• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.1-12
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• 2011

Objectives : The purpose of this study is to review laser acupuncture studies to find possibility for applying high intensity laser to acupuncture and moxibustion treatment. Methods : Searching papers was performed using search engines of five electronic databases, including Pubmed, Thomson ISI, EMBASE, Sciencedirect, and EBSCO, from inception to May 2011 without language limitation. Inclusion criteria were clinical studies with human, randomized controlled trials (RCTs), case-control studies, and case reports. Selecting papers was performed with titles and abstracts in first step, scrutinize full text in second step, and then the extrated data was analyzed by two authors independently. The methodological quality for RCTs was evaluated using Jadad's scale. Results : Total 8 papers, (3 RCTs, 5 controlld studies, and 1 case reports), were finally selected. The study dealt with surgical laser, argon and $CO_2$ laser was one for each, with GaAs laser was two, and with new semiconductor laser, GaN, were four. The output range was from 110 mW to 15 W. The study diseases were alcohol addiction, knee osteoarthritis, bronchopneumonia and asthma for children, and circulation. All studies reported positive effect. The methodological quality in all RCTs was low because of below 3 points and all studies had few subject numbers. Conclusions : We suggest that high intensity laser can be applied to acupuncture and moxibustion. Further rigorous and well-designed study will be needed for various disease. The oriental medical society needs to take active measures to study and clinical application of acupuncture and moxibustion treatment with high intensity laser.

• Parasites, Hosts and Diseases
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• v.44 no.4 s.140
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• pp.331-341
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• 2006

Actin binding proteins play key roles in cell structure and movement particularly as regulators of the assembly, stability and localization of actin filaments in the cytoplasm. In the present study, a cDNA clone encoding an actin bundling protein named as AhABP was isolated from Acanthamoeba healyi, a causative agent of granulomatous amebic encephalitis. This clone exhibited high similarity with genes of Physarum polycephalum and Dictyostelium discoideum, which encode actin bundling proteins. Domain search analysis revealed the presence of essential conserved regions, i.e., an active actin binding site and 2 putative calcium binding EF-hands. Transfected amoeba cells demonstrated that AhABP is primarily localized in phagocytic cups, peripheral edges, pseudopods, and in cortical cytoplasm where actins are most abundant. Moreover, AhABP after the deletion of essential regions formed ellipsoidal inclusions within transfected cells. High-speed co-sedimentation assays revealed that AhABP directly interacted with actin in the presence of up to $10{\mu}M$ of calcium. Under the electron microscope, thick parallel bundles were formed by full length AhABP, in contrast to the thin actin bundles formed by constructs with deletion sites. In the light of these results, we conclude that AhABP is a novel actin bundling protein that is importantly associated with actin filaments in the cytoplasm.

• Journal of the Korean Society for Library and Information Science
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• v.40 no.1
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• pp.263-292
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• 2006

The purpose of this study is to analyze the characteristics of OPAC displays of the National Library of Korea and the Library of Congress. based on the 'OPAC Display Guidelines(Draft)' published by IFLA. Discussed are such topics as a basic search process and the headings list, a brief display and the arrangement of bibliographic records, a brief record and a full record, use of terms and labels. link between records, and organization of screens for the OPAC display. It is strongly suggested that when compared with the LC's OPAC, the OPAC display of the National Library of Korea should be much improved by following the recommendations of the 'OPAC Display Guidelines(Draft)'.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.28 no.3
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• pp.225-236
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• 2017

In this paper, a simulation test bed is presented which operates to provide full-scale simulation of airborne multi-function phased array radars. This simulation test bed provides a capability to evaluate the target tracking performance. To realize aircraft operation scenario, we developed 6DOF aircraft dynamics model which can generate trajectories and attitude of an aircraft. This procedure includes steady state flight trim search, autopilot design, and aircraft guidance command design. Also, the radar-environment integrated simulator includes target detection/measurement model and tracking filter. Developed simulator is validated by creating an air-to-air scenario.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.23 no.2
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• pp.121-131
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• 2020

Purpose: To determine the long-term efficacy of the anti-tumor necrosis factor (TNF) agents, infliximab (IFX) and adalimumab (ADA), in pediatric luminal Crohn's disease (CD) by performing a systematic literature review. Methods: An electronic search was performed in Medline, Embase, and the Cochrane Library from inception to September 26, 2019. Eligible studies were cohort studies with observation periods that exceeded 1 year. Studies that reported time-to-event analyses were included. Events were defined as discontinuation of anti-TNF therapy for secondary loss of response. We extracted the probabilities of continuing anti-TNF therapy 1, 2, and 3 years after initiation. Results: In total, 2,464 papers were screened, 94 were selected for full text review, and 13 studies (11 on IFX, 2 on ADA) met our eligibility criteria for inclusion. After 1 year, 83-97% of patients were still receiving IFX therapy. After 2 and 3 years the probability of continuing IFX therapy decreased to 67-91% and 61-85%, respectively. In total, 5 of the 11 studies subgrouped by concomitant medication consistently showed that the probabilities of continuing IFX therapy in patients with prolonged immunomodulator use were higher than those in patients on IFX monotherapy. Conclusion: This review of real-world evidence studies confirms the long-term therapeutic benefit of IFX therapy in diverse cohorts of children with luminal CD. Moreover, it supports the view that combination therapy with an immunomodulator prolongs the durability of IFX therapy in patients who previously failed to recover following first-line therapy. The limited number of time-to-event studies in patients on ADA prevented us from drawing definite conclusions about its long-term efficacy.

• The Journal of the Korea Contents Association
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• v.8 no.6
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• pp.261-268
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• 2008

An author of a paper is represented as his/her personal name in a bibliographic record. However, the use of names to indicate authors may deteriorate recall and precision of paper and/or author search, since the same name can be shared by many different individuals and a person can write his/her name in different forms. To solve this problem, it is required to disambiguate same-name author names into different persons. As features for author resolution, previous studies have exploited bibliographic attributes such as co-authors, titles, publication information, etc. This study attempts to apply email addresses of authors to disambiguate author names. For this, we first handle the extraction of email addresses from full-text papers, and then evaluate and analyze the effect of email addresses on author resolution using a large-scale test set.

• Journal of Microbiology and Biotechnology
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• v.14 no.3
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• pp.620-627
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• 2004

On the foundation of a database of genome sequences and protein analyses, the ability to clone a gene based on a peptide analysis is becoming more feasible and effective for identifying a specific gene and its protein product of interest. As such, the current study conducted a protein analysis using 2-D PAGE followed by MALDI- TOF and ESI-MS to identify a highly expressed gene product of C. parasitica. A distinctive and highly expressed protein spot with a molecular size of 47.2 kDa was randomly selected and MALDI-TOF MS analysis was conducted. A homology search indicated that the protein appeared to be a fungal enolase (enol). Meanwhile, multiple alignments of fungal enolases revealed a conserved amino acid sequence, from which degenerated primers were designed. A screening of the genomic $\lambda$ library of C. parasitica, using the PCR amplicon as a probe, was conducted to obtain the full-length gene, while RT-PCR was performed for the cDNA. The E. coli-expressed eno 1 exhibited enolase enzymatic activity, indicating that the cloned gene encoded the C. parasitica enolase. Moreover, ESI-MS of two of the separated peptides resolved from the protein spot on 2-D PAGE revealed sequences identical to the deduced sequences, suggesting that the cloned gene indeed encoded the resolved protein spot. Northern blot analysis indicated a consistent accumulation of an eno1 transcript during the cultivation.

• The Journal of the Korea Contents Association
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• v.16 no.2
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• pp.277-286
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• 2016

This study proposes customized design process and methodology for wordpress web service based on structural analysis of wordpress theme components to enhance design quality of wordpress sites and increase designer's role in wordpress service domain. Firstly, we have identified problems of wordpress theme information through exploring theme search and theme information analysis in main wordpress theme markets. Secondly, we set up case study to experiment full process of wordpress theme based web design, then found unique problems in each design phases. As a result, customized design process and methodology are proposed for wordpress theme based web design.

• International Journal of Contents
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• v.14 no.3
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• pp.7-16
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• 2018

The extent and depth of the event plan determines the scope of pedagogical experience in situations and consequently the quality of immersive learning based on our simulated world. In contrast to planning in conventional narrative-based systems mainly pursuing dramatic interests, planning in virtual world-based pedagogical systems strive to provide realistic experiences in immersed situations. Instead of story plot comprising predetermined situations, our inter-event planning method aims at simulating diverse situations that each involve multiple events coupled via their associated agents' conditions and meaningful associations between events occurring in a background world. The specific techniques to realize our planning method include, two-phase planning based on inter-event search and intra-event decomposition (down to the animated action level); autonomous and independent agents to behave proactively with their own belief and planning capability; full-blown background world to be used as the comprehensive stage for all events to occur in; coupling events via realistic association types including deontic associations as well as conventional causality; separation of agents from event roles; temporal scheduling; and parallel and concurrent event progression mechanism. Combining all these techniques, diverse exogenous events can be derived and seamlessly (i.e., semantically meaningfully) integrated with the original event to form a wide scope of situations providing chances of abundant pedagogical experiences. For effective implementation of plan execution, we devise an execution scheme based on multiple priority queues, particularly to realize concurrent progression of many simultaneous events to simulate its corresponding reality. Specific execution mechanisms include modeling an action in terms of its component motions, adjustability of priority for agent across different events, and concurrent and parallel execution method for multiple actions and its expansion for multiple events.

• Spatial Information Research
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• v.11 no.4
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• pp.493-508
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• 2003

This study proposes a framework of a GIS service network to connect local governments'Land Management Information Systems(LMIS) together. Databases constructed far LMIS's are very crucial information on both administrative business and civil affairs administration. However, they did not give full play to their values because they could not be shared sufficiently. Local governments build their databases individually using diverse GIS solutions. It causes some problems on sharing them. To demonstrate their geniuses, they should be connected to each other within a network for the whole country, and are served whenever and wherever to people who require them. for this, there are two main problems to be solved. Firstly, a GIS service network that handles heterogeneous and distributed computing environments is organized to link every LMIS each other by the GIS service network vertically and horizontally. Secondly, a mechanism should be developed to access the GIS service network readily and to search GIS data efficiently. The needs from every types of user should be satisfied by the mechanism. As the result of investigation of the issues, one of the most possible solution was suggested in this study, which is a Web based approach. To take into account the advance of information technology in the future and the requirements of e-government, stepwise strategies that integrate the LMIS's into a Web based system was recommended.