• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.25 no.1
• /
• pp.19-26
• /
• 2012

In this study the progressive collapse behavior of a moment frame with infill steel panels is evaluated using nonlinear static pushdown analysis. The analysis model is a two story two span structure designed only for gravity load, and the load-displacement relationship is obtained with the center column removed. To obtain local stress and strain as well as the global structural behavior, finite element analysis is conducted using ABACUS. Through the analysis the effect of the span length and the thickness of the steel plate on the progressive collapse behavior of the structure is investigated, and the effect of the dividing the infill panel using stud columns is also studied. According to the analysis results, the thickness of the panels required to prevent progressive collapse increases as the span length increases, and as the number of panel division increases the progressive collapse resisting capacity increases slightly but the effect is not significant. It is also observed that when the infill panel is installed in only a part of the span the progressive collapse resisting capacity is somewhat increased.

• Proceedings of the Korean Biophysical Society Conference
• /
• 2003.06a
• /
• pp.50-50
• /
• 2003

We have identified and analysed a putative response regulator two-component gene (CaSKN7) from Candida albicans and its encoding protein (CaSkn7). CaSKN7 has an open reading frame of 1677bp. CaSKN7 encodes a 559 amino acid protein (CaSkn7) with an estimated molecular mass of 61.1 kDa. CaSKN7 is a homologue of a Saccharomyces cerevisiae SKN7 that is the regulator involved in the oxidative stress response. To study the role of CaSKN7, we constructed a CAI4-derived mutant strain carrying a homozygous deletion of the CaSKN7 gene. In the caskn7 disruptant cells, the formation of germ tube require shorter time than that in the congenic wild-type strain but the growth of mycelium delayed in liquid media. In contrast, the caskn7 disruptant cells attenuate the differentiation in solid media and the virulence in mouse model system. Expression level of hypha-specific and virulence genes - HYR1, ECE1, HWP1, and ALS1 - in the caskn7 disruptant cells increased as compared with that in the congenic wild-type strain in 10％ serum YPD. Skn7 in 5. cerevisiae was found to bind the HSE element from the SSA promoter, Also, CaSkn7 contains heat shock factor DNA-binding domain and the promoters of these genes have HSE-like sties. Therefore these results show that CaSKN7 regulate the differentiation and virulence of C. albicans.

• Journal of Ginseng Research
• /
• v.34 no.1
• /
• pp.17-22
• /
• 2010

Sesquiterpenes are found naturally in plants and insects as defensive agents or pheromones. They are produced in the cytosolic acetate/mevalonate pathway for isoprenoid biosynthesis. The inducible sesquiterpene synthases (STS), which are responsible for the transformation of the precursor farnesyl diphosphate, appear to generate very few olefinic products that are converted to biologically active metabolites. In this study, we isolated the STS gene from Panax ginseng C.A. Meyer, designated PgSTS, and investigated the correlation between its expression and various abiotic stresses using real-time PCR. PgSTS cDNA was observed to be 1,883 nucleotides long with an open reading frame of 1,707 bp, encoding a protein of 568 amino acids. The molecular mass of the mature protein was determined to be 65.5 kDa, with a predicted isoelectric point of 5.98. A GenBank BlastX search revealed the deduced amino acid sequence of PgSTS to be homologous to STS from other plants, with the highest similarity to an STS from Lycopersicon hirsutum (55% identity, 51% similarity). Real-time PCR analysis showed that different abiotic stresses triggered significant induction of PgSTS expression at different time points.

• Child Health Nursing Research
• /
• v.8 no.3
• /
• pp.322-333
• /
• 2002

Purpose: The purpose of study was : 1) to analyse the trend of research on the sensory stimulation in newborn in Korea, 2) to suggest direction for further study on the sensory stimulation in newborn and contributing to the use of intervention in newborn. Method: Research studies on the sensory stimulation in newborn were selected from the dissertations, parents-child health. Academic Society Journal, and from Korean Journal of Pediatrcs which were conducted between 1984 and 2002. The total numbers of the studies were 15. These studies were analyzed for 1) time of publication or presentation 2) thesis for a degree or nondegree 3) characteristics of subjects 4) sample size 5) research design 6) type of sensory stimualtion 7) meaurement tool 8) result. Result : 1)The most year of studies were the 1996's～ 2000's. 2) The degree of studies were higher than nondegree. 3) The most characteristics of subjects were the premature infants. 4) The most frequent sample sizes were 11-20. 5) The all research design was nonequivalent control group pretest-posttest design in quasi experimental basis. 6) The most type of sensory stimulation was Field massage(tactile and kinesthetic). 7) The measurement tool used all objective tools. 8) The most research data were collected by the measure of the weight, heart rate, behavior state, respiration, stress hormon and positive results. Conclusion: 1) Human sensory stimulation did not seem to harm the infants. 2) several positive effects of sensory stimulation that have been reported previously must be reevaluated. 3) further research will be required large sample size, long-term outcome, individualized stimulation program, early parent-infant contact in order to enhance the development of attachment, to determine the underlying mechanism and theorical frame for these stimulation effect.

• Journal of Korean Association for Spatial Structures
• /
• v.16 no.2
• /
• pp.61-68
• /
• 2016

Behavior of RC(Reinforced-concrete) beam-column connections has been subjected to the earthquake loading has been determined by shear and attachment mechanism. However, since the shear and attachment are very fragile for cycle loadings. Through occurring plastic hinges at the beam, the column and the connection should remain elastic condition and the beam should dissipate the energy from the earthquake. This study was investigate on the seismic performance of 6 RC beam - column connections built with the high strength reinforcements (700MPa) based on design and detailing requirements in the ACI 318-05 Provision and KCI-07 appendix II. This is aimed to evaluate the effect of the high-strength reinforcements as used the beam-column connection members. The main comparisons were the seismic performance of the connections affect the seismic performance in terms of strength, stiffness and ductility, joint shear stress-strain. A total of 6 beam-column specimens were built with a 1/2 scale and subjected to the cyclic loadings. Main design considerations were the area of the longitudinal reinforcements of the beam and details of the beam-column joint designed based on the seismic code. Cyclic test results are given and recommendations for the usage of high strength reinforcements for the seismic design is provided.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.65 no.3
• /
• pp.411-418
• /
• 2016

In accordance with global energy conservation policies such as MEPS(Minimum Energy Performance Standard), electric motor industry is moving to super-high-efficiency machines and research to develop IE4 (International Energy Efficiency Class4) motors has been launched. In this situation, SynRM (Synchronous Reluctance Motor) has been attracting attention in place of induction motor which hardly provides super premium efficiency. As a result, much research on SynRM is being performed at home and abroad. Also, some products have already been appearing in the market. Compared to induction motor, SynRM has better efficiency per unit area and wider operating range. Although the utilization of control system in synchronous motor results in higher prices, we still need to concentrate on developments of SynRM so as to comply with the new policies. This study demonstrated the electromagnetic design methods of super-premium SynRM while maintaining the frame of existing IE3 induction motor for blower. We documented the design procedures for generating high saliency which is the most essential and mechanical stress analysis is also treated. In conclusion, we proved the validity of our design by manufacturing and testing our SynRM models.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2017.05a
• /
• pp.205-206
• /
• 2017

Casual games are often have simple rule and easy to play. Like Angry birds, players can sling a bird as a bomb to destroy target. But the film adaption encounters numerous questions. games in pursuit of strong sensed presence, pay attention to experience; film stress the integrity of the story, attaches great importance to plot. However, casual games don't have story and plot. This paper take angry birds as example, analyzes the difficulties and method of adaptation from leisure mobile games to films, summarizes the key successful elements of adaption, such as subdivided the target group, chose an appropriate genre, write a script follow the basic logic and frame of film, set contradiction, complicated the character and still contain key elements of the game, in order to provide new ideas in the future development of integration of game and movie industry.

• Journal of architectural history
• /
• v.23 no.1
• /
• pp.7-19
• /
• 2014

This study considers the proper repair techniques by examining the most representative repair cases of the Korean arch bridges and proposes the constructional manual which can apply similar occasions. The cases are Seonamsa Seungseongyo and Songgwangsa Geukrockgyo where this researcher had taken part in the repair works. This Study proposes the maintenance construction manual about the performance degradation drew by performance degradation of the both Korean arch bridges in the maintenance process. First, arch bridge maintenance should be carried out in the dry season, when water is impermeable in the bottom surface of the bridge. Moreover, risk factors of the maintenance should be excluded to secure the water vally flow, the bypass and the temporary bridge. Second, prior to repair, it has to precede (1)3D shooting (2)formal examination (3)structure safety test (4)geological and lithic surveys (5)arch curvature establishment and makeshift frame settlement before transformation (6)relationship expert comments. Third, if the baduk and the foundation stones are inevitable to replace due to performance degradation on the foundation, it should use the high quality stones and secure greater stress by extending the standard range. The foundation on irregular rock needs to be flattened and underside on the replaced materials require Grengyijil to deliver the equal loads. Fourth, In the process of dismantling the stones of the arched bridge, it could make heavy weathering degree and not reuse the materials. Charge should converge the expert advices to choose the reuseable, the conservate and the alternative materials, and increase the reutilization of the raw materials by preservation and reinforcement treatments. Fifth, the side wall should be repaired by the rubble work technique which is not able to pile compost satiety, so it must use long depth of masonary stones for reinforcement. It is considered to reinforce the stone wall in shore as much as possible and protect the abutment and the side wall on the upstream for the arch bridge maintenance works.

• Journal of Ginseng Research
• /
• v.44 no.1
• /
• pp.79-85
• /
• 2020

Background: Helicobacter pylori increases reactive oxygen species (ROS) and induces oxidative DNA damage and apoptosis in gastric epithelial cells. DNA damage activates DNA damage response (DDR) which includes ataxia-telangiectasia-mutated (ATM) activation. ATM increases alternative reading frame (ARF) but decreases mouse double minute 2 (Mdm2). Because p53 interacts with Mdm2, H. pylori-induced loss of Mdm2 stabilizes p53 and induces apoptosis. Previous study showed that Korean Red Ginseng extract (KRG) reduces ROS and prevents cell death in H. pylori-infected gastric epithelial cells. Methods: We determined whether KRG inhibits apoptosis by suppressing DDRs and apoptotic indices in H. pylori-infected gastric epithelial AGS cells. The infected cells were treated with or without KRG or an ATM kinase inhibitor KU-55933. ROS levels, apoptotic indices (cell death, DNA fragmentation, Bax/Bcl-2 ratio, caspase-3 activity) and DDRs (activation and levels of ATM, checkpoint kinase 2, Mdm2, ARF, and p53) were determined. Results: H. pylori induced apoptosis by increasing apoptotic indices and ROS levels. H. pylori activated DDRs (increased p-ATM, p-checkpoint kinase 2, ARF, p-p53, and p53, but decreased Mdm2) in gastric epithelial cells. KRG reduced ROS and inhibited increase in apoptotic indices and DDRs in H. pylori-infected gastric epithelial cells. KU-55933 suppressed DDRs and apoptosis in H. pylori-infected gastric epithelial cells, similar to KRG. Conclusion: KRG suppressed ATM-mediated DDRs and apoptosis by reducing ROS in H. pylori-infected gastric epithelial cells. Supplementation with KRG may prevent the oxidative stress-mediated gastric impairment associated with H. pylori infection.

• Journal of Biomedical Engineering Research
• /
• v.23 no.5
• /
• pp.385-390
• /
• 2002

Nowadays, there are many attempts to develop domestic medical-equipments. In this study, it is performed to developed a new vertebral fusion device. The basic models are a rectangular-frame type and a screw type which are generally used for the patients. The main purpose of the development of a new device is to reduce the amount of bone taken out for the insertion of a device to vertebral disc and this paper is focused on th concept of a new device shape. In the results, two types are devised. One is a folding type and the other is a separate-push-in type device both are in primitive stage. However, in a folding type there are mechanical pins and the analysis of pins and the lock system is still in study and needs some time. Therefore a separate-push-in type is introduced in this study mainly and a prototype and 3-D finite element model are made and experimented and stress analyzed. From the results it is considered that it is stable for the basic loading condition of vertebra, however, it is required to develop a supporting operational equipment for the convenience of the operation in practice.