대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

해조환(海藻丸)이 갑상선(甲狀腺) 기능항진증(機能亢進症)에서 항산화(抗酸化) 효과(效果)에 미치는 영향(影響)

Underlying mechanism of antioxidant action of Haejohwan in thyroxine-induced hyperthyroid rats

  • 박종혁 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 강정준 (한서대학교 한방병원 내과) ;
  • 서종은 (한서대학교 한방병원 내과) ;
  • 신억섭 (동국대학교 의료원 약제과) ;
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Park, Jong-Hyuck (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Seo, Un-Kyo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.) ;
  • Kang, Jeong-Jun (Dept. of Internal Medicine, Oriental Medical Hospital, Hanseo Univ.) ;
  • Seo, Jong-Eun (Dept. of Internal Medicine, Oriental Medical Hospital, Hanseo Univ.) ;
  • Shin, Uk-Seob (Dept. of Pharmacy, Dongguk Medical Center) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk Univ.)
  • 발행 : 2000.11.30
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초록

This study was carried out to examine if Haejohwan (HJ) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats. Triiodothyronine $(T_3)$, thyroxine $(T_4)$, lipid peroxidation, xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in HJ extract's pre-applied group. Glutathione level, activities of glutathione peroxidase, glutathione Stransferase and glutathione reductase were decreased in thyroxine treated group. But, they were increased in HJ extract's pre-applied group. These results suggest that in thyroxine-induced hyperthyroid rats HJhas an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities, and prevents lipid peroxidation.

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참고문헌

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