• Journal of Genetic Medicine
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• 제1권1호
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• pp.17-22
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• 1997

The angiotensin converting enzyme (ACE) is a key component of the renin-angiotensin system thought to be important in the pathogenesis of hypertension and cardiovascular diseases. Deletion polymorphism in the ACE gene may be a risk factor for myocardial infarction. The insertion/deletion (I/D) polymorphism of the ACE detected by PCR analysis appears to be associated with hypertension in Koreans and its nucleotide was subcloned into T-vector and its nucleotide sequences were determined. We also examined an association between hypertension and genetic variance of ACE. We identified the angiotensin I-converting enzyme genotype in 127 hypertensive and 189 normotensive Korean subjects. The distribution of ACE genotype II, ID, DD were 39.2%, 40.2%, 20.6% respectively and the frequency for ACE alleles I and D were 0.593 and 0.407, respectively in all subjects. The frequency of D allele in Korean males is higher than that of Korean females (male; 0.438 : female; 0.267), and the frequency of I allele in Korean females is higher than that of Korean males (female; 0.733 : male; 0.562). Genotype distributions of angiotensin I-converting enzyme genes in Korean normal adult population were different from that of Caucasians (P<0.001). There were no significant differences in genotype frequency between the hypertensive control group (n=127) and the normotensive group (n=189). We observed significant differences of ACE genotype distribution between the male group and the female group in total (P=0.001) and in hypertensive Korean subjects (P=0.013).

• 한국음향학회지
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• 제23권5호
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• pp.362-369
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• 2004

수층과 사질 퇴적층이 이루는 경계면이 평탄할지라도 고주파수 (30∼120 ㎑) 음파의 반사손실은 퇴적물의 입도와 입사파의 파장에 따라 거친 경계면에서의 반사 효과를 갖게 된다. 경계면 거칠기 영향은 음향학적 거칠기 (acoustical roughness, g/sub R/)로 표현하며 사질 퇴적물의 경우 g/sub R/∼ O(1)이고 주파수에 따른 종속성을 가진다. 따라서 입도분포에 따른 반사손실의 편차 (deviation)와 주파수에 따른 종속성을 포함하는 개선된 해저면 반사손실 모델 (HYBRL 모델, Hanyang University Bottom Reflection Loss model)을 제안한다. 그리고 주파수 종속성과 해저면 물성이 갖는 편차를 포함하는 반사손실 모델을 검증하기 위해 수조실험과 해상실험을 실시하였다. 수조실험 및 해상실험에서 측정된 해저면 반사손실 결과 사질 퇴적물에서 모델의 특성을 잘 반영한다.

• 한국방재학회 논문집
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• 제7권2호통권25호
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• pp.53-63
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• 2007

국내의 경우 매년 발생하는 홍수에 대해서는 많은 분석과 대비를 하고 있지만, 겨울철 폭설에 대한 연구는 미비한 실정이다. 본 연구에서는 기상청 산하 52개 관측지점의 30년 이상의 최심신적설량 자료를 수집하고 각 지점별 적설량의 최적분포형을 결정하여 확률적설량을 산정하였으며, 지역별 확률적설량의 분포를 파악하기 쉽게 재현기간별 확률적설량도를 작성 제시하였다. 지점별 최심신적설량의 적정분포형으로는 2모수 gamma분포가 우세하였고, 과거 주요폭설기록의 재현기간은 약 500년 내외를 보인 2005년, 재현기간 약 200년 정도를 보인 2004년의 확률적 규모를 볼 때 설하중에 대한 설계기준의 확립이 긴요하다. 우리나라의 확률적설량은 남부지방인 영 호남 지역 보다 중부지방으로 올라 갈수록 증가하고 있으며, 특히 태백산맥과 소백산맥을 경계로 서쪽과 동쪽의 편차가 뚜렷한 차이를 보이고 있다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2006년도 학술발표회 논문집
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• pp.1191-1195
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• 2006

Now days, heavy storm occur to be continue. It is hard to use before frequency based on flood discharge for decision that design water pocket structure. We need to estimation of frequency based on flood discharge on the important basin likely city or basin that damage caused by flood recurrence. In this paper flood discharge calculated by Clark watershed method and SCS synthetic unit hydrograph method about upside during each minute of among time distribution method of rainfall, Huff method choosing Bocheong Stream basin that is representative basin of International Hydrologic Project (IHP) about time distribution of rainfall that exert big effect at flood discharge estimate to research target basin because of and the result is as following. Relation between probability flood discharge that is calculated through frequency analysis about flood discharge data and rainfall - runoff that is calculated through outward flow model was assumed about $48.1{\sim}95.9%$ in the case of $55.8{\sim}104.0%$, SCS synthetic unit hydrograph method in case of Clark watershed method, and Clark watershed method has big value overly in case of than SCS synthetic unit hydrograph method in case of basin that see, but branch of except appeared little more similarly with frequency flood discharge that calculate using survey data. In the case of Critical duration, could know that change is big area of basin is decrescent. When decide time distribution type of rainfall, apply upside during most Huff 1-ST because heavy rain phenomenon of upsides appears by the most things during result 1-ST about observation recording of target area about Huff method to be method to use most in business, but maximum value of peak flood discharge appeared on Huff 3-RD too in the case of upside, SCS synthetic unit hydrograph method during Huff 3-RD incidental of this research and case of Clark watershed method. That is, in the case of Huff method, latitude is decide that it is decision method of reasonable design floods that calculate applying during all $1-ST{\sim}4-TH$.

• 한국농공학회지
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• 제29권3호
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• pp.138-144
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• 1987

This study was conducted to pursue the normalization of frequency distribution by making approach the coefficient of skewness to nearly zero tbrough SMEMAX transformation and to get probable minimum flows can be acquired by means of transforrnation equation which has been derivated by SMEMAX method to the annual minimum flow series of five watersheds along Geum river basin. The results obtained through SMEMAX method were compared with probable minimum flows according to return periods by Type III extremal distribution which has been determined as the best fitted one among probablility distributions for the analysis of minimum flow. All the results obtained through this study are summarized as follows. 1.SMEMAX transformation based on median value was proved to be the best method when the coefficient of skewness has less reliability because of the short duration for the observation and were not affected by accidental outliers. 2.SMEMAX transformation has found to be the best one for the coefficient of skewness to be made nearly zero in comparison with log and cubic root transformation. 3.Probable minimum flows according to the return periods were derivated by transformation equations obtained through theoretical analysis of SMEM AX transformation. 4.In general, probable minimum flows by SMEMAX method were appeared as higher values in the range of five and twenty years and as lower ones in the range of below than five and more than fifty years in return periods respectively, in comparison with the results of type III extremal distribution. 5.Relative errors in the probable minimum flows of SMEMAX method to the results of type III extremal distribution were shown to be within ten percent except those of one hundred years in return periods. 6.SMEMAX method was also confirmed to be useful for the analysis of minimum flow frequency as well as flood frequency analysis.

• Journal of Periodontal and Implant Science
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• 제39권sup2호
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• pp.269-278
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• 2009

Purpose: The aim of this study was to investigate matrix metalloproteinase 1 (MMP-1) gene polymorphism (1G/2G at -1607 and A/G at -519) in Korean subject and to assess the association between polymorphism and periodontal status. Methods: Forty nine generalized aggressive periodontitis (GAP) patients and 57 periodontally healthy children were recruited and genomic DNA was extracted from buccal swab. The polymorphisms of MMP-1 promoter genes were determined by polymerase chain reaction and restriction fragment length product (PCR-RFLP) method. The distribution of genotype and allele frequency was compared between 2 groups by ${\chi}^2$ test. Results: There was a significant difference in the distribution of genotypes and frequency of alleles between the GAP and reference groups at the position - 519 of MMP-1 gene promoter (P<0.05). Allele G carrier rate was significantly lower in GAP group than that of the reference group (P< 0.001). At the position -1607 of MMP-1 gene promoter, genotype distribution and allele frequency showed no statistically significant difference between the groups. However, in the female group, a significant difference was observed between the groups for the genotype distribution, allele frequency and allele 1G carrier rate (P< 0.05). Conclusions: The DNA polymorphism at the MMP-1 gene promoter might be associated with GAP in Korean.

• 대한치과교정학회지
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• 제24권2호
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• pp.247-273
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• 1994

The purpose of this study was to evaluate the dental arch morphology and the occlusal characteristics in the Koreans from the dental-anthropological point of view. The sample consisted of dental stone casts obtained from 120 Korean adults and 142 Japanese adults. Japanese casts and Caucasian data had been preserved at the Dept, of Orthodontics of Tokyo Medical and Dental University. Tooth size and dental arch morphology of the Koreans were compared with that of the Japanese. On the other hand, the variations of 30 crown traits, categorized and quantitatively graded, were compared between two peoples and the frequency distribution of each crown traits were analyzed by means of Chi-square test. The results were summerized as followings ; 1. There was a significant sexual difference in dental arch length and width in the Korean, in which male had a longer and wider dental arch than female. There was a close resemblance for dental arch morphology between the Koreans and the Japanese, except for a little longer mandibular arch of the Japanese. 2. In general, Korean male had wider crown than female, particulary in central incisor,canine,1st molar of maxilla and canine, 1st and 2nd molar of mandible with significance. The Korean had wider maxillary first molar, smaller mandibular first and second molar than the Japanese in both sex. 3. In crown traits of the Korean, shovel-shaped incisor showed lower frequency distribution than in the Japanese, but higher than in the Caucasians. Frequency of incisor reduction was shown higher distribution than in the Japanese and the Caucasians. Carabelli's tubercle showed higher frequency distribution than in Japanese, but remarkably lower than in Caucasians.

• 대한토목학회논문집
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• 제32권6D호
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• pp.679-686
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• 2012

지난 2004년 4월 경부고속철도 1단계 개통이후, 2단계 사업은 2010년 11월 개통하였으며, 고속철도 개통이후 타 교통수단에 비해 속도 경쟁의 장점을 가지고 있어 고속철도의 수요는 계속 증가하고 있다. 이러한 고속철도의 개통은 인구의 이동, 기업의 입지, 공간구조의 개편 등과 같은 사회적, 경제적, 교통적인 변화를 주도하고 있는 실정이며. 특히 고속철도의 고속운행으로 지역간의 이동시간을 단축한다는 점에서 고속철도 수요는 계속적인 증가 추세로 전망된다. 본 연구에서는 고속철도 서울역 설문조사의 데이터를 이용한 EMME/2 프로그램의 2-Dimentional Blancing을 활용한 고속철도 역 접근수단별 통행분포 모형의 파라메타 추정을 통하여 조사 통행분포를 추정 통행분포와 같이 재현하고자 하였으며, 분석 결과 접근수단별로 파라메타(${\theta}$)는 승용차 0.0395, 버스 0.0390, 지하철 0.0415, 택시 0.0650으로 분석되었고, 통행거리빈도분포(Trip Length Frequency Distribution: TLFD)를 기준으로 조사치와 모형치를 비교한 결과 $R^2$는 승용차 0.909, 버스0.923, 지하철 0.922, 택시 0.745로 조사치와 모형치는 유사한 것으로 분석 되었으며, F검증 결과 P값이 모두 0.05보다 매우 작게 분석되어 95%신뢰수준으로 유의할 만 한 것으로 판단되었다. 통행거리빈도분포를 5km 단위로 설정하여 분석 하였으나, 향후에는 통행거리빈도분포를 중죤단위에서 소죤단위(행정동)로 세분화 연구가 필요하며, 통행거리 0~5km 구간의 분포을 반영할수 있는 결합함수(Combined function)을 활용한 중력모형과 3-Dimentional Blancing을 적용한 연구가 필요 할 것으로 판단된다.

• 암석학회지
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• 제20권1호
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• pp.23-37
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• 2011

제3기 결정질 응회암에서 발달하는 미세균열 모집단의 길이분포에 대한 스케일링 성질을 조사하였다. 15개 방향각 및 5개 그룹 (I~V)에 대한 길이범위의 분포도에서 미세균열의 방향성에 따른 평균길이의 체계적인 변화가 나타난다. 분포도는 거의 남-북방향을 경계로 하여 좌우 대칭형태를 취하는 것이 특징이다. 미세균열의 모집단에 대한 길이-누적빈도 도표의 전 영역은 상관곡선의 분포양상에 의하여 3개 구간으로 구분할 수 있다. 특히, 5개 그룹에 대한 각 도표의 선형의 중앙구간은 멱함수 분포를 지시한다. 5개 그룹에 대한 중앙의 선형구간의 빈도비는 46.6%~67.8T의 범위이다. 한편 각 그룹에 대한 선형의 중앙구간의 기울기는 그룹 V($N60{\sim}90^{\circ}E$, -2.02) > 그룹 IV($N20{\sim}60^{\circ}E$, -1.55) > 그룹 I($N60{\sim}90^{\circ}W$, -1.48), 그룹 II($N10{\sim}60^{\circ}W$, -1.48) > 그룹 III($N10^{\circ}W{\sim}N20^{\circ}E$, -1.06)의 순으로 나타난다. 거의 멱함수의 길이분포를 따르는 부집단(5개 그룹)에서는 지수(-1.06~-2.02)의 범위가 넓다. 5개 그룹간의 이러한 지수의 상대적인 차이는 방향성 효과의 중요성을 강조한다. 또한, 곡선의 하부에서의 기울기의 분리는 보다 긴 미세균열의 급격한 발달을 대변하며, 멱함수 지수의 감소로 반영된다. 특히, 이러한 분포양식은 $N10{\sim}20^{\circ}E,\;N10{\sim}20^{\circ}W$ 및 $N60{\sim}70^{\circ}W$의 방향각에 대한 도표에서 볼 수 있다. 이들 3개 방향각은 연구지역 일대에서 발달한 단층의 주방향과 부합한다. 15개 방향각에 대한 길이-누적빈도 도표의 개개 특성을 보여주는 분포도를 작성하였다 상기한 도표들을 3개 그룹(A, B and C)의 범주에 따라 배열함으로서 이들 그룹간 길이-빈도 분포의 차이를 용이하게 도출할 수 있다. 분포도는 미세균열 조들에 대한 개별적인 분리의 중요성을 보여준다. 관계도에서, 보다 짧은 미세균열의 출현빈도는 그룹A > 그룹 B > 그룹 C의 순서를 보인다. 이들 3가지 유형의 분포양상은 미세균열이 성장하는 동안 발생한 과정들에 대한 중요한 정보를 드러낼 수 있다.

• 한국농공학회논문집
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• 제64권2호
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• pp.47-55
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• 2022

The objective of this study was to analyze the effect of the duration and time distribution of probability rainfall on farmland inundation for the paddy fields in the drainage improvement project site. In this study, eight drainage improvement project sites were selected for inundation modeling. Hourly rainfall data were collected, and 20- and 30-year frequency probability rainfalls were estimated for 14 different durations. Probability rainfalls were distributed using Intensity-Duration-Frequency (IDF) and Huff time distribution methods. Design floods were calculated for 48 hr and critical duration, and IDF time distribution and Huff time distribution were used for 48 hr duration and critical duration, respectively. Inundation modeling was carried out for each study district using 48 hr and critical duration rainfalls. The result showed that six of the eight districts had a larger flood discharge using the method of applying critical duration and Huff distribution. The results of inundation depth analysis showed similar trends to those of design flood calculations. However, the inundation durations showed different tendencies from the inundation depth. The IDF time distribution is a distribution in which most of the rainfall is concentrated at the beginning of rainfall, and the theoretical background is unclear. It is considered desirable to apply critical duration and Huff time distribution to agricultural production infrastructure design standards in consideration of uniformity with other design standards such as flood calculation standard guidelines.