for the isolates were cloned and their nucleotide sequences were determined. The CP similarity (218 amino acids) was highly homologous (>97％) with that of subgroup I CMV strains. However, an additional 20-nulcleotide long segment was only present in 3' NCR of lily isolates, which form an additional stem-loop RNA structure. By using chimeric construct exchange cDNA containing 3'NCR of LK-CMV into the full-length cDNA clone of RNA3 of Fny-CMV, this additional segment may prove to be significant in the identification and fitness of the virus in lily plants. The pathology of zucchini squash infected by F1F2L3-CMV, a pseudorecombinant virus was showed to change drastically the severe mosaic and stunting symptom into a mild chlorotic spot on systemic leave, compared with Fny-CMV. To delimit the sequence of RNA3 affected the pathology, various RNA3 chimeras were constructed between two strains of CMV. The symptom determinants of F1F2L3-CMV were mapped to the positions amino acid 234, 239, and 250 in 3a movement protein (MP). RNA3 chimeras changed the sequences encoding three amino acids were resulted in alteration of systemic symptom.

• The Plant Pathology Journal
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• v.33 no.2
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• pp.163-169
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• 2017

$SIMAPKKK{\alpha}$, a tomato (Solanum lycopersicum) mitogen-activated protein kinase kinase kinase, is a positive regulator of Pto-mediated effector-triggered immunity, which elicits programmed cell death (PCD) in plants. In this study, we examined whether putative phosphorylation sites in the conserved activation segment of the $SIMAPKKK{\alpha}$ kinase domain are critical for eliciting PCD. Three amino acids, $threonine^{353}$, $serine^{360}$ ($Ser^{360}$), or $serine^{364}$ ($Ser^{364}$), in the conserved activation segment of $SIMAPKKK{\alpha}$ kinase domain were substituted to alanine (T353A, S360A, or S364A), and these variants were transiently expressed in tomato and Nicotiana benthamiana plants. Two alanine substitutions, S360A and S364A, completely abolished $SIMAPKKK{\alpha}$ PCD-eliciting activity in both plants, while T353A substitution did not affect its PCD-eliciting activity. $SIMAPKKK{\alpha}$ wild type and variant proteins accumulated to similar levels in plant leaves. However, $SIMAPKKK{\alpha}$ protein with the largest size was missed when either S360A or S364A substitutions were expressed, whereas proteins with the smaller masses were more accumulated than those of full-length of $SIMAPKKK{\alpha}$ and T353A. These results suggest that phosphorylation of $SIMAPKKK{\alpha}$ at $Ser^{360}$ and $Ser^{364}$ is critical for PCD elicitation in plants.

• Steel and Composite Structures
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• v.34 no.1
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• pp.107-122
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• 2020

Moment resisting stub columns (MRSCs) have increasingly adopted in special moment-resisting frame (SMF) systems in steel building structures, especially in Asian countries. The MRSCs typically provide a lower deformation capacity compared to shear-panel stub columns, a limited post-yield stiffness, and severe strength degradation as adopting slender webs. A new MRSC design with cored configuration, consisting of a core-segment and two side-segments using different steel grades, has been proposed in the study to improve the demerits mentioned above. Several full-scale components of the cored MRSC were experimentally investigated focusing on the hysteretic performance of plastic hinges at the ends. The effects of the depths of the core-segment and the adopted reduced column section details on the hysteretic behavior of the components were examined. The measured hysteretic responses verified that the cored MRSC enabled to provide early yielding, great ductility and energy dissipation, enhanced post-yield stiffness and limited strength degradation due to local buckling of flanges. A parametric study upon the dimensions of the cored MRSC was then conducted using numerical discrete model validated by the measured responses. Finally, a set of model equations were established based on the results of the parametric analysis to accurately estimate strength backbone curves of the cored MRSCs under increasing-amplitude cyclic loadings.

• Smart Structures and Systems
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• v.15 no.1
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• pp.99-117
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• 2015

The Stonecutters Bridge (SCB) in Hong Kong is the third-longest cable-stayed bridge in the world with a main span stretching 1,018 m between two 298 m high single-leg tapering composite towers. A Wind and Structural Health Monitoring System (WASHMS) is being implemented on SCB by the Highways Department of The Hong Kong SAR Government, and the SCB-WASHMS is composed of more than 1,300 sensors in 15 types. In order to establish a linkage between structural health monitoring and maintenance management, a Structural Health Rating System (SHRS) with relevant rating tools and indices is devised. On the basis of a 3D space frame finite element model (FEM) of SCB and model updating, this paper presents the development of an SHR-oriented 3D multi-scale FEM for the purpose of load-resistance analysis and damage evaluation in structural element level, including modeling, refinement and validation of the multi-scale FEM. The refined 3D structural segments at deck and towers are established in critical segment positions corresponding to maximum cable forces. The components in the critical segment region are modeled as a full 3D FEM and fitted into the 3D space frame FEM. The boundary conditions between beam and shell elements are performed conforming to equivalent stiffness, effective mass and compatibility of deformation. The 3D multi-scale FEM is verified by the in-situ measured dynamic characteristics and static response. A good agreement between the FEM and measurement results indicates that the 3D multi-scale FEM is precise and efficient for WASHMS and SHRS of SCB. In addition, stress distribution and concentration of the critical segments in the 3D multi-scale FEM under temperature loads, static wind loads and equivalent seismic loads are investigated. Stress concentration elements under equivalent seismic loads exist in the anchor zone in steel/concrete beam and the anchor plate edge in steel anchor box of the towers.

• Archives of Plastic Surgery
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• v.49 no.1
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• pp.70-75
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• 2022

Background Fingertip injuries are very common; however, the reconstruction of volar pulp defects with nail bed defects is challenging in the absence of the amputated segment. We reconstructed fingertip amputations with nail bed defects using a new surgical approach: a subcutaneous flap and composite graft. Methods We treated 10 fingertip amputation patients without an amputated segment, with exposed distal phalangeal bone and full-thickness nail bed defects between February 2018 and December 2020. All patients underwent two-stage surgery: in the first stage, a subcutaneous flap was performed to cover the exposed distal phalanx, and in the second stage, a composite graft, consisting of nail bed, hyponychium, and volar pulp skin, was applied over the subcutaneous flap. Results All flaps survived and all composite grafts were successful. The wounds healed without any significant complications, including the donor site. The average follow-up duration was 11.2 months (range, 3-27 months). The new nail and the shape of the volar pulp were evaluated during follow-up. All patients were satisfied with their natural fingertip shapes and the new nails did not have any serious deformities. Conclusions A subcutaneous flap in combination with a composite graft fitting the shape of the defect could be another option for fingertip injuries without amputated segments.

• Journal of the Korea Society of Computer and Information
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• v.15 no.7
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• pp.91-98
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• 2010

Large corpus-based concatenating Text-to-Speech (TTS) systems can generate natural synthetic speech without additional signal processing. Because the improvements in the natualness, personality, speaking style, emotions of synthetic speech need the increase of the size of speech DB, it is necessary to prune the redundant speech segments in a large speech segment DB. In this paper, we propose a new method to construct a segmental speech DB for the Korean TTS system based on a clustering algorithm to downsize the segmental speech DB. For the performance test, the synthetic speech was generated using the Korean TTS system which consists of the language processing module, prosody processing module, segment selection module, speech concatenation module, and segmental speech DB. And MOS test was executed with the a set of synthetic speech generated with 4 different segmental speech DBs. We constructed 4 different segmental speech DB by combining CM1(or CM2) tree clustering method and full DB (or reduced DB). Experimental results show that the proposed method can reduce the size of speech DB by 23% and get high MOS in the perception test. Therefore the proposed method can be applied to make a small sized TTS.

• Journal of the Korean Society of Clothing and Textiles
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• v.33 no.7
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• pp.1109-1120
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• 2009

This study develops a fitted torso type basic pattern for men by utilizing 3D body scan data. Recent fashion trends are reflected in the development of the pattern. The subjects were 15 men in their 20's, who wear size 95 (M size). Body scan data was obtained through a 3D whole body scanner (WB4, Cyberware, USA), and a body surface development figure for developing male fitted torso type basic pattern was attained through the use of Rapid Form 2006 as well as Auto CAD 2006 programs. The results are as follows: A body surface development figure through body surface segment method showed high exactitude in an error range of 100$\pm$1%. In addition, it occurred in an error range of 100:1:3% because of the hard scanning conditions in the incline of the shoulder and armpit areas. However, the body surface development figure as well as the direct measurement results can be used as basic data for the given patternmaking since the error range falls into 100$\pm$3%. Dart amounts obtained from the average cross section were center back 2.2cm (24.3%), back armpit point 3.8cm (41.8%), front armpit point 3.0cm (33.9%). As shown the jacket pattern, the biggest dart amount was portioned out at the back armpit point. The drafting equations for the development pattern acquired are as follows; Full width=C/2+5cm, back length=height/4-1cm, armhole depth=(C/10+12cm)+3cm, back width=2C/10+2cm, front width=2C/10. The development pattern was a fitted torso basic pattern that was composed of 3 pieces, so it would be very useful in developing shirt or jacket patterns. According to the results of the evaluation of the developed pattern appearance, it obtained higher scores of over 3.5 points in almost items, meaning that the developed pattern is appropriate for a male fitted torso type basic pattern. It suggests a possibility of patternmaking from a body surface development figure in 2-D to prototype.

• The Plant Pathology Journal
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• v.29 no.4
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• pp.397-409
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• 2013

The full-genome sequences of fourteen isolates of Broad bean wilt virus 2 (BBWV2), collected from broad bean, pea, spinach, bell pepper and paprika plants in Korea during the years 2006-2012, were determined and analyzed comparatively along with fifteen previously reported BBWV2 genome sequences. Sequence analyses showed that RNA-1 and RNA-2 sequences of BBWV2 Korean isolates consisted of 5950-5956 and 3568-3604 nucleotides, respectively. Full-length genome sequence-based phylogenetic analyses revealed that the BBWV2 Korean isolates could be divided into three major groups comprising GS-I (isolates BB2 and RP7) along with isolate IP, GS-II (isolates BB5, P2, P3 and RP3) along with isolate B935, and GS-III including 16 BBWV2 Korean isolates. Interestingly, GS-III appears to be newly emerged and predominant in Korea. Recombination analyses identified two recombination events in the analyzed BBWV2 population: one in the RNA-1 of isolate K and another one in the RNA-2 of isolate XJ14-3. However, no recombination events were detected in the other 21 Korean isolates. On the other hand, out of 29 BBWV2 isolates, 16 isolates were found to be re-assortants, of which each RNA segment (i.e. RNA1 and RNA2) was originated from different parental isolates. Our findings suggested that reassortment rather than recombination is a major evolutionary force in the genetic diversification of BBWV population in Korea.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.3A
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• pp.421-428
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• 2006

This study was performed by using experiment to minimize behavior difference of Monolithic and segmental Girder and to prove the design concept of the PSI (Precast PSC-Segmental I Grider). A full scale girder test was performed in four different cases, the monolithic girder, the segmental girder type-1, the segmental girder type-2 and the segmental girder type-3. The monolithic girder that was produced in one body 25 m span and the segmental girder that was jointed 5-sliced 5 m segment. The girder was built by as one body prestressing the tendons after manufacturing the segmental girder, and second prestressing after the casting of the slab concrete. The test result shows that the measured values were almost same or slightly bigger than the theoretical values which means that the PSI girder bridges concept came out to be reliable.