• Title/Summary/Keyword: Free Thyroxine

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Serum Thyroxine to Thyroxine-Binding Globulin Ratio in Pregnancy and Newborn (신부(娠婦)와 신생아(新生兒)에서 혈청(血淸)Thyroxine/Thyroxine-Binding Globulin 비(比))

  • Kim, Ji-Yeul
    • The Korean Journal of Nuclear Medicine
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    • v.16 no.2
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    • pp.59-61
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    • 1982
  • To evaluate the diagnostic value of the ratio of serum tyroxine$(T_4)$/thyroxine-binding globulin (TBG) for the thyroid status in pregnancy and newborn serum thyroxine, TBG, triiodothyronine, and free thyroxine levels were radioimmunoassayed in normal pregnant women at each of the trimesters, and the calculated serum $T_4/TBG$ ratios were compared with other parameters such as $T_3/TBG$ ratio and free $T_4/TBG$ ratio and free $T_4/TBG$ ratio. Serum $T_4$ levels were elevated with the propotionate increase in TBG levels during pregnancy, leading to the nearly constant value of serum $T_4/TBG$ ratios as in normal non-pregnant controls. In contrast, serum $T_3/TBG$ and free $T_4/TBG$ ratios varied considerably during pregnancy. In newborn, $T_4$ levels were nearly not changed with compared non-pregnant control value and TBG levels were elevated. The results indicate that serum $T_4/TBG$ ratio is a better parameter than others in evaluating the thyroid status during pregnancy and but newborn is a no better.

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A Study on the Specific Hormone Characteristics on the Blood in Four Types of Physical Constitution (체질(體質)에 따른 혈중(血中) Hormone 특성(特性)에 관한 연구(硏究))

  • Kim, Dae Seong;Kim, Gyeong-Yo;Han, Jong-Hyeon
    • Journal of Sasang Constitutional Medicine
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    • v.4 no.1
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    • pp.193-212
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    • 1992
  • Comparative hormones quantities on the blood analysis was carried out to investigate the hormones specific characters on the blood in four types of physical constitution. Thyroid-stimulating (TSH), triiodothyronine($T_3$), triiodothyronine uptake($T_3$ uptake), free triiodothyronine(free $T_3$), thyroxine($T_4$), free thyroxine (free $T_4$), thyroxine-binding globulin(TBG), adrenocorticotropic hormone(ACTH), luteinizing hormone(LH), testosterone were measured. The results obtained were summarized as follows: 1. The value of thyroid-stimulating hormone(TSH) on the constitution didn't shown significant difference, while the value of So-EUM-IN was increased and SO-YANG-IN was decreased. 2. The value of triiodothyronine($T_3$) on the constitution didn't shown significant difference, while the value of TAE-EUM-IN was decreased. 3. The value of triiodothyronine uptake($T_3$ uptake) on the constitution didn't shown significant difference, but between the value of TAE-EUM-IN and SO-EUM-IN, TAE-EUM-In and SO-YANG-IN showed significant difference. 4. The value of free triiodothyronine(free $T_3$) on the constitution didn't shown signifcant difference, but between the value of TAE-EUM-IN and SO-EUM-In, TAE-EUM-In and SO-YANG-IN showed significant difference. 5. The value of thyroxine($T_4$) on the constitution didn't shown significant difference, while the value of TAE-EUM-IN and SO-YANG-IN showed difference. 6. The value of free thyroxine(free $T_4$) on the constitution didn't shown significant difference, but between the value of TAE-EUM-IN and SO-YANG-IN showed significant difference. 7. The value of thyroxine-binding globulin(TBG) on the constitution didn't shown significant difference. 8. The value of adrenocorticotropic hormone(ACTH) on the constitution didn't shown significant difference. 9. The value of luteinizing hormone(LH) on the constitution didn't shown significant difference, but between the value of TAE-EUM-IN and SO-EUM-IN, TAE-EUM-IN and SO-YANG-IN showed significant difference. 10. The value of testosterone on the constitution didn't shown significant difference.

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Underlying mechanism of antioxidant action of Haejohwan in thyroxine-induced hyperthyroid rats (해조환(海藻丸)이 갑상선(甲狀腺) 기능항진증(機能亢進症)에서 항산화(抗酸化) 효과(效果)에 미치는 영향(影響))

  • Park, Jong-Hyuck;Yoon, Cheol-Ho;Seo, Un-Kyo;Kang, Jeong-Jun;Seo, Jong-Eun;Shin, Uk-Seob;Jeong, Ji-Cheon
    • The Journal of Internal Korean Medicine
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    • v.21 no.3
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    • pp.399-407
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    • 2000
  • This study was carried out to examine if Haejohwan (HJ) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats. Triiodothyronine $(T_3)$, thyroxine $(T_4)$, lipid peroxidation, xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in HJ extract's pre-applied group. Glutathione level, activities of glutathione peroxidase, glutathione Stransferase and glutathione reductase were decreased in thyroxine treated group. But, they were increased in HJ extract's pre-applied group. These results suggest that in thyroxine-induced hyperthyroid rats HJhas an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities, and prevents lipid peroxidation.

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Preliminary Studies on the Measurement of the Free Thyroxine in the Serum by the Radioimmunoassay (방사면역측정법(放射免疫測定法)에 의한 혈중(血中) 유리(遊離) Thyroxine 농도측정(濃度測定)에 대(對)한 기초적(基礎的) 검토(檢討))

  • Lee, Joon-Il
    • Journal of radiological science and technology
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    • v.10 no.1
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    • pp.85-90
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    • 1987
  • Preliminary studies on the measurement of the free thyroxine in the serum with Amerlex $FT_{4}$ RIA kit were investigated using a tracer as $^{125}I-T_{4}$ derivative which is not almostly bound to thyroxine binding globulin, etc. The results are followed: 1. Linearity was tested on standards at various concentrations, and reproducibility and accuracy was excellent. 2. The antibody specificity is also excellent, and standard calibration curve of total $T_{4}$ was similar that of adding the TBG inhibitor. 3. Each value of $T_{4}$ in serum (the normal group, the hypothyroidism patients the pregnant women and the TBG dificiency patients) was not significant. As mentioned above, this method is more simple and rapid, compared to the other method.

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Influence of Thyroxine on the Hepatotoxicity of Carbon Tetrachloride ($CC1_4$의 간장독작용(肝臟毒作用)에 미치는 Thyroxine의 영향(影響))

  • Hong, Ki-Sung;Cheon, Yun-Sook
    • The Korean Journal of Pharmacology
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    • v.16 no.2 s.27
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    • pp.31-38
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    • 1980
  • Calvert et al. formulated the hypothesis that carbon tetrachloride ($CCl_4$) acted on the central nervous system to produce and intensify sympathetic discharge which resulted in anoxic necrosis of the liver. Recknagel suggested that the essential feature of $CCl_4$ hepatotoxicity depended on the cleavage of it to $CCl_3$(free radical) and the peroxidative decomposition of cytoplasmic membrane structural lipids. And there are many reports which show the increase of adrenergic activity in hyperthyroidism. In this paper, the influence of thyroxine on the hepatotexicity of carbon tetrachloride was investigated in mice. The results obtained were summarized as follows; 1) Hepatic total lipid and lipid peroxide contents were slightly decreased by L-sodium thyroxine injection(4mg/kg/day for 4days or 6days), but hepatic glycogen content was significantly decreased. 2) Hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were significantly increased by $CCl_4$ (4 ml/kg single dose or triple dose: 4ml/kg/day for 3days), but hepatic glycogen content was significantly decreased. 3) The increase of hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity induced by $CCl_4$ were significantly inhitited by the pretreatment of thyroxine. 4) The decrease of hepatic glycogen induced by $CCl_4$ was not affected by the pretreatment of thyroxine.

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The association of Osteoporosis and Thyroid Hormone in euthyroid adults (갑상선기능이 정상인 성인에서 골다공증과 갑상선호르몬의 관련성)

  • Yoon, Hyun;Ryu, Eun-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.2
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    • pp.1137-1144
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    • 2015
  • This study examined the impact of osteoporosis on thyroid hormone in health check-up examinees. The study subjects were 1,117 adults, 20 years and over (636 males, 481 females), who underwent a health package check-up at the general hospital G from January to December, 2011. After adjusting for factors, such as year and gender, the mean thyroid stimulating hormone increased with decreasing T-score (Normal[${\geq}-1g/cm^2$], $1.61{\pm}0.07{\mu}IU/m{\ell}$ and osteopenia[-1 >, ${\geq}-2.5g/cm^2$],$1.82{\pm}0.08{\mu}IU/m{\ell}$ and osteoporosis[< $-2.5g/cm^2$],$3.14{\pm}0.27{\mu}IU/m{\ell}$). After adjusting for factors, such as gender and FBS, the mean free thyroxine decreased with decreasing T-score(Normal, $1.30{\pm}0.01ng/d{\ell}$, and osteopenia, $1.22{\pm}0.01ng/d{\ell}$, and osteoporosis, $1.13{\pm}0.04ng/d{\ell}$). Conclusion. These results suggest that a decrease in T-score might increase the thyroid stimulating hormone and decrease the free thyroxine levelin euthyroid adults.

A Case Report of Cerebral Infarction in an Elderly Patient with Subclinical Hypothyroidism (불현성 갑상선기능저하증이 병발한 고령의 뇌졸중 환자의 호전 1례)

  • Woo, Sung-Ho;Kim, Byung-Chul;Shim, Hyo-Ju;Na, Eu-Jin;Kang, Rae-Yeop;Kim, Jin-Won;Seo, Ho-Seok;Kim, Jung-Uk;Kim, Yong-Ho
    • The Journal of Internal Korean Medicine
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    • v.28 no.3
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    • pp.624-631
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    • 2007
  • Hypothyroidism is a common disease of the endocrinal system, characterized by fatigue, cold intolerance, bradycardia, and so on. Subclinical hypothyroidism is a common biochemical abnormality which can be found in routine screening tests of thyroid function. It is defined as an asymptomatic state which characterized by normal free thyroxine(FT4) and elevated thyroid stimulating hormone(TSH) levels. The purpose of this study was to evaluate the effect of treatment with palmijihwang-tang and to observe the changes in triiodothyronine(T3), free thyroxine(FT4), thyroid stimulating hormone(TSH) level and VAS of cold intolerance, hoarseness, dry skin. After the treatment, triiodothyronine(T3) increased from 57.12ng/dl to 120.53ng/dl. Free thyroxine(FT4) increased from 12.59pg/ml to 14.21pg/ml. Thyroid stimulating hormone(TSH) decreased from 10.61mU/L to 1.57mU/L. Cold intolerance, hoarseness and dry skin changed for the better. These results support a role for oriental medical therapy in treating subclinical hypothyroidism. Further case studies of herbal treatment of this ailment are needed.

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Studies on the Clinical Significance of Free Thyroxine Concentration in Serum by Radioimmunoassay (방사면역측정법(放射免疫測定法)에 의한 혈중(血中) 유리(遊離) Thyroxine 농도측정(濃度測定)의 임상적(臨床的) 의의(意義)에 대(對)한 검토(檢討))

  • Lee, Joon-Il
    • Journal of radiological science and technology
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    • v.11 no.1
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    • pp.25-31
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    • 1988
  • Studies on the clinical significance with Amerlex $FT_{4}$ RIA kit observing the determination of $FT_{4}$ were investigated using a tracer as $^{125}I-T_{4}$ derivative which is not almostly bound to thyroxine binding globulin, etc. The results are followed; 1. $FT_{4}$ value($1,55{\pm}0.38ng/100ml$) of normal group was not accorded that of hyperthyroidism with Amerlex $FT_{4}$ RIA kit, and was higher than that of hypothyroidism. 2. $FT_{4}$ value was lower level in chronic-kidney disfunction syndrome whereas, it was normal in a cancer patient, a woman in pregnancy and a patient in TBG disfunction. 3. The value of this method is a good corelationship at that of equilibrium dialysis method. (r=0.931) 4. $FT_{4}$ value by this kit was linear relationship to those of the other kit (Gamma Coat and Liquisol), and the normal value of each methods was also similar. As mentioned above, this method is more simple and rapid, compared to the other method. Therefore, it was thought that this method is a very useful clinically.

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